LOCUS       NM_001395246            5122 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens polycomb group ring finger 3 (PCGF3), transcript
            variant 4, mRNA.
ACCESSION   NM_001395246
VERSION     NM_001395246.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5122)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5122)
  AUTHORS   Hu,Y., Cheng,Y., Jiang,X., Zhang,Y., Wang,H., Ren,H., Xu,Y.,
            Jiang,J., Wang,Q., Su,H., Zhang,B. and Qiu,X.
  TITLE     PCGF3 promotes the proliferation and migration of non-small cell
            lung cancer cells via the PI3K/AKT signaling pathway
  JOURNAL   Exp Cell Res 400 (2), 112496 (2021)
   PUBMED   33485844
  REMARK    GeneRIF: PCGF3 promotes the proliferation and migration of
            non-small cell lung cancer cells via the PI3K/AKT signaling
            pathway.
REFERENCE   3  (bases 1 to 5122)
  AUTHORS   Mu,G., Xiang,Q., Zhang,Z., Liu,C., Zhang,H., Liu,Z., Pang,X.,
            Jiang,J., Xie,Q., Zhou,S., Wang,Z., Hu,K., Wang,Z., Jiang,S.,
            Qin,X. and Cui,Y.
  TITLE     PNPT1 and PCGF3 variants associated with angiotensin-converting
            enzyme inhibitor-induced cough: a nested case-control genome-wide
            study
  JOURNAL   Pharmacogenomics 21 (9), 601-614 (2020)
   PUBMED   32397904
  REMARK    GeneRIF: PNPT1 and PCGF3 variants associated with
            angiotensin-converting enzyme inhibitor-induced cough: a nested
            case-control genome-wide study.
REFERENCE   4  (bases 1 to 5122)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5122)
  AUTHORS   Purohit,G., Mukherjee,A.K., Sharma,S. and Chowdhury,S.
  TITLE     Extratelomeric Binding of the Telomere Binding Protein TRF2 at the
            PCGF3 Promoter Is G-Quadruplex Motif-Dependent
  JOURNAL   Biochemistry 57 (16), 2317-2324 (2018)
   PUBMED   29589913
  REMARK    GeneRIF: We demonstrate that promoter binding by TRF2 mediates
            PCGF3 promoter activity, and both the N-terminal and C-terminal
            domains of TRF2 are necessary for promoter activity.
REFERENCE   6  (bases 1 to 5122)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   7  (bases 1 to 5122)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   8  (bases 1 to 5122)
  AUTHORS   Woodsmith,J., Jenn,R.C. and Sanderson,C.M.
  TITLE     Systematic analysis of dimeric E3-RING interactions reveals
            increased combinatorial complexity in human ubiquitination networks
  JOURNAL   Mol Cell Proteomics 11 (7), M111.016162 (2012)
   PUBMED   22493164
REFERENCE   9  (bases 1 to 5122)
  AUTHORS   Oudot-Mellakh,T., Cohen,W., Germain,M., Saut,N., Kallel,C.,
            Zelenika,D., Lathrop,M., Tregouet,D.A. and Morange,P.E.
  TITLE     Genome wide association study for plasma levels of natural
            anticoagulant inhibitors and protein C anticoagulant pathway: the
            MARTHA project
  JOURNAL   Br J Haematol 157 (2), 230-239 (2012)
   PUBMED   22443383
REFERENCE   10 (bases 1 to 5122)
  AUTHORS   Vandamme,J., Volkel,P., Rosnoblet,C., Le Faou,P. and Angrand,P.O.
  TITLE     Interaction proteomics analysis of polycomb proteins defines
            distinct PRC1 complexes in mammalian cells
  JOURNAL   Mol Cell Proteomics 10 (4), M110.002642 (2011)
   PUBMED   21282530
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC107464.5 and AC139887.3.
