LOCUS       NM_006031              10526 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens pericentrin (PCNT), transcript variant 1, mRNA.
ACCESSION   NM_006031
VERSION     NM_006031.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10526)
  AUTHORS   Majumder,S., Chattopadhyay,A., Wright,J.M., Guan,P., Buja,L.M.,
            Kwartler,C.S. and Milewicz,D.M.
  TITLE     Pericentrin deficiency in smooth muscle cells augments
            atherosclerosis through HSF1-driven cholesterol biosynthesis and
            PERK activation
  JOURNAL   JCI Insight 8 (21), e173247 (2023)
   PUBMED   37937642
  REMARK    GeneRIF: Pericentrin deficiency in smooth muscle cells augments
            atherosclerosis through HSF1-driven cholesterol biosynthesis and
            PERK activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10526)
  AUTHORS   Wang,X., Yang,J., Luo,L., Li,X. and Zhang,Y.
  TITLE     PCNT is a prognostic biomarker correlated with tumor immune
            microenvironment in hepatocellular carcinoma and promotes tumor
            progression by inhibiting cell cycle arrest
  JOURNAL   Aging (Albany NY) 15 (10), 4122-4143 (2023)
   PUBMED   37211383
  REMARK    GeneRIF: PCNT is a prognostic biomarker correlated with tumor
            immune microenvironment in hepatocellular carcinoma and promotes
            tumor progression by inhibiting cell cycle arrest.
REFERENCE   3  (bases 1 to 10526)
  AUTHORS   Zhou,J., Chen,C., Zhao,X., Jiang,T., Jiang,Y., Dai,J. and Chen,J.
  TITLE     Coding variants in the PCNT and CEP295 genes contribute to breast
            cancer risk in Chinese women
  JOURNAL   Pathol Res Pract 225, 153581 (2021)
   PUBMED   34418690
  REMARK    GeneRIF: Coding variants in the PCNT and CEP295 genes contribute to
            breast cancer risk in Chinese women.
REFERENCE   4  (bases 1 to 10526)
  AUTHORS   Jung,G.I. and Rhee,K.
  TITLE     Triple deletion of TP53, PCNT, and CEP215 promotes centriole
            amplification in the M phase
  JOURNAL   Cell Cycle 20 (15), 1500-1517 (2021)
   PUBMED   34233584
  REMARK    GeneRIF: Triple deletion of TP53, PCNT, and CEP215 promotes
            centriole amplification in the M phase.
REFERENCE   5  (bases 1 to 10526)
  AUTHORS   Nguyen,T.H., Nguyen,N.L., Vu,C.D., Ngoc,C.T.B., Nguyen,N.K. and
            Nguyen,H.H.
  TITLE     Identification of three novel mutations in PCNT in vietnamese
            patients with microcephalic osteodysplastic primordial dwarfism
            type II
  JOURNAL   Genes Genomics 43 (2), 115-121 (2021)
   PUBMED   33460028
  REMARK    GeneRIF: Identification of three novel mutations in PCNT in
            vietnamese patients with microcephalic osteodysplastic primordial
            dwarfism type II.
REFERENCE   6  (bases 1 to 10526)
  AUTHORS   Mayor,T., Stierhof,Y.D., Tanaka,K., Fry,A.M. and Nigg,E.A.
  TITLE     The centrosomal protein C-Nap1 is required for cell cycle-regulated
            centrosome cohesion
  JOURNAL   J Cell Biol 151 (4), 837-846 (2000)
   PUBMED   11076968
REFERENCE   7  (bases 1 to 10526)
  AUTHORS   Flory,M.R., Moser,M.J., Monnat,R.J. Jr. and Davis,T.N.
  TITLE     Identification of a human centrosomal calmodulin-binding protein
            that shares homology with pericentrin
  JOURNAL   Proc Natl Acad Sci U S A 97 (11), 5919-5923 (2000)
   PUBMED   10823944
REFERENCE   8  (bases 1 to 10526)
  AUTHORS   Chen,H., Gos,A., Morris,M.A. and Antonarakis,S.E.
