LOCUS       NM_006315               5067 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens polycomb group ring finger 3 (PCGF3), transcript
            variant 2, mRNA.
ACCESSION   NM_006315 NM_153250
VERSION     NM_006315.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5067)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5067)
  AUTHORS   Hu,Y., Cheng,Y., Jiang,X., Zhang,Y., Wang,H., Ren,H., Xu,Y.,
            Jiang,J., Wang,Q., Su,H., Zhang,B. and Qiu,X.
  TITLE     PCGF3 promotes the proliferation and migration of non-small cell
            lung cancer cells via the PI3K/AKT signaling pathway
  JOURNAL   Exp Cell Res 400 (2), 112496 (2021)
   PUBMED   33485844
  REMARK    GeneRIF: PCGF3 promotes the proliferation and migration of
            non-small cell lung cancer cells via the PI3K/AKT signaling
            pathway.
REFERENCE   3  (bases 1 to 5067)
  AUTHORS   Mu,G., Xiang,Q., Zhang,Z., Liu,C., Zhang,H., Liu,Z., Pang,X.,
            Jiang,J., Xie,Q., Zhou,S., Wang,Z., Hu,K., Wang,Z., Jiang,S.,
            Qin,X. and Cui,Y.
  TITLE     PNPT1 and PCGF3 variants associated with angiotensin-converting
            enzyme inhibitor-induced cough: a nested case-control genome-wide
            study
  JOURNAL   Pharmacogenomics 21 (9), 601-614 (2020)
   PUBMED   32397904
  REMARK    GeneRIF: PNPT1 and PCGF3 variants associated with
            angiotensin-converting enzyme inhibitor-induced cough: a nested
            case-control genome-wide study.
REFERENCE   4  (bases 1 to 5067)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5067)
  AUTHORS   Purohit,G., Mukherjee,A.K., Sharma,S. and Chowdhury,S.
  TITLE     Extratelomeric Binding of the Telomere Binding Protein TRF2 at the
            PCGF3 Promoter Is G-Quadruplex Motif-Dependent
  JOURNAL   Biochemistry 57 (16), 2317-2324 (2018)
   PUBMED   29589913
  REMARK    GeneRIF: We demonstrate that promoter binding by TRF2 mediates
            PCGF3 promoter activity, and both the N-terminal and C-terminal
            domains of TRF2 are necessary for promoter activity.
REFERENCE   6  (bases 1 to 5067)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   7  (bases 1 to 5067)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   8  (bases 1 to 5067)
  AUTHORS   Woodsmith,J., Jenn,R.C. and Sanderson,C.M.
  TITLE     Systematic analysis of dimeric E3-RING interactions reveals
            increased combinatorial complexity in human ubiquitination networks
  JOURNAL   Mol Cell Proteomics 11 (7), M111.016162 (2012)
   PUBMED   22493164
REFERENCE   9  (bases 1 to 5067)
  AUTHORS   Oudot-Mellakh,T., Cohen,W., Germain,M., Saut,N., Kallel,C.,
            Zelenika,D., Lathrop,M., Tregouet,D.A. and Morange,P.E.
  TITLE     Genome wide association study for plasma levels of natural
            anticoagulant inhibitors and protein C anticoagulant pathway: the
            MARTHA project
  JOURNAL   Br J Haematol 157 (2), 230-239 (2012)
   PUBMED   22443383
REFERENCE   10 (bases 1 to 5067)
  AUTHORS   Vandamme,J., Volkel,P., Rosnoblet,C., Le Faou,P. and Angrand,P.O.
  TITLE     Interaction proteomics analysis of polycomb proteins defines
            distinct PRC1 complexes in mammalian cells
  JOURNAL   Mol Cell Proteomics 10 (4), M110.002642 (2011)
   PUBMED   21282530
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC107464.5 and AC139887.3.
            
            On Jun 16, 2021 this sequence version replaced NM_006315.6.
