LOCUS       NM_033026              20284 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens piccolo presynaptic cytomatrix protein (PCLO),
            transcript variant 1, mRNA.
ACCESSION   NM_033026 XM_168530 XM_374484
VERSION     NM_033026.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 20284)
  AUTHORS   Huang,T.T., Smith,R., Bacos,K., Song,D.Y., Faull,R.M.,
            Waldvogel,H.J. and Li,J.Y.
  TITLE     No symphony without bassoon and piccolo: changes in synaptic active
            zone proteins in Huntington's disease
  JOURNAL   Acta Neuropathol Commun 8 (1), 77 (2020)
   PUBMED   32493491
  REMARK    GeneRIF: No symphony without bassoon and piccolo: changes in
            synaptic active zone proteins in Huntington's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20284)
  AUTHORS   Mbarek,H., Milaneschi,Y., Hottenga,J.J., Ligthart,L., de
            Geus,E.J.C., Ehli,E.A., Willemsen,G., Davies,G.E., Smit,J.H.,
            Boomsma,D.I. and Penninx,B.W.J.H.
  TITLE     Genome-Wide Significance for PCLO as a Gene for Major Depressive
            Disorder
  JOURNAL   Twin Res Hum Genet 20 (4), 267-270 (2017)
   PUBMED   28540843
  REMARK    GeneRIF: In an analysis comparing 1,942 cases with lifetime
            diagnosis of MDD and 4,565 controls, PCLO showed a genome-wide
            significant association with major depressive disorder at SNP
            (rs2715157, p = 2.91 x 10-8) and gene-based (p = 1.48 x 10-7)
            level.
REFERENCE   3  (bases 1 to 20284)
  AUTHORS   Zhang,W., Hong,R., Xue,L., Ou,Y., Liu,X., Zhao,Z., Xiao,W.,
            Dong,D., Dong,L., Fu,M., Ma,L., Lu,N., Chen,H., Song,Y. and Zhan,Q.
  TITLE     Piccolo mediates EGFR signaling and acts as a prognostic biomarker
            in esophageal squamous cell carcinoma
  JOURNAL   Oncogene 36 (27), 3890-3902 (2017)
   PUBMED   28263981
  REMARK    GeneRIF: Piccolo contributes to tumor aggressiveness in esophageal
            squamous cell carcinoma, likely by stabilizing EGFR and promoting
            EGFR-dependent signaling.
REFERENCE   4  (bases 1 to 20284)
  AUTHORS   Siddique,A., Willoughby,J. and McNeill,A.
  CONSRTM   DDD Study
  TITLE     A 7q21.11 microdeletion presenting with apparent intellectual
            disability without epilepsy
  JOURNAL   Am J Med Genet A 173 (4), 1128-1130 (2017)
   PUBMED   28240412
  REMARK    GeneRIF: we report an additional patient with the 7q21.11 deletion
            syndrome and provide evidence that haploinsufficiency for a single
            gene may not be the disease mechanism. In vitro studies of the
            interaction between PCLO and CACNA2D1 will be required to examine
            the hypothesis that combined haploinsufficiency for these two
            synaptic proteins results in neuronal dysfunction
REFERENCE   5  (bases 1 to 20284)
  AUTHORS   Mateos-Hernandez,L., Villar,M., Doncel-Perez,E.,
            Trevisan-Herraz,M., Garcia-Forcada,A., Ganuza,F.R., Vazquez,J. and
            de la Fuente,J.
  TITLE     Quantitative proteomics reveals Piccolo as a candidate serological
            correlate of recovery from Guillain-Barre syndrome
  JOURNAL   Oncotarget 7 (46), 74582-74591 (2016)
   PUBMED   27776345
  REMARK    GeneRIF: The results showed that Piccolo, a protein that is
            essential in the maintenance of active zone structure, constitutes
            a potential serological correlate of recovery from GBS.
REFERENCE   6  (bases 1 to 20284)
  AUTHORS   Sudhof,T.C.
  TITLE     The synaptic vesicle cycle
  JOURNAL   Annu Rev Neurosci 27, 509-547 (2004)
   PUBMED   15217342
  REMARK    Review article
REFERENCE   7  (bases 1 to 20284)
  AUTHORS   Fenster,S.D. and Garner,C.C.
  TITLE     Gene structure and genetic localization of the PCLO gene encoding
            the presynaptic active zone protein Piccolo
  JOURNAL   Int J Dev Neurosci 20 (3-5), 161-171 (2002)
   PUBMED   12175852
REFERENCE   8  (bases 1 to 20284)
  AUTHORS   Fenster,S.D., Chung,W.J., Zhai,R., Cases-Langhoff,C., Voss,B.,
            Garner,A.M., Kaempf,U., Kindler,S., Gundelfinger,E.D. and
            Garner,C.C.
  TITLE     Piccolo, a presynaptic zinc finger protein structurally related to
            bassoon
  JOURNAL   Neuron 25 (1), 203-214 (2000)
   PUBMED   10707984
REFERENCE   9  (bases 1 to 20284)
  AUTHORS   Wang,X., Kibschull,M., Laue,M.M., Lichte,B., Petrasch-Parwez,E. and
            Kilimann,M.W.
  TITLE     Aczonin, a 550-kD putative scaffolding protein of presynaptic
            active zones, shares homology regions with Rim and Bassoon and
            binds profilin
  JOURNAL   J Cell Biol 147 (1), 151-162 (1999)
   PUBMED   10508862
REFERENCE   10 (bases 1 to 20284)
  AUTHORS   Cases-Langhoff,C., Voss,B., Garner,A.M., Appeltauer,U., Takei,K.,
            Kindler,S., Veh,R.W., De Camilli,P., Gundelfinger,E.D. and
            Garner,C.C.
