LOCUS       NM_001395251            5143 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens polycomb group ring finger 3 (PCGF3), transcript
            variant 9, mRNA.
ACCESSION   NM_001395251
VERSION     NM_001395251.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5143)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5143)
  AUTHORS   Hu,Y., Cheng,Y., Jiang,X., Zhang,Y., Wang,H., Ren,H., Xu,Y.,
            Jiang,J., Wang,Q., Su,H., Zhang,B. and Qiu,X.
  TITLE     PCGF3 promotes the proliferation and migration of non-small cell
            lung cancer cells via the PI3K/AKT signaling pathway
  JOURNAL   Exp Cell Res 400 (2), 112496 (2021)
   PUBMED   33485844
  REMARK    GeneRIF: PCGF3 promotes the proliferation and migration of
            non-small cell lung cancer cells via the PI3K/AKT signaling
            pathway.
REFERENCE   3  (bases 1 to 5143)
  AUTHORS   Mu,G., Xiang,Q., Zhang,Z., Liu,C., Zhang,H., Liu,Z., Pang,X.,
            Jiang,J., Xie,Q., Zhou,S., Wang,Z., Hu,K., Wang,Z., Jiang,S.,
            Qin,X. and Cui,Y.
  TITLE     PNPT1 and PCGF3 variants associated with angiotensin-converting
            enzyme inhibitor-induced cough: a nested case-control genome-wide
            study
  JOURNAL   Pharmacogenomics 21 (9), 601-614 (2020)
   PUBMED   32397904
  REMARK    GeneRIF: PNPT1 and PCGF3 variants associated with
            angiotensin-converting enzyme inhibitor-induced cough: a nested
            case-control genome-wide study.
REFERENCE   4  (bases 1 to 5143)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5143)
  AUTHORS   Purohit,G., Mukherjee,A.K., Sharma,S. and Chowdhury,S.
  TITLE     Extratelomeric Binding of the Telomere Binding Protein TRF2 at the
            PCGF3 Promoter Is G-Quadruplex Motif-Dependent
  JOURNAL   Biochemistry 57 (16), 2317-2324 (2018)
   PUBMED   29589913
  REMARK    GeneRIF: We demonstrate that promoter binding by TRF2 mediates
            PCGF3 promoter activity, and both the N-terminal and C-terminal
            domains of TRF2 are necessary for promoter activity.
REFERENCE   6  (bases 1 to 5143)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   7  (bases 1 to 5143)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   8  (bases 1 to 5143)
  AUTHORS   Woodsmith,J., Jenn,R.C. and Sanderson,C.M.
  TITLE     Systematic analysis of dimeric E3-RING interactions reveals
            increased combinatorial complexity in human ubiquitination networks
  JOURNAL   Mol Cell Proteomics 11 (7), M111.016162 (2012)
   PUBMED   22493164
REFERENCE   9  (bases 1 to 5143)
  AUTHORS   Oudot-Mellakh,T., Cohen,W., Germain,M., Saut,N., Kallel,C.,
            Zelenika,D., Lathrop,M., Tregouet,D.A. and Morange,P.E.
  TITLE     Genome wide association study for plasma levels of natural
            anticoagulant inhibitors and protein C anticoagulant pathway: the
            MARTHA project
  JOURNAL   Br J Haematol 157 (2), 230-239 (2012)
   PUBMED   22443383
REFERENCE   10 (bases 1 to 5143)
  AUTHORS   Vandamme,J., Volkel,P., Rosnoblet,C., Le Faou,P. and Angrand,P.O.
  TITLE     Interaction proteomics analysis of polycomb proteins defines
            distinct PRC1 complexes in mammalian cells
  JOURNAL   Mol Cell Proteomics 10 (4), M110.002642 (2011)
   PUBMED   21282530
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC107464.5 and AC139887.3.