  TITLE     Localization of a human homolog of the mouse pericentrin gene
            (PCNT) to chromosome 21qter
  JOURNAL   Genomics 35 (3), 620-624 (1996)
   PUBMED   8812505
REFERENCE   9  (bases 1 to 10526)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
REFERENCE   10 (bases 1 to 10526)
  AUTHORS   Duker,A., Jackson,A. and Bober,M.B.
  TITLE     Microcephalic Osteodysplastic Primordial Dwarfism Type II
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   34978779
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP312870.1, AF515282.1,
            BP311784.1, DC345793.1, AB007862.3 and AW452809.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006031.5.
            
            Summary: The protein encoded by this gene binds to calmodulin and
            is expressed in the centrosome. It is an integral component of the
            pericentriolar material (PCM). The protein contains a series of
            coiled-coil domains and a highly conserved PCM targeting motif
            called the PACT domain near its C-terminus. The protein interacts
            with the microtubule nucleation component gamma-tubulin and is
            likely important to normal functioning of the centrosomes,
            cytoskeleton, and cell-cycle progression. Mutations in this gene
            cause Seckel syndrome-4 and microcephalic osteodysplastic
            primordial dwarfism type II. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF515282.1, SRR14038193.561832.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359568.10/ ENSP00000352572.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                BP312870.1         35-107
            74-2183             AF515282.1         1-2110
            2184-2227           BP311784.1         533-576
            2228-2628           AF515282.1         2155-2555
            2629-2707           DC345793.1         262-340
            2708-10080          AF515282.1         2635-10007
            10081-10522         AB007862.3         10041-10482
            10523-10526         AW452809.1         14-17               c
FEATURES             Location/Qualifiers
     source          1..10526
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..10526
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /note="pericentrin"
                     /db_xref="GeneID:5116"
                     /db_xref="HGNC:HGNC:16068"
                     /db_xref="MIM:605925"
     exon            1..127
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..10084
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pericentrin-2; pericentrin-380; kendrin; pericentrin-B"
                     /codon_start=1
                     /product="pericentrin isoform 1"
                     /protein_id="NP_006022.3"
                     /db_xref="CCDS:CCDS33592.1"
                     /db_xref="GeneID:5116"
                     /db_xref="HGNC:HGNC:16068"
                     /db_xref="MIM:605925"
                     /translation="MEVEQEQRRRKVEAGRTKLAHFRQRKTKGDSSHSEKKTAKRKGS
                     AVDASVQEESPVTKEDSALCGGGDICKSTSCDDTPDGAGGAFAAQPEDCDGEKREDLE
                     QLQQKQVNDHPPEQCGMFTVSDHPPEQHGMFTVGDHPPEQRGMFTVSDHPPEQHGMFT
                     VSDHPPEQRGMFTISDHQPEQRGMFTVSDHTPEQRGIFTISDHPAEQRGMFTKECEQE
                     CELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKETA
                     LTELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVVLRCGQEAAELKEKLQS
                     EMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQNQFQKELAEQRAELE
