LOCUS       NM_014736               2132 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens PCNA clamp associated factor (PCLAF), transcript
            variant 1, mRNA.
ACCESSION   NM_014736
VERSION     NM_014736.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2132)
  AUTHORS   Zhang,J. and Lv,G.
  TITLE     Knockdown of LINC01138 protects human chondrocytes against
            IL-1beta-induced damage by regulating the hsa-miR-1207-5p/KIAA0101
            axis
  JOURNAL   Immun Inflamm Dis 11 (1), e744 (2023)
   PUBMED   36705420
  REMARK    GeneRIF: Knockdown of LINC01138 protects human chondrocytes against
            IL-1beta-induced damage by regulating the hsa-miR-1207-5p/KIAA0101
            axis.
REFERENCE   2  (bases 1 to 2132)
  AUTHORS   Chen,Y., Qian,S., Chen,Y., Liu,K., Yin,W. and Luo,X.
  TITLE     KIAA0101 and IL2RA Were Identified as Core Genes in
            Hormone-Resistant Nephropathy
  JOURNAL   Dis Markers 2022, 6545266 (2022)
   PUBMED   36164371
  REMARK    GeneRIF: KIAA0101 and IL2RA Were Identified as Core Genes in
            Hormone-Resistant Nephropathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2132)
  AUTHORS   Sun,Z., Zhang,S., Zhang,N., Wang,J., Wang,J. and Liu,J.
  TITLE     Circ_0005231 promotes the progression of esophageal squamous cell
            carcinoma via sponging miR-383-5p and regulating KIAA0101
  JOURNAL   Thorac Cancer 13 (12), 1751-1762 (2022)
   PUBMED   35524161
  REMARK    GeneRIF: Circ_0005231 promotes the progression of esophageal
            squamous cell carcinoma via sponging miR-383-5p and regulating
            KIAA0101.
REFERENCE   4  (bases 1 to 2132)
  AUTHORS   Liu,X., Cai,Y., Cheng,C., Gu,Y., Hu,X., Chen,K., Wu,Y. and Wu,Z.
  TITLE     PCLAF promotes neuroblastoma G1/S cell cycle progression via the
            E2F1/PTTG1 axis
  JOURNAL   Cell Death Dis 13 (2), 178 (2022)
   PUBMED   35210406
  REMARK    GeneRIF: PCLAF promotes neuroblastoma G1/S cell cycle progression
            via the E2F1/PTTG1 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2132)
  AUTHORS   Wang,K., Li,J. and Zhou,B.
  TITLE     KIAA0101 knockdown inhibits glioma progression and glycolysis by
            inactivating the PI3K/AKT/mTOR pathway
  JOURNAL   Metab Brain Dis 37 (2), 489-499 (2022)
   PUBMED   34792707
  REMARK    GeneRIF: KIAA0101 knockdown inhibits glioma progression and
            glycolysis by inactivating the PI3K/AKT/mTOR pathway.
REFERENCE   6  (bases 1 to 2132)
  AUTHORS   Guo,M., Li,J., Wan,D. and Gu,J.
  TITLE     KIAA0101 (OEACT-1), an expressionally down-regulated and
            growth-inhibitory gene in human hepatocellular carcinoma
  JOURNAL   BMC Cancer 6, 109 (2006)
   PUBMED   16646990
  REMARK    GeneRIF: KIAA0101 protein expression was down-regulated in
            hepatocellular carcinoma; this gene could inhibit the HCC cell
            growth in vitro and presumably by its blocking effect on cell cycle
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2132)
  AUTHORS   Simpson,F., Lammerts van Bueren,K., Butterfield,N., Bennetts,J.S.,
            Bowles,J., Adolphe,C., Simms,L.A., Young,J., Walsh,M.D.,
            Leggett,B., Fowles,L.F. and Wicking,C.
  TITLE     The PCNA-associated factor KIAA0101/p15(PAF) binds the potential
            tumor suppressor product p33ING1b
  JOURNAL   Exp Cell Res 312 (1), 73-85 (2006)
   PUBMED   16288740
  REMARK    GeneRIF: The PCNA-associated factor KIAA0101/p15(PAF) binds the
            potential tumor suppressor product p33ING1b.
REFERENCE   8  (bases 1 to 2132)
  AUTHORS   Mizutani,K., Onda,M., Asaka,S., Akaishi,J., Miyamoto,S.,
            Yoshida,A., Nagahama,M., Ito,K. and Emi,M.