            
            Summary: The protein encoded by this gene contains a C3HC4 type
            RING finger, which is a motif known to be involved in
            protein-protein interactions. The specific function of this protein
            has not yet been determined. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' UTR compared to variant 1. Variants 1-7 all encode the same
            isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.533208.1,
                                           SRR14038196.3559349.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000362003.10/ ENSP00000354724.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AC107464.5         97400-97538
            140-178             AC107464.5         122198-122236
            179-319             AC107464.5         122538-122678
            320-437             AC107464.5         125240-125357
            438-534             AC107464.5         126499-126595
            535-590             AC107464.5         129034-129089
            591-701             AC139887.3         5251-5361
            702-790             AC139887.3         6377-6465
            791-928             AC139887.3         23056-23193
            929-1009            AC139887.3         26761-26841
            1010-5067           AC139887.3         27809-31866
FEATURES             Location/Qualifiers
     source          1..5067
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..5067
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /note="polycomb group ring finger 3"
                     /db_xref="GeneID:10336"
                     /db_xref="HGNC:HGNC:10066"
                     /db_xref="MIM:617543"
     exon            1..139
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            140..178
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            179..319
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            320..437
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             329..1057
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /note="isoform a is encoded by transcript variant 2; ring
                     finger protein 3; polycomb group RING finger protein 3;
                     RING finger protein 3A"
                     /codon_start=1
                     /product="polycomb group RING finger protein 3 isoform a"
                     /protein_id="NP_006306.2"
                     /db_xref="CCDS:CCDS3339.2"
                     /db_xref="GeneID:10336"
                     /db_xref="HGNC:HGNC:10066"
                     /db_xref="MIM:617543"
                     /translation="MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVK
                     YLEENNTCPTCRIVIHQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGM
                     EVPGDIKGETCSAKQHLDSHRNGETKADDSSNKEAAEEKPEEDNDYHRSDEQVSICLE
                     CNSSKLRGLKRKWIRCSAQATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTLKF
                     VVVTRWRFKKAPLLLHYRPKMDLL"
     exon            438..534
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            535..590
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            591..701
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            702..790
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            791..928
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1009
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..5067
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1556..1561