  TITLE     Piccolo, a novel 420 kDa protein associated with the presynaptic
            cytomatrix
  JOURNAL   Eur J Cell Biol 69 (3), 214-223 (1996)
   PUBMED   8900486
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093461.4, AC004903.2,
            AC004886.1, AC080093.6, AC004082.1 and AC004006.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_033026.5.
            
            Summary: The protein encoded by this gene is part of the
            presynaptic cytoskeletal matrix, which is involved in establishing
            active synaptic zones and in synaptic vesicle trafficking.
            Variations in this gene have been associated with bipolar disorder
            and major depressive disorder. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333891.14/ ENSP00000334319.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC093461.4         12677-12679         c
            4-540               AC093461.4         12140-12676         c
            541-2185            AC093461.4         4543-6187           c
            2186-3592           AC004903.2         100914-102320       c
            3593-4309           AC004886.1         75599-76315         c
            4310-9389           AC004886.1         61684-66763         c
            9390-11404          AC004886.1         59304-61318         c
            11405-13592         AC004886.1         24514-26701         c
            13593-13729         AC004886.1         18705-18841         c
            13730-13820         AC004886.1         12479-12569         c
            13821-13946         AC080093.6         26487-26612         c
            13947-14055         AC004082.1         92118-92226         c
            14056-14123         AC004082.1         91546-91613         c
            14124-14338         AC004082.1         90250-90464         c
            14339-14389         AC004082.1         86438-86488         c
            14390-14514         AC004082.1         83197-83321         c
            14515-14541         AC004082.1         80646-80672         c
            14542-14635         AC004082.1         72852-72945         c
            14636-14707         AC004082.1         71568-71639         c
            14708-14888         AC004082.1         69215-69395         c
            14889-15083         AC004082.1         67474-67668         c
            15084-15225         AC004082.1         50667-50808         c
            15226-15299         AC004082.1         46497-46570         c
            15300-15434         AC004082.1         6338-6472           c
            15435-15580         AC004082.1         5618-5763           c
            15581-19274         AC004082.1         1-3694              c
            19275-20284         AC004006.1         118244-119253       c
FEATURES             Location/Qualifiers
     source          1..20284
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.11"
     gene            1..20284
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /note="piccolo presynaptic cytomatrix protein"
                     /db_xref="GeneID:27445"
                     /db_xref="HGNC:HGNC:13406"
                     /db_xref="MIM:604918"
     exon            1..540
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            541..2185
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..3592
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            3593..4309
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            4310..9389
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            9390..11404
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            11405..13592
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            13593..13729
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            13730..13820
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            13821..13946
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            13947..14055
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            14056..14123
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            14124..14338
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            14339..14389
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            14390..14514
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            14515..14541
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            14542..14635
