LOCUS       NM_018929               4797 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens protocadherin gamma subfamily C, 5 (PCDHGC5),
            transcript variant 1, mRNA.
ACCESSION   NM_018929
VERSION     NM_018929.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4797)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   2  (bases 1 to 4797)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   3  (bases 1 to 4797)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   4  (bases 1 to 4797)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   5  (bases 1 to 4797)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008781.7 and AF152339.1.
            
            On Jun 2, 2019 this sequence version replaced NM_018929.2.
            
            Summary: This gene is a member of the protocadherin gamma gene
            cluster, one of three related clusters tandemly linked on
            chromosome five. These gene clusters have an immunoglobulin-like
            organization, suggesting that a novel mechanism may be involved in
            their regulation and expression. The gamma gene cluster includes 22
            genes divided into 3 subfamilies. Subfamily A contains 12 genes,
            subfamily B contains 7 genes and 2 pseudogenes, and the more
            distantly related subfamily C contains 3 genes. The tandem array of
            22 large, variable region exons are followed by a constant region,
            containing 3 exons shared by all genes in the cluster. Each
            variable region exon encodes the extracellular region, which
            includes 6 cadherin ectodomains and a transmembrane region. The
            constant region exons encode the common cytoplasmic region. These
            neural cadherin-like cell adhesion proteins most likely play a
            critical role in the establishment and function of specific
            cell-cell connections in the brain. Alternative splicing has been
            described for the gamma cluster genes. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) includes the constant region
            exons and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.155508.1,
                                           SRR1803611.7528.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252087.3/ ENSP00000252087.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AC008781.7         161857-162016       c
            161-4797            AF152339.1         1-4637
FEATURES             Location/Qualifiers
     source          1..4797
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..4797
                     /gene="PCDHGC5"
                     /gene_synonym="PCDH-GAMMA-C5"
                     /note="protocadherin gamma subfamily C, 5"
                     /db_xref="GeneID:56097"
                     /db_xref="HGNC:HGNC:8718"
                     /db_xref="MIM:606306"
     exon            1..2620
                     /gene="PCDHGC5"
                     /gene_synonym="PCDH-GAMMA-C5"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..2995
                     /gene="PCDHGC5"
                     /gene_synonym="PCDH-GAMMA-C5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protocadherin gamma-C5"
                     /codon_start=1
                     /product="protocadherin gamma-C5 isoform 1 precursor"
                     /protein_id="NP_061752.1"
                     /db_xref="CCDS:CCDS4263.1"
                     /db_xref="GeneID:56097"
                     /db_xref="HGNC:HGNC:8718"
                     /db_xref="MIM:606306"
                     /translation="MGPKTLPQLAGKWQVLCMLSLCCWGWVSGQLRYSVVEESEPGTL
                     VGNVAQDLGLKMTDLLSRRLQLGSEENGRYFSLSLMSGALAVNQKIDRESLCGASTSC
                     LLPVQVVTEHPLELIRVEVEILDLNDNSPSFATPEREMRISESAASGARFPLDSAQDP
                     DVGTNTVSFYTLSPNSHFSLNVKTLKDGKPFPELVLEQQLDREAQARHQLVLTAVDGG
