LOCUS       NM_001352659            2128 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens pericentriolar material 1 (PCM1), transcript variant
            31, mRNA.
ACCESSION   NM_001352659
VERSION     NM_001352659.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2128)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 2128)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2128)
  AUTHORS   Wang,L., Paudyal,S.C., Kang,Y., Owa,M., Liang,F.X., Spektor,A.,
            Knaut,H., Sanchez,I. and Dynlacht,B.D.
  TITLE     Regulators of tubulin polyglutamylation control nuclear shape and
            cilium disassembly by balancing microtubule and actin assembly
  JOURNAL   Cell Res 32 (2), 190-209 (2022)
   PUBMED   34782749
REFERENCE   4  (bases 1 to 2128)
  AUTHORS   Liu,W.N., Wu,K.X., Wang,X.T., Lin,L.R., Tong,M.L. and Liu,L.L.
  TITLE     LncRNA-ENST00000421645 promotes T cells to secrete IFN-gamma by
            sponging PCM1 in neurosyphilis
  JOURNAL   Epigenomics 13 (15), 1187-1203 (2021)
   PUBMED   34382410
  REMARK    GeneRIF: LncRNA-ENST00000421645 promotes T cells to secrete
            IFN-gamma by sponging PCM1 in neurosyphilis.
REFERENCE   5  (bases 1 to 2128)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2128)
  AUTHORS   Corvi,R., Berger,N., Balczon,R. and Romeo,G.
  TITLE     RET/PCM-1: a novel fusion gene in papillary thyroid carcinoma
  JOURNAL   Oncogene 19 (37), 4236-4242 (2000)
   PUBMED   10980597
REFERENCE   7  (bases 1 to 2128)
  AUTHORS   Engelender,S., Sharp,A.H., Colomer,V., Tokito,M.K., Lanahan,A.,
            Worley,P., Holzbaur,E.L. and Ross,C.A.
  TITLE     Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued
            subunit of dynactin
  JOURNAL   Hum Mol Genet 6 (13), 2205-2212 (1997)
   PUBMED   9361024
REFERENCE   8  (bases 1 to 2128)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
REFERENCE   9  (bases 1 to 2128)
  AUTHORS   Ohata,H., Fujiwara,Y., Koyama,K. and Nakamura,Y.
  TITLE     Mapping of the human autoantigen pericentriolar material 1 (PCM1)
            gene to chromosome 8p21.3-p22
  JOURNAL   Genomics 24 (2), 404-406 (1994)
   PUBMED   7698772
REFERENCE   10 (bases 1 to 2128)
  AUTHORS   Balczon,R., Bao,L. and Zimmer,W.E.
  TITLE     PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle
            distribution
  JOURNAL   J Cell Biol 124 (5), 783-793 (1994)
   PUBMED   8120099
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087273.5 and AC087625.12.
            
            On Aug 13, 2020 this sequence version replaced NM_001352659.1.
            
            Summary: The protein encoded by this gene is a component of
            centriolar satellites, which are electron dense granules scattered
            around centrosomes. Inhibition studies show that this protein is
            essential for the correct localization of several centrosomal
            proteins, and for anchoring microtubules to the centrosome.
            Chromosomal aberrations involving this gene are associated with
            papillary thyroid carcinomas and a variety of hematological
            malignancies, including atypical chronic myeloid leukemia and
            T-cell lymphoma. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Oct
            2015].
            
