LOCUS       NM_001011663            2236 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens polycomb group ring finger 6 (PCGF6), transcript
            variant 1, mRNA.
ACCESSION   NM_001011663
VERSION     NM_001011663.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2236)
  AUTHORS   Lan,X., Ding,S., Zhang,T., Yi,Y., Li,C., Jin,W., Chen,J., Liang,K.,
            Wang,H. and Jiang,W.
  TITLE     PCGF6 controls neuroectoderm specification of human pluripotent
            stem cells by activating SOX2 expression
  JOURNAL   Nat Commun 13 (1), 4601 (2022)
   PUBMED   35933409
  REMARK    GeneRIF: PCGF6 controls neuroectoderm specification of human
            pluripotent stem cells by activating SOX2 expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2236)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2236)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 2236)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   5  (bases 1 to 2236)
  AUTHORS   Yang,C.S., Chang,K.Y., Dang,J. and Rana,T.M.
  TITLE     Polycomb Group Protein Pcgf6 Acts as a Master Regulator to Maintain
            Embryonic Stem Cell Identity
  JOURNAL   Sci Rep 6, 26899 (2016)
   PUBMED   27247273
  REMARK    GeneRIF: Pcgf6 acts as a master regulator to maintain embryonic
            stem cell identity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2236)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   7  (bases 1 to 2236)
  AUTHORS   Suzuki,M., Mizutani-Koseki,Y., Fujimura,Y., Miyagishima,H.,
            Kaneko,T., Takada,Y., Akasaka,T., Tanzawa,H., Takihara,Y.,
            Nakano,M., Masumoto,H., Vidal,M., Isono,K. and Koseki,H.
  TITLE     Involvement of the Polycomb-group gene Ring1B in the specification
            of the anterior-posterior axis in mice
  JOURNAL   Development 129 (18), 4171-4183 (2002)
   PUBMED   12183370
REFERENCE   8  (bases 1 to 2236)
  AUTHORS   Akasaka,T., Takahashi,N., Suzuki,M., Koseki,H., Bodmer,R. and
            Koga,H.
  TITLE     MBLR, a new RING finger protein resembling mammalian Polycomb gene
            products, is regulated by cell cycle-dependent phosphorylation
  JOURNAL   Genes Cells 7 (8), 835-850 (2002)
   PUBMED   12167161
  REMARK    GeneRIF: regulation by cell cycle-dependent phosphorylation
REFERENCE   9  (bases 1 to 2236)
  AUTHORS   Trimarchi,J.M., Fairchild,B., Wen,J. and Lees,J.A.
  TITLE     The E2F6 transcription factor is a component of the mammalian
            Bmi1-containing polycomb complex
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1519-1524 (2001)
   PUBMED   11171983
REFERENCE   10 (bases 1 to 2236)
  AUTHORS   Kanno,M., Hasegawa,M., Ishida,A., Isono,K. and Taniguchi,M.
  TITLE     mel-18, a Polycomb group-related mammalian gene, encodes a
            transcriptional negative regulator with tumor suppressive activity
  JOURNAL   EMBO J 14 (22), 5672-5678 (1995)
   PUBMED   8521824
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL591408.19, BC010235.1 and
            BC007602.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001011663.1.
            
            Summary: The protein encoded by this gene contains a RING finger
            motif, which is most closely related to those of polycomb group
            (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to
            form protein complexes and function as transcription repressors.
            This protein has been shown to interact with some PcG proteins and
            act as a transcription repressor. The activity of this protein is
            found to be regulated by cell cycle dependent phosphorylation.
            Alternatively spliced transcript variants encoding different
            isoforms have been identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript, and   encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010235.1, SRR1660809.187491.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369847.4/ ENSP00000358862.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AL591408.19        103064-103069       c
            7-157               BC010235.1         1-151
            158-1920            BC010235.1         158-1920
            1921-2236           BC007602.1         1641-1956
FEATURES             Location/Qualifiers
     source          1..2236
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.33"
     gene            1..2236
                     /gene="PCGF6"
                     /gene_synonym="MBLR; RNF134"
                     /note="polycomb group ring finger 6"
                     /db_xref="GeneID:84108"
                     /db_xref="HGNC:HGNC:21156"
                     /db_xref="MIM:607816"
     exon            1..434
                     /gene="PCGF6"
                     /gene_synonym="MBLR; RNF134"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1127
                     /gene="PCGF6"
                     /gene_synonym="MBLR; RNF134"
                     /note="isoform a is encoded by transcript variant 1; ring
                     finger protein 134; Mel18 and Bmi1-like RING finger
                     protein; polycomb group RING finger protein 6"
                     /codon_start=1
                     /product="polycomb group RING finger protein 6 isoform a"
                     /protein_id="NP_001011663.1"
                     /db_xref="CCDS:CCDS31275.1"
