LOCUS       NM_022104               2689 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens phosphorylated CTD interacting factor 1 (PCIF1), mRNA.
ACCESSION   NM_022104
VERSION     NM_022104.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2689)
  AUTHORS   Zhong,W., Wang,C. and Sun,Y.
  TITLE     LncRNA PCIF1 promotes aerobic glycolysis in A549/DDP cells by
            competitively binding miR-326 to regulate PKM expression
  JOURNAL   Mol Cell Probes 77, 101977 (2024)
   PUBMED   39074568
  REMARK    GeneRIF: LncRNA PCIF1 promotes aerobic glycolysis in A549/DDP cells
            by competitively binding miR-326 to regulate PKM expression.
REFERENCE   2  (bases 1 to 2689)
  AUTHORS   Xie,S., Kuang,W., Guo,M., Yang,F., Jin,H., Chen,X., Yi,L., Huo,C.,
            Xu,Z., Lin,A., Liu,W., Mao,J., Shu,Q. and Zhou,T.
  TITLE     m6Am methyltransferase PCIF1 negatively regulates ciliation by
            inhibiting BICD2 expression
  JOURNAL   J Cell Biol 223 (6) (2024)
   PUBMED   38526325
  REMARK    GeneRIF: m6Am methyltransferase PCIF1 negatively regulates
            ciliation by inhibiting BICD2 expression.
REFERENCE   3  (bases 1 to 2689)
  AUTHORS   Li,K., Chen,J., Zhang,C., Cheng,M., Chen,S., Song,W., Yang,C.,
            Ling,R., Chen,Z., Wang,X., Xiong,G., Ma,J., Zhu,Y., Yuan,Q.,
            Liu,Q., Peng,L., Chen,Q. and Chen,D.
  TITLE     The CTBP2-PCIF1 complex regulates m6Am modification of mRNA in head
            and neck squamous cell carcinoma
  JOURNAL   J Clin Invest 133 (20), e170173 (2023)
   PUBMED   37643007
  REMARK    GeneRIF: The CTBP2-PCIF1 complex regulates m6Am modification of
            mRNA in head and neck squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2689)
  AUTHORS   Wang,L., Wu,L., Zhu,Z., Zhang,Q., Li,W., Gonzalez,G.M., Wang,Y. and
            Rana,T.M.
  TITLE     Role of PCIF1-mediated 5'-cap N6-methyladeonsine mRNA methylation
            in colorectal cancer and anti-PD-1 immunotherapy
  JOURNAL   EMBO J 42 (2), e111673 (2023)
   PUBMED   36514940
  REMARK    GeneRIF: Role of PCIF1-mediated 5'-cap N6-methyladeonsine mRNA
            methylation in colorectal cancer and anti-PD-1 immunotherapy.
REFERENCE   5  (bases 1 to 2689)
  AUTHORS   Gao,S., Zhou,J., Hu,Z., Zhang,S., Wu,Y., Musunuru,P.P., Zhang,T.,
            Yang,L., Luo,X., Bai,J., Meng,Q. and Yu,R.
  TITLE     Effects of the m6Am methyltransferase PCIF1 on cell proliferation
            and survival in gliomas
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1868 (11), 166498 (2022)
   PUBMED   35868483
  REMARK    GeneRIF: Effects of the m6Am methyltransferase PCIF1 on cell
            proliferation and survival in gliomas.
REFERENCE   6  (bases 1 to 2689)
  AUTHORS   Kathiresan,S., Willer,C.J., Peloso,G.M., Demissie,S., Musunuru,K.,
            Schadt,E.E., Kaplan,L., Bennett,D., Li,Y., Tanaka,T., Voight,B.F.,
            Bonnycastle,L.L., Jackson,A.U., Crawford,G., Surti,A., Guiducci,C.,
            Burtt,N.P., Parish,S., Clarke,R., Zelenika,D., Kubalanza,K.A.,
            Morken,M.A., Scott,L.J., Stringham,H.M., Galan,P., Swift,A.J.,
            Kuusisto,J., Bergman,R.N., Sundvall,J., Laakso,M., Ferrucci,L.,
            Scheet,P., Sanna,S., Uda,M., Yang,Q., Lunetta,K.L., Dupuis,J., de
            Bakker,P.I., O'Donnell,C.J., Chambers,J.C., Kooner,J.S.,
            Hercberg,S., Meneton,P., Lakatta,E.G., Scuteri,A., Schlessinger,D.,
            Tuomilehto,J., Collins,F.S., Groop,L., Altshuler,D., Collins,R.,
            Lathrop,G.M., Melander,O., Salomaa,V., Peltonen,L.,
            Orho-Melander,M., Ordovas,J.M., Boehnke,M., Abecasis,G.R.,
            Mohlke,K.L. and Cupples,L.A.