            Transcript Variant: This variant (31), as well as variant 32,
            encodes isoform 23.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000453.2, SRR14038192.3766270.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AC087273.5         21663-21863         c
            202-269             AC087273.5         20071-20138         c
            270-387             AC087273.5         9145-9262           c
            388-633             AC087273.5         7472-7717           c
            634-903             AC087273.5         5842-6111           c
            904-1074            AC087273.5         4990-5160           c
            1075-1191           AC087273.5         4693-4809           c
            1192-1369           AC087625.12        64792-64969
            1370-1479           AC087625.12        68221-68330
            1480-1696           AC087625.12        70576-70792
            1697-2128           AC087625.12        73076-73507
FEATURES             Location/Qualifiers
     source          1..2128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p22"
     gene            1..2128
                     /gene="PCM1"
                     /gene_synonym="PTC4; RET/PCM-1"
                     /note="pericentriolar material 1"
                     /db_xref="GeneID:5108"
                     /db_xref="HGNC:HGNC:8727"
                     /db_xref="MIM:600299"
     exon            1..201
                     /gene="PCM1"
                     /gene_synonym="PTC4; RET/PCM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            202..269
                     /gene="PCM1"
                     /gene_synonym="PTC4; RET/PCM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            270..387
                     /gene="PCM1"
                     /gene_synonym="PTC4; RET/PCM-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..1884
                     /gene="PCM1"
                     /gene_synonym="PTC4; RET/PCM-1"
                     /note="isoform 23 is encoded by transcript variant 31;
                     pericentriolar material 1 protein; pericentriolar material
                     1, PCM1; PCM-1; hPCM-1"
                     /codon_start=1
                     /product="pericentriolar material 1 protein isoform 23"
                     /protein_id="NP_001339588.2"
                     /db_xref="CCDS:CCDS87582.1"
                     /db_xref="GeneID:5108"
                     /db_xref="HGNC:HGNC:8727"
                     /db_xref="MIM:600299"
                     /translation="MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRS
                     SEKNKKKFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMSQMSVPEQAELEK
                     LKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTNP
                     PNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITK
                     ASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARENEEEDVRTIDSA
                     VGSGSVAESTSLNIDVQSEASDTTARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRA
                     LQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQL
                     RDSQPPAVPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMD
                     KLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPT
                     ASLVSQNESENEGHLNPSEKLQ"
     exon            388..633
                     /gene="PCM1"
                     /gene_synonym="PTC4; RET/PCM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..903
                     /gene="PCM1"
                     /gene_synonym="PTC4; RET/PCM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1074
                     /gene="PCM1"
                     /gene_synonym="PTC4; RET/PCM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1191
                     /gene="PCM1"
                     /gene_synonym="PTC4; RET/PCM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1369
                     /gene="PCM1"
                     /gene_synonym="PTC4; RET/PCM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1479
                     /gene="PCM1"
                     /gene_synonym="PTC4; RET/PCM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1696
                     /gene="PCM1"
                     /gene_synonym="PTC4; RET/PCM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..2128
                     /gene="PCM1"
                     /gene_synonym="PTC4; RET/PCM-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2110..2115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCM1"
                     /gene_synonym="PTC4; RET/PCM-1"
                     /note="hexamer: AATAAA"
     polyA_site      2128
                     /gene="PCM1"
                     /gene_synonym="PTC4; RET/PCM-1"
                     /note="major polyA site"
ORIGIN      
        1 acaatgagat cctaagatgg cggtggctgc ggcggttggc gctgcgtagc tgaggtcgaa
       61 aaggcggcca ctggggccga ggcagccagg aaacgtgtgg gcctctctgc tgcggtctcc
      121 gagggccgac cgctgccggc ggcgggtcgt gggggctgac tgtcgctctg cctttgacag
      181 gagaggctgc ttcttgtaga ggaaacagct ttgaagtgtg gagcgggaaa ggagcagttt
      241 ctgagctgca aaaactagtt tctaaacaga gagttaattg ttaaatccag tatggccaca
      301 ggaggaggtc cctttgaaga tggcatgaat gatcaggatt taccaaactg gagtaatgag
      361 aatgttgatg acaggctcaa caatatggat tggggtgccc aacagaagaa agcaaataga
      421 tcatcagaaa agaataagaa aaagtttggt gtagaaagtg ataaaagagt aaccaatgat
      481 atttctccgg agtcgtcacc aggagttgga aggcgaagaa caaagactcc acatacgttc
      541 ccacacagta gatacatgag tcagatgtct gtcccagagc aggcagaatt agagaaactg
      601 aaacagcgga taaacttcag tgatttagat cagagaagca ttggaagtga ttcccaaggt
      661 agagcaacag ctgctaacaa caaacgtcag cttagtgaaa accgaaagcc cttcaacttt
      721 ttgcctatgc agattaatac taacaagagc aaagatgcat ctacaaaccc cccaaacaga
      781 gaaacgattg gatcagcaca gtgtaaagag ttgtttgctt ctgctttaag taatgacctc
      841 ttgcaaaact gtcaggtgtc tgaagaagat gggaggggag aacctgcaat ggagagcagc
      901 cagattgtaa gcaggcttgt tcaaattcgc gattatatta ctaaagctag ttccatgcgg
      961 gaagatcttg tagagaaaaa tgagagatct gctaatgttg agcgccttac tcatctaata
     1021 gatcacctta aagaacaaga gaagtcatat atgaaatttc ttaaaaaaat ccttgctaga
     1081 gaaaatgagg aggaggatgt tcggactata gattcagctg tgggatctgg ttctgtagct
     1141 gagagcacat cgctaaacat agatgtgcag tctgaggctt cagataccac ggccagagat
     1201 cctcagcagg agcctatgga agagatagaa aatttgaaga aacaacatga tttattaaaa
     1261 agaatgttac aacagcagga gcaactaaga gctctacagg gacggcaggc tgcacttcta
     1321 gctctgcaac ataaagcaga gcaagctatt gcagtgatgg atgattctgt tgttgcagaa
     1381 actgcaggta gcttatctgg cgtcagtatc acatctgaac taaatgaaga attgaatgac
     1441 ttaattcagc gttttcataa tcagcttcgt gattctcagc ctccagctgt tccagacaat
     1501 agaagacagg cagaaagtct ttcattaact agggaggttt cccagagcag gaaaccatca
     1561 gcttcagaac gtttacctga tgagaaagtc gaacttttta gcaaaatgag agtgctacag
     1621 gaaaagaaac aaaaaatgga caaattgctt ggagaacttc atacacttcg agatcagcat
     1681 cttaacaatt catcatcctc tccacaaagg agtgtcgatc agagaagtac ttcagctccc
     1741 tctgcttctg taggcttggc accggttgtc aatggagaat ccaatagcct cacatcatct
     1801 gttccttatc ctactgcttc tctagtatct cagaatgaga gtgaaaacga aggccacctc
     1861 aatccatctg aaaaactcca gtaaaacatt tataatcatt gtttacatga agttaaataa
     1921 tagggataaa ttctgttttt ttttttatgt tgaaaattct gcaaaacgag atttatttaa
     1981 tattgttgta aacattctta agggataggt agaagaggcg tgtgtgtgtt gtgtgggcat
     2041 aatttgagtt gtctaagaga tgtgatgtaa catagtttct gtgaactgat gttactttct
     2101 tgtttttcaa ataaaggatc aaaaataa
//