            
            Summary: The protein encoded by this gene contains a C3HC4 type
            RING finger, which is a motif known to be involved in
            protein-protein interactions. The specific function of this protein
            has not yet been determined. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.903110.1,
                                           SRR14038194.953798.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AC107464.5         97400-97538
            140-178             AC107464.5         122198-122236
            179-319             AC107464.5         122538-122678
            320-374             AC107464.5         124012-124066
            375-492             AC107464.5         125240-125357
            493-589             AC107464.5         126499-126595
            590-645             AC107464.5         129034-129089
            646-756             AC139887.3         5251-5361
            757-845             AC139887.3         6377-6465
            846-983             AC139887.3         23056-23193
            984-1064            AC139887.3         26761-26841
            1065-5122           AC139887.3         27809-31866
FEATURES             Location/Qualifiers
     source          1..5122
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..5122
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /note="polycomb group ring finger 3"
                     /db_xref="GeneID:10336"
                     /db_xref="HGNC:HGNC:10066"
                     /db_xref="MIM:617543"
     exon            1..139
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            140..178
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            179..319
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            320..374
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            375..492
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             384..1112
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /note="isoform a is encoded by transcript variant 4; ring
                     finger protein 3; polycomb group RING finger protein 3;
                     RING finger protein 3A"
                     /codon_start=1
                     /product="polycomb group RING finger protein 3 isoform a"
                     /protein_id="NP_001382175.1"
                     /db_xref="CCDS:CCDS3339.2"
                     /db_xref="GeneID:10336"
                     /db_xref="HGNC:HGNC:10066"
                     /db_xref="MIM:617543"
                     /translation="MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVK
                     YLEENNTCPTCRIVIHQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGM
                     EVPGDIKGETCSAKQHLDSHRNGETKADDSSNKEAAEEKPEEDNDYHRSDEQVSICLE
                     CNSSKLRGLKRKWIRCSAQATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTLKF
                     VVVTRWRFKKAPLLLHYRPKMDLL"
     exon            493..589
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            590..645
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            646..756
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            757..845
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            846..983
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1064
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..5122
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1611..1616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /note="hexamer: TATAAA"