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /note="hexamer: TATAAA"
     polyA_site      1580
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /note="major polyA site"
     regulatory      2820..2825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /note="hexamer: AATAAA"
     polyA_site      2846
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
     regulatory      5044..5049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /note="hexamer: AATAAA"
     polyA_site      5067
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /note="major polyA site"
ORIGIN      
        1 atttccgcct ctttgtttta aactccggac gggctttttt ctcctcctct tgggggggac
       61 ccagagggag cggcgccccc tcccccctcc ggcgcggacc ccgcgtgcgc cttgctcgcc
      121 cgcagccccg agaccgcagg cgtcacaatg tagcagggac cccaggcgtc gtgctcagaa
      181 aatggaaaaa gagccagggc cggaaggagg gtgcagaagc gagtccgcgt gcggagccag
      241 gaggcagcgt cgcgtgggag tgctggcctg aagcctccat gccccggcag agggacggac
      301 acgcggacgt ctagcggaga agccaaagat gttgaccagg aagatcaagc tgtgggacat
      361 caacgcccac atcacctgcc gcctgtgcag cgggtacctc atcgacgcca ccacggtgac
      421 cgagtgtctg cacaccttct gcaggagctg cctggtgaag tacctggagg agaacaacac
      481 ctgccccacc tgcaggattg tgatccacca gagccacccc ctgcagtaca tcggtcatga
      541 cagaaccatg caagatattg tttacaaatt ggtaccaggc ctccaagaag cggaaatgag
      601 aaagcagagg gagttctatc acaaattggg catggaggtg ccgggagaca tcaaggggga
      661 gacctgctct gcaaaacagc acttagattc ccatcggaat ggtgaaacca aagcagacga
      721 cagttcaaac aaagaggccg cggaggagaa gccggaggag gacaacgact accaccgcag
      781 cgacgagcag gtgagcatct gcctggagtg taacagcagc aaactgcgcg ggctgaagcg
      841 gaagtggatc cgctgctcag cccaggcgac cgtcttgcat ctgaagaagt tcatcgccaa
      901 aaaactcaac ctttcatcct ttaacgagct ggacatttta tgcaacgagg agatcctggg
      961 caaggaccac acactcaagt tcgtggttgt cactaggtgg agattcaaga aggcgccgct
     1021 cctgctgcac tacagaccca agatggactt gctgtgaatg gtgccacaca gcgcccacag
     1081 actgggccct cgcacccttg ggtgctcccg gccgccgcgc ttaagaacat tgcctctggg
     1141 tgtcatgtgg accagacttc tgaatagaga atatttataa cttttgtatg agagagaatt
     1201 cacactcaac aagacactac cagcaccacg tttacagagg atgaaaacac ttcacagtct
     1261 cccagagccg atcgtcctct cccccgcccc accccgtgct tcagccttgc agggagagtg
     1321 atgctccagg caacacggtt ctgagtcacc ttctgacacg agctccctct gcttgctttc
     1381 caggtcttga aaatctgaat tcacttcagt ttagtttatg aattttaggt ttcatgataa
     1441 gcctcaagtg tagttggact tttattgaat ccttcctaag ttattgaaaa aatgtctttt
     1501 catggtgaat gacaatattt atgttgcctt tagcttcttg aagatttaga agttatataa
     1561 aaaattaatt taaaagcaaa ccaaaagagg tttccattaa cattatgatt taaccattgt
     1621 atttaatttc ccaccttatg aaacacaaca gcagctccct gactggttcg cctttcattg
     1681 tgtgaggtcg gcacttggac tcactcagaa ctgtcgctca cctgtggctg acacacccag
     1741 ccctggaaac ggggccccag acgccacgtc gggatttctg acatgctcag caggtagacc
     1801 agaggccgtg tgaccagctc agtgctggtt tacggaacaa ctcttacttt taaaaattac
     1861 ttgttccccc aaattgttga gtgccgccgt ttggtttcct atgttttctt tccctgtttt
     1921 gattttgctg aagggagagg tggtggtggt taggatcaga gctctcctgg catccgtggg
     1981 gaggatttgc tggtggtggc ttcgggctca tgcccagaca cactcactgc cccgtctgtc
     2041 caaggcctcc ccttcccctt tgctggtggg aggagctcgt gtgctccttg gccgcttact
     2101 ggaagggcgt ttttcagagc tgcagggaca gggtgagcag ctgaagggct aggagggaag
     2161 ccggcccccg ctctgcagaa gctgcatttc agctgaatct gtgtttcagc ctcagttggt
     2221 tgcaccgtta gcccctctcc tcccggatgg tcatgttttt gtcacattag agaataaaca