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            14636..14707
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            14708..14888
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            14889..15083
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            15084..15225
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            15226..15299
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            15300..15434
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            15435..15580
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            15581..20284
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      20265..20270
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /note="hexamer: AATAAA"
     polyA_site      20284
                     /gene="PCLO"
                     /gene_synonym="ACZ; PCH3"
                     /note="major polyA site"
ORIGIN      
        1 agatctgctt ctccccggct cggggcgccg aggcggcgtc cgggaggtgt cttctgcaaa
       61 ggttgcctgg cgctgtccaa catggaggag gcaccggcag cgggcgttac ctgcgagcgg
      121 gactaacccc tgcctggcgt tccgggcggc agtgcctggt ccagagtcca gggactcggc
      181 tgcctgcacg ccccgaggcg gaccccggct ctgactgctc ccctggccgc gggcttctcg
      241 actgggacgc ggcgcgagga gggagcgcgg cggccccgag tctccctgag ccatgggcaa
      301 cgaggcgagc ttggaagggg aagggctccc cgaagggctg gcggcggccg cagcggctgg
      361 aggaggagct agcggggcgg ggagcccctc tcacaccgcg atcccggccg gcatggaggc
      421 ggatttgagc cagctgagcg aagaggagag gagacagatc gccgctgtca tgtcaagggc
      481 gcaggggctg cccaagggaa gcgtcccccc ggccgctgcg gagtcgcctt ccatgcacag
      541 gaaacaagag ttggatagta gtcatcctcc aaagcaatca ggaagacccc cggaccctgg
      601 gcgtccagct caacctggtc tcagtaaaag tagaactaca gacactttca ggtcagagca
      661 gaaattgcct gggaggagtc cttccactat tagcttgaaa gaatcaaagt ccagaactga
      721 tttaaaggaa gagcacaagt ctagtatgat gcctggcttc ctctcagagg ttaacgcttt
      781 aagtgctgtt tcctctgttg taaataaatt caaccctttt gatttgatat cagactctga
      841 ggcatcccag gaagaaacca ccaagaaaca aaaagtggtt cagaaggagc aaggaaaacc
      901 tgaaggaatc ataaaacctc ctttacaaca acagccaccc aagccgattc ctaagcagca
      961 aggacctggt agggatccgc ttcagcagga tggcactccc aaatcaatat cttctcaaca
     1021 accagaaaaa attaaatcac aacctccagg tacaggaaag ccaattcagg gtcctaccca
     1081 gactcctcag acagaccatg caaaattgcc acttcaacga gatgcatcca ggcctcagac
     1141 taaacaggca gacatagtaa ggggagaatc agttaaaccc tcactgccaa gcccatccaa
     1201 accacctatt cagcaaccaa ctcctggaaa acctccagca cagcagcctg gacatgaaaa
     1261 atcacagcct gggcctgcaa agcccccagc tcagccctca gggctaacaa agccattggc
     1321 tcaacaacca gggacagtga aacccccagt ccagccacca gggacaacaa agcctccagc
     1381 tcagcctctt ggtcctgcta agcctccagc tcagcagact gggtcagaga agccttcatc
     1441 ggagcagcct gggccaaagg ctttagctca gcctcctgga gttggaaaga ctccagctca
     1501 acagccaggg ccagcaaagc ctccaaccca gcaggtgggg acaccaaaac ccctagctca
     1561 acaacctggg ctacagtctc cagctaaggc acctgggcct acaaagactc cagttcagca
     1621 gcctgggcca ggaaagattc cagctcaaca ggcaggaccc ggaaagactt ctgcccagca
     1681 gactggccca acaaagcctc cttcacaact gcctggccca gcaaagcccc cacctcaaca
     1741 gcctggccca gcaaagcccc cacctcaaca gcctggctca gcaaagcccc catctcaaca
     1801 gcctggctca acaaaacccc cacctcaaca gcctggccca gcaaagccct cacctcaaca
     1861 gcctggctca acaaaacccc catctcaaca gcctggctca gcaaaaccct cagctcaaca
     1921 gcctagccca gcaaagccct cggctcagca atctacaaaa ccagtaagcc aaacaggatc
     1981 tggaaaacct ctgcagccac caacagtgtc tccatctgca aaacagcctc cttcacaagg
     2041 cctccctaaa accatctgtc ctctttgcaa taccactgaa cttctgttgc atgttccaga
     2101 aaaggccaat tttaacacat gcactgagtg tcaaaccact gtctgtagtc tctgtggttt
     2161 taatcccaat cctcatttaa cggaggtaaa agagtggctc tgtttgaact gtcaaatgaa
     2221 aagagctcta ggcggggatc tggctccagt tccgtcatca ccccagccca aactgaagac
     2281 tgcacctgtt accactacat cagcagtgag caaatcatcc ccacagccac agcagacttc
     2341 cccaaagaag gatgctgcac caaaacagga tctctccaag gcacctgagc ctaaaaagcc
     2401 accaccacta gtgaaacaac caacccttca tggctctcct tcagccaagg ccaagcagcc
     2461 ccctgaggca gattctttgt ccaagccagc ccctcccaaa gaaccttctg tcccatctga
     2521 gcaggacaag gcccctgttg ctgatgataa accaaagcag cccaagatgg taaagccaac
     2581 cactgacctt gtatcttcat catcagcaac aacaaaacct gatattccaa gctccaaagt
     2641 acagtcacaa gctgaagaga aaacaacccc tcctctaaaa acagactctg ccaaaccctc
     2701 acagagtttt ccaccaacag gggaaaaagt cagcccattt gattctaaag ccatacctcg