                     TPARSGTTLISVIVLDINDNAPTFQSSVLRVGIPENAPIGTLLLRLNATDPDEGTNGQ
                     LDYSFGDHTSEAVRNLFGLDPSSGAIHVLGPIDFEESRFYEIHARARDQGQPAMEGHC
                     VIQVDVGDVNDNAPEVLLASLANPVLESTPVGTVVGLFNVRDRDSGRNGEVSLDISPD
                     LPFQIKPSENHYSLLTSQPLDREATSHYIIELLASDAGSPSLHKHLTIRLNISDVNDN
                     APRFNQQLYTAYILENRPPGSLLCTVAASDPDTGDNARLTYSIVGNQVQGAPASSFVY
                     VNPEDGRIFAQRTFDYELLQMLQIVVGVRDSGSPPLHANTSLHVFVLDENDNAPAVLH
                     PRPDWEHSAPQRLPRSAPPGSLVTKVTAVDADAGHNAWLSYSLLPQSTAPGLFLVSTH
                     TGEVRTARALLEDDSDTQQVVVLVRDNGDPSLSSTATVLLVLEDEDPEEMPKSSDFLI
                     HPPERSDLTLYLIVALATVSLLSLVTFTFLSAKCLQGNADGDGGGGQCCRRQDSPSPD
                     FYKQSSPNLQVSSDGTLKYMEVTLRPTDSQSHCYRTCFSPASDGSDFTFLRPLSVQQP
                     TALALEPDAIRSRSNTLRERSQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFD
                     TEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNA
                     TLTNAAGKRDGKAPAGGNGNKKKSGKKEKK"
     exon            2621..2679
                     /gene="PCDHGC5"
                     /gene_synonym="PCDH-GAMMA-C5"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2768
                     /gene="PCDHGC5"
                     /gene_synonym="PCDH-GAMMA-C5"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..4797
                     /gene="PCDHGC5"
                     /gene_synonym="PCDH-GAMMA-C5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4776..4781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHGC5"
                     /gene_synonym="PCDH-GAMMA-C5"
                     /note="hexamer: AATAAA"
     polyA_site      4797
                     /gene="PCDHGC5"
                     /gene_synonym="PCDH-GAMMA-C5"
                     /note="major polyA site"
ORIGIN      
        1 actcggtgac taagaactgc tgcaagcagg caaacctccg agcagttttt aagaggctgg
       61 aaggagacat aagagacttc agctgctgca ttccaagccc tgggtctacc ttggagacag
      121 gacagcacag acttactctc cacaaaggga cttctgggtc atggggccca agacactccc
      181 acagctcgct gggaaatggc aagtgctgtg catgttgtcc ttgtgctgct ggggctgggt
      241 gtctgggcag cttcgttact cagtggtgga ggagtctgag ccggggacgc tggtggggaa
      301 tgttgctcag gatctgggct taaagatgac agatctgttg agccggcggc tgcaattggg
      361 ctctgaggag aatgggcgct atttttccct gagcttgatg agtggtgccc tggcagtgaa
      421 tcaaaagatt gaccgagaaa gcctatgtgg agccagcacc agctgcctgc tgccagtgca
      481 ggtggtgact gaacaccccc tggagctaat ccgtgtagag gtagagatcc tggatctcaa
      541 tgacaactct cctagctttg ccacccctga gcgagagatg cgcatctcag aatcagcagc
      601 atctggggca cgattcccac tggacagtgc ccaggatccg gatgtgggca ccaatactgt
      661 gagcttttac actctaagcc ccaacagcca cttctctctg aatgtgaaga ccctaaaaga
      721 tgggaagcca ttcccagagc tggtgctaga gcagcagctg gatcgtgaag cccaggcaag
      781 acatcagctg gtgcttactg ctgtggatgg ggggacccca gcccgctcag ggaccaccct
      841 tatctctgtc atcgtgctgg acatcaatga taatgctcca accttccaat cctcagttct
      901 acgtgtggga atcccagaga atgcacccat tggtactctg ctgctccgcc tcaatgccac
      961 tgatccagac gagggcacca acggccaact agactattct tttggagacc acacatctga
     1021 ggcagtgcgg aacctctttg gcctagaccc tagcagtggg gcaatccatg tgttgggtcc
     1081 catagacttt gaggagtcac gtttctatga aattcatgca agagcccgtg accagggaca
     1141 gcctgccatg gagggccact gtgtgattca agtggatgtg ggggatgtca atgacaatgc
     1201 cccagaggtg ctattggcct ctttggccaa ccctgtccta gagagcacac cagtgggcac
     1261 agtagtgggg ttgtttaatg tgcgagaccg ggactcaggt agaaatggtg aagtgagcct
     1321 tgatatctct ccggacctgc catttcagat taagccttct gagaaccact actcgctgct
     1381 aaccagccag cctttggacc gggaggccac atcccactat atcatcgagc tgctggccag
     1441 cgatgctggt tcaccttccc tacacaaaca tctcaccatc aggctcaaca tttcagatgt
     1501 caatgacaat gcaccccgct tcaaccagca gctttacact gcttacatcc tagaaaaccg
     1561 gcctccgggc tcccttcttt gcactgtggc tgcctcagat ccagacactg gggataatgc
     1621 ccgcctcacc tactccattg taggaaatca ggttcaggga gccccagcct cctcctttgt
