LOCUS       NM_022760               1979 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens PC-esterase domain containing 1A (PCED1A), transcript
            variant 1, mRNA.
ACCESSION   NM_022760
VERSION     NM_022760.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1979)
  AUTHORS   Anantharaman,V. and Aravind,L.
  TITLE     Novel eukaryotic enzymes modifying cell-surface biopolymers
  JOURNAL   Biol Direct 5, 1 (2010)
   PUBMED   20056006
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1979)
  AUTHORS   Akoh,C.C., Lee,G.C., Liaw,Y.C., Huang,T.H. and Shaw,J.F.
  TITLE     GDSL family of serine esterases/lipases
  JOURNAL   Prog Lipid Res 43 (6), 534-552 (2004)
   PUBMED   15522763
  REMARK    Review article
REFERENCE   3  (bases 1 to 1979)
  AUTHORS   Lee,S.Y., Obata,Y., Yoshida,M., Stockert,E., Williamson,B.,
            Jungbluth,A.A., Chen,Y.T., Old,L.J. and Scanlan,M.J.
  TITLE     Immunomic analysis of human sarcoma
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2651-2656 (2003)
   PUBMED   12601173
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161656.20.
            
            On Aug 31, 2019 this sequence version replaced NM_022760.5.
            
            Summary: The protein encoded by this gene is a member of the
            GDSL/SGNH superfamily. Members of this family are hydrolytic
            enzymes with esterase and lipase activity and broad substrate
            specificity. This protein belongs to the Pmr5-Cas1p-esterase
            subfamily in that it contains the catalytic triad comprised of
            serine, aspartate and histidine and lacks two conserved regions
            (glycine after strand S2 and GxND motif). A pseudogene of this gene
            has been identified on the long arm of chromosome 2. Alternative
            splicing results in multiple transcript variants that encode
            different protein isoforms. [provided by RefSeq, Sep 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056353.1, BC051816.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360652.7/ ENSP00000353868.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-445               AL161656.20        20902-21346         c
            446-590             AL161656.20        20480-20624         c
            591-670             AL161656.20        19883-19962         c
            671-909             AL161656.20        19535-19773         c
            910-1060            AL161656.20        19287-19437         c
            1061-1307           AL161656.20        18923-19169         c
            1308-1583           AL161656.20        16730-17005         c
            1584-1979           AL161656.20        16005-16400         c
FEATURES             Location/Qualifiers
     source          1..1979
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..1979
                     /gene="PCED1A"
                     /gene_synonym="bA12M19.1; C20orf81; FAM113A"
                     /note="PC-esterase domain containing 1A"
                     /db_xref="GeneID:64773"
                     /db_xref="HGNC:HGNC:16212"
     exon            1..445
                     /gene="PCED1A"
                     /gene_synonym="bA12M19.1; C20orf81; FAM113A"
                     /inference="alignment:Splign:2.1.0"
     exon            446..590
                     /gene="PCED1A"
                     /gene_synonym="bA12M19.1; C20orf81; FAM113A"
                     /inference="alignment:Splign:2.1.0"
     CDS             467..1831
                     /gene="PCED1A"
                     /gene_synonym="bA12M19.1; C20orf81; FAM113A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sarcoma antigen NY-SAR-23; family with sequence similarity
                     113, member A; PC-esterase domain-containing protein 1A"
                     /codon_start=1
                     /product="PC-esterase domain-containing protein 1A isoform
                     1"
                     /protein_id="NP_073597.2"
                     /db_xref="CCDS:CCDS13035.1"
                     /db_xref="GeneID:64773"
                     /db_xref="HGNC:HGNC:16212"
                     /translation="MVFCLSSEEPRRPLRSDMVHFQASEVQQLLHNKFVVILGDSIQR
                     AVYKDLVLLLQKDSLLTAAQLKAKGELSFEQDQLVAGGQLGELHNGTQYREVRQFCSG
                     SGHHLVRFYFLTRVYSEYLEDVLEELTYGPAPDLVIINSCLWDLSRYGRCSMESYREN