            
            Summary: The protein encoded by this gene contains a C3HC4 type
            RING finger, which is a motif known to be involved in
            protein-protein interactions. The specific function of this protein
            has not yet been determined. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.269834.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465403 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC107464.5         116724-116797
            75-113              AC107464.5         122198-122236
            114-254             AC107464.5         122538-122678
            255-372             AC107464.5         125240-125357
            373-610             AC107464.5         126358-126595
            611-666             AC107464.5         129034-129089
            667-777             AC139887.3         5251-5361
            778-866             AC139887.3         6377-6465
            867-1004            AC139887.3         23056-23193
            1005-1085           AC139887.3         26761-26841
            1086-5143           AC139887.3         27809-31866
FEATURES             Location/Qualifiers
     source          1..5143
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..5143
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /note="polycomb group ring finger 3"
                     /db_xref="GeneID:10336"
                     /db_xref="HGNC:HGNC:10066"
                     /db_xref="MIM:617543"
     exon            1..74
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            75..113
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            114..254
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            255..372
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            373..610
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             507..1133
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /note="isoform b is encoded by transcript variant 9; ring
                     finger protein 3; polycomb group RING finger protein 3;
                     RING finger protein 3A"
                     /codon_start=1
                     /product="polycomb group RING finger protein 3 isoform b"
                     /protein_id="NP_001382180.1"
                     /db_xref="GeneID:10336"
                     /db_xref="HGNC:HGNC:10066"
                     /db_xref="MIM:617543"
                     /translation="MTVCRSCLVKYLEENNTCPTCRIVIHQSHPLQYIGHDRTMQDIV
                     YKLVPGLQEAEMRKQREFYHKLGMEVPGDIKGETCSAKQHLDSHRNGETKADDSSNKE
                     AAEEKPEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRCSAQATVLHLKKFIAKKLN
                     LSSFNELDILCNEEILGKDHTLKFVVVTRWRFKKAPLLLHYRPKMDLL"
     exon            611..666
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            667..777
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            778..866
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1004
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1085
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..5143
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1632..1637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /note="hexamer: TATAAA"
     polyA_site      1656
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /note="major polyA site"
     regulatory      2896..2901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /note="hexamer: AATAAA"
