LOCUS       NM_001127202            1897 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens PCI domain containing 2 (PCID2), transcript variant 1,
            mRNA.
ACCESSION   NM_001127202
VERSION     NM_001127202.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1897)
  AUTHORS   Zhang,N., Zhang,Z., Zhang,Y., Song,X., Zhang,X., Li,J., Zuo,L. and
            Hu,J.
  TITLE     [PCID2 is highly expressed in gastric cancer and affects the
            prognosis by regulating cancer cell cycle and proliferation]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 44 (2), 324-332 (2024)
   PUBMED   38501418
  REMARK    GeneRIF: [PCID2 is highly expressed in gastric cancer and affects
            the prognosis by regulating cancer cell cycle and proliferation].
REFERENCE   2  (bases 1 to 1897)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1897)
  AUTHORS   Zhang,J., Zhai,J., Wong,C.C., Chen,H., Wang,X., Ji,J. and Yu,J.
  TITLE     A novel amplification gene PCI domain containing 2 (PCID2) promotes
            colorectal cancer through directly degrading a tumor suppressor
            promyelocytic leukemia (PML)
  JOURNAL   Oncogene 40 (49), 6641-6652 (2021)
   PUBMED   34625711
  REMARK    GeneRIF: A novel amplification gene PCI domain containing 2 (PCID2)
            promotes colorectal cancer through directly degrading a tumor
            suppressor promyelocytic leukemia (PML).
REFERENCE   4  (bases 1 to 1897)
  AUTHORS   Gondo,N., Sakai,Y., Zhang,Z., Hato,Y., Kuzushima,K., Phimsen,S.,
            Kawashima,Y., Kuroda,M., Suzuki,M., Okada,S., Iwata,H., Toyama,T.,
            Rezano,A. and Kuwahara,K.
  TITLE     Increased chemosensitivity via BRCA2-independent DNA damage in
            DSS1- and PCID2-depleted breast carcinomas
  JOURNAL   Lab Invest 101 (8), 1048-1059 (2021)
   PUBMED   34031538
  REMARK    GeneRIF: Increased chemosensitivity via BRCA2-independent DNA
            damage in DSS1- and PCID2-depleted breast carcinomas.
REFERENCE   5  (bases 1 to 1897)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1897)
  AUTHORS   Umlauf,D., Bonnet,J., Waharte,F., Fournier,M., Stierle,M.,
            Fischer,B., Brino,L., Devys,D. and Tora,L.
  TITLE     The human TREX-2 complex is stably associated with the nuclear pore
            basket
  JOURNAL   J Cell Sci 126 (Pt 12), 2656-2667 (2013)
   PUBMED   23591820
REFERENCE   7  (bases 1 to 1897)
  AUTHORS   Jani,D., Lutz,S., Hurt,E., Laskey,R.A., Stewart,M. and
            Wickramasinghe,V.O.
  TITLE     Functional and structural characterization of the mammalian TREX-2
            complex that links transcription with nuclear messenger RNA export
  JOURNAL   Nucleic Acids Res 40 (10), 4562-4573 (2012)
   PUBMED   22307388
REFERENCE   8  (bases 1 to 1897)
  AUTHORS   Ellisdon,A.M., Dimitrova,L., Hurt,E. and Stewart,M.
  TITLE     Structural basis for the assembly and nucleic acid binding of the
            TREX-2 transcription-export complex
  JOURNAL   Nat Struct Mol Biol 19 (3), 328-336 (2012)
   PUBMED   22343721
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1897)
  AUTHORS   Nakaya,T., Kuwahara,K., Ohta,K., Kitabatake,M., Toda,T., Takeda,N.,
            Tani,T., Kondo,E. and Sakaguchi,N.