     polyA_site      1635
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /note="major polyA site"
     regulatory      2875..2880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /note="hexamer: AATAAA"
     polyA_site      2901
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
     regulatory      5099..5104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /note="hexamer: AATAAA"
     polyA_site      5122
                     /gene="PCGF3"
                     /gene_synonym="DONG1; RNF3; RNF3A"
                     /note="major polyA site"
ORIGIN      
        1 atttccgcct ctttgtttta aactccggac gggctttttt ctcctcctct tgggggggac
       61 ccagagggag cggcgccccc tcccccctcc ggcgcggacc ccgcgtgcgc cttgctcgcc
      121 cgcagccccg agaccgcagg cgtcacaatg tagcagggac cccaggcgtc gtgctcagaa
      181 aatggaaaaa gagccagggc cggaaggagg gtgcagaagc gagtccgcgt gcggagccag
      241 gaggcagcgt cgcgtgggag tgctggcctg aagcctccat gccccggcag agggacggac
      301 acgcggacgt ctagcggagc cccgcaggga ggaggagaag gggaggattt gactttggaa
      361 gtctctgtga ccagaagcca aagatgttga ccaggaagat caagctgtgg gacatcaacg
      421 cccacatcac ctgccgcctg tgcagcgggt acctcatcga cgccaccacg gtgaccgagt
      481 gtctgcacac cttctgcagg agctgcctgg tgaagtacct ggaggagaac aacacctgcc
      541 ccacctgcag gattgtgatc caccagagcc accccctgca gtacatcggt catgacagaa
      601 ccatgcaaga tattgtttac aaattggtac caggcctcca agaagcggaa atgagaaagc
      661 agagggagtt ctatcacaaa ttgggcatgg aggtgccggg agacatcaag ggggagacct
      721 gctctgcaaa acagcactta gattcccatc ggaatggtga aaccaaagca gacgacagtt
      781 caaacaaaga ggccgcggag gagaagccgg aggaggacaa cgactaccac cgcagcgacg
      841 agcaggtgag catctgcctg gagtgtaaca gcagcaaact gcgcgggctg aagcggaagt
      901 ggatccgctg ctcagcccag gcgaccgtct tgcatctgaa gaagttcatc gccaaaaaac
      961 tcaacctttc atcctttaac gagctggaca ttttatgcaa cgaggagatc ctgggcaagg
     1021 accacacact caagttcgtg gttgtcacta ggtggagatt caagaaggcg ccgctcctgc
     1081 tgcactacag acccaagatg gacttgctgt gaatggtgcc acacagcgcc cacagactgg
     1141 gccctcgcac ccttgggtgc tcccggccgc cgcgcttaag aacattgcct ctgggtgtca
     1201 tgtggaccag acttctgaat agagaatatt tataactttt gtatgagaga gaattcacac
     1261 tcaacaagac actaccagca ccacgtttac agaggatgaa aacacttcac agtctcccag
     1321 agccgatcgt cctctccccc gccccacccc gtgcttcagc cttgcaggga gagtgatgct
     1381 ccaggcaaca cggttctgag tcaccttctg acacgagctc cctctgcttg ctttccaggt
     1441 cttgaaaatc tgaattcact tcagtttagt ttatgaattt taggtttcat gataagcctc
     1501 aagtgtagtt ggacttttat tgaatccttc ctaagttatt gaaaaaatgt cttttcatgg
     1561 tgaatgacaa tatttatgtt gcctttagct tcttgaagat ttagaagtta tataaaaaat
     1621 taatttaaaa gcaaaccaaa agaggtttcc attaacatta tgatttaacc attgtattta
     1681 atttcccacc ttatgaaaca caacagcagc tccctgactg gttcgccttt cattgtgtga
     1741 ggtcggcact tggactcact cagaactgtc gctcacctgt ggctgacaca cccagccctg
     1801 gaaacggggc cccagacgcc acgtcgggat ttctgacatg ctcagcaggt agaccagagg
     1861 ccgtgtgacc agctcagtgc tggtttacgg aacaactctt acttttaaaa attacttgtt
     1921 cccccaaatt gttgagtgcc gccgtttggt ttcctatgtt ttctttccct gttttgattt
     1981 tgctgaaggg agaggtggtg gtggttagga tcagagctct cctggcatcc gtggggagga
     2041 tttgctggtg gtggcttcgg gctcatgccc agacacactc actgccccgt ctgtccaagg
     2101 cctccccttc ccctttgctg gtgggaggag ctcgtgtgct ccttggccgc ttactggaag
     2161 ggcgtttttc agagctgcag ggacagggtg agcagctgaa gggctaggag ggaagccggc
     2221 ccccgctctg cagaagctgc atttcagctg aatctgtgtt tcagcctcag ttggttgcac
     2281 cgttagcccc tctcctcccg gatggtcatg tttttgtcac attagagaat aaacagccac