     2281 gccacacaca catttttttt tttcctttaa aacagtaact tggaaatatg aaaaggccag
     2341 aaggaggagc aagggctgtt ttctggagtg gttgaggtgt tgtcctgcag ttgtcattgt
     2401 cttctccacc gggctgttcc catttatttc ctgtggaact gaatccctcc tccctccact
     2461 ccttgggagc ccaggtggtc cttggccacc attcaggctt tccaagaagc caaccacctt
     2521 ggagattttt tttcttgaat ttcgctgttt tcttctgctt cctttagata aaaagcagct
     2581 caagagacct tatcttaggg atgagaaaaa catgcatatt aattccatct gagtgattgt
     2641 cagtgtaagg ccttttaaaa caaaagcaag ttctttgtta ggaattggtc aaaattcatc
     2701 tctttcttta agcccatcaa ctcccaggac ggtttgagtt actcagttac ctaagcttgc
     2761 tattcatcca aatcattttc tagagtcact gtataagggt ctatgagtag ctgtgtatga
     2821 ataaatatta cctgtctacc tcaaaataca catactgctg aagcattctg tacaaccgtg
     2881 tgttatcaca gtgcagtttt aagtgtaacg ttagaactta ggcattttcc tgtgtggcgg
     2941 aataagaaag gattaaacag ttacaagcct ccaaattcaa ataaaattaa atcacagttc
     3001 agatgaaact gaatatcatt gtaataatct cataatatat atttgtaact ttgtagctat
     3061 ctttgaaatc acttgacttt gcaatggtgc taagctgata gatttaaata cacagacggg
     3121 cgagtggcgc ccgtgtcgat gtcttcagcc agtggtgacc ctgcttttgt aaccgcgtta
     3181 acctgacaaa acctcagcag cagaagtccc tatttttcta ggagttcatc gtgcagacag
     3241 tcttcactac aggactcggc cctggggcct ctgcctctcg tctgaccttg cagccttagt
     3301 cgttggaggc tggagcgcaa tggccctgcc gtctgtggag cctctgggcg gccttctttc
     3361 ctttctgtca acctctcatt tcacagaaaa aggctgaatt tcattttttc cagcatgaaa
     3421 gccaggatcg gttagtggtt ggattctatt ggtttttttt ttttaaacag atggagttac
     3481 tgtgaagaag ttttcacaac tatttatgct ggtaaaacaa atgctgttaa atcaccttat
     3541 gcgtcgtttt caacagcagt ggggctaatt acccggaata cggtctcacc gatgcagttt
     3601 tcatggacat agaaaattca aatagaatat ataatattga atttaagatt tggggggtta
     3661 aaaaagaaaa cttaacttta taaaattatt tattctattt taagccttct atcatatttt
     3721 cccatccaat tgtttggttt cagtggtcca gctttattta caggcatata aaatgaaatt
     3781 gtgagatgtt ttgcaagctt ctttttactt tgagtagctt ttaatttgta tgtttttatg
     3841 tggatgaaga gcatttttta tgcttttgtg caataggttc caatatgcat ttattagaca
     3901 tctgtttaaa tggtaatgta gcatttattt tgctaaattg aaagggaaca tagatggaat
     3961 tccaaaatat gtacattcag ctgtttggtt tttcgttttt cattgttatt attgtgagaa
     4021 tgctgttatt ggggttgtgt gtgagtgccc gtcagccagt gatgcctcgg gccacgctgt
     4081 ggggccacct cagtcctgcc tgggtcctgg tgccttggac cccacgtgct tgtggccagg
     4141 ctgcccctgg gcagggccat gtggcctcag accacaagag cggagctgcc ctggcccaag
     4201 cactgcagct gcctgcaccc ccgggcttcg cagccttgct tgttttctct gaacagcaac
     4261 agaacagtgt tcacagcgat tcaaagggtg gcattgggtt ggacgttctg ggtacaagcc
     4321 aacctagtcc cacgttgtac gtgaatgttt aatgtgctct caaaacatgg aaaataagtt
     4381 tagtgcacat agctaaatca caaaacatcc aatttctctg tttcctcagg aagtcattac
     4441 tgcgccacca catcacatga ccttaacatg atcaatgtat ttctctgcct tgacatttaa
     4501 atacataaat tgagataagt agattagaaa atcattcaaa tgataccata atttgtacgg
     4561 gacagggtgc gggcaatggc cacgtggcca aggccctgca ggaacgcgcc gaggtctccc
     4621 tcaccctcca ggtgtccttc gcacccaaca gtgcgtctga ggaacgagct gcagtttgag
     4681 cgttcccctg agatgtgcgt agcctccgtg taaatgtcca ctcccatggc ttaattgcct
     4741 atcagacgca ttttcccaga cgaaagcaat gttgggttgg ggaagacagt gcagccaccc
     4801 agcctttacc agcagcgtac ggcagacgaa ggcagtcgag gtgtggaggt gatcacgaag
     4861 atacatgtgt ttgactgttt aatttgaaag tttacatttt ttatgctttg tgttggtgtg
     4921 taatttttgt actcttggtg gctagttttt gtcaaatctt ttttggaata ttgcttaaat
     4981 gttttgattt tatgatagtg aagcttgtat tcagtgtttt gccaattaat attatatgct
     5041 tgtaataaaa gcaaaagaaa agcttaa
//