  TITLE     Critical role of Pcid2 in B cell survival through the regulation of
            MAD2 expression
  JOURNAL   J Immunol 185 (9), 5180-5187 (2010)
   PUBMED   20870947
REFERENCE   10 (bases 1 to 1897)
  AUTHORS   Szafranski,K., Schindler,S., Taudien,S., Hiller,M., Huse,K.,
            Jahn,N., Schreiber,S., Backofen,R. and Platzer,M.
  TITLE     Violating the splicing rules: TG dinucleotides function as
            alternative 3' splice sites in U2-dependent introns
  JOURNAL   Genome Biol 8 (8), R154 (2007)
   PUBMED   17672918
  REMARK    GeneRIF: validated occurrence of an unusual TG 3' splice site in
            intron 2
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK001185.1, AA779868.1,
            AI272719.1 and AL137002.19.
            
            On May 17, 2019 this sequence version replaced NM_001127202.3.
            
            Summary: This gene encodes a component of the TREX-2 complex
            (transcription and export complex 2), which regulates mRNA export
            from the nucleus. This protein regulates expression of Mad2 mitotic
            arrest deficient-like 1, a cell division checkpoint protein. This
            protein also interacts with and stabilizes Brca2 (breast cancer 2)
            protein. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Mar 2016].
            
            Transcript Variant: This variant (1) encodes isoform 1. Variants 1,
            2, and 3 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.264579.1,
                                           SRR1660803.152166.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337344.9/ ENSP00000337405.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1783              AK001185.1         10-1792
            1784-1822           AA779868.1         4-42                c
            1823-1894           AI272719.1         1-72                c
            1895-1897           AL137002.19        102179-102181       c
FEATURES             Location/Qualifiers
     source          1..1897
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q34"
     gene            1..1897
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /note="PCI domain containing 2"
                     /db_xref="GeneID:55795"
                     /db_xref="HGNC:HGNC:25653"
                     /db_xref="MIM:613713"
     exon            1..71
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1235
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /note="isoform 1 is encoded by transcript variant 1; PCI
                     domain-containing protein 2; CSN12-like protein"
                     /codon_start=1
                     /product="PCI domain-containing protein 2 isoform 1"
                     /protein_id="NP_001120674.1"
                     /db_xref="CCDS:CCDS9532.2"
                     /db_xref="GeneID:55795"
                     /db_xref="HGNC:HGNC:25653"
                     /db_xref="MIM:613713"
                     /translation="MAHITINQYLQQVYEAIDSRDGASCAELVSFKHPHVANPRLQMA
                     SPEEKCQQVLEPPYDEMFAAHLRCTYAVGNHDFIEAYKCQTVIVQSFLRAFQAHKEEN
                     WALPVMYAVALDLRVFANNADQQLVKKGKSKVGDMLEKAAELLMSCFRVCASDTRAGI
                     EDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKDDYSTAQRVTYKYYVGR
                     KAMFDSDFKQAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPTVELLKKYHL
                     MQFAEVTRAVSEGNLLLLHEALAKHEAFFIRCGIFLILEKLKIITYRNLFKKVYLLLK
                     THQLSLDAFLVALKFMQVEDVDIDEVQCILANLIYMGHVKGYISHQHQKLVVSKQNPF
                     PPLSTVC"
     exon            72..161
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /inference="alignment:Splign:2.1.0"
     exon            162..235
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /inference="alignment:Splign:2.1.0"
     exon            236..301
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /inference="alignment:Splign:2.1.0"
     exon            302..343