                     KIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESEKEKQLELE
                     NLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVEDLEQLKQRE
                     KTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGL
                     EEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRC
                     CVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHKVQLS
                     LLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNAKQKTEL
                     MKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAEMRQ
                     LQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAALHV
                     KEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLLS
                     VTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLE
                     SCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRKHEGELQSV
                     RDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEK
                     ESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGANLLSMLKA
                     DVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAP
                     ALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQS
                     LSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEES
                     AAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQE
                     QAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQM
                     KILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREE
                     FQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKES
                     ADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSL
                     LLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMKGD
                     LESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQE
                     NQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPR
                     GQALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNV
                     ALREAEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALAR
                     IRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQVELDRRQARRATAH
                     TRVPGAHPQPRMDGGAKAQVTGDVEASHDAALEPVVPDPQGDLQPVLVTLKDAPLCKQ
                     EGVMSVLTVCQRQLQSELLLVKNEMRLSLEDGGKGKEKVLEDCQLPKVDLVAQVKQLQ
                     EKLNRLLYSMTFQNVDAADTKSLWPMASAHLLESSWSDDSCDGEEPDISPHIDTCDAN
                     TATGGVTDVIKNQAIDACDANTTPGGVTDVIKNWDSLIPDEMPDSPIQEKSECQDMSL
                     SSPTSVLGGSRHQSHTAEAGPRKSPVGMLDLSSWSSPEVLRKDWTLEPWPSLPVTPHS
                     GALSLCSADTSLGDRADTSLPQTQGPGLLCSPGVSAAALALQWAESPPADDHHVQRTA
                     VEKDVEDFITTSFDSQETLSSPPPGLEGKADRSEKSDGSGFGARLSPGSGGPEAQTAG
                     PVTPASISGRFQPLPEAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHP
                     PRKEDEIQDISLHGGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSD
                     LGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEK
                     LQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQ
                     KLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQE
                     LESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQ
                     TAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQ
                     LSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQK
                     HCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQE
                     GRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESK
                     DEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVN
                     DWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALS
                     TVTQEKLELSRAVSKLEKLLKHHLQKGCSPSRSERSAWKPDETAPQSSLRRPDPGRLP
                     PAASEEAHTSNVKMEKLYLHYLRAESFRKALIYQKKYLLLLIGGFQDSEQETLSMIAH
                     LGVFPSKAERKITSRPFTRFRTAVRVVIAILRLRFLVKKWQEVDRKGALAQGKAPRPG
                     PRARQPQSPPRTRESPPTRDVPSGHTRDPARGRRLAAAASPHSGGRATPSPNSRLERS
                     LTASQDPEHSLTEYIHHLEVIQQRLGGVLPDSTSKKSCHPMIKQ"
     exon            128..340
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            341..712
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            713..793
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            794..1049
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1105
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1280
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1417
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1529
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1752
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1834
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..2009
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2227
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2682
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..3238
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            3239..3385
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            3386..3537
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3680
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            3681..3913
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            3914..4076
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            4077..4289
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            4290..4519
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            4520..4636
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            4637..4657
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            4658..4864
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            4865..5035
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            5036..5188
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            5189..6067
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            6068..6223
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            6224..6994
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            6995..7097
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            7098..7252
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            7253..7393
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            7394..7567
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            7568..7763
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            7764..7986
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            7987..8137
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            8138..8824
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            8825..9069
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            9070..9172
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            9173..9346
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            9347..9466
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            9467..9696
