LOCUS       NM_032673                907 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens polycomb group ring finger 1 (PCGF1), mRNA.
ACCESSION   NM_032673
VERSION     NM_032673.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 907)
  AUTHORS   Wijdeven,R.H., Luk,S.J., Schoufour,T.A.W., van der Zanden,S.Y.,
            Cabezuelo,M., Heemskerk,M.H.M. and Neefjes,J.
  TITLE     Balanced Epigenetic Regulation of MHC Class I Expression in Tumor
            Cells by the Histone Ubiquitin Modifiers BAP1 and PCGF1
  JOURNAL   J Immunol 212 (3), 446-454 (2024)
   PUBMED   38088808
  REMARK    GeneRIF: Balanced Epigenetic Regulation of MHC Class I Expression
            in Tumor Cells by the Histone Ubiquitin Modifiers BAP1 and PCGF1.
REFERENCE   2  (bases 1 to 907)
  AUTHORS   Liang,Y., Wu,D., Qu,Q., Li,Z. and Yin,H.
  TITLE     MORC4 plays a tumor-promoting role in colorectal cancer via
            regulating PCGF1/CDKN1A axis in vitro and in vivo
  JOURNAL   Cancer Gene Ther 30 (7), 985-996 (2023)
   PUBMED   36932196
  REMARK    GeneRIF: MORC4 plays a tumor-promoting role in colorectal cancer
            via regulating PCGF1/CDKN1A axis in vitro and in vivo.
REFERENCE   3  (bases 1 to 907)
  AUTHORS   Xie,L., Ding,N., Sheng,S., Zhang,H., Yin,H., Gao,L., Zhang,H.,
            Ma,S., Yang,A., Li,G., Jiao,Y., Shi,Q., Jiang,Y. and Zhang,H.
  TITLE     Cooperation between NSPc1 and DNA methylation represses HOXA11
            expression and promotes apoptosis of trophoblast cells during
            preeclampsia
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (2), 1-13 (2023)
   PUBMED   36815373
  REMARK    GeneRIF: Cooperation between NSPc1 and DNA methylation represses
            HOXA11 expression and promotes apoptosis of trophoblast cells
            during preeclampsia.
REFERENCE   4  (bases 1 to 907)
  AUTHORS   Ji,G., Zhou,W., Du,J., Zhou,J., Wu,D., Zhao,M., Yang,L. and Hao,A.
  TITLE     PCGF1 promotes epigenetic activation of stemness markers and
            colorectal cancer stem cell enrichment
  JOURNAL   Cell Death Dis 12 (7), 633 (2021)
   PUBMED   34148069
  REMARK    GeneRIF: PCGF1 promotes epigenetic activation of stemness markers
            and colorectal cancer stem cell enrichment.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 907)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 907)
  AUTHORS   Gearhart,M.D., Corcoran,C.M., Wamstad,J.A. and Bardwell,V.J.
  TITLE     Polycomb group and SCF ubiquitin ligases are found in a novel BCOR
            complex that is recruited to BCL6 targets
  JOURNAL   Mol Cell Biol 26 (18), 6880-6889 (2006)
   PUBMED   16943429
REFERENCE   7  (bases 1 to 907)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   8  (bases 1 to 907)
  AUTHORS   Gong,Y., Wang,X., Liu,J., Shi,L., Yin,B., Peng,X., Qiang,B. and
            Yuan,J.
  TITLE     NSPc1, a mainly nuclear localized protein of novel PcG family
            members, has a transcription repression activity related to its PKC
            phosphorylation site at S183
  JOURNAL   FEBS Lett 579 (1), 115-121 (2005)
   PUBMED   15620699
REFERENCE   9  (bases 1 to 907)
  AUTHORS   Valk-Lingbeek,M.E., Bruggeman,S.W. and van Lohuizen,M.
  TITLE     Stem cells and cancer; the polycomb connection
  JOURNAL   Cell 118 (4), 409-418 (2004)
   PUBMED   15315754
  REMARK    GeneRIF: polycomb has a role in stem cell fate and development of
            cancer (review)
            Review article
REFERENCE   10 (bases 1 to 907)
  AUTHORS   Nunes,M., Blanc,I., Maes,J., Fellous,M., Robert,B. and
            McElreavey,K.
  TITLE     NSPc1, a novel mammalian Polycomb gene, is expressed in neural
            crest-derived structures of the peripheral nervous system
  JOURNAL   Mech Dev 102 (1-2), 219-222 (2001)
   PUBMED   11287196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005041.2, BU602498.1 and BC004952.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032673.2.
