LOCUS       NM_138371               2310 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens PC-esterase domain containing 1B (PCED1B), transcript
            variant 1, mRNA.
ACCESSION   NM_138371 XM_005269225
VERSION     NM_138371.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2310)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2310)
  AUTHORS   Anantharaman,V. and Aravind,L.
  TITLE     Novel eukaryotic enzymes modifying cell-surface biopolymers
  JOURNAL   Biol Direct 5, 1 (2010)
   PUBMED   20056006
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC072670.1 and CR985281.1.
            
            On Nov 23, 2018 this sequence version replaced NM_138371.2.
            
            Summary: This gene encodes a protein that belongs to the
            GDSL/SGNH-like acyl-esterase family. Members of this family are
            hydrolases thought to function in modification of biopolymers on
            the cell surface. Alternate splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Jul
            2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072670.1, BM543579.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152719, SAMEA2161920
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000546455.6/ ENSP00000446688.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               BC072670.1         19-189
            172-188             CR985281.1         169-185
            189-2310            BC072670.1         205-2326
FEATURES             Location/Qualifiers
     source          1..2310
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.11"
     gene            1..2310
                     /gene="PCED1B"
                     /gene_synonym="FAM113B"
                     /note="PC-esterase domain containing 1B"
                     /db_xref="GeneID:91523"
                     /db_xref="HGNC:HGNC:28255"
     exon            1..105
                     /gene="PCED1B"
                     /gene_synonym="FAM113B"
                     /inference="alignment:Splign:2.1.0"
     exon            106..188
                     /gene="PCED1B"
                     /gene_synonym="FAM113B"
                     /inference="alignment:Splign:2.1.0"
     exon            189..656
                     /gene="PCED1B"
                     /gene_synonym="FAM113B"
                     /inference="alignment:Splign:2.1.0"
     exon            657..2310
                     /gene="PCED1B"
                     /gene_synonym="FAM113B"
                     /inference="alignment:Splign:2.1.0"
     CDS             714..2012
                     /gene="PCED1B"
                     /gene_synonym="FAM113B"
                     /note="family with sequence similarity 113, member B"
                     /codon_start=1
                     /product="PC-esterase domain-containing protein 1B"
                     /protein_id="NP_612380.1"
                     /db_xref="CCDS:CCDS8752.1"
                     /db_xref="GeneID:91523"
                     /db_xref="HGNC:HGNC:28255"
                     /translation="MILLRASEVRQLLHNKFVVILGDSVHRAVYKDLVLLLQKDRLLT
                     PGQLRARGELNFEQDELVDGGQRGHMHNGLNYREVREFRSDHHLVRFYFLTRVYSDYL
                     QTILKELQSGEHAPDLVIMNSCLWDISRYGPNSWRSYLENLENLFQCLGQVLPESCLL
                     VWNTAMPVGEEVTGGFLPPKLRRQKATFLKNEVVKANFHSATEARKHNFDVLDLHFHF
                     RHARENLHWDGVHWNGRVHRCLSQLLLAHVADAWGVELPHRHPVGEWIKKKKPGPRVE