  TITLE     Overexpressed in anaplastic thyroid carcinoma-1 (OEATC-1) as a
            novel gene responsible for anaplastic thyroid carcinoma
  JOURNAL   Cancer 103 (9), 1785-1790 (2005)
   PUBMED   15789362
  REMARK    GeneRIF: Overexpression of KIAA0101 is associated with anaplastic
            thyroid carcinoma
REFERENCE   9  (bases 1 to 2132)
  AUTHORS   Petroziello,J., Yamane,A., Westendorf,L., Thompson,M., McDonagh,C.,
            Cerveny,C., Law,C.L., Wahl,A. and Carter,P.
  TITLE     Suppression subtractive hybridization and expression profiling
            identifies a unique set of genes overexpressed in non-small-cell
            lung cancer
  JOURNAL   Oncogene 23 (46), 7734-7745 (2004)
   PUBMED   15334068
REFERENCE   10 (bases 1 to 2132)
  AUTHORS   Yu,P., Huang,B., Shen,M., Lau,C., Chan,E., Michel,J., Xiong,Y.,
            Payan,D.G. and Luo,Y.
  TITLE     p15(PAF), a novel PCNA associated factor with increased expression
            in tumor tissues
  JOURNAL   Oncogene 20 (4), 484-489 (2001)
   PUBMED   11313979
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF691807.1, BC005832.2 and AC087632.10.
            
            On Nov 24, 2018 this sequence version replaced NM_014736.5.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290748.1, SRR1163655.601241.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA2142680, SAMEA2149398
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300035.9/ ENSP00000300035.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BF691807.1         70-77
            9-11                BF691807.1         79-81
            12-1138             BC005832.2         1-1127
            1139-1139           AC087632.10        65861-65861
            1140-1442           BC005832.2         1129-1431
            1443-2132           AC087632.10        66165-66854
FEATURES             Location/Qualifiers
     source          1..2132
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..2132
                     /gene="PCLAF"
                     /gene_synonym="KIAA0101; L5; NS5ATP9; OEATC; OEATC-1;
                     OEATC1; p15(PAF); p15/PAF; p15PAF; PAF; PAF15"
                     /note="PCNA clamp associated factor"
                     /db_xref="GeneID:9768"
                     /db_xref="HGNC:HGNC:28961"
                     /db_xref="MIM:610696"
     exon            1..116
                     /gene="PCLAF"
                     /gene_synonym="KIAA0101; L5; NS5ATP9; OEATC; OEATC-1;
                     OEATC1; p15(PAF); p15/PAF; p15PAF; PAF; PAF15"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..406
                     /gene="PCLAF"
                     /gene_synonym="KIAA0101; L5; NS5ATP9; OEATC; OEATC-1;
                     OEATC1; p15(PAF); p15/PAF; p15PAF; PAF; PAF15"
                     /note="isoform 1 is encoded by transcript variant 1;
                     overexpressed in anaplastic thyroid carcinoma 1;
                     PCNA-associated factor of 15 kDa; HCV NS5A-transactivated
                     protein 9; hepatitis C virus NS5A-transactivated protein
                     9"
                     /codon_start=1
                     /product="PCNA-associated factor isoform 1"
                     /protein_id="NP_055551.1"
                     /db_xref="CCDS:CCDS10193.1"
                     /db_xref="GeneID:9768"
                     /db_xref="HGNC:HGNC:28961"
                     /db_xref="MIM:610696"
                     /translation="MVRTKADSVPGTYRKVVAARAPRKVLGSSTSATNSTSVSSRKAE
                     NKYAGGNPVCVRPTPKWQKGIGEFFRLSPKDSEKENQIPEEAGSSGLGKAKRKACPLQ
                     PDHTNDEKE"
     exon            117..197
                     /gene="PCLAF"
                     /gene_synonym="KIAA0101; L5; NS5ATP9; OEATC; OEATC-1;
                     OEATC1; p15(PAF); p15/PAF; p15PAF; PAF; PAF15"
                     /inference="alignment:Splign:2.1.0"
     exon            198..360
                     /gene="PCLAF"
                     /gene_synonym="KIAA0101; L5; NS5ATP9; OEATC; OEATC-1;