            
            Summary: PCGF1 is a mammalian homolog of the Drosophila polycomb
            group genes, which act as transcriptional repressors to regulate
            anterior-posterior patterning in early embryonic development (Nunes
            et al., 2001 [PubMed 11287196]). See also PCGF2 (MIM
            600346).[supplied by OMIM, Aug 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004952.1, BI457391.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233630.11/ ENSP00000233630.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC005041.2         27604-27604
            2-36                BU602498.1         4-38
            37-907              BC004952.1         1-871
FEATURES             Location/Qualifiers
     source          1..907
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.1"
     gene            1..907
                     /gene="PCGF1"
                     /gene_synonym="2010002K04Rik; NSPC1; RNF3A-2; RNF68"
                     /note="polycomb group ring finger 1"
                     /db_xref="GeneID:84759"
                     /db_xref="HGNC:HGNC:17615"
                     /db_xref="MIM:610231"
     exon            1..120
                     /gene="PCGF1"
                     /gene_synonym="2010002K04Rik; NSPC1; RNF3A-2; RNF68"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..807
                     /gene="PCGF1"
                     /gene_synonym="2010002K04Rik; NSPC1; RNF3A-2; RNF68"
                     /note="RING finger protein 68; nervous system Polycomb-1"
                     /codon_start=1
                     /product="polycomb group RING finger protein 1"
                     /protein_id="NP_116062.2"
                     /db_xref="CCDS:CCDS1946.2"
                     /db_xref="GeneID:84759"
                     /db_xref="HGNC:HGNC:17615"
                     /db_xref="MIM:610231"
                     /translation="MASPQGGQIAIAMRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEH
                     IVCCLCAGYFVDATTITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDR
                     VMQDIVYKLVPGLQDSEEKRIREFYQSRGLDRVTQPTGEEPALSNLGLPFSSFDHSKA
                     HYYRYDEQLNLCLERLSSGKDKNKSVLQNKYVRCSVRAEVRHLRRVLCHRLMLNPQHV
                     QLLFDNEVLPDHMTMKQIWLSRWFGKPSPLLLQYSVKEKRR"
     exon            121..226
                     /gene="PCGF1"
                     /gene_synonym="2010002K04Rik; NSPC1; RNF3A-2; RNF68"
                     /inference="alignment:Splign:2.1.0"
     exon            227..379
                     /gene="PCGF1"
                     /gene_synonym="2010002K04Rik; NSPC1; RNF3A-2; RNF68"
                     /inference="alignment:Splign:2.1.0"
     exon            380..451
                     /gene="PCGF1"
                     /gene_synonym="2010002K04Rik; NSPC1; RNF3A-2; RNF68"
                     /inference="alignment:Splign:2.1.0"
     exon            452..557
                     /gene="PCGF1"
                     /gene_synonym="2010002K04Rik; NSPC1; RNF3A-2; RNF68"
                     /inference="alignment:Splign:2.1.0"
     exon            558..591
                     /gene="PCGF1"
                     /gene_synonym="2010002K04Rik; NSPC1; RNF3A-2; RNF68"
                     /inference="alignment:Splign:2.1.0"
     exon            592..678
                     /gene="PCGF1"
                     /gene_synonym="2010002K04Rik; NSPC1; RNF3A-2; RNF68"
                     /inference="alignment:Splign:2.1.0"
     exon            679..759
                     /gene="PCGF1"
                     /gene_synonym="2010002K04Rik; NSPC1; RNF3A-2; RNF68"
                     /inference="alignment:Splign:2.1.0"
     exon            760..907
                     /gene="PCGF1"
                     /gene_synonym="2010002K04Rik; NSPC1; RNF3A-2; RNF68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      887..892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCGF1"
                     /gene_synonym="2010002K04Rik; NSPC1; RNF3A-2; RNF68"
                     /note="hexamer: AATAAA"
     polyA_site      907
                     /gene="PCGF1"
                     /gene_synonym="2010002K04Rik; NSPC1; RNF3A-2; RNF68"
                     /note="major polyA site"
ORIGIN      
        1 agtggccggc tgggatcagc ctttaagatg gcgtctcctc aggggggcca gattgcgatc
       61 gcgatgaggc ttcggaacca gctccagtca gtgtacaaga tggacccgct acggaacgag
      121 gaggaggttc gagtgaagat caaagacttg aatgaacaca ttgtttgctg cctatgcgcc
      181 ggctacttcg tggatgccac caccatcaca gagtgtcttc atactttctg caagagttgt
      241 attgtgaagt acctccaaac tagcaagtac tgccccatgt gcaacattaa gatccacgag
      301 acacagccac tgctcaacct caaactggac cgggtcatgc aggacatcgt gtataagctg
      361 gtgcctggct tgcaagacag tgaagagaaa cggattcggg aattctacca gtcccgaggt
      421 ttggaccggg tcacccagcc cactggggaa gagccagcac tgagcaacct cggcctcccc
      481 ttcagcagct ttgaccactc taaagcccac tactatcgct atgatgagca gttgaacctg
      541 tgcctggagc ggctgagttc tggcaaagac aagaataaaa gcgtcctgca gaacaagtat
      601 gtccgatgtt ctgttagagc tgaggtacgc catctccgga gggtcctgtg tcaccgcttg
      661 atgctaaacc ctcagcatgt gcagctcctt tttgacaatg aagttctccc tgatcacatg
      721 acaatgaagc agatatggct ctcccgctgg ttcggcaagc catccccttt gcttttacaa
      781 tacagtgtga aagagaagag gaggtagggg ccaagccccc accccatccc actccccttc
      841 cctccccaga tatttatgtg aaatgaactg cagctttatt ttttgaaata aaaactttta
      901 aaaagca
//