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            9697..9773
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            9774..9912
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            9913..10040
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            10041..10526
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10474..10479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /note="hexamer: AACAAA"
     regulatory      10494..10499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /note="hexamer: AATAAA"
     polyA_site      10495
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /note="major polyA site"
     polyA_site      10526
                     /gene="PCNT"
                     /gene_synonym="KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2;
                     SCKL4"
                     /note="major polyA site"
ORIGIN      
        1 agtgtaaata gagcgaaggc tgctctgtgt cagccccgtc accgccgggc ggcccgcgcg
       61 gagtctgagg gagatggaag ttgagcaaga gcagcggcgc agaaaggtgg aggccgggag
      121 gacgaagctt gctcacttcc gacagagaaa aacaaaaggt gacagttcgc attcggagaa
      181 aaagacggcg aagaggaagg gctcggctgt cgatgcgtct gtccaggagg agagtccggt
      241 aaccaaggag gacagcgcac tctgtggagg aggggacatt tgcaaaagca catcatgtga
      301 cgacacccct gatggggcag gaggggcctt tgcagctcag ccggaggact gtgatggaga
      361 gaagagagag gacttggaac agctgcagca gaagcaagtc aatgaccatc ctccagagca
      421 gtgtgggatg ttcacagtca gtgaccaccc accagaacag catgggatgt tcacagtcgg
      481 tgaccaccca ccagaacagc gtgggatgtt cacagtcagt gaccacccac cagaacagca
      541 tgggatgttc acagtcagtg accacccacc agaacagcgt gggatgttca caatcagtga
      601 ccaccaaccg gaacagcgtg ggatgttcac agtcagtgac cacacaccag aacagcgtgg
      661 gatcttcaca atcagtgacc acccagcaga acagcgtggg atgttcacaa aggagtgtga
      721 acaagaatgt gaacttgcca ttactgacct ggagagcggc cgtgaagatg aggctggcct
      781 gcatcagagt caggccgtgc atggccttga gctggaggcg ctgcgcctga gtctgagcaa
      841 catgcacacg gcgcagctgg agctgacaca ggccaacctc cagaaggaga aggagacggc
      901 attgacggag ctgcgggaga tgctcaacag ccggcgtgcc caggagctgg ccctgctaca
      961 gagcaggcag cagcacgagc tggagctcct cagggagcag cacgcacggg agaaggagga
     1021 ggtggtgctc aggtgtggac aggaagcagc tgagctgaag gagaagttac aatcagaaat
     1081 ggagaaaaac gcccagatag taaagaccct gaaggaagat tgggaatctg aaaaagattt
     1141 atgtttagaa aatctacgca aagaactgtc tgcaaagcat caatcagaaa tggaggattt
     1201 acaaaaccag tttcagaaag aattggcaga acagagagct gagttggaga agatttttca
     1261 agacaaaaac caggctgaac gggcccttag gaacctggag agtcatcatc aagcagccat
     1321 tgagaagtta cgtgaagacc tgcagtccga gcacggccgg tgtttagaag acttggagtt
     1381 caagttcaaa gagagcgaga aagaaaaaca gctggagtta gagaatcttc aagcatcata
     1441 tgaagacctg aaggcacaat cacaagaaga gatcaggcgc ttgtggtccc agcttgattc
     1501 tgccaggacc agtagacagg aattgagtga gctacatgag caactcctgg cgcgcacctc
     1561 tcgtgtggaa gatttagaac agctgaagca gcgagaaaaa acccagcatg agtccgaact
     1621 ggagcaactg aggatttatt ttgaaaagaa gttaagggat gctgagaaaa cttaccaaga
     1681 agacctaacc ctgttacagc agaggctgca gggggcgagg gaagatgctc ttctggactc
     1741 tgtggaagtt gggttgtcct gtgtgggttt agaagagaaa cctgagaaag gaagaaaaga
     1801 tcacgttgat gaactcgagc ctgagcgaca taaggagagc ctgccacgct tccaggcgga
     1861 gttagaagaa agccacaggc accagctgga agcgctggag tctcccctct gcatccagca
     1921 cgaggggcat gtctcagaca gatgctgcgt agagacttca gcattgggac acgagtggcg
     1981 tctggaaccc tctgaagggc acagccaaga gcttccctgg gtgcatctcc agggtgtgca
     2041 ggacggggac ttggaggccg acacagagcg ggcagccaga gtcttgggtc tggaaactga
