LOCUS       NM_007144               2634 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens polycomb group ring finger 2 (PCGF2), transcript
            variant 1, mRNA.
ACCESSION   NM_007144
VERSION     NM_007144.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2634)
  AUTHORS   Wang,K., Li,M., Duan,H., Fan,M., Xu,C. and Yu,F.
  TITLE     SLCO4A1-AS1 triggers the malignant behaviours of melanoma cells via
            sponging miR-1306-5p to enhance PCGF2
  JOURNAL   Exp Dermatol 31 (8), 1220-1233 (2022)
   PUBMED   35427425
  REMARK    GeneRIF: SLCO4A1-AS1 triggers the malignant behaviours of melanoma
            cells via sponging miR-1306-5p to enhance PCGF2.
REFERENCE   2  (bases 1 to 2634)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2634)
  AUTHORS   Mai,J., Peng,X.D., Tang,J., Du,T., Chen,Y.H., Wang,Z.F.,
            Zhang,H.L., Huang,J.H., Zhong,Z.Y., Yang,D., Li,Z.L., Huang,Y.,
            Feng,G.K., Zhu,X.F. and Deng,R.
  TITLE     AKT-mediated regulation of chromatin ubiquitylation and
            tumorigenesis through Mel18 phosphorylation
  JOURNAL   Oncogene 40 (13), 2422-2436 (2021)
   PUBMED   33664452
  REMARK    GeneRIF: AKT-mediated regulation of chromatin ubiquitylation and
            tumorigenesis through Mel18 phosphorylation.
REFERENCE   4  (bases 1 to 2634)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2634)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2634)
  AUTHORS   Levine,S.S., Weiss,A., Erdjument-Bromage,H., Shao,Z., Tempst,P. and
            Kingston,R.E.
  TITLE     The core of the polycomb repressive complex is compositionally and
            functionally conserved in flies and humans
  JOURNAL   Mol Cell Biol 22 (17), 6070-6078 (2002)
   PUBMED   12167701
REFERENCE   7  (bases 1 to 2634)
  AUTHORS   Miyazaki,K., Inoue,H., Onai,N., Ishihara,H. and Kanno,M.
  TITLE     Chemokine-mediated thymopoiesis is regulated by a mammalian
            Polycomb group gene, mel-18
  JOURNAL   Immunol Lett 80 (2), 139-143 (2002)
   PUBMED   11750047
  REMARK    GeneRIF: The mouse counterpart of this gene regulates the
            expression of various chemokines and chemokine receptors, which may
            be important for T cell migration and differentiation.
REFERENCE   8  (bases 1 to 2634)
  AUTHORS   Matsuo,F., Yano,K., Saito,H., Morotomi,K., Kato,M., Yoshimoto,M.,
            Kasumi,F., Akiyama,F., Sakamoto,G. and Miki,Y.
  TITLE     Mutation analysis of the mel-18 gene that shows decreased
            expression in human breast cancer cell lines
  JOURNAL   Breast Cancer 9 (1), 33-38 (2002)
   PUBMED   12196719
REFERENCE   9  (bases 1 to 2634)
  AUTHORS   Kimura,M., Koseki,Y., Yamashita,M., Watanabe,N., Shimizu,C.,
            Katsumoto,T., Kitamura,T., Taniguchi,M., Koseki,H. and Nakayama,T.
  TITLE     Regulation of Th2 cell differentiation by mel-18, a mammalian
            polycomb group gene
  JOURNAL   Immunity 15 (2), 275-287 (2001)
   PUBMED   11520462
  REMARK    GeneRIF: The mouse counterpart of this gene regulates the
            expression of Th2 cytokines, and plays a critical role in Th2 cell
            differentiation and Th-2 dependent immune responses.
REFERENCE   10 (bases 1 to 2634)
  AUTHORS   Ishida,A., Asano,H., Hasegawa,M., Koseki,H., Ono,T., Yoshida,M.C.,
            Taniguchi,M. and Kanno,M.
  TITLE     Cloning and chromosome mapping of the human Mel-18 gene which
            encodes a DNA-binding protein with a new 'RING-finger' motif
  JOURNAL   Gene 129 (2), 249-255 (1993)
   PUBMED   8325509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006449.19.
            
            On Nov 25, 2018 this sequence version replaced NM_007144.2.