     2761 acctgcatca gattcaaaaa ttatttcaca tcctggtccc agttcagaga gcaaaggtca
     2821 aaaacaagtt gaccccgtac aaaagaagga agaacccaag aaagcacaaa ccaaaatgag
     2881 tcctaaacca gatgccaagc caatgccaaa agggtcacca acaccccctg gcccacgacc
     2941 taccgctggc caaactgtcc ccacacctca acagtcccca aagcctcagg agcagtcaag
     3001 gcgtttcagt ctgaatctgg gaagtattac tgatgccccc aaatcacagc ctacaactcc
     3061 tcaagagacc gtgactggga aactctttgg gtttggagca tcaatcttca gccaggcatc
     3121 aaatttaatt tccactgcag gccaacctgg acctcattca caaagtggac caggggcccc
     3181 aatgaaacaa gcccctgccc cttcacagcc acctacttca caagggccac ccaaatccac
     3241 aggtcaagca ccaccagcac ctgcaaaaag tatacctgtg aaaaaggaaa caaaagcccc
     3301 agcagctgaa aaattagagc ccaaagctga acaagctcca acagtaaaaa gaacagaaac
     3361 agaaaaaaag ccaccaccta ttaaggatag caaatcttta acagctgagc ctcaaaaggc
     3421 tgtccttccc acaaaactgg agaaatcgcc caaaccagaa tcaacctgtc ctctctgcaa
     3481 aactgaactc aacataggtt ctaaggatcc tcctaacttc aatacttgca ctgaatgcaa
     3541 gaatcaagtg tgtaatctct gtggatttaa ccctacacca catttgactg agattcaaga
     3601 atggctttgt ttaaattgcc aaacccagag agcaatatca ggacagcttg gagacatacg
     3661 caaaatgcca cctgcaccat caggacccaa agcatctcct atgcctgttc ctacagaatc
     3721 atcatctcag aaaacagcag tgcctcccca agtaaaatta gtgaaaaagc aagaacaaga
     3781 agtaaaaacg gaagctgaaa aagtcattct ggaaaaagta aaggaaacac tatcaatgga
     3841 aaaaattcct cctatggtaa ccacagatca aaaacaagaa gagagtaaac tagagaaaga
     3901 caaagcttca gctcttcaag aaaaaaagcc actccctgaa gaaaaaaaac taatccctga
     3961 agaagaaaag atacgttctg aagaaaaaaa gccactccta gaagaaaaaa agccaacccc
     4021 tgaagacaaa aagctactcc cagaggcaaa aacatcagcc ccagaagaac agaaacatga
     4081 cttacttaaa tctcaagtac aaattgctga agaaaagctt gaaggcagag tggctccaaa
     4141 gacagtgcaa gaagggaaac aaccacagac caagatggaa ggtttaccat ctggcacacc
     4201 tcagagttta cctaaagaag atgataagac aaccaaaaca ataaaagaac agccacagcc
     4261 accatgcaca gcaaaacctg atcaggtgga acctgggaaa gaaaaaacag aaaaggaaga
     4321 tgacaaatca gacacctcaa gttctcagca gcctaaaagc ccccaaggtc tgagcgacac
     4381 gggatattct tccgatggaa tatcaagctc acttggtgaa attccaagtc ttattccaac
     4441 tgatgaaaag gatattctca agggactcaa aaaggactct ttttcacaag aaagcagccc
     4501 ttccagcccc tcagatttgg ctaagttaga aagtacagtc ctatctattt tggaagctca
     4561 agcaagtaca cttgctgatg aaaagtcaga aaagaaaaca caaccccatg aagtttctcc
     4621 tgaacagcct aaagaccaag agaaaactca gagtttatct gaaaccttgg aaattactat
     4681 ttcagaagag gagatcaaag agagtcaaga agaaaggaaa gacactttta aaaaagatag
     4741 ccaacaagat attccttcca gcaaggacca taaagagaag tctgagtttg ttgatgacat
     4801 aactactaga agagagcctt atgattcagt tgaagagagt agtgaaagtg aaaactcacc
     4861 tgttccacaa agaaaacgaa gaactagtgt tggctcatca agcagtgatg agtataaaca
     4921 ggaagacagc caaggatcag gggaagagga ggacttcatt cgaaaacaaa tcatagaaat
     4981 gagtgctgat gaagatgctt caggttctga agatgatgag ttcatcagaa accagctcaa
     5041 agagattagt agcagtactg agagccagaa gaaggaagaa acaaagggaa aaggcaaaat
     5101 aacagcaggg aaacacagac gactgactcg aaaaagtagc acaagcattg atgaagatgc
     5161 aggaagacgt cactcatggc atgatgaaga cgatgaagca tttgatgaaa gtcctgaact
     5221 taaatacaga gaaactaaaa gtcaggaaag tgaagaactt gtagttactg gaggaggagg
     5281 gctacgccga tttaaaacaa ttgagctcaa cagtacaata gcagataaat attctgcaga
     5341 gtcatcacag aaaaaaacaa gtttgtattt tgacgaagag ccagaattgg aaatggaaag
     5401 cctgacagac tcacctgaag ataggtcaag gggagaggga tcttcgagtc tgcatgcttc
     5461 cagcttcact cctggtacat cccctacatc agtatcatca cttgatgagg acagtgacag
     5521 tagcccgagt cacaaaaaag gagagagcaa acagcaacgc aaagctcggc acagaccaca
     5581 tggccctctt ttgcctacta ttgaagattc ttcagaggaa gaagaattga gagaggaaga
     5641 agaattatta aaggagcaag aaaagcagag ggaaatagaa cagcaacaaa gaaagagttc
     5701 tagtaaaaaa tcaaagaaag acaaagatga acttcgagct cagagaagaa gggaaaggcc
     5761 aaagacacca cctagtaatc tctctcccat tgaagatgca tctccgacag aagagttacg
     5821 tcaggctgca gaaatggagg agctccatag atcttcttgt tctgaatatt cacctagcat
     5881 agagtcagac ccagaaggtt ttgaaataag cccggaaaaa ataatagaag tacaaaaagt
     5941 ttataaattg cccacagctg tttcattata ctcaccaaca gatgagcaat ctattatgca
     6001 gaaagaaggt agccaaaagg cgttaaaaag tgctgaggag atgtatgaag aaatgatgca
     6061 taaaacacac aaatacaaag cttttccagc tgcaaatgaa cgagatgaag tgtttgaaaa
     6121 agagcctttg tatggtggga tgctaataga ggattatatt tatgaatctt tagtagaaga
     6181 cacgtacaat ggatcggtag atggcagtct gctaacaagg caagaagaag aaaatggatt
     6241 tatgcagcag aaaggaagag agcaaaagat aagactttca gaacagattt atgaagatcc