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /inference="alignment:Splign:2.1.0"
     exon            344..398
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /inference="alignment:Splign:2.1.0"
     exon            399..502
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /inference="alignment:Splign:2.1.0"
     exon            503..578
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /inference="alignment:Splign:2.1.0"
     exon            579..720
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /inference="alignment:Splign:2.1.0"
     exon            721..821
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /inference="alignment:Splign:2.1.0"
     exon            822..895
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1021
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1145
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1897
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1657..1662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /note="hexamer: ATTAAA"
     polyA_site      1681
                     /gene="PCID2"
                     /gene_synonym="F10"
     regulatory      1797..1802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /note="hexamer: AATAAA"
     polyA_site      1822
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /note="major polyA site"
     regulatory      1880..1885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /note="hexamer: AATACA"
     polyA_site      1897
                     /gene="PCID2"
                     /gene_synonym="F10"
ORIGIN      
        1 gtagggggtg gcgctctccg ttcggcggcg ctcccatggc gcacattacc attaaccagt
       61 acctgcagca ggtgtacgaa gccatcgaca gcagagatgg agcatcttgt gcagagttgg
      121 tgtcttttaa acatcctcat gttgcaaacc cacgacttca aatggcctct ccagaggaga
      181 agtgtcaaca agtcttggaa cccccttatg atgaaatgtt tgcagctcat ttaaggtgca
      241 cttatgcagt ggggaatcat gacttcatag aggcatacaa gtgccagacc gtgatagtcc
      301 aatcattctt gcgagcattc caggcccaca aagaagaaaa ctgggctctg cctgtcatgt
      361 atgcagtagc gcttgacctt cgagtgtttg ccaataatgc agatcaacag ttggtaaaga
      421 aaggaaaaag caaagttggg gacatgttgg aaaaagcagc agagttactg atgagctgtt
      481 tccgggtctg tgccagcgac acccgtgctg gtatagagga ctctaagaag tggggcatgc
      541 tgtttctggt gaaccagctg tttaaaatct acttcaagat caacaaactc catttatgta
      601 aacccctaat tagagcaatt gacagctcaa acctgaaaga cgattacagc actgcacaga
      661 gagtaacata caaatactac gttggacgca aggctatgtt tgacagcgat tttaagcaag
      721 ctgaggagta cctgtcattt gcctttgagc attgtcaccg ttctagtcag aagaacaaaa
      781 ggatgattct gatctatttg cttccagtaa aaatgctatt gggtcacatg cccactgtgg
      841 agctcctgaa aaagtatcac ctgatgcagt ttgcggaagt aaccagagct gtgagcgagg
      901 gcaacctgct gctgctgcac gaggcgctgg cgaagcacga ggccttcttc attcgctgcg
      961 gaatcttcct catcctggag aagctgaaga tcatcaccta caggaacctc tttaagaaag
     1021 tgtatttgtt actgaaaaca caccagctgt ctctggatgc ttttctggtt gccttgaagt
     1081 tcatgcaggt ggaggacgtg gacattgacg aagttcagtg tattctggct aacttgatat
     1141 acatgggaca cgtcaaaggc tacatatcgc atcagcatca gaagctggtg gtcagcaagc
     1201 agaacccatt tcctcccctg tccacggtgt gttgaaagta cacggagccc cgaggacggg
     1261 tgagcagttg tttctttcca ctttggttgt gctgatgaga ccggtccggt actgcaacaa
     1321 ggctccctga agccggaact cttggaggcg cttttcccag ggatgctgag gctgagattt
     1381 tcagcacacc cgagttaatc tccttcattt gtaactaatt tcagcctgat gaaaacctgg
     1441 aattcctttt tcacagactc ggctggttct ggagtctttg tgagacttct ttgaaggagg
     1501 ctttgcgtga aggctgctcg gctcactttt cctaagtgtg gttcctgaag gctgtctttg
     1561 taactttttg tagttctttg tgtaaaaagc gtattctgaa tttatacaca tggcatgttc
     1621 ttcattatat cttccaggat acatctattt ttatatatta aatttgaatg tgttatcaaa
     1681 atgcttggtt aacttaaggc acctttttaa aagcagaatt taatttgatt taaattttcc
     1741 agattttata gcttgcctgt atggatgctc ctcaatttat gatagggtta catcccaata
     1801 aacttatttt atttgccttt gctttgttgg ttaaaaaaaa atttctttta aaaaaccatc
     1861 ttaaattgaa aatacattta atacacctgc tactaaa
//