  TITLE     Common variants at 30 loci contribute to polygenic dyslipidemia
  JOURNAL   Nat Genet 41 (1), 56-65 (2009)
   PUBMED   19060906
REFERENCE   7  (bases 1 to 2689)
  AUTHORS   Hirose,Y., Iwamoto,Y., Sakuraba,K., Yunokuchi,I., Harada,F. and
            Ohkuma,Y.
  TITLE     Human phosphorylated CTD-interacting protein, PCIF1, negatively
            modulates gene expression by RNA polymerase II
  JOURNAL   Biochem Biophys Res Commun 369 (2), 449-455 (2008)
   PUBMED   18294453
  REMARK    GeneRIF: These data suggest that icariin exerts its potent
            osteogenic effect through induction of Runx2 expression, production
            of BMP-4 and activation of BMP signaling.
REFERENCE   8  (bases 1 to 2689)
  AUTHORS   Liu,A., Desai,B.M. and Stoffers,D.A.
  TITLE     Identification of PCIF1, a POZ domain protein that inhibits PDX-1
            (MODY4) transcriptional activity
  JOURNAL   Mol Cell Biol 24 (10), 4372-4383 (2004)
   PUBMED   15121856
REFERENCE   9  (bases 1 to 2689)
  AUTHORS   Fan,H., Sakuraba,K., Komuro,A., Kato,S., Harada,F. and Hirose,Y.
  TITLE     PCIF1, a novel human WW domain-containing protein, interacts with
            the phosphorylated RNA polymerase II
  JOURNAL   Biochem Biophys Res Commun 301 (2), 378-385 (2003)
   PUBMED   12565871
  REMARK    GeneRIF: Data suggest that phosphorylated CTD interacting factor 1
            (PCIF1) may play a role in mRNA synthesis by modulating RNA
            polymerase II activity.
REFERENCE   10 (bases 1 to 2689)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ684226.1 and BC013365.2.
            
            On Nov 22, 2018 this sequence version replaced NM_022104.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.66768.1,
                                           SRR1803611.132152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372409.8/ ENSP00000361486.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-432               BQ684226.1         72-503
            433-2689            BC013365.2         409-2665
FEATURES             Location/Qualifiers
     source          1..2689
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..2689
                     /gene="PCIF1"
                     /gene_synonym="C20orf67; CAPAM; hCAPAM; hPCIF1; MT-A70;
                     PPP1R121"
                     /note="phosphorylated CTD interacting factor 1"
                     /db_xref="GeneID:63935"
                     /db_xref="HGNC:HGNC:16200"
                     /db_xref="MIM:618626"
     exon            1..122
                     /gene="PCIF1"
                     /gene_synonym="C20orf67; CAPAM; hCAPAM; hPCIF1; MT-A70;
                     PPP1R121"
                     /inference="alignment:Splign:2.1.0"
     exon            123..290
                     /gene="PCIF1"
                     /gene_synonym="C20orf67; CAPAM; hCAPAM; hPCIF1; MT-A70;
                     PPP1R121"
                     /inference="alignment:Splign:2.1.0"
     exon            291..433
                     /gene="PCIF1"
                     /gene_synonym="C20orf67; CAPAM; hCAPAM; hPCIF1; MT-A70;
                     PPP1R121"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..2424
                     /gene="PCIF1"
                     /gene_synonym="C20orf67; CAPAM; hCAPAM; hPCIF1; MT-A70;
                     PPP1R121"
                     /EC_number="2.1.1.62"
                     /note="PDX-1 C terminus-interacting factor 1; protein
                     phosphatase 1, regulatory subunit 121; cap-specific
                     adenosine methyltransferase; PDX1 C-terminal inhibiting
                     factor 1"
                     /codon_start=1
                     /product="mRNA
                     (2'-O-methyladenosine-N(6)-)-methyltransferase"
                     /protein_id="NP_071387.1"
                     /db_xref="CCDS:CCDS13388.1"
                     /db_xref="GeneID:63935"