                     LERVFVRMDQVLPDSCLLVWNMAMPLGERITGGFLLPELQPLAGSLRRDVVEGNFYSA
                     TLAGDHCFDVLDLHFHFRHAVQHRHRDGVHWDQHAHRHLSHLLLTHVADAWGVELPKR
                     GYPPDPWIEDWAEMNHPFQGSHRQTPDFGEHLALLPPPPSSLPPPMPFPYPLPQPSPP
                     PLFPPLPQDTPFFPGQPFPPHEFFNYNPVEDFSMPPHLGCGPGVNFVPGPLPPPIPGP
                     NPHGQHWGPVVHRGMPRYVPNSPYHVRRMGGPCRQRLRHSERLIHTYKLDRRPPAHSG
                     TWPG"
     exon            591..670
                     /gene="PCED1A"
                     /gene_synonym="bA12M19.1; C20orf81; FAM113A"
                     /inference="alignment:Splign:2.1.0"
     exon            671..909
                     /gene="PCED1A"
                     /gene_synonym="bA12M19.1; C20orf81; FAM113A"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1060
                     /gene="PCED1A"
                     /gene_synonym="bA12M19.1; C20orf81; FAM113A"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1307
                     /gene="PCED1A"
                     /gene_synonym="bA12M19.1; C20orf81; FAM113A"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1583
                     /gene="PCED1A"
                     /gene_synonym="bA12M19.1; C20orf81; FAM113A"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1979
                     /gene="PCED1A"
                     /gene_synonym="bA12M19.1; C20orf81; FAM113A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1950..1955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCED1A"
                     /gene_synonym="bA12M19.1; C20orf81; FAM113A"
                     /note="hexamer: AATAAA"
     polyA_site      1979
                     /gene="PCED1A"
                     /gene_synonym="bA12M19.1; C20orf81; FAM113A"
                     /note="major polyA site"
ORIGIN      
        1 accactgtgg gcagcctcac ttggctgccg ccccgagacc ccagcccgta cctgggcttc
       61 gcgcccgcca agtgggccca gccctggctc ctgcgccctg tggcggccac ctccatcgcc
      121 ttgctttccc ttcgggcact gggggtcgct cagggcggga catgggtgaa cggaagtgga
      181 agctgtgagc gtcgcagccc gaggcgccga ggcctgaggc gccgtcgggg ccacagcgac
      241 gctcgcatgg agagcgctgg gcgctgggct gtgcaccgac ggctaacctg gacccacggt
      301 ctctgcgggg cgggagcttt gcagaaccga ctggccgact ggggcgcggg aacatgaggc
      361 ttggctagga gcccgctgcg ggccaggcgc gcggtgcgca ggcatacccg ggtcgcgggt
      421 gaacaccgcg gagccccggg acttgcctgt cgttgctggt ggcggcatgg tcttctgtct
      481 gtcgagcgag gagccgcgcc gcccgctgcg aagcgacatg gtccacttcc aggcctcgga
      541 agtccagcag ctgctacaca acaagttcgt ggtcatcttg ggggactcca ttcagagggc
      601 tgtgtacaag gacctggtgc tcttgctcca gaaagactca ctgctcacag ctgcccagct
      661 gaaagccaag ggggagctga gctttgaaca ggaccagctg gtggctgggg gccagctggg
      721 cgagctgcac aacgggacac agtatcgtga ggtccgccag ttctgctcgg gctctggcca
      781 ccaccttgtg cgcttctact tcctcactcg tgtttactcc gagtaccttg aggatgttct
      841 ggaagagctg acatatggac ctgccccgga cctggtgatc atcaactcct gcctctggga
      901 tctctccaga tatggtcgct gctcaatgga gagctaccgg gagaacctgg agcgggtgtt
      961 tgtgcgcatg gaccaagtat tgccagactc ctgcctgctg gtgtggaaca tggcgatgcc
     1021 cctcggggaa cgtatcactg ggggtttcct cctgccagag ctccagcccc tggcaggctc
     1081 cctgcggcgg gatgtggttg aagggaactt ctacagtgct acgctggccg gggaccactg
     1141 ctttgatgtc ctagacctcc actttcactt ccggcatgca gtacagcacc gtcatcggga
     1201 tggtgtccac tgggaccagc atgcacaccg ccacctctca cacctgcttc tgacccatgt
     1261 ggctgacgcc tggggcgtgg agctgcccaa gcgtggctat ccccctgacc cgtggattga
     1321 ggactgggca gagatgaatc atccattcca gggaagccat aggcagaccc cagacttcgg
     1381 ggagcacctg gccttgctcc cacccccacc ttcttctttg cctcctccca tgccttttcc
     1441 ctacccgctt cctcagccct cgccacctcc cctcttccca cccctgcccc aggatacccc
     1501 ttttttccca ggccagccct tcccacccca tgaattcttc aactataatc cagtggagga
     1561 cttctcgatg ccaccccact taggatgtgg ccctggagtg aactttgtgc ctggccctct
     1621 gccacctcca atccctggcc ctaatcccca tggtcagcac tggggcccag tggtccaccg
     1681 ggggatgcca cgctatgttc ctaacagccc ctaccatgtg cggagaatgg gggggccctg
     1741 caggcagcgg ctcagacact cagagagact gatccacaca tacaaactgg acagacggcc
     1801 tcctgcccat tcggggacat ggcctgggta gactggatct tgggctggga ctggatgtgc
     1861 caatggccct tcagggcctg cctggcacct caggtactgg gctagggtgt ctgctatgcc
     1921 tggtattgtt cttgtccatt gctgtcacca ataaaggcat ggaagaacag agtgacaaa
//