     6301 tatgcagaaa attacagacc tccagaaaga gttttatgag ttagaaagct tacattctgt
     6361 tgtgcctcag gaagatattg tttcaagctc ttttatcatc ccagaaagcc atgagatagt
     6421 ggacctgggt actatggtaa cttctacaga agaagaaagg aaactactag atgctgatgc
     6481 tgcctatgaa gaacttatga agaggcaaca gatgcaatta acacctggat ctagcccaac
     6541 ccaggccccc attggtgagg atatgacaga gtccaccatg gactttgaca gaatgccaga
     6601 tgcctctttg acatcaagtg ttctctcagg agcgtctctt acagattcga ccagcagtgc
     6661 aacactctct atcccagatg ttaaaataac ccaacatttt tcaacagaag aaattgagga
     6721 tgaatatgta accgattata caagagaaat tcaagagata attgcccatg aatcgctgat
     6781 tttgacctac tcggagcctt cagaaagtgc tacatctgtc ccaccctctg acacaccttc
     6841 tctcacatca tctgtttctt cggtctgtac cacagatagc tcttcaccca ttactaccct
     6901 ggatagcata accacagttt atacagagcc agtggacatg ataactaaat ttgaagattc
     6961 tgaggaaatt tcttcatcaa cttattttcc aggcagcatt atagactatc cagaagaaat
     7021 aagtgtatct ttagatcgga ctgccccacc agatggtaga gctagtgctg atcatattgt
     7081 tatttcctta tctgatatgg catcttctat catagaatct gtagtaccta aacctgaagg
     7141 gccagttgct gacactgttt ctactgactt acttatatct gaaaaggacc cagtgaagaa
     7201 agccaagaag gaaactggga atggaatcat tctggaagtt ttggaagctt acagagataa
     7261 aaaggagttg gaggccgaac gaacaaaaag tagcttatcc gaaaccgtgt ttgatcaccc
     7321 accttcttct gtaatagccc ttccaatgaa agagcagctt tcaactacat actttacatc
     7381 tggagagacc tttggtcagg aaaaacctgc atctcagtta ccatctggca gtccttctgt
     7441 ttcctctctt ccagctaaac ctcgcccatt ctttagaagt tcttctttgg atatatcagc
     7501 tcaacctcct ccccctcctc cccctccccc tcctcctcct cctccaccac caccccctcc
     7561 tcccccacca cttcctccac caacttcacc taaaccaact attcttccta aaaaaaagtt
     7621 aacagttgca tctccagtga ctacagctac acctctgttt gatgctgtta ctactctaga
     7681 gaccacagct gttctgagaa gtaatggatt acctgttaca agaatatgta ctactgcacc
     7741 tcctcctgtt cctcctaagc catcttcaat tccatctgga cttgtattta cccacaggcc
     7801 tgagccaagc aaacctccaa tcgcccccaa accagtgatt cctcagcttc caacaactac
     7861 acaaaaacca acagatatac accccaaacc aacaggccta tctttaactt caagtatgac
     7921 cttaaattta gtgacttcag cagattataa attgccttcc cctacctccc cactttcccc
     7981 acactccaac aagtcttcac caagattttc caaatccctc acagaaactt atgtagttat
     8041 tacattgcca tctgaaccag ggactccaac agattcttct gctagtcaag caattaccag
     8101 ttggcccttg ggatcaccct ccaaagatct ggtttctgtt gaacctgtgt tttctgtagt
     8161 tcctcctgtg acagctgtag aaattccaat ttcttcagaa cagaccttct acatctctgg
     8221 agctttacag acattttctg ctacccctgt cacagcaccc tcttcatttc aagcagctcc
     8281 cacatcagtt acacagtttc tcactactga agtttccaag actgaggttt cagcaaccag
     8341 aagtacagct cctagtgttg gtctcagcag catttccata acaattcctc cagagcctct
     8401 tgctctagat aacatacatt tagagaagcc tcagtataaa gaagatggaa aattgcaact
     8461 tgttggtgat gtaattgatt tgcgtacagt accaaaggta gaagttaaaa caactgataa
     8521 atgtattgat ctttctgctt ctacaatgga tgtgaaaagg cagatcacag caaatgaagt
     8581 ttatgggaaa caaattagtg ctgtccaacc ctctattata aatcttagtg tgacatcatc
     8641 aatagtgact cctgtatctc tggccactga gacagtgacc tttgtcacat gcacagctag
     8701 tgcaagttac actacaggca cagaaagcct agtgggtgca gaacatgcaa tgacaacacc
     8761 actccaactt acaacatcaa agcatgctga gcccccatac aggataccaa gtgaccaggt
     8821 ctttcctata gctagggaag aagcaccaat aaacttatct ctaggtactc cagcacatgc
     8881 agtgacattg gctattacaa aacctgtcac tgtgcctcct gttggtgtca caaatggatg
     8941 gactgatagc accgtatccc agggaatcac tgatggggaa gtagtggatc tcagtacaac
     9001 caagtctcac agaacagtcg taacaatgga tgagtctact tcaagtgtga tgaccaaaat
     9061 aatagaagat gaaaaacccg ttgatttaac cgcagggaga agagctgtgt gctgtgatgt
     9121 ggtttataaa ttaccatttg gaaggagctg cacagcacag cagcctgcaa ctactcttcc
     9181 tgaggatcgt tttggttata gggatgacca ctatcagtat gatcgatcag ggccatatgg
     9241 ttatagaggg attgggggaa tgaagccttc catgtctgac acaaatttag cagaagctgg
     9301 acattttttc tataaaagta agaatgcttt tgattattct gaaggaactg acacagcagt
     9361 agatctgact tcagggagag ttactacagg tgaggtaatg gattattcaa gcaagactac
     9421 aggtccatat ccagaaacac gacaagtcat ttcaggagct gggattagta ccccacagta
     9481 ttccacagca agaatgacac caccaccagg accccagtat tgtgtgggga gtgttttgag
     9541 gtcatctaat ggtgttgtct attcttcagt agcaactcca acaccctcta catttgctat
     9601 caccacacaa cctggctcca ttttcagcac cacagtgagg gatttgtctg gtattcatac
     9661 ggctgatgca gtgacttcat tacctgccat gcaccatagc cagccaatgc ctagatcata
     9721 ttttataaca acaggtgcat ctgaaacgga cattgcagta actggtattg atatcagtgc