     polyA_site      2922
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
     regulatory      5120..5125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /note="hexamer: AATAAA"
     polyA_site      5143
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /note="major polyA site"
ORIGIN      
        1 ctgcgcttct gtggttggtt ttgatgagga ctcgtatttc agctcctgtc tctccttgtc
       61 agaggccgtg tgaggcgtca caatgtagca gggaccccag gcgtcgtgct cagaaaatgg
      121 aaaaagagcc agggccggaa ggagggtgca gaagcgagtc cgcgtgcgga gccaggaggc
      181 agcgtcgcgt gggagtgctg gcctgaagcc tccatgcccc ggcagaggga cggacacgcg
      241 gacgtctagc ggagaagcca aagatgttga ccaggaagat caagctgtgg gacatcaacg
      301 cccacatcac ctgccgcctg tgcagcgggt acctcatcga cgccaccacg gtgaccgagt
      361 gtctgcacac ctaagctgag agccacaagg aggacagcag tgagcatctg cacagaaacg
      421 agctcagaga cgcccgtgtt cagtggagca cgccgatggg gtgggcgccc tggctctaga
      481 cgctctccta acacacctgt gctttgatga cagtctgcag gagctgcctg gtgaagtacc
      541 tggaggagaa caacacctgc cccacctgca ggattgtgat ccaccagagc caccccctgc
      601 agtacatcgg tcatgacaga accatgcaag atattgttta caaattggta ccaggcctcc
      661 aagaagcgga aatgagaaag cagagggagt tctatcacaa attgggcatg gaggtgccgg
      721 gagacatcaa gggggagacc tgctctgcaa aacagcactt agattcccat cggaatggtg
      781 aaaccaaagc agacgacagt tcaaacaaag aggccgcgga ggagaagccg gaggaggaca
      841 acgactacca ccgcagcgac gagcaggtga gcatctgcct ggagtgtaac agcagcaaac
      901 tgcgcgggct gaagcggaag tggatccgct gctcagccca ggcgaccgtc ttgcatctga
      961 agaagttcat cgccaaaaaa ctcaaccttt catcctttaa cgagctggac attttatgca
     1021 acgaggagat cctgggcaag gaccacacac tcaagttcgt ggttgtcact aggtggagat
     1081 tcaagaaggc gccgctcctg ctgcactaca gacccaagat ggacttgctg tgaatggtgc
     1141 cacacagcgc ccacagactg ggccctcgca cccttgggtg ctcccggccg ccgcgcttaa
     1201 gaacattgcc tctgggtgtc atgtggacca gacttctgaa tagagaatat ttataacttt
     1261 tgtatgagag agaattcaca ctcaacaaga cactaccagc accacgttta cagaggatga
     1321 aaacacttca cagtctccca gagccgatcg tcctctcccc cgccccaccc cgtgcttcag
     1381 ccttgcaggg agagtgatgc tccaggcaac acggttctga gtcaccttct gacacgagct
     1441 ccctctgctt gctttccagg tcttgaaaat ctgaattcac ttcagtttag tttatgaatt
     1501 ttaggtttca tgataagcct caagtgtagt tggactttta ttgaatcctt cctaagttat
     1561 tgaaaaaatg tcttttcatg gtgaatgaca atatttatgt tgcctttagc ttcttgaaga
     1621 tttagaagtt atataaaaaa ttaatttaaa agcaaaccaa aagaggtttc cattaacatt
     1681 atgatttaac cattgtattt aatttcccac cttatgaaac acaacagcag ctccctgact
     1741 ggttcgcctt tcattgtgtg aggtcggcac ttggactcac tcagaactgt cgctcacctg
     1801 tggctgacac acccagccct ggaaacgggg ccccagacgc cacgtcggga tttctgacat
     1861 gctcagcagg tagaccagag gccgtgtgac cagctcagtg ctggtttacg gaacaactct
     1921 tacttttaaa aattacttgt tcccccaaat tgttgagtgc cgccgtttgg tttcctatgt
     1981 tttctttccc tgttttgatt ttgctgaagg gagaggtggt ggtggttagg atcagagctc
     2041 tcctggcatc cgtggggagg atttgctggt ggtggcttcg ggctcatgcc cagacacact
     2101 cactgccccg tctgtccaag gcctcccctt cccctttgct ggtgggagga gctcgtgtgc
     2161 tccttggccg cttactggaa gggcgttttt cagagctgca gggacagggt gagcagctga
     2221 agggctagga gggaagccgg cccccgctct gcagaagctg catttcagct gaatctgtgt
     2281 ttcagcctca gttggttgca ccgttagccc ctctcctccc ggatggtcat gtttttgtca
     2341 cattagagaa taaacagcca cacacacatt tttttttttc ctttaaaaca gtaacttgga
     2401 aatatgaaaa ggccagaagg aggagcaagg gctgttttct ggagtggttg aggtgttgtc