            
            Summary: The protein encoded by this gene contains a RING finger
            motif and is similar to the polycomb group (PcG) gene products. PcG
            gene products form complexes via protein-protein interaction and
            maintain the transcription repression of genes involved in
            embryogenesis, cell cycles, and tumorigenesis. This protein was
            shown to act as a negative regulator of transcription and has tumor
            suppressor activity. The expression of this gene was detected in
            various tumor cells, but is limited in neural organs in normal
            tissues. Knockout studies in mice suggested that this protein may
            negatively regulate the expression of different cytokines,
            chemokines, and chemokine receptors, and thus plays an important
            role in lymphocyte differentiation and migration, as well as in
            immune responses. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.883288.1, BC024255.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000620225.5/ ENSP00000482815.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AC006449.19        193199-193339       c
            142-234             AC006449.19        192882-192974       c
            235-386             AC006449.19        185294-185445       c
            387-483             AC006449.19        184589-184685       c
            484-539             AC006449.19        184201-184256       c
            540-590             AC006449.19        184071-184121       c
            591-699             AC006449.19        183756-183864       c
            700-754             AC006449.19        183544-183598       c
            755-850             AC006449.19        183356-183451       c
            851-931             AC006449.19        181093-181173       c
            932-2634            AC006449.19        178901-180603       c
FEATURES             Location/Qualifiers
     source          1..2634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..2634
                     /gene="PCGF2"
                     /gene_synonym="MEL-18; RNF110; TPFS; ZNF144"
                     /note="polycomb group ring finger 2"
                     /db_xref="GeneID:7703"
                     /db_xref="HGNC:HGNC:12929"
                     /db_xref="MIM:600346"
     exon            1..141
                     /gene="PCGF2"
                     /gene_synonym="MEL-18; RNF110; TPFS; ZNF144"
                     /inference="alignment:Splign:2.1.0"
     exon            142..234
                     /gene="PCGF2"
                     /gene_synonym="MEL-18; RNF110; TPFS; ZNF144"
                     /inference="alignment:Splign:2.1.0"
     exon            235..386
                     /gene="PCGF2"
                     /gene_synonym="MEL-18; RNF110; TPFS; ZNF144"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..1309
                     /gene="PCGF2"
                     /gene_synonym="MEL-18; RNF110; TPFS; ZNF144"
                     /note="ring finger protein 110; zinc finger protein 144;
                     DNA-binding protein Mel-18"
                     /codon_start=1
                     /product="polycomb group RING finger protein 2"
                     /protein_id="NP_009075.1"
                     /db_xref="CCDS:CCDS32638.1"
                     /db_xref="GeneID:7703"
                     /db_xref="HGNC:HGNC:12929"
                     /db_xref="MIM:600346"
                     /translation="MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIV
                     RYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYP
                     LTEVPNGSNEDRGEVLEQEKGALSDDEIVSLSIEFYEGARDRDEKKGPLENGDGDKEK
                     TGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWR
                     RNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSL
                     PSPATPSHGSPSSHGPPATHPTSPTPPSTASGATTAANGGSLNCLQTPSSTSRGRKMT
                     VNGAPVPPLT"
     exon            387..483
                     /gene="PCGF2"
                     /gene_synonym="MEL-18; RNF110; TPFS; ZNF144"
                     /inference="alignment:Splign:2.1.0"
     exon            484..539
                     /gene="PCGF2"
                     /gene_synonym="MEL-18; RNF110; TPFS; ZNF144"
                     /inference="alignment:Splign:2.1.0"
     exon            540..590
                     /gene="PCGF2"
                     /gene_synonym="MEL-18; RNF110; TPFS; ZNF144"
                     /inference="alignment:Splign:2.1.0"
     exon            591..699
                     /gene="PCGF2"
                     /gene_synonym="MEL-18; RNF110; TPFS; ZNF144"
                     /inference="alignment:Splign:2.1.0"
     exon            700..754
                     /gene="PCGF2"
                     /gene_synonym="MEL-18; RNF110; TPFS; ZNF144"