     9781 cagtttgcaa actattacta tggagtctct tactgctgag acgatagact ctgttcccac
     9841 tttaaccaca gcatccgaag tgtttcctga agtggtggga gatgaaagtg ctcttttaat
     9901 tgtccctgaa gaagataaac aacagcagca gctagacttg gagcgtgagc tcctggaact
     9961 ggagaaaatt aagcaacagc gctttgctga ggaattggag tgggaacgtc aggaaattca
    10021 aaggttccga gaacaagaaa agatcatggt tcagaaaaag ttggaggagc tgcagtctat
    10081 gaagcaacac cttctctttc agcaagaaga agagcggcaa gcccagttca tgatgaggca
    10141 ggagacgtta gctcagcaac agttacagct tgagcagatc caacagctgc aacaacagct
    10201 tcaccagcag ctggaggagc aaaagattcg gcagatctac cagtataact atgacccttc
    10261 tggaactgct tctccacaaa ccactacaga gcaggcaatt ttggaaggtc agtatgctgc
    10321 tctggaaggc agtcaatttt gggcaactga agatgcaacc accacagctt cagctgttgt
    10381 ggcaattgaa ataccacaaa gccaaggatg gtacaccgtt cagtctgatg gtgttactca
    10441 gtacattgcc ccacctggta tcctgagcac tgtttcagaa atacctctaa cagatgttgt
    10501 tgtgaaagag gaaaaacaac ccaaaaagag aagttctgga gctaaagtcc gaggacagta
    10561 tgatgacatg ggagaaaata tgacagatga tccccgaagt tttaaaaaga tagtggacag
    10621 tggtgtacaa acggatgacg aagatgccac agatcggagc tatgtgagta ggagaaggag
    10681 aactaaaaag agtgtggata caagcgtcca aactgatgat gaagatcagg atgagtggga
    10741 tatgcctact agatcaagga ggaaagctcg tgtagggaaa tatggtgaca gcatgacaga
    10801 ggctgacaag accaaacccc tttccaaagt ctccagcata gcagttcaaa cggtagcaga
    10861 gatatctgtg caaactgaac cagttggaac cataagaaca ccctccatac gggcacgagt
    10921 ggatgccaag gtagaaataa ttaaacacat ttcagcacct gaaaagactt acaaaggggg
    10981 cagtttagga tgtcaaacag aagcagattc agacacacaa agtcctcaat atctgagtgc
    11041 cacatctcca cccaaagaca agaaacgccc aacaccttta gagattggtt attcatctca
    11101 cctccgggca gattccacag tacagctggc tccttcccca cccaaatccc ccaaagtcct
    11161 ttactcaccc atctcaccac tttcaccagg caaagcctta gaatcagcct ttgtacctta
    11221 tgaaaaaccc ctccctgatg atataagtcc acagaaagta ctgcatccag atatggctaa
    11281 agttccccca gcaagtccta agacagccaa gatgatgcag cgttctatgt ctgaccccaa
    11341 gcctctgagt ccaacagcag acgaaagttc cagggctcct tttcagtata ccgagggcta
    11401 tacgactaaa ggttctcaaa ccatgacatc ctctggagcc cagaaaaaag ttaaaagaac
    11461 tctgccaaat ccacctcctg aggagatttc cacaggaact caatccacat tcagcacaat
    11521 gggcacagtt tccaggagaa ggatctgcag aaccaacaca atggcacgag ccaagattct
    11581 ccaggacata gacagagagc ttgatcttgt ggaaagggag tctgcaaaac ttcgaaagaa
    11641 acaagcagag cttgatgaag aagaaaagga gattgatgct aagctacgat acctggaaat
    11701 gggaattaac aggaggaaag aggccctatt aaaggagaga gaaaagagag aacgagccta
    11761 cctccaggga gtagctgagg atcgtgatta catgtctgac agtgaagtga gtagcacaag
    11821 accaacccga atagaaagtc agcatggcat tgagcgacca agaactgctc cccaaactga
    11881 attcagccag tttataccac cacaaaccca aacagaatct caactagttc ctccgacaag
    11941 tccttacaca caataccagt actcttcccc tgctcttcct acccaagcac ccacctcata
    12001 cactcaacag tctcattttg agcaacaaac tttgtaccat cagcaagttt caccttatca
    12061 gactcagcca acattccaag ctgtggcaac aatgtccttc acacctcaag ttcaacctac
    12121 accaacccca cagccttctt atcagttacc ttcacagatg atggtgatac aacagaagcc
    12181 acggcaaact acattatatt tggagcccaa gataacctca aactatgaag tgattcgcaa
    12241 ccaacccctt atgatagcac ctgtttctac ggataacaca tttgctgttt cccatcttgg
    12301 tagtaagtac aatagtttag acttgagaat aggtttggag gaaagaagta gcatggcaag
    12361 cagtccaata tcaagcatat ctgcagattc tttctatgca gatattgatc accatactcc
    12421 acgaaattat gtcctaattg acgacattgg agagatcacc aaaggaacag cggcattaag
    12481 caccgcattt agccttcatg aaaaggatct gtcaaaaaca gaccgtctcc ttcgaaccac
    12541 tgagacacgc cggtctcaag aagtgacaga tttcctagca cctttacagt cttcctctag
    12601 attgcatagt tatgtgaagg cggaggaaga cccaatggag gatccttacg agttaaagct
    12661 tctgaaacat cagattaaac aggaatttcg tagagggaca gagagcttag atcaccttgc
    12721 tggtctttct cattattacc atgctgatac tagctacaga cattttccaa aatctgagaa
    12781 gtatagcatc agtagactca cacttgaaaa acaagcagca aaacaactgc cagcagccat
    12841 actttatcaa aagcagtcaa agcataagaa atcactaatt gaccctaaaa tgtcaaaatt
    12901 ttcacctatt caagaaagta gagaccttga acctgattat tcaagctata tgacttctag
    12961 cacttcatct attggtggca tttcctccag ggcaaggctc cttcaagatg acatcacttt
    13021 tggcctcaga aaaaatatta cagaccaaca aaaatttatg ggatcttctc ttggcacagg
    13081 actgggcaca ttaggaaata ccatacgctc agctctgcag gatgaagcgg ataagccata
    13141 cagtagtggc agcaggtcca gaccttcctc cagaccttcc tctgtctatg ggcttgattt
    13201 atcaattaaa agggattctt ctagctcttc cctaagactg aaagctcaag aggctgaagc