     2101 gcacaaggtg caactttcgc ttcttcagac tgagctcaaa gaagaaattg aactcctaaa
     2161 aatagaaaat agaaatttgt atgggaagtt gcagcatgaa actcgtctga aggacgattt
     2221 ggagaaggta aaacacaatc taattgaaga ccaccagaag gaactaaata atgctaagca
     2281 aaagactgag ctgatgaaac aggaattcca aagaaaagaa acggactgga aagttatgaa
     2341 ggaggagcta cagcgggaag ctgaggagaa gttaacattg atgctacttg aactgagaga
     2401 aaaggctgaa tccgagaaac agaccatcat aaacaagttt gagcttcgag aagctgaaat
     2461 gaggcagctt caggaccaac aggcagccca gatcctggat ctggagaggt ccttgacgga
     2521 gcagcagggc cgcctgcagc agctggaaca ggacctcact tcagacgacg ccctgcattg
     2581 cagccagtgt gggcgggagc cgcccacagc ccaggacggg gagcttgctg cgctccacgt
     2641 gaaggaagac tgcgccctgc agctgatgct ggcccggagc aggtttttag aggaacgtaa
     2701 agagatcacc gagaaattca gtgcggaaca agatgccttc ctgcaggagg cccaggagca
     2761 gcatgcccgt gagctgcagc tcctccagga gagacaccag cagcagctcc tgtcagtgac
     2821 ggcggagctc gaggccagac accaggccgc gttgggcgag ctgacagcct ccttagagag
     2881 caagcagggg gctctgctgg ctgcacgtgt ggccgaactg cagacaaaac acgctgccga
     2941 cctcggcgct ctggagacca gacatctgtc cagccttgat tctttggaat cctgttacct
     3001 ctctgaattt cagaccatcc gtgaggagca caggcaggcc ctagagctct tacgagcaga
     3061 ctttgaggaa caactgtgga aaaaggactc tcttcaccaa acgattttga ctcaagagtt
     3121 ggagaaactg aagcggaaac acgaagggga gctacagtct gtgcgggacc acctgcgaac
     3181 cgaagtgagc acagagctcg ccggaaccgt ggctcacgag ctgcagggag tgcaccaggg
     3241 tgaatttgga agtgaaaaga aaactgcttt gcatgaaaaa gaggagacac ttcggcttca
     3301 gagtgcacag gcacagcctt ttcaccaaga ggagaaagag tctttgtctc tgcagcttca
     3361 aaagaagaat caccaagtcc agcagctgaa agaccaggtt ttatccttaa gtcacgagat
     3421 agaagagtgc cgctccgagt tggaggtgct gcagcagagg cgggagcggg agaaccggga
     3481 aggcgcaaac ctcctctcca tgctcaaggc cgacgtcaac ctgtcccaca gcgaaagagg
     3541 ggccctccag gacgccctgc gcaggctgct gggtttgttt ggagagacgc tgagggcagc
     3601 cgtcaccctg aggagccgga tcggggagcg cgtggggctc tgcctggatg acgcgggcgc
     3661 aggcctggcc ctgtcgacag ctccggcgct ggaggagaca tggtctgatg tggccctccc
     3721 ggagttggac agaactttgt ctgaatgtgc agagatgtct tccgtggctg aaattagcag
     3781 ccacatgcgt gaaagctttc tcatgagccc agaaagtgtg cgggagtgtg agcagcccat
     3841 ccggagggtc ttccagagcc tcagcctggc cgtggacggc ctcatggaga tggccctgga
     3901 ctccagcagg cagctggaag aagcacgcca aattcattct cgttttgaaa aagaatttag
     3961 ttttaagaat gaggagacag cacaggttgt caggaagcac caggagctgc tggagtgttt
     4021 gaaggaggag agcgcagcaa aggcagagct ggcgctggag ctgcacaaga ctcagggtac
     4081 ccttgaggga ttcaaggtgg agacagcaga tctgaaggag gtgctggccg ggaaggagga
     4141 ttccgagcac cgtctggtgc tggagctgga gagcctgaga cggcagctgc agcaggcggc
     4201 ccaggagcag gcggcgctga gggaggagtg cacccgtctg tggagtcggg gggaggccac
     4261 agccacggac gccgaggcca gagaagctgc tctccggaag gaagtggagg atctgaccaa
     4321 agaacagtcg gagaccagga agcaggctga gaaggaccgc tcagccctgc tctcccagat
     4381 gaagattttg gagtctgagt tagaagaaca gctgtctcag catcgcgggt gtgccaagca
     4441 ggcggaggcc gtcactgccc tggaacagca ggtggcatct ctggacaagc atttgcgcaa
     4501 ccagcggcaa ttcatggatg agcaggcagc cgagcgggag cacgagcgcg aggagttcca
     4561 gcaggagatt cagaggctgg aggggcagct ccgccaggcg gccaagccgc agccctgggg
     4621 ccctcgcgac agccagcagg cgccgctgga tggagaggtt gagttgttac aacaaaagtt
     4681 gagagaaaag ttggatgaat ttaatgaatt ggctatacag aaagagtcgg cagatagaca
     4741 agtgttaatg caggaagaag aaattaaacg tctggaggag atgaacatca acatcaggaa
     4801 aaaagtggcc cagctccagg aagaagtgga aaaacagaaa aacatcgtga aagggctgga
     4861 acaggataaa gaggtgttaa agaaacagca gatgagtagc ttgcttctgg cgtccacgtt