                     /db_xref="HGNC:HGNC:16200"
                     /db_xref="MIM:618626"
                     /translation="MANENHGSPREEASLLSHSPGTSNQSQPCSPKPIRLVQDLPEEL
                     VHAGWEKCWSRRENRPYYFNRFTNQSLWEMPVLGQHDVISDPLGLNATPLPQDSSLVE
                     TPPAENKPRKRQLSEEQPSGNGVKKPKIEIPVTPTGQSVPSSPSIPGTPTLKMWGTSP
                     EDKQQAALLRPTEVYWDLDIQTNAVIKHRGPSEVLPPHPEVELLRSQLILKLRQHYRE
                     LCQQREGIEPPRESFNRWMLERKVVDKGSDPLLPSNCEPVVSPSMFREIMNDIPIRLS
                     RIKFREEAKRLLFKYAEAARRLIESRSASPDSRKVVKWNVEDTFSWLRKDHSASKEDY
                     MDRLEHLRRQCGPHVSAAAKDSVEGICSKIYHISLEYVKRIREKHLAILKENNISEEV
                     EAPEVEPRLVYCYPVRLAVSAPPMPSVEMHMENNVVCIRYKGEMVKVSRNYFSKLWLL
                     YRYSCIDDSAFERFLPRVWCLLRRYQMMFGVGLYEGTGLQGSLPVHVFEALHRLFGVS
                     FECFASPLNCYFRQYCSAFPDTDGYFGSRGPCLDFAPLSGSFEANPPFCEELMDAMVS
                     HFERLLESSPEPLSFIVFIPEWREPPTPALTRMEQSRFKRHQLILPAFEHEYRSGSQH
                     ICKKEEMHYKAVHNTAVLFLQNDPGFAKWAPTPERLQELSAAYRQSGRSHSSGSSSSS
                     SSEAKDRDSGREQGPSREPHPT"
     exon            434..558
                     /gene="PCIF1"
                     /gene_synonym="C20orf67; CAPAM; hCAPAM; hPCIF1; MT-A70;
                     PPP1R121"
                     /inference="alignment:Splign:2.1.0"
     exon            559..696
                     /gene="PCIF1"
                     /gene_synonym="C20orf67; CAPAM; hCAPAM; hPCIF1; MT-A70;
                     PPP1R121"
                     /inference="alignment:Splign:2.1.0"
     exon            697..827
                     /gene="PCIF1"
                     /gene_synonym="C20orf67; CAPAM; hCAPAM; hPCIF1; MT-A70;
                     PPP1R121"
                     /inference="alignment:Splign:2.1.0"
     exon            828..982
                     /gene="PCIF1"
                     /gene_synonym="C20orf67; CAPAM; hCAPAM; hPCIF1; MT-A70;
                     PPP1R121"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1130
                     /gene="PCIF1"
                     /gene_synonym="C20orf67; CAPAM; hCAPAM; hPCIF1; MT-A70;
                     PPP1R121"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1214
                     /gene="PCIF1"
                     /gene_synonym="C20orf67; CAPAM; hCAPAM; hPCIF1; MT-A70;
                     PPP1R121"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1314
                     /gene="PCIF1"
                     /gene_synonym="C20orf67; CAPAM; hCAPAM; hPCIF1; MT-A70;
                     PPP1R121"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1477
                     /gene="PCIF1"
                     /gene_synonym="C20orf67; CAPAM; hCAPAM; hPCIF1; MT-A70;
                     PPP1R121"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1650
                     /gene="PCIF1"
                     /gene_synonym="C20orf67; CAPAM; hCAPAM; hPCIF1; MT-A70;
                     PPP1R121"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1737
                     /gene="PCIF1"
                     /gene_synonym="C20orf67; CAPAM; hCAPAM; hPCIF1; MT-A70;
                     PPP1R121"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1922
                     /gene="PCIF1"
                     /gene_synonym="C20orf67; CAPAM; hCAPAM; hPCIF1; MT-A70;
                     PPP1R121"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2016
                     /gene="PCIF1"
                     /gene_synonym="C20orf67; CAPAM; hCAPAM; hPCIF1; MT-A70;
                     PPP1R121"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2192
                     /gene="PCIF1"
                     /gene_synonym="C20orf67; CAPAM; hCAPAM; hPCIF1; MT-A70;
                     PPP1R121"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2689
                     /gene="PCIF1"
                     /gene_synonym="C20orf67; CAPAM; hCAPAM; hPCIF1; MT-A70;
