LOCUS       NP_055797               2341 aa            linear   PRI 28-APR-2025
DEFINITION  pecanex-like protein 1 isoform 1 [Homo sapiens].
ACCESSION   NP_055797
VERSION     NP_055797.2
DBSOURCE    REFSEQ: accession NM_014982.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 2341)
  AUTHORS   Li,J., Tian,H., Pan,J., Jiang,N., Yang,J., Zhou,C., Xu,D., Meng,X.
            and Gong,Z.
  TITLE     Pecanex functions as a competitive endogenous RNA of S-phase kinase
            associated protein 2 in lung cancer
  JOURNAL   Cancer Lett 406, 36-46 (2017)
   PUBMED   28789966
  REMARK    GeneRIF: High PCNX expression is associated with lung cancer.
REFERENCE   2  (residues 1 to 2341)
  AUTHORS   Cai,D.C., Fonteijn,H., Guadalupe,T., Zwiers,M., Wittfeld,K.,
            Teumer,A., Hoogman,M., Arias-Vasquez,A., Yang,Y., Buitelaar,J.,
            Fernandez,G., Brunner,H.G., van Bokhoven,H., Franke,B.,
            Hegenscheid,K., Homuth,G., Fisher,S.E., Grabe,H.J., Francks,C. and
            Hagoort,P.
  TITLE     A genome-wide search for quantitative trait loci affecting the
            cortical surface area and thickness of Heschl's gyrus
  JOURNAL   Genes Brain Behav 13 (7), 675-685 (2014)
   PUBMED   25130324
REFERENCE   3  (residues 1 to 2341)
  AUTHORS   Cummings,A.C., Jiang,L., Velez Edwards,D.R., McCauley,J.L.,
            Laux,R., McFarland,L.L., Fuzzell,D., Knebusch,C., Caywood,L.,
            Reinhart-Mercer,L., Nations,L., Gilbert,J.R., Konidari,I.,
            Tramontana,M., Cuccaro,M.L., Scott,W.K., Pericak-Vance,M.A. and
            Haines,J.L.
  TITLE     Genome-wide association and linkage study in the Amish detects a
            novel candidate late-onset Alzheimer disease gene
  JOURNAL   Ann Hum Genet 76 (5), 342-351 (2012)
   PUBMED   22881374
REFERENCE   4  (residues 1 to 2341)
  AUTHORS   Frank,J., Cichon,S., Treutlein,J., Ridinger,M., Mattheisen,M.,
            Hoffmann,P., Herms,S., Wodarz,N., Soyka,M., Zill,P., Maier,W.,
            Mossner,R., Gaebel,W., Dahmen,N., Scherbaum,N., Schmal,C.,
            Steffens,M., Lucae,S., Ising,M., Muller-Myhsok,B., Nothen,M.M.,
            Mann,K., Kiefer,F. and Rietschel,M.
  TITLE     Genome-wide significant association between alcohol dependence and
            a variant in the ADH gene cluster
  JOURNAL   Addict Biol 17 (1), 171-180 (2012)
   PUBMED   22004471
REFERENCE   5  (residues 1 to 2341)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (residues 1 to 2341)
  AUTHORS   Geisinger,A., Alsheimer,M., Baier,A., Benavente,R. and Wettstein,R.
  TITLE     The mammalian gene pecanex 1 is differentially expressed during
            spermatogenesis
  JOURNAL   Biochim Biophys Acta 1728 (1-2), 34-43 (2005)
   PUBMED   15777640
REFERENCE   7  (residues 1 to 2341)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y. PMID: 37491470]
REFERENCE   8  (residues 1 to 2341)
  AUTHORS   Roux,A.F., Rommens,J.M., Read,L., Duncan,A.M. and Cox,D.W.
  TITLE     Physical and transcription map in the region 14q24.3:
            identification of six novel transcripts
  JOURNAL   Genomics 43 (2), 130-140 (1997)
   PUBMED   9244429
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004825.2, AF233450.1,
            AK027062.1, AC005230.1, AC004817.2 and AW137672.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 8, 2007 this sequence version replaced NP_055797.1.
            
            Summary: This gene encodes an evolutionarily conserved
            transmembrane protein similar to the pecanex protein in Drosophila.
            The fly protein is a component of the Notch signaling pathway,
            which functions in several developmental processes. [provided by
            RefSeq, Jul 2016].