     4921 gcagtctaca ctagatgcag gcagatgtcc cgagcctcct tcgggcagcc ctcctgaggg
     4981 tccagaaata cagttagagg tgacacagag agcactcctg cggcgcgaga gcgaggtttt
     5041 ggacttaaaa gaacagctag aaaagatgaa aggtgactta gaaagtaaaa atgaagaaat
     5101 actacatctg aacttaaaat tggacatgca gaacagccag actgctgtca gcctcagaga
     5161 acttgaggaa gagaacacga gcttgaaggt catatatacc agaagttctg agattgaaga
     5221 gctgaaagcc actattgaaa atctgcaaga gaatcagaaa cgattacaaa aggagaaagc
     5281 agaggaaatt gaacaactcc atgaagtcat tgagaagctg cagcacgagc tgtccctcat
     5341 ggggcctgtg gtgcacgaag tcagcgacag tcaggctggc agtctgcaga gcgagctgct
     5401 ctgctcccag gccgggggcc ctcgtgggca ggccctacag ggcgagctcg aggctgcgct
     5461 ggaagccaag gaggccctga gccggctgct ggctgaccag gagcgcaggc acagccaggc
     5521 cctggaggcc ctgcagcagc gcctccaggg cgcagaggag gctgcggagc tacagctggc
     5581 tgagctggag cgcaatgtag ccctcaggga ggctgaggtc gaagacatgg cctcccggat
     5641 ccaggagttc gaagcggccc tgaaagcaaa ggaagcgacg attgccgaga gaaatttaga
     5701 aatcgacgct ctgaaccagc ggaaggcggc ccactctgcc gagctggagg ccgtcctgtt
     5761 ggccttggcc cgcatccgcc gcgccctgga gcagcagccc ctggcagccg gggcggcgcc
     5821 tcccgagctg cagtggctcc gagcgcagtg tgcccgcctc agccgccagc tgcaggtgct
     5881 gcaccagcgg ttcctgaggt gccaggtgga gctggacagg cggcaggccc gcagagccac
     5941 agctcacaca cgggtgcccg gggcccaccc acagcctcgc atggatggtg gcgccaaggc
     6001 ccaggtcacc ggcgacgtgg aggcctccca tgatgctgct ttggagccgg ttgtccctga
     6061 cccacagggt gatctgcagc ctgtcctggt gacgttgaag gatgcacctc tctgcaagca
     6121 agaaggcgtg atgtcagtgc tcaccgtctg ccagaggcag ctgcagtcgg agctgctctt
     6181 ggtgaaaaat gaaatgcgcc tgagtctgga ggacggcggc aagggtaaag aaaaagtact
     6241 ggaagattgt cagctgccga aggtcgatct cgtagctcag gtgaaacagc ttcaggaaaa
     6301 actgaaccgt ttgctgtatt ccatgacctt ccagaatgtg gatgctgccg acaccaaatc
     6361 tctgtggccc atggcctcag cacacctgtt ggagagcagc tggagtgatg attcctgtga
     6421 cggagaagag cctgacatat caccccacat agacacatgt gatgccaata cagccacggg
     6481 gggtgtaact gatgttatca aaaatcaggc catagacgcg tgtgatgcca atacaacccc
     6541 agggggtgta actgatgtta tcaaaaattg ggattccttg ataccagatg aaatgccaga
     6601 ttctcccatt caagaaaaat cagaatgtca ggacatgtct ctttcttcac cgaccagcgt
     6661 acttggtggc tcccgccacc agagccacac tgcagaggct gggccccgga agagcccggt
     6721 cgggatgctg gacctgtctt cctggagctc ccctgaggtc ctcaggaagg actggaccct
     6781 ggagccctgg cccagcctcc ccgtgacacc ccactcagga gccctgagcc tgtgcagtgc
     6841 cgacacatcc ctgggggaca gggcggacac ctcgctgcca cagacccagg ggccggggct
     6901 gctttgttcc ccaggcgtgt ctgcagcagc gctggcactg cagtgggccg agtctccgcc
     6961 ggctgacgac caccatgtgc agaggacggc tgtggagaaa gatgtcgaag attttatcac
     7021 aacatccttt gattctcaag aaacattaag ttcacctcct cctggattag aaggaaaagc
     7081 tgatagaagt gagaaaagtg acggctcggg ttttggagca agactgagcc cggggtcagg
     7141 aggccctgag gctcaaactg ctggtcctgt gacccctgct tccatctctg gaaggtttca
     7201 gccgctgccg gaagccatga aggagaagga agtgcgtccg aagcacgtga aggctttact
     7261 gcagatggtg cgtgacgaga gccaccagat cctggcgctg tcagaaggcc ttgcaccccc
     7321 aagcggcgag ccacacccac cccggaagga agacgagata caggacatct cgctccatgg
     7381 gggaaagacg caggaagtgc ccaccgcgtg ccccgattgg agaggggacc ttctgcaggt
     7441 tgtgcaagag gcctttgaaa aagagcagga gatgcagggg gttgagctgc agccccgact
     7501 cagtggctca gatctggggg gtcacagctc cctgctcgaa aggctggaga agatcatccg
     7561 tgagcaggga gacctgcagg aaaagtccct ggagcatctt cgcttgccgg accggagcag
     7621 cctgctgtcc gagatccagg cgctgcgtgc ccagctgcgc atgacgcacc tgcagaacca
     7681 ggagaagctg cagcacttgc gcacggcgct gacaagcgca gaggcgcgcg ggagccagca