     2461 ctgcagttgt cattgtcttc tccaccgggc tgttcccatt tatttcctgt ggaactgaat
     2521 ccctcctccc tccactcctt gggagcccag gtggtccttg gccaccattc aggctttcca
     2581 agaagccaac caccttggag attttttttc ttgaatttcg ctgttttctt ctgcttcctt
     2641 tagataaaaa gcagctcaag agaccttatc ttagggatga gaaaaacatg catattaatt
     2701 ccatctgagt gattgtcagt gtaaggcctt ttaaaacaaa agcaagttct ttgttaggaa
     2761 ttggtcaaaa ttcatctctt tctttaagcc catcaactcc caggacggtt tgagttactc
     2821 agttacctaa gcttgctatt catccaaatc attttctaga gtcactgtat aagggtctat
     2881 gagtagctgt gtatgaataa atattacctg tctacctcaa aatacacata ctgctgaagc
     2941 attctgtaca accgtgtgtt atcacagtgc agttttaagt gtaacgttag aacttaggca
     3001 ttttcctgtg tggcggaata agaaaggatt aaacagttac aagcctccaa attcaaataa
     3061 aattaaatca cagttcagat gaaactgaat atcattgtaa taatctcata atatatattt
     3121 gtaactttgt agctatcttt gaaatcactt gactttgcaa tggtgctaag ctgatagatt
     3181 taaatacaca gacgggcgag tggcgcccgt gtcgatgtct tcagccagtg gtgaccctgc
     3241 ttttgtaacc gcgttaacct gacaaaacct cagcagcaga agtccctatt tttctaggag
     3301 ttcatcgtgc agacagtctt cactacagga ctcggccctg gggcctctgc ctctcgtctg
     3361 accttgcagc cttagtcgtt ggaggctgga gcgcaatggc cctgccgtct gtggagcctc
     3421 tgggcggcct tctttccttt ctgtcaacct ctcatttcac agaaaaaggc tgaatttcat
     3481 tttttccagc atgaaagcca ggatcggtta gtggttggat tctattggtt tttttttttt
     3541 aaacagatgg agttactgtg aagaagtttt cacaactatt tatgctggta aaacaaatgc
     3601 tgttaaatca ccttatgcgt cgttttcaac agcagtgggg ctaattaccc ggaatacggt
     3661 ctcaccgatg cagttttcat ggacatagaa aattcaaata gaatatataa tattgaattt
     3721 aagatttggg gggttaaaaa agaaaactta actttataaa attatttatt ctattttaag
     3781 ccttctatca tattttccca tccaattgtt tggtttcagt ggtccagctt tatttacagg
     3841 catataaaat gaaattgtga gatgttttgc aagcttcttt ttactttgag tagcttttaa
     3901 tttgtatgtt tttatgtgga tgaagagcat tttttatgct tttgtgcaat aggttccaat
     3961 atgcatttat tagacatctg tttaaatggt aatgtagcat ttattttgct aaattgaaag
     4021 ggaacataga tggaattcca aaatatgtac attcagctgt ttggtttttc gtttttcatt
     4081 gttattattg tgagaatgct gttattgggg ttgtgtgtga gtgcccgtca gccagtgatg
     4141 cctcgggcca cgctgtgggg ccacctcagt cctgcctggg tcctggtgcc ttggacccca
     4201 cgtgcttgtg gccaggctgc ccctgggcag ggccatgtgg cctcagacca caagagcgga
     4261 gctgccctgg cccaagcact gcagctgcct gcacccccgg gcttcgcagc cttgcttgtt
     4321 ttctctgaac agcaacagaa cagtgttcac agcgattcaa agggtggcat tgggttggac
     4381 gttctgggta caagccaacc tagtcccacg ttgtacgtga atgtttaatg tgctctcaaa
     4441 acatggaaaa taagtttagt gcacatagct aaatcacaaa acatccaatt tctctgtttc
     4501 ctcaggaagt cattactgcg ccaccacatc acatgacctt aacatgatca atgtatttct
     4561 ctgccttgac atttaaatac ataaattgag ataagtagat tagaaaatca ttcaaatgat
     4621 accataattt gtacgggaca gggtgcgggc aatggccacg tggccaaggc cctgcaggaa
     4681 cgcgccgagg tctccctcac cctccaggtg tccttcgcac ccaacagtgc gtctgaggaa
     4741 cgagctgcag tttgagcgtt cccctgagat gtgcgtagcc tccgtgtaaa tgtccactcc
     4801 catggcttaa ttgcctatca gacgcatttt cccagacgaa agcaatgttg ggttggggaa
     4861 gacagtgcag ccacccagcc tttaccagca gcgtacggca gacgaaggca gtcgaggtgt
     4921 ggaggtgatc acgaagatac atgtgtttga ctgtttaatt tgaaagttta cattttttat
     4981 gctttgtgtt ggtgtgtaat ttttgtactc ttggtggcta gtttttgtca aatctttttt
     5041 ggaatattgc ttaaatgttt tgattttatg atagtgaagc ttgtattcag tgttttgcca
     5101 attaatatta tatgcttgta ataaaagcaa aagaaaagct taa
//