    13261 tctagatgtt tcctttagtc atgcatcatc ctctgccaga actaagccga ccagtttgcc
    13321 aattagtcaa agtagaggaa gaataccaat tgtggcccag aattctgaag aagaaagccc
    13381 actcagtcct gttggccagc caatgggaat ggccagggct gcagctggac ccctgccacc
    13441 aatatctgca gacaccaggg atcagtttgg atcaagccac tcattgcctg aagttcagca
    13501 acacatgagg gaagaatcac ggactcgagg ctatgaccgt gacatagcat tcatcatgga
    13561 tgacttccaa catgccatgt cagacagtga agcctatcat ctgcgtcgtg aggaaacaga
    13621 ttggtttgat aaacccaggg agtctcgttt ggaaaatgga catggtctgg accgaaaact
    13681 gccggaaaga ttggtccact ctagaccact cagtcaacat caagagcaaa ttatacagat
    13741 gaacgggaaa actatgcact acatctttcc tcacgcaagg ataaaaataa caagagactc
    13801 aaaggatcac acagtttcag gtaatggatt aggaattaga attgtgggtg gtaaagaaat
    13861 cccgggacat agtggagaaa ttggagccta tattgccaag attcttcctg ggggaagtgc
    13921 ggaacagacg gggaagctta tggaagggat gcaagtattg gaatggaatg gaattccctt
    13981 gacttctaaa acatatgaag aagttcagag tatcattagt cagcaaagtg gggaagcaga
    14041 aatatgtgta agactggacc tcaatatgct atcagattct gaaaattccc agcatctgga
    14101 acttcatgag ccaccaaaag ctgtggataa ggcgaaatcc ccaggggttg atcctaagca
    14161 gttggcagca gaactccaga aggtttcact acagcagtca ccgctggttc tgtcatcagt
    14221 tgttgaaaaa ggatctcatg ttcattcagg tcctacatca gcaggatcca gttccgttcc
    14281 cagccctggg caaccagggt ccccctcagt gagcaaaaag aagcacggca gcagcaagcc
    14341 taccgatgga acaaaggttg tctctcatcc aattacagga gaaattcagc ttcaaattaa
    14401 ctatgatctt ggaaatctca taatacatat tctccaagca agaaatcttg ttcctcgaga
    14461 caacaatggt tattctgacc cttttgtgaa agtgtacctt cttccaggga gaggtcaagt
    14521 catggttgtc cagaatgcaa gtgctgagta caagagaagg actaaacatg tccagaaaag
    14581 tcttaatcct gagtggaatc aaacagtaat ttataaaagt atttccatgg aacagctcaa
    14641 gaagaaaaca ctggaggtga cagtttggga ttatgataga ttttcatcca acgacttcct
    14701 tggggaggta ttgattgatt tatctagcac atctcacctc gataacactc caaggtggta
    14761 tcctctcaaa gaacagactg aaagcattga tcatggcaag tctcattcca gtcagagcag
    14821 ccagcagtcc ccaaagccat ctgttatcaa aagcagaagc catggtatct tccctgaccc
    14881 atcaaaggac atgcaggttc ccaccattga gaaatcccat agtagtcctg gtagctcaaa
    14941 atcatcatca gaaggccatc tccgttctca tggaccatct cgcagtcaaa gcaaaaccag
    15001 cgtcactcag acccacctgg aagatgcagg ggctgccata gctgctgccg aagctgccgt
    15061 gcaacaactc cgcattcaac caacaaagcc tcccaatcac cggcctgcag aaagctctgt
    15121 gtccaccggc tcctcgggca gcagctttgg cagtgggtat agcgtggaca gtgaaggaag
    15181 cagcagcact gcaggggaga ctaatctatt tcctattccg aggataggga agatgggaca
    15241 gaatggacaa gagcctgtaa aacagccagg ggtaggagta ggactagcag acactgaagc
    15301 taaaactcag gtaatgggag aaatcaagat tgcattgaag aaggaaatga agacagatgg
    15361 tgaacaacta atagttgaaa ttctccaatg cagaaatatt acatacaaat ttaagtctcc
    15421 tgatcatcta ccagatttat atgtgaaaat atatgtgatg aatatttcta cccaaaaaaa
    15481 ggtgatcaag aaaaaaacaa gagtatgcag acatgatcga gagccttcgt ttaatgaaac
    15541 ttttcgattc agtctaagtc ctgcaggaca ttctcttcag attttacttt tctccaatgg
    15601 agggaagttt atgaaaaaga ccttgattgg tgaagcctgt atctggcttg acaaagtgga
    15661 tctcagaaaa agaatagtca actggcacaa acttttggtc agtcctactc aaacgcattg
    15721 aagaaacatg tcttctcagg gtatagaaac tgctctaaat agcctcacat caagactata
    15781 gttgaatact attgtacaaa gctaagtttt gagaggcaaa cataagagtg ggaacaacaa
    15841 gcaaaaacat acttaagacc ttgtacattt attgttgtgg atcacacaaa gatattcaac
    15901 tgaaaaagtt cacatactga aaacaagaag aatggagttc tgagaccttg aatttcccat
    15961 ggctgtgaag agaaactgtg aaacaaattt tgattactta agacaataat ctttgagtag
    16021 agttgagcta tagcttaaga caggctcaaa gattaatgtg gttttcatgc agcacaaagg
    16081 taattcttta tgcaaaggag ccttggttga aaggaaagga ctgatgtaac aaatctcagt
    16141 tttcaaaact tcaaaaatct tccttcatcg tcttctattc agacaacttg ctgctttcag
    16201 attctgacat aagatatacc tacagtatgt gtccagggct ggaagtgagg tggctgtgtt
    16261 cttagggaaa atggaagagg agatgtagaa attgtggctt tcaggccata ttttaccagt
    16321 tttctctgtg tctaaatgtt acaagcatat acaacactga ctttggaatc catgtggtaa
    16381 aagcacattt gtttctgtat catttgaaac aaggtagagt gaagataata ctcagtagaa
    16441 ataaaattga atttatctag aaataaaact atgactggct aacaaagaag aatgttgccc
    16501 cataaaatat tggaattttg gttgaaacca tcaaaatctt cataatttac cattaagcca
    16561 agacatcttc agtctatgta ccaaaggacc tagagtaaac tgatatgttc taggaagcat
    16621 gataacttac tctttgtgaa actgcaaata aatgtattat cctgcacatt tcctttctgt
    16681 tgagcgatgc attgacagag aaagaaaatt ctttctctgg caaacaaacc atattaatct
    16741 tgtgacattg attaattaaa tggatcctca tttcataata ttttatgctt ttttccttaa