     7741 ggagcaccag ctgcgcaggc aggttgaact gctggcttat aaagtagagc aggagaagtg
     7801 cattgctggt gacttgcaga agacgctgag tgaagagcaa gagaaggcaa acagcgtgca
     7861 gaagctcctg gcggcggagc agactgtagt gcgagatttg aagtccgacc tctgtgagag
     7921 caggcagaag agcgaacagc tgtcccggtc cctctgcgag gtgcagcagg aggtcctcca
     7981 gctgagatcc atgctgagca gtaaggagaa cgagctgaag gccgcgcttc aggagctgga
     8041 gagtgagcag gggaaggggc gtgccctgca gagccagctg gaggaggagc agctgcggca
     8101 cctgcagagg gagagccaga gtgccaaggc cctggaggag ctgcgggcgt ctttggagac
     8161 acagcgtgct cagagcagtc gactctgcgt ggcactgaaa cacgagcaga cggccaagga
     8221 caacctgcag aaggagctgc gtatcgagca ctcacgctgc gaggccttgc tggctcagga
     8281 gcggagccag ctctctgagc tccagaagga ccttgcggct gagaagagcc gcaccctgga
     8341 gctgtcagag gccttgcggc acgagcggct cctgaccgag cagctgagcc agaggacaca
     8401 ggaggcttgc gtgcaccagg acacacaggc ccatcacgct ctgctgcaga agctgaagga
     8461 ggagaagtcc cgggtggtgg acttgcaagc gatgcttgaa aaggtgcagc agcaagccct
     8521 gcattctcag cagcagcttg aggctgaggc tcagaagcac tgtgaggcgc tcaggagaga
     8581 gaaggaggta agtgccacac tgaagtcgac ggtggaagcc ctgcacaccc aaaaacgaga
     8641 gctgagatgc tctctggaga gagagaggga gaaaccagcg tggttgcagg cagaattaga
     8701 gcagtcacac ccacggttga aagagcaaga aggacgcaag gctgcgagga ggagcgcgga
     8761 ggccaggcag agcccagcgg ctgcggagca gtggaggaag tggcagagag acaaggagaa
     8821 gctgcgagaa ttagaactgc agcgtcagcg tgacttgcat aagatcaagc agcttcagca
     8881 gacagtgaga gacctggagt cgaaggacga ggtgcctggc agccgcctcc acctaggttc
     8941 tgcccgcagg gctgccggct cggatgcgga ccacctccgg gaacagcagc gagagctgga
     9001 ggcgatgagg cagcggctgc tctctgccgc ccggcttctc accagcttca ccagccaggc
     9061 cgtggacagg acagttaatg attggacgtc atccaatgag aaagcagtga tgtctttact
     9121 gcacacgttg gaggagctga agtctgactt gagcaggccc acctcctccc agaaaaaaat
     9181 ggcagcagag ctgcagttcc agtttgtgga cgtcctgctg aaagacaatg tttccctcac
     9241 aaaagcgctc agcacggtga cccaggagaa gctggagctg agcagagccg tgtctaagct
     9301 tgagaagttg ctgaagcacc atctgcagaa gggctgcagc ccaagcaggt cggaaaggtc
     9361 tgcttggaag ccagacgaaa cggctccaca gagttccctg aggcgcccag accccggccg
     9421 gcttccacca gctgccagcg aggaagcaca caccagcaat gtcaagatgg aaaaattgta
     9481 cctgcattac ttgagagcag agagctttag aaaagctctg atttatcaaa agaagtatct
     9541 tttgctgttg attggtggat tccaggattc tgaacaagaa acactctcca tgattgccca
     9601 tttgggggta tttccttcca aagcagaacg gaaaatcaca tctcgtcctt tcaccaggtt
     9661 ccgcacggcc gtcagggtgg tcattgcaat attaagatta cgttttttgg ttaagaaatg
     9721 gcaagaagta gatcggaaag gagctctggc acaaggcaaa gcccctcgcc cagggccccg
     9781 agcacgacag ccgcagtctc cacccagaac cagagagtcc cccccaaccc gggatgtacc
     9841 ctctggccac accagggacc ctgccagagg ccgcagactg gcagcagcag cctccccaca
     9901 cagtggggga agagccactc catccccaaa ttcaagatta gaaagatccc tgactgcttc
     9961 tcaagatcca gaacattcct tgacagagta tattcaccat ttagaagtga tccagcaaag
    10021 attgggaggg gtactaccag attctacttc aaagaaatcc tgccacccga tgattaaaca
    10081 gtgaataaaa tgtcatggct ctttcctgcg acaattctat ttgaggaaaa gatttgtttt
    10141 tcccttttcc caaggaagct cgtgggacag catgggcact actcttcatg tgcggtgaca
    10201 ccagccccca gatgccttga attaagtgtc ctcaccttta tgcatgactg caaagccagc
    10261 tggagcattt tctatggagc ctccgtatgt tttaggccca tgaccttcgt gaggtgacgg
    10321 gcactcactc ccatgagccc tggctgtgtg ctgttgtgtg cctatcggca gatccatcct
    10381 tcctgcctcc aaggaggata cacagagaat ggcttcctgt tgttttgttt attttcttaa
    10441 cgtgtacaga tggaaacttc atttaaaaat aaaaacaaaa caactcaaaa aggaataaaa
    10501 tttaatcact gttttgtttg tgaata
//