     2341 acacacattt ttttttttcc tttaaaacag taacttggaa atatgaaaag gccagaagga
     2401 ggagcaaggg ctgttttctg gagtggttga ggtgttgtcc tgcagttgtc attgtcttct
     2461 ccaccgggct gttcccattt atttcctgtg gaactgaatc cctcctccct ccactccttg
     2521 ggagcccagg tggtccttgg ccaccattca ggctttccaa gaagccaacc accttggaga
     2581 ttttttttct tgaatttcgc tgttttcttc tgcttccttt agataaaaag cagctcaaga
     2641 gaccttatct tagggatgag aaaaacatgc atattaattc catctgagtg attgtcagtg
     2701 taaggccttt taaaacaaaa gcaagttctt tgttaggaat tggtcaaaat tcatctcttt
     2761 ctttaagccc atcaactccc aggacggttt gagttactca gttacctaag cttgctattc
     2821 atccaaatca ttttctagag tcactgtata agggtctatg agtagctgtg tatgaataaa
     2881 tattacctgt ctacctcaaa atacacatac tgctgaagca ttctgtacaa ccgtgtgtta
     2941 tcacagtgca gttttaagtg taacgttaga acttaggcat tttcctgtgt ggcggaataa
     3001 gaaaggatta aacagttaca agcctccaaa ttcaaataaa attaaatcac agttcagatg
     3061 aaactgaata tcattgtaat aatctcataa tatatatttg taactttgta gctatctttg
     3121 aaatcacttg actttgcaat ggtgctaagc tgatagattt aaatacacag acgggcgagt
     3181 ggcgcccgtg tcgatgtctt cagccagtgg tgaccctgct tttgtaaccg cgttaacctg
     3241 acaaaacctc agcagcagaa gtccctattt ttctaggagt tcatcgtgca gacagtcttc
     3301 actacaggac tcggccctgg ggcctctgcc tctcgtctga ccttgcagcc ttagtcgttg
     3361 gaggctggag cgcaatggcc ctgccgtctg tggagcctct gggcggcctt ctttcctttc
     3421 tgtcaacctc tcatttcaca gaaaaaggct gaatttcatt ttttccagca tgaaagccag
     3481 gatcggttag tggttggatt ctattggttt ttttttttta aacagatgga gttactgtga
     3541 agaagttttc acaactattt atgctggtaa aacaaatgct gttaaatcac cttatgcgtc
     3601 gttttcaaca gcagtggggc taattacccg gaatacggtc tcaccgatgc agttttcatg
     3661 gacatagaaa attcaaatag aatatataat attgaattta agatttgggg ggttaaaaaa
     3721 gaaaacttaa ctttataaaa ttatttattc tattttaagc cttctatcat attttcccat
     3781 ccaattgttt ggtttcagtg gtccagcttt atttacaggc atataaaatg aaattgtgag
     3841 atgttttgca agcttctttt tactttgagt agcttttaat ttgtatgttt ttatgtggat
     3901 gaagagcatt ttttatgctt ttgtgcaata ggttccaata tgcatttatt agacatctgt
     3961 ttaaatggta atgtagcatt tattttgcta aattgaaagg gaacatagat ggaattccaa
     4021 aatatgtaca ttcagctgtt tggtttttcg tttttcattg ttattattgt gagaatgctg
     4081 ttattggggt tgtgtgtgag tgcccgtcag ccagtgatgc ctcgggccac gctgtggggc
     4141 cacctcagtc ctgcctgggt cctggtgcct tggaccccac gtgcttgtgg ccaggctgcc
     4201 cctgggcagg gccatgtggc ctcagaccac aagagcggag ctgccctggc ccaagcactg
     4261 cagctgcctg cacccccggg cttcgcagcc ttgcttgttt tctctgaaca gcaacagaac
     4321 agtgttcaca gcgattcaaa gggtggcatt gggttggacg ttctgggtac aagccaacct
     4381 agtcccacgt tgtacgtgaa tgtttaatgt gctctcaaaa catggaaaat aagtttagtg
     4441 cacatagcta aatcacaaaa catccaattt ctctgtttcc tcaggaagtc attactgcgc
     4501 caccacatca catgacctta acatgatcaa tgtatttctc tgccttgaca tttaaataca
     4561 taaattgaga taagtagatt agaaaatcat tcaaatgata ccataatttg tacgggacag
     4621 ggtgcgggca atggccacgt ggccaaggcc ctgcaggaac gcgccgaggt ctccctcacc
     4681 ctccaggtgt ccttcgcacc caacagtgcg tctgaggaac gagctgcagt ttgagcgttc
     4741 ccctgagatg tgcgtagcct ccgtgtaaat gtccactccc atggcttaat tgcctatcag
     4801 acgcattttc ccagacgaaa gcaatgttgg gttggggaag acagtgcagc cacccagcct
     4861 ttaccagcag cgtacggcag acgaaggcag tcgaggtgtg gaggtgatca cgaagataca
     4921 tgtgtttgac tgtttaattt gaaagtttac attttttatg ctttgtgttg gtgtgtaatt
     4981 tttgtactct tggtggctag tttttgtcaa atcttttttg gaatattgct taaatgtttt
     5041 gattttatga tagtgaagct tgtattcagt gttttgccaa ttaatattat atgcttgtaa
     5101 taaaagcaaa agaaaagctt aa
//