                     PPP1R121"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2671..2676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCIF1"
                     /gene_synonym="C20orf67; CAPAM; hCAPAM; hPCIF1; MT-A70;
                     PPP1R121"
                     /note="hexamer: AATACA"
     polyA_site      2689
                     /gene="PCIF1"
                     /gene_synonym="C20orf67; CAPAM; hCAPAM; hPCIF1; MT-A70;
                     PPP1R121"
                     /note="major polyA site"
ORIGIN      
        1 gcggagtccc ggcccgggac acaagatggc ggcagcggcg ctggggaggg cgaggcggag
       61 gcggcaaaac gggcggtcga gcagaacgtg tagccgcgtc ccctccagtc cgctccgggc
      121 agctgctgat gcaaggaatc ccctgggctc ccgtccactc cactgctgac cagcccattc
      181 gcctgtgctg agtcttcctg caggcctttc cttgcctctg tgggaccctg tgggggtcca
      241 tccggctgga gaagaaaagc ctctcatgct aacgttgcag accccagagg gtcctgtgtg
      301 ggtgtggaga tggccaatga gaatcacggc agcccccggg aggaagcgtc cctgctgagt
      361 cactccccag gtacctccaa tcagagccag ccctgttctc caaagccaat ccgcctggtt
      421 caggacctcc cagaggagct ggtgcatgca ggctgggaga agtgctggag ccggagggag
      481 aatcgtccct actacttcaa ccgattcacc aaccagtccc tgtgggagat gcccgtgctg
      541 gggcagcacg atgtgatttc ggaccctttg gggctgaatg cgaccccact gccccaagac
      601 tcaagcttgg tggaaactcc cccggctgag aacaagccca gaaagcggca gctctcggaa
      661 gagcagccaa gcggcaatgg tgtgaagaag cccaagattg aaatcccagt gacacccaca
      721 ggccagtcgg tgcccagctc ccccagtatc ccaggaaccc caacgctgaa gatgtggggt
      781 acgtcccctg aagataaaca gcaggcagct ctcctacgac ccactgaggt ctactgggac
      841 ctggacatcc agaccaatgc tgtcatcaag caccgggggc cttcagaggt gctgcccccg
      901 catcccgaag tggaactgct ccgctctcag ctcatcctga agcttcggca gcactatcgg
      961 gagctgtgcc agcagcgaga gggcattgag cctccacggg agtctttcaa ccgctggatg
     1021 ctggagcgca aggtggtaga caaaggatct gaccccctgt tgcccagcaa ctgtgaacca
     1081 gtcgtgtcac cttccatgtt tcgtgaaatc atgaacgaca ttcctatcag gttatcccga
     1141 atcaagttcc gggaggaagc caagcgcctg ctctttaaat atgcggaggc cgccaggcgg
     1201 ctcatcgagt ccaggagtgc atcccctgac agtaggaagg tggtcaaatg gaatgtggaa
     1261 gacaccttta gctggcttcg gaaggaccac tcagcctcca aggaggacta catggatcgc
     1321 ctggagcatc tgcggaggca gtgtggcccc cacgtctcgg ccgcagccaa ggactccgtg
     1381 gaaggcatct gcagtaagat ctaccacatc tccctggagt acgtcaaacg gatccgagag
     1441 aagcaccttg ccatcctcaa ggaaaacaac atctcagagg aggtggaggc ccctgaggtg
     1501 gagccccgcc tagtgtactg ctacccagtc cggctggctg tgtctgcacc gcccatgccc
     1561 agcgtggaga tgcacatgga gaacaacgtg gtctgcatcc ggtataaggg agagatggtc
     1621 aaggtcagcc gcaactactt cagcaagctg tggctccttt accgctacag ctgcattgat
     1681 gactctgcct ttgagaggtt cctgccccgg gtctggtgtc ttctccgacg gtaccagatg
     1741 atgttcggcg tgggcctcta cgaggggact ggcctgcagg gatcgctgcc tgtgcatgtc
     1801 tttgaggccc tccaccgact ctttggcgtc agcttcgagt gcttcgcctc acccctcaac
     1861 tgctacttcc gccagtactg ttctgccttc cccgacacag acggctactt tggctcccgc
     1921 gggccctgcc tagactttgc tccactgagt ggttcatttg aggccaaccc tcccttctgc
     1981 gaggagctca tggatgccat ggtctctcac tttgagagac tgcttgagag ctcaccggag
     2041 cccctgtcct tcatcgtgtt catccctgag tggcgggaac ccccaacacc agcgctcacc
     2101 cgcatggagc agagccgctt caaacgccac cagttgatcc tgcctgcctt tgagcatgag
     2161 taccgcagtg gctcccagca catctgcaag aaggaggaaa tgcactacaa ggccgtccac
     2221 aacacggctg tgctcttcct acagaacgac cctggctttg ccaagtgggc gccgacgcct
     2281 gaacggctgc aggagctgag tgctgcctac cggcagtcag gccgcagcca cagctctggt
     2341 tcttcctcat cgtcctcctc ggaggccaag gaccgggact cgggccgtga gcagggtcct
     2401 agccgcgagc ctcaccccac ttaacatatc ctgcggggag gaggagcccc aggggtgcta
     2461 gtctggactg ctgggactcg ggcccctggg gcctcagagg gaccccggct gccactgaca
     2521 tatgaagatt atggttctgc cagggctccc ctccctgcct gtccccaagt cctcacctca
     2581 aactccctcc aagtcccatg tatataggtc ctgatgcctt cccaaccccg cccctcaccc
     2641 tgttgccacc ttgtttcatt tgtaaaagga aatacagaaa cccccccaa
//