     1681 gtatgtcaac ccagaggatg gacggatctt tgcccagcgt acctttgact atgaattgct
     1741 gcagatgctg cagattgtgg tgggggttcg agactccggc tctcccccat tgcatgccaa
     1801 cacatctctg catgtgtttg tcctagacga gaatgataat gccccagctg tgctgcaccc
     1861 acggccagac tgggaacact cagcccccca gcgtctccct cgctctgctc ctcctggctc
     1921 cttggtcacc aaggtgacag ccgtggatgc tgatgcaggc cacaatgcgt ggctctccta
     1981 ctcactgttg ccacagtcca cagccccagg actgttcctc gtgtctacac acactggtga
     2041 ggtgcgcaca gcccgggcct tactggagga tgactctgac acccagcagg tggtggtcct
     2101 ggtgagggac aatggtgacc cttcactctc ctccacagcc acagtgctgc tggttctgga
     2161 ggatgaggac cctgaggaaa tgcccaaatc cagtgacttc ctcatacacc ctcctgagcg
     2221 ttcagacctt accctttacc tcattgtggc tctagcgacc gtcagtctct tatccctagt
     2281 caccttcacc tttctgtcag cgaagtgcct tcagggaaac gcagacgggg acgggggtgg
     2341 agggcagtgc tgcaggcgcc aggactcacc ctccccggac ttctataagc agtccagccc
     2401 caacctgcag gtgagctcgg acggcacgct caagtacatg gaggtgacgc tgcggcccac
     2461 agactcgcag agccactgct acaggacgtg cttttcaccg gcctcggacg gcagtgactt
     2521 cacttttcta agacccctca gcgttcagca gcccacagct ctggcgctgg agcctgacgc
     2581 catccggtcc cgctctaata cgctgcggga gcggagccag caagccccgc ccaacacgga
     2641 ctggcgtttc tctcaggccc agagacccgg caccagcggc tcccaaaatg gcgatgacac
     2701 cggcacctgg cccaacaacc agtttgacac agagatgctg caagccatga tcttggcgtc
     2761 cgccagtgaa gctgctgatg ggagctccac cctgggaggg ggtgccggca ccatgggatt
     2821 gagcgcccgc tacggacccc agttcaccct gcagcacgtg cccgactacc gccagaatgt
     2881 ctacatccca ggcagcaatg ccacactgac caacgcagct ggcaagcggg atggcaaggc
     2941 cccagcaggt ggcaatggca acaagaagaa gtcgggcaag aaggagaaga agtaacatgg
     3001 aggccaggcc aagagccaca gggcggcctc tccccaacca gcccagcttc tccttacctg
     3061 cacccaggcc tcagagtttc agggctaacc cccagaatac tggtaggggc caaggccatg
     3121 ctccccttgg gaaacagaaa caagtgccca gtcagcacct accccttccc ccccaggggg
     3181 ttgaatatgc aaaagcagtt ccgctgggaa cccccatcca atcaactgct gtacccatgg
     3241 gggtagtggg gttactgtag acaccaagaa ccatttgcca caccccgttt agttacagct
     3301 gaactcctcc atcttccaaa tcaatcaggc ccatccatcc catgcctccc tcctccccac
     3361 cccactccaa cagttcctct ttcccgagta aggtggttgg ggtgttgaag taccaagtaa
     3421 cctacaagcc tcctagttct gaaaagttgg aagggcatca tgacctcttg gcctctcctt
     3481 tgattctcaa tcttccccca aagcatggtt tggtgccagc cccttcacct ccttccagag
     3541 cccaagatca atgctcaagt tttggaggac atgatcacca tccccatggt actgatgctt
     3601 gctggattta gggagggcat tttgctacca agcctcttcc caacgccctg gggaccagtc
     3661 ttctgttttg tttttcattg tttgacgttt ccactgcatg ccttgacttc ccccacctcc
     3721 tcctcaaaca agagactcca ctgcatgttc caagacagta tggggtggta agataaggaa
     3781 gggaagtgtg tggatgtgga tggtgggggc atggacaaag cttgacacat caagttatca
     3841 aggccttgga ggaggctctg tatgtcctca ggggactgac aacatcctcc agattccagc
     3901 cataaaccaa taactaggct ggacccttcc cactacataa tagggctcag cccaggcagc
     3961 cagctttggg ctgagctaac aggaccaatg gattaaactg gcatttcagt ccaaggaagc
     4021 tcgaagcagg tttaggacca ggtccccttg agaggtcaga ggggcctctg tgggtgctgg
     4081 gtactccaga ggtgccactg gtggaagggt cagcggagcc ccagcaggaa gggtgggcca
     4141 gccaggccat tcttagtccc tgggttgggg aggcagggag ctagggcagg gaccaaatga
     4201 acagaaagtc tcagcccagg atggggcttc ttcaacaggg cccctgccct cctgaagcct
     4261 cagtccttca ccttgccagg tgccgtttct cttccgtgaa ggccactgcc caggtcccca
     4321 gtgcgccccc tagtggccat agcctggtta aagttcccca gtgcctcctt gtgcatagac
     4381 cttcttctcc cacccccttc tgcccctggg tccccggcca tccagcgggg ctgccagaga
     4441 accccagacc tgcccttaca gtagtgtagc gccccctccc tctttcggct ggtgtagaat
     4501 agccagtagt gtagtgcggt gtgcttttac gtgatggcgg gtgggcagcg ggcggcgggc
     4561 tccgcgcagc cgtctgtcct tgatctgccc gcggcggccc gtgttgtgtt ttgtgctgtg
     4621 tccacgcgct aaggcgaccc cctcccccgt actgacttct cctataagcg cttctcttcg
     4681 catagtcacg tagctcccac cccaccctct tcctgtgtct cacgcaagtt ttatactcta
     4741 atatttatat ggcttttttt cttcgacaaa aaaataataa aacgtttctt ctgaaaa
//