                     /db_xref="GeneID:84108"
                     /db_xref="HGNC:HGNC:21156"
                     /db_xref="MIM:607816"
                     /translation="MEGVAVVTAGSVGAAKTEGAAALPPPPPVSPPALTPAPAAGEEG
                     PAPLSETGAPGCSGSRPPELEPERSLGRFRGRFEDEDEELEEEEELEEEEEEEEEDMS
                     HFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLHTFCKSCIV
                     RHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHDFYKERG
                     LEVPKPAVPQPVPSSKGRSKKVLESVFRIPPELDMSLLLEFIGANEGTGHFKPLEKKF
                     VRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDG
                     LLVLHYGLVVSPLKIT"
     exon            435..534
                     /gene="PCGF6"
                     /gene_synonym="MBLR; RNF134"
                     /inference="alignment:Splign:2.1.0"
     exon            535..631
                     /gene="PCGF6"
                     /gene_synonym="MBLR; RNF134"
                     /inference="alignment:Splign:2.1.0"
     exon            632..687
                     /gene="PCGF6"
                     /gene_synonym="MBLR; RNF134"
                     /inference="alignment:Splign:2.1.0"
     exon            688..747
                     /gene="PCGF6"
                     /gene_synonym="MBLR; RNF134"
                     /inference="alignment:Splign:2.1.0"
     exon            748..856
                     /gene="PCGF6"
                     /gene_synonym="MBLR; RNF134"
                     /inference="alignment:Splign:2.1.0"
     exon            857..884
                     /gene="PCGF6"
                     /gene_synonym="MBLR; RNF134"
                     /inference="alignment:Splign:2.1.0"
     exon            885..983
                     /gene="PCGF6"
                     /gene_synonym="MBLR; RNF134"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1070
                     /gene="PCGF6"
                     /gene_synonym="MBLR; RNF134"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..2236
                     /gene="PCGF6"
                     /gene_synonym="MBLR; RNF134"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2215..2220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCGF6"
                     /gene_synonym="MBLR; RNF134"
                     /note="hexamer: AATAAA"
     polyA_site      2236
                     /gene="PCGF6"
                     /gene_synonym="MBLR; RNF134"
                     /note="major polyA site"
ORIGIN      
        1 agtggtggcg tccgaggccg gccgaactcc cgcgctctcc cgccgcctcg cctcgcctgg
       61 tgtctctccc gaccatggag ggggtcgcgg tggtgacggc gggcagcgta ggcgctgcca
      121 aaaccgaggg agctgcagcc ttgccgcctc cgcctcctgt ctccccgccc gccctcaccc
      181 ctgcacccgc agcgggtgag gagggaccgg cgcctctgtc tgagacgggg gctcccggct
      241 gctccggctc ccggccccct gagctggagc cggagcgcag cctgggccgc ttcagaggcc
      301 gcttcgagga cgaggacgag gagttggaag aagaagagga gctggaggag gaagaagagg
      361 aggaggagga ggacatgagt cacttctcgt tgaggctgga gggaggccgg caggactcgg
      421 aggacgagga ggagcgcctg attaatctct ctgagctgac cccatacatc ttgtgttcca
      481 tttgcaaagg ttacttaata gatgcaacta ccatcacaga atgtcttcat accttttgta
      541 aaagctgcat cgtaagacat ttttactaca gcaacagatg tccaaaatgc aatatagtag
      601 tacatcagac acaacctctt tataacataa ggttggaccg acagttacaa gacatagtgt
      661 acaaattagt gatcaatcta gaggaaagag aaaaaaagca aatgcatgat ttctataaag
      721 aaagaggtct agaagtacct aaacctgctg ttccacagcc agtcccttca agcaaaggaa
      781 gatctaaaaa agtcctagaa tcagtgtttc gtattccacc tgaacttgat atgtctttat
      841 tactggagtt cattggtgct aatgaaggca cgggacattt taagccattg gaaaagaagt
      901 ttgttcgagt ttcaggagaa gcaactattg gacatgtaga aaaattcctc agaagaaaaa
      961 tgggtcttga tccagcttgt caggtagata taatctgtgg tgatcacctg ttggagcagt
     1021 atcaaactct aagggaaatc cgacgtgcaa taggtgatgc agcaatgcag gatggtctgc
     1081 ttgtccttca ttatggtctt gtggtttctc ctctgaagat aacttgaaga ttctaggcac
     1141 attatgagga gggaaacaaa ggaggcttct gcaggactgc atctcaccaa agatttccat
     1201 gaaatgtaat tgctaccact ttgctgttca agacataact tacctatttt tagcaccaag
     1261 aattatagcg tttataagta caacttggaa cgatggaatg catctgttac tagagactgt
     1321 atataaaaag cagccaaagc tcaggggaaa tttttcaaaa attgaatttt aaaatttctt
     1381 atgattttaa ataccttgac attgattttg cttcccatct ttgaagtaat tggttagttt
     1441 tctttgttca gccatttcaa gttggtggtt gggatatctg ctctctggga tggcatcagt
     1501 tgggcagtca tctttttgga agagaagtgt gcttttgagt ggaagattca aagccagtct
     1561 ttgttaaact gcagggtgta ctctcaaaga ccaaaactat tggccacttt tgtatgttgc
     1621 cagcatattt tgaacttgta ccttttttta tactagcaac actacaaagg agaagttact
     1681 catttcaaaa tggatgaatt gttattatgt gtgaagagac tctgagttta tgatctgtgc
     1741 cataaaattt cagtgtaata agacttcttc aatacatctt ccaataaggg gtgcttcttt
     1801 gtgacagtat ttttatttct gacattcatt ttatttgggt acatagtgtg gttgttgata
     1861 ccttgcaata gtattgcttc tgaaagtaat aaaaaatttt aggagaattt gagaagttta
     1921 cagaattact tattcattgt tttcttagta agtcagttta atgtttattt ttctcattat
     1981 ttcatcactg caataaagaa taagggtgtt tgagctcacc tccatgcaaa gacttcagtt
     2041 ttaaaacatt atttgcctaa aattagcatt gtgatgcttt ctgaaagaaa tattttataa
     2101 atcctgttta acagcagaat ttctgaatgt gtagagacta ctacaaaatt ggaaaaagat
     2161 tggcaattct ttgtaaagaa tttgtgaatt gtgtataaat ttattctaac atttaataaa
     2221 aatgtatttt aaccta
//