            
            Transcript Variant: This transcript represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF233450.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304743.7/ ENSP00000304192.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2341
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     Protein         1..2341
                     /product="pecanex-like protein 1 isoform 1"
                     /note="pecanex-like protein 1; pecanex homolog 1"
                     /calculated_mol_wt=258546
     Site            28..50
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            57..74
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RV3.2)"
     Region          98..163
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            109
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            215
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q96RV3.2)"
     Region          270..294
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RV3.2)"
     Region          311..331
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RV3.2)"
     Region          344..689
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            348
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            394
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            702
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q96RV3.2)"
     Region          756..834
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            852
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            863
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            1003..1025
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            1032..1049
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            1067..1089
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            1091
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            1110..1132
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            1155
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            1160..1182
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            1194..1213
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            1266..1288
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            1295..1312
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            1579
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            1720
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q96RV3.2)"
     Region          1782..2008
                     /region_name="Pecanex_C"
                     /note="Pecanex protein (C-terminus); pfam05041"
                     /db_xref="CDD:461533"
     Site            1982
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q96RV3.2)"
     Region          2062..2120
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            2062
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            2072
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q96RV3.2)"
     Region          2217..2237
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            2234
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q96RV3.2)"
     Site            2260
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q96RV3.2)"
     CDS             1..2341
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="NM_014982.3:393..7418"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS9806.1"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mgsqtlqilr qgvwaalsgg wyydphqatf vnalhlylwl fllglpftly malpstmiiv
       61 avycpviaav fivlkmvnyr lhraldagev vdrtaneftd qrtkaeqgnc strrkdsngp
      121 sdpgggiems efireatppv gcssrnsyag ldpsnqigsg ssrlgtaati kgdtdtakts
      181 ddislslgqs sslckegsee qdlaadrklf rlvsndsfis iqpslsscgq dlprdfsdkv
      241 nlpshnhhhh vdqslssacd tevaslvplh shsyrkdhrp rgvprtsssa vafpdtslnd
      301 fplyqqrrgl dpvselessk plsgskeslv ensglsgefq lagdlkints qpptksgksk
      361 plkaeksmds lrslstrssg stesycsgtd rdtnstvssy kseqtssthi esilsehees
      421 pkagtksgrk keccagpeek nscasdkrts sekiameast nsgvheakdp tpsdemhnqr
      481 glstsaseea nknphaneft sqgdrppgnt aenkeeksdk savsvdskvr kdvggkqkeg
      541 dvrpksssvi hrtasahksg rrrtgkkras sfdssrhrdy vcfrgvsgtk phsaifchde
      601 dssdqsdlsr assvqsahqf ssdsssstts hscqspegry salktkhthk ergtdsehth
      661 kahlvpegts kkratrrtss tnsaktrarv lsldsgtvac lndsnrlmap esikplttsk
      721 sdleakegev ldelsllgra sqletvtrsr nslpnqvafp egeeqdavsg aaqaseeavs
      781 frrerstfrr qavrrrhnag snptpptlli gsplslqdgq qgqqstaqvk vqsrppsqaa
      841 vlsasasllv rngsvhleas hdnasavggs slhdelgkfs stlyetggcd mslvnfepaa
      901 rrasnicdtd shvssstsvr fyphdvlslp qirlnrllti dtdlleqqdi dlspdlaaty
      961 gpteeaaqkv khyyrfwilp qlwiginfdr ltllalfdrn reilenvlav ilailvaflg
     1021 silliqgffr diwvfqfclv iascqysllk svqpdssspr hghnriiays rpvyfciccg
     1081 liwlldygsr nltatkfkly gitftnplvf isardlvivf tlcfpivffi gllpqvntfv
     1141 mylceqldih ifggnattsl laalysfics ivavallygl cygalkdswd gqhipvlfsi
     1201 fcgllvavsy hlsrqssdps vlfslvqski fpkteeknpe dplsevkdpl peklrnsvse
     1261 rlqsdlvvci vigvlyfaih vstvftvlqp alkyvlytlv gfvgfvthyv lpqvrkqlpw
     1321 hcfshpllkt leynqyevrn aatmmwfekl hvwllfvekn iiyplivlne lsssaetias
     1381 pkklntelga lmitvaglkl lrssfsspty qyvtviftvl ffkfdyeafs etmlldlffm
     1441 silfnklwel lyklqfvyty iapwqitwgs afhafaqpfa vphsamlfiq aavsaffstp
     1501 lnpflgsaif itsyvrpvkf werdyntkrv dhsntrlasq ldrnpgsddn nlnsifyehl
     1561 trslqhslcg dlllgrwgny stgdcfilas dylnalvhli eignglvtfq lrglefrgty
     1621 cqqreveait egveedegfc ccepghiphm lsfnaafsqr wlawevivtk yilegysitd
     1681 nsaasmlqvf dlrkvlttyy vkgiiyyvtt sskleewlan etmqeglrlc adrnyvdvdp
     1741 tfnpnidedy dhrlagisre sfcviylnwi eycssrrakp vdvdkdsslv tlcyglcvlg
     1801 rralgtashh mssnlesfly glhalfkgdf rissirdewi fadmellrkv vvpgirmsik
     1861 lhqdhftspd eyddptvlye aivsheknlv iahegdpawr savlanspsl lalrhvmddg
     1921 tneykiimln rrylsfrvik vnkecvrglw agqqqelvfl rnrnpergsi qnakqalrnm
     1981 insscdqpig ypifvspltt sysdsheqlk dilggpislg nirnfivstw hrlrkgcgag
     2041 cnsggnieds dtgggtsctg nnattannph snvtqgsign pgqgsgtglh ppvtsypptl
     2101 gtshsshsvq sglvrqspar asvasqssyc yssrhsslrm sttgfvpcrr sstsqislrn
     2161 lpssiqsrls mvnqmepsgq sglacvqhgl pssssssqsi packhhtlvg flateggqss
     2221 atdaqpgntl spannshsrk aeviyrvqiv dpsqilegin lskrkelqwp degirlkagr
     2281 nswkdwspqe gmeghvihrw vpcsrdpgtr shidkavllv qiddkyvtvi etgvlelgae
     2341 v
//