                     OEATC1; p15(PAF); p15/PAF; p15PAF; PAF; PAF15"
                     /inference="alignment:Splign:2.1.0"
     exon            361..2132
                     /gene="PCLAF"
                     /gene_synonym="KIAA0101; L5; NS5ATP9; OEATC; OEATC-1;
                     OEATC1; p15(PAF); p15/PAF; p15PAF; PAF; PAF15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      843..848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCLAF"
                     /gene_synonym="KIAA0101; L5; NS5ATP9; OEATC; OEATC-1;
                     OEATC1; p15(PAF); p15/PAF; p15PAF; PAF; PAF15"
                     /note="hexamer: ATTAAA"
     polyA_site      848
                     /gene="PCLAF"
                     /gene_synonym="KIAA0101; L5; NS5ATP9; OEATC; OEATC-1;
                     OEATC1; p15(PAF); p15/PAF; p15PAF; PAF; PAF15"
                     /note="major polyA site"
     regulatory      2101..2106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCLAF"
                     /gene_synonym="KIAA0101; L5; NS5ATP9; OEATC; OEATC-1;
                     OEATC1; p15(PAF); p15/PAF; p15PAF; PAF; PAF15"
                     /note="hexamer: AATAAA"
     polyA_site      2132
                     /gene="PCLAF"
                     /gene_synonym="KIAA0101; L5; NS5ATP9; OEATC; OEATC-1;
                     OEATC1; p15(PAF); p15/PAF; p15PAF; PAF; PAF15"
ORIGIN      
        1 ccttgtccag tgaaacaccc tcggctggga agtcagttcg ttctctcctc tcctctcttc
       61 ttgtttgaac atggtgcgga ctaaagcaga cagtgttcca ggcacttaca gaaaagtggt
      121 ggctgctcga gcccccagaa aggtgcttgg ttcttccacc tctgccacta attcgacatc
      181 agtttcatcg aggaaagctg aaaataaata tgcaggaggg aaccccgttt gcgtgcgccc
      241 aactcccaag tggcaaaaag gaattggaga attctttagg ttgtccccta aagattctga
      301 aaaagagaat cagattcctg aagaggcagg aagcagtggc ttaggaaaag caaagagaaa
      361 agcatgtcct ttgcaacctg atcacacaaa tgatgaaaaa gaatagaact ttctcattca
      421 tctttgaata acgtctcctt gtttaccctg gtattctaga atgtaaattt acataaatgt
      481 gtttgttcca attagctttg ttgaacaggc atttaattaa aaaatttagg tttaaattta
      541 gatgttcaaa agtagttgtg aaatttgaga atttgtaaga ctaattatgg taacttagct
      601 tagtattcaa tataatgcat tgtttggttt cttttaccaa attaagtgtc tagttcttgc
      661 taaaatcaag tcattgcatt gtgttctaat tacaagtatg ttgtatttga gatttgctta
      721 gattgttgta ctgctgccat ttttattggt gtttgattat tggaatggtg ccatattgtc
      781 actccttcta cttgctttaa aaagcagagt tagatttttg cacattaaaa aattcagtat
      841 taattaaaca ttacttattc taccctcttt tttggcaagg aggacaaata cgcaatgttg
      901 gaaaaccttg gatggatatc ttctctttaa aaaaatgtaa agataatttg gtcttgaggg
      961 tttaaacggt tgataatgcc tctacaacaa caagaaaaaa gataaaatac taggatagaa
     1021 tcatggtggg cacagtggct tctcaggagg ctgaggaggg aggtttgctt gagtccagga
     1081 gttggagacc agcccaggca acatagcgta aaccctatct ctaaaacaat ttttagccgg
     1141 gtgcggtggc tcacgcctgt aatcccagca ctctgggagg ccgaggcggg tggatcatga
     1201 ggtcaggaga tcgagaccat cctgcctaac aaggtgaaac cccgtctcta ctaaaaatac
     1261 aaaaaattag ccgggcgcgg tggcgggcgc ctgtagtccc agctactcgg gaggctgagg
     1321 caggagaatg gcgtgaaccc gggaagtgga gcttgcagtg agccgagatt gcgccactgc
     1381 agtcggcagt ccggcttggg cgacagagcg agactccgtc tcaaaaaaaa aaaaaaaaaa
     1441 aattttaaaa aaggctgagt gcagtggctc acacctgtaa tcccagcact ttgggaggcc
     1501 aaggcaggtg gatcacctga gataggagtt caagaccagc ctggccagca tggtgaaact
     1561 gtcactacta aaaatgaaaa aatgagccag gcatggtggc acatgcctgt aatcccagct
     1621 actcaggagg ctgaggcagg agaatcgctt gaacctggga ggtggaggtt gcagtgagcc
     1681 cagattgtgc cactgcactc cagcctgaac aacagagtga gacaatgtct taaaaaaaaa
     1741 aaaagaaaga aaagaaaaaa atatatattt atatatgaac aataaaaaat tagcctggca
     1801 tggtggcaca cacagtggaa ccagatccca tctcttaaaa gaaattttcc taggatttgc
     1861 atttgattcg ctatcataaa atataatttt aaagttggaa gtcaatataa catgaaaggc
     1921 aaatcatgcc ataaacccat aggcatggca aaactcctaa gagctactat gacatttttc
     1981 aacataacca gaggtataat tgaagaagtg ggtataatat tcctcatcac cctttttgca
     2041 gcagcctgtt gtcaaaagta atcatatttt agtaggcata tttttctgaa atacgtttgt
     2101 aataaatgca tacttatttt tacaatacac ta
//