    16801 tgacttaatt catttactga ttgtatcatg aaaacatgac actaaactcg agttctctct
    16861 agtgctctat tttcttactt tagtgacagt atcacagtga tcaagttcat caatgttggg
    16921 aaaatatgtg aaaagtcaac atttacctga gattaaaata tactttgagc tattttaata
    16981 ataatgaata aaacaactaa tgtccaagtc ttaaaatgaa gcaccctctt ctctatcagc
    17041 attattaatt aaggaagtaa cgtgaagttg tggaaaaaac actcagcagg gaataaaagc
    17101 ctgtcttctg gtcttagttc taccactgac tgtgtcactt tgcacatgtc acttacactc
    17161 actttacccc agttttctta tctataggat aaaaacaatt atatattctt aaccttccaa
    17221 atgagatgtt gtgatgataa atcaatgatc catgaaagat gaaagcacat ttccaaatat
    17281 agttttatac acagaagtga ggaataatta ttacatatct ttttaattct caaattttat
    17341 atgtgaaaaa catcatctaa accaatggca aggattgaca tggataaaag cagtaaatta
    17401 gccacaaaac ttatttttta tttaaaatat aaactttaac ctgactaaag gtgaagaatt
    17461 acatgaaaat gcaaattttg ctatcccaaa ttaaatgaat aatgctggtc ttaccctagt
    17521 cctatattcc acccaaaaga aataaatcaa attgcttctc agagcattct gagcttaaaa
    17581 cctgctgctt tatttaaggg tgaagtgtta gtggaattag agaaaaccaa ctctagatat
    17641 tggttggata ttgaattttc tcatttttaa agaaaaaatg ctctaaattt gagaggactg
    17701 taaagcacta aaaataagag aatttctaat atatcccagg atatatatat atatatatga
    17761 cttcagaata caaattcgat cttccccaaa ctgagaaaga taaccataac ttttcttccc
    17821 tctatttttt aatccccctc cactgacaat acaatgtcat ttaccattga cattgctctc
    17881 aaatgagcat gggagagtgg aatcatcaaa gacattatat tgctagtatt ttatttttag
    17941 aaactattag atctgctgat ggttgccatg gatatttcca gcagaagcta gcacttgaag
    18001 aagcctataa tcatcactca taattgggga agaaaaggtc caaggagatc tccttctgac
    18061 ataaaaaggc tctggtattt gcccttaaaa gaaaaccctg actcatctct gatcctcttt
    18121 tgcagccact catatccata ggtatgcatg agagtttgta tgaccagtta gctttcttca
    18181 ttccagttgc aatttctttt agaataatat aaatggaggg atcaccaaaa caaagattat
    18241 ctctttggta gctatttaac ctgaaagcgt aggagtcttt ccattataga agcccctccg
    18301 ttccaaggaa ctagcgatgg ggctaggtca atcagcagag ttgacaacag ggcttctttt
    18361 tgtgcaccag cattcccctt cagagagcat aagatcctgc cagtgtgcca agtttgcagc
    18421 tgaccaaact tctaggttgt actggaatta ttctatgcaa cactgatcct tatatgaatg
    18481 cgtttcttct gaatgatgtt gactaccctt cttacaacaa aactgtttct tttttattgc
    18541 aaatagggct cttggtgttt tttacttttt tgtacatatc acagtacatg gtttttcact
    18601 ctttagttta tttcatttta ttggaattaa ctttttttta ttctaatact gacagagttt
    18661 gtaatctcta tataatacgt aattactcca attacagcac ttttaccttg aagagcatct
    18721 cagtttttcc cacaatttca ttgagtcatc agagactgat gttgcttctt ggtttcaaat
    18781 ttggtcctaa agaaactttc ggctgtagaa acaaaagcac agagtgaatt ttttacaaaa
    18841 gacagggaat atagaatagt cattacagac acaaataacc ctagtagcac gaagttggtg
    18901 ttttctctgt ttttacttaa gattaagaag atttttggtg actctgaact ctttatttat
    18961 atttcagttt aaaatatcaa gactaagggg catcagttat ctttactctt taatattgcc
    19021 catattttaa taaattacac taattaaacg catattttca gcataccagt ggaattaatt
    19081 ttgtggatca cacacattta aatagtcata ttgtgggaat attatagctg gtaaccagct
    19141 gatattgatt cttattatag gaatgactgt aatgatagtg gtggtagcag tagtgatatt
    19201 agcggtggtg gtgatgtgaa gtaaaataaa agtatatatt atattgtgcc caatttatta
    19261 gaaattattt gatcaatgct tcatttcatt aaaatatcat aaagatgttt atagtatttt
    19321 tttactttat tatttaaatc ataactaaca atatttttaa aaacttattt tcattgctac
    19381 aatgtcaaat attccaaaat cagccaacta cagctatata tgtgttatgt gtgacagaag
    19441 tgatcttcct tccctctttt tgagcttgac atgaaagtga aagaagactc aatgaataat
    19501 tatgagctat ttatttaata attacttgcc ttgggtgtaa tacagtaatg aatgagtgaa
    19561 acaaatattc tcattgaata tgatacaatg ctgttttctg tatgtttcat gttctattat
    19621 taaaggtatc cattaggcca aaattattta atcaaattct ttatctgata ggtagattga
    19681 gagcattttc ttaatgcatt accttgtaca taagtataca cttggtaaag tagacgaagt
    19741 tgaaatatta atttcatttg gcatttagca tgtgaatatg attattgttt gattgtgtct
    19801 gtatatttgt ttggtgacgt gctcaggtgc tcccactact gattaatgtg tgtgctaata
    19861 tcctaaaaac acatatgagg tttaagaaaa aattttcttg tctgaaaaca taaacatctt
    19921 aataaaactg attttgaaat aaaaactaaa gtacttgaag atatgtcttg tttctaacta
    19981 tatgttgcat gccatgttgg tgatttgcta atgtgttttt ttgtttgttt gttttaccca
    20041 aatccctttg gaaaatctaa tggacaaatg caaattcttg gactaaggac tgtataaatt
    20101 gacctgaaaa tacatgagag ttgcatttaa aaaaaaatgc ttgtaaatcc gtcttgagtt
    20161 ttactctatg taaaaatatg tcttggtttt gtgattgtat acaagatgta tcttgataac
    20221 ttatgtaaac tgtgccgtat aaaggctgtt gcctcagcct tactaataaa tactgaaaat
    20281 atca
//