                     GPPQANRNHPALPLSPPLPSPTYRPLLGFPPQRLPLLPLLSPQPPPPILHHQGMPRFP
                     QGPPDACFSSDHTFQSDQFYCHSDVPSSAHAGFFVEDNFMVGPQLPMPFFPTPRYQRP
                     APVVHRGFGRYRPRGPYTPWGQRPRPSKRRAPANPEPRPQ"
     regulatory      2291..2296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCED1B"
                     /gene_synonym="FAM113B"
                     /note="hexamer: AATAAA"
     polyA_site      2310
                     /gene="PCED1B"
                     /gene_synonym="FAM113B"
                     /note="major polyA site"
ORIGIN      
        1 ggagtttcaa gcagccgcgg cggcagcagc agccctggac gcagcagcca agctcttcgc
       61 tggctcccgg gggctctccc gggttcctct cattgcaggc tgaaggtaat gagaggccct
      121 aagatcccag aggatgccat aagaggaaaa gtcaggggag tgttgaagac tctgcctcct
      181 acaaatatcc gtgaacatac cacaccagca agaacaataa gagccaaggg tctgaattgt
      241 ttaatcaaag gaagagtcaa aataagctac acccagatta ctgagaaagg tgaaatgaaa
      301 acaagctcaa aaccaaattc caggaagatg ctgtctttgt attgacttac catttcatgt
      361 tttcacacat gtcaaagtct tgaagcttcg gtcattagtc ttccgcttcc taaagcaaga
      421 aactaaatgc tgacttgtgt cgtttgcccc agatgccacc ggaaatgtca tcttctcccc
      481 agacgctggc ttgcaagcac agcagcaccc agaggctaac ctatttcccc tatagcccaa
      541 gctctgagat ctcccgtctg gtcacaatga tctacaggag aggaagaaag ctatctaggg
      601 acgagatcta gaatcaactg agagagatgc ttaaaaatca ccagttactt taatgaccat
      661 ccgcagagcc atcctgtgca aaggaaggag ctaggctgtg cgccctgggc gtcatgatcc
      721 ttctgcgggc ctccgaagtg cggcagctgc ttcacaataa gttcgtggtc atcctggggg
      781 actctgtgca tagggcagta tacaaggacc tggtgcttct gctgcagaag gaccgcctgc
      841 tcactcccgg gcagcttaga gcaagggggg agctgaactt cgaacaagat gagctggtgg
      901 acggaggcca gcggggccac atgcacaacg gccttaacta ccgtgaggtc cgcgagttcc
      961 gctccgacca ccatctggta cgtttttact tcctcacccg cgtgtactcc gattacctcc
     1021 agaccatctt gaaagagctg cagtcgggcg agcacgcccc cgacctggtc atcatgaatt
     1081 cctgcctctg ggacatctcc aggtatggtc cgaactcctg gagaagctac ctggagaacc
     1141 tggagaacct gttccagtgc ctgggccagg tgctgcccga gtcttgcctc ctggtgtgga
     1201 acacggccat gcctgtgggc gaggaagtca ccgggggttt tcttccgccc aagctccggc
     1261 ggcagaaggc caccttcctg aaaaacgaag tggtcaaagc caacttccac agcgccaccg
     1321 aggcacgtaa acataacttc gatgtactgg acttgcattt ccacttccgc cacgcgaggg
     1381 agaacctgca ctgggacggg gtgcactgga atggacgtgt gcaccgctgc ctctcccagc
     1441 tgctgctggc ccacgtggcc gacgcctggg gtgtggagct gccccaccgc caccccgtgg
     1501 gcgagtggat caagaagaaa aaacctggcc cgagagtcga agggccgccc caggccaaca
     1561 gaaatcaccc ggccttacct ctgtccccac ccttaccttc ccccacatac cgccccctgc
     1621 ttgggttccc accccagcgc ttgccgctgc tcccgctcct gtccccacag cctcctcctc
     1681 ccattctcca tcaccaggga atgccccggt tcccacaggg tcccccagat gcctgttttt
     1741 cctcagacca tactttccag tcggatcaat tctattgcca ttcagatgtc ccctcatcag
     1801 cccatgcagg tttcttcgtc gaagacaatt ttatggttgg tcctcagctg cctatgccct
     1861 tcttccccac accccgttat cagcggcctg ccccagtggt acataggggt tttggcaggt
     1921 atcgtccccg tggcccctat acgccctggg gacagcggcc tcgaccttca aagagaaggg
     1981 ccccagccaa tcctgagcca aggcctcaat agacggacct aggccttatt tcctctttat
     2041 gaacatggat tggacagatc tgacacttcc tttccattgc ttggcctgaa cagactgacc
     2101 ttgttaactt aagcctggag tccatgcctc gtcttccttt tgttcattgc tgttaccaag
     2161 aaagccaagg aagagcagcc tgactcattc ttcttggctg cagcctcttc cccacttcct
     2221 gggagtgacc cagcgttatt cctgcctcct cactcctatt ctctttgcct ttgtgtaaaa
     2281 ataaaatgga aataaacaag ttgcacagaa
//