                     /inference="alignment:Splign:2.1.0"
     exon            755..850
                     /gene="PCGF2"
                     /gene_synonym="MEL-18; RNF110; TPFS; ZNF144"
                     /inference="alignment:Splign:2.1.0"
     exon            851..931
                     /gene="PCGF2"
                     /gene_synonym="MEL-18; RNF110; TPFS; ZNF144"
                     /inference="alignment:Splign:2.1.0"
     exon            932..2634
                     /gene="PCGF2"
                     /gene_synonym="MEL-18; RNF110; TPFS; ZNF144"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1441..1446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCGF2"
                     /gene_synonym="MEL-18; RNF110; TPFS; ZNF144"
                     /note="hexamer: AATATA"
     polyA_site      1469
                     /gene="PCGF2"
                     /gene_synonym="MEL-18; RNF110; TPFS; ZNF144"
                     /note="major polyA site"
     polyA_site      1532
                     /gene="PCGF2"
                     /gene_synonym="MEL-18; RNF110; TPFS; ZNF144"
                     /note="major polyA site"
     regulatory      2615..2620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCGF2"
                     /gene_synonym="MEL-18; RNF110; TPFS; ZNF144"
                     /note="hexamer: AATAAA"
     polyA_site      2634
                     /gene="PCGF2"
                     /gene_synonym="MEL-18; RNF110; TPFS; ZNF144"
                     /note="major polyA site"
ORIGIN      
        1 gctttcacaa actcctttct taccgtaggt ttctcccctc ccgccgcccg ggcgagcgac
       61 acggctgcgg cccccctccc ctcccttccc tccctccctc ccatcccccc ctccccgaga
      121 cccaccggac cccgaaccca gatggccgaa acgggctccc cgtcttaacg atttggcgtc
      181 tccctcgacc accacctctt tgtgcagcag cccccgggca gaccctgttc cgagggcaac
      241 gctccccagt ccccccaccc ccgaccccgg aatcatgcat cggactacac ggatcaaaat
      301 cacagagctg aacccccacc tcatgtgtgc cctctgcggg gggtacttca tcgacgccac
      361 cactatcgtg gagtgcctgc attccttctg caaaacctgc atcgtgcgct acctggagac
      421 caacaaatac tgccccatgt gtgacgtgca ggtccataaa acccggccgc tgctgagcat
      481 caggtctgac aaaacacttc aagacattgt ctacaaattg gtccctgggc tttttaaaga
      541 tgagatgaaa cggcggcggg atttctatgc agcgtacccc ctgacggagg tccccaacgg
      601 ctccaatgag gaccgcggcg aggtcttgga gcaggagaag ggggctctga gtgatgatga
      661 gattgtcagc ctctccatcg aattctacga aggtgccagg gaccgggacg agaagaaggg
      721 ccccctggag aatggggatg gggacaaaga gaaaacaggg gtgcgcttcc tgcgatgccc
      781 agcagccatg accgtcatgc atcttgccaa gtttctccgc aacaagatgg atgtgcccag
      841 caagtacaag gtggaggttc tgtacgagga cgagccactg aaggaatact acaccctcat
      901 ggacatcgcc tacatctacc cctggcggcg gaacgggcct ctccccctca agtaccgtgt
      961 ccagccagcc tgcaagcggc tcaccctagc cacggtgccc accccctccg agggcaccaa
     1021 caccagcggg gcgtccgagt gtgagtcagt cagcgacaag gctcccagcc ctgccaccct
     1081 gccagccacc tcctcctccc tgcccagccc agccacccca tcccatggct ctcccagttc
     1141 ccatgggcct ccagccaccc accctacctc ccccactccc ccttcgacag ccagtggggc
     1201 caccacagct gccaacgggg gtagcttgaa ctgcctgcag acaccatcct ccaccagcag
     1261 ggggcgcaag atgactgtca acggcgctcc cgtgcccccc ttaacttgag gccagggacc
     1321 ctctcccttc ttccagccaa gcctctccac tccttccact ttttctgggc ccttttttcc
     1381 acctcttcta ctttccccag ctcttcccac cttgggggtg gggggcgggt tttataaata
     1441 aatatatata tatatgtaca taggaaaaac caaatataca tacttatttt ctatggacca
     1501 accagattaa tttaaatgcc acaggaaaca aactttatgt gtgtgtgtat gtgtggaaaa
     1561 tggtgttcat tttttttggg gggggtcttg tgtaatttgc tgtttttggg ggtgcctgga
     1621 gatgaactgg atgggccact ggagtctcaa taaagctctg caccatcctc gctgtttccc
     1681 aaggcaggtg gtgtgttggg ggccccttca gacccaaagc tttaggcatg attccaactg
     1741 gctgcatata ggagtcagtt agaatcgttt ctttctctcc ccgtttctct ccccatcttg
     1801 gctgctgtcc tgcctctgac cagtggccgc cccccacgtt gttgaatgtc cagaaattgc
     1861 taagaacagt gccttttaca aatgcagttt atccctggtt ctgaggagca agtgcagggt
     1921 ggaggtggca cctgcatcac ctcctcctct tgcagtggaa actttgtgca aagaatagat
     1981 agttctgcct cttttttttt ttttcctgtg tgtgtggcct ttgcatcatt tatcttgtgg
     2041 aaaagaagat tcaggccctg agaggtctca gctcttggag gagggctaag gctttagcat
     2101 tgtgaagcgc tgcaccccca ccaaccttac cctcaccggg gaaccctcac tagcaggact
     2161 ggtggtggag tctcacctgg ggcctagagt ggaagtgggg gtgggttaac ctcacacaag
     2221 cacagatccc agactttgcc agaggcaaac agccttccaa ttgcccctcc acccccagct
     2281 gaggcccggt cacctggtca ggacagagca actgcatcta aaagcacaag aagacagaaa
     2341 cctgtaagct ctgaccccac ccccacccct tgagaggtca gcggaccacc tccttaggga
     2401 cagaccctgg caggtcgctg cccaccgaga tttcctcaag tgtgcataga tctgagagga
     2461 gtcgggagtc gagactcgag attccatcat agcgtaggtg tgtggggttg ggagccccct
     2521 gatgggcttg tctgtgtttg caccttgtcc tgtgtctgag gtcctgtgac tgtaccctcc
     2581 tttgccctgg gacatctgta tctcttggct ttgtaataaa tgctgcatac tttc
//
