LOCUS       NM_018928               4763 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens protocadherin gamma subfamily C, 4 (PCDHGC4),
            transcript variant 1, mRNA.
ACCESSION   NM_018928
VERSION     NM_018928.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4763)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   2  (bases 1 to 4763)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   3  (bases 1 to 4763)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   4  (bases 1 to 4763)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   5  (bases 1 to 4763)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008781.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 16, 2020 this sequence version replaced NM_018928.2.
            
            Summary: This gene is a member of the protocadherin gamma gene
            cluster, one of three related clusters tandemly linked on
            chromosome five. These gene clusters have an immunoglobulin-like
            organization, suggesting that a novel mechanism may be involved in
            their regulation and expression. The gamma gene cluster includes 22
            genes divided into 3 subfamilies. Subfamily A contains 12 genes,
            subfamily B contains 7 genes and 2 pseudogenes, and the more
            distantly related subfamily C contains 3 genes. The tandem array of
            22 large, variable region exons are followed by a constant region,
            containing 3 exons shared by all genes in the cluster. Each
            variable region exon encodes the extracellular region, which
            includes 6 cadherin ectodomains and a transmembrane region. The
            constant region exons encode the common cytoplasmic region. These
            neural cadherin-like cell adhesion proteins most likely play a
            critical role in the establishment and function of specific
            cell-cell connections in the brain. Alternative splicing has been
            described for the gamma cluster genes. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) includes the constant region
            exons and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF152338.1, SRR11853560.23764.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306593.2/ ENSP00000306918.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2586              AC008781.7         163482-166067       c
            2587-2645           AC008781.7         156232-156290       c
            2646-2734           AC008781.7         145616-145704       c
            2735-4763           AC008781.7         138122-140150       c
FEATURES             Location/Qualifiers
     source          1..4763
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..4763
                     /gene="PCDHGC4"
                     /gene_synonym="NEDGS; PCDH-GAMMA-C4"
                     /note="protocadherin gamma subfamily C, 4"
                     /db_xref="GeneID:56098"
                     /db_xref="HGNC:HGNC:8717"
                     /db_xref="MIM:606305"
     exon            1..2586
                     /gene="PCDHGC4"
                     /gene_synonym="NEDGS; PCDH-GAMMA-C4"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..2961
                     /gene="PCDHGC4"
                     /gene_synonym="NEDGS; PCDH-GAMMA-C4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protocadherin gamma-C4"
                     /codon_start=1
                     /product="protocadherin gamma-C4 isoform 1 precursor"
                     /protein_id="NP_061751.1"
                     /db_xref="CCDS:CCDS4262.1"
                     /db_xref="GeneID:56098"
                     /db_xref="HGNC:HGNC:8717"
                     /db_xref="MIM:606305"
                     /translation="MLRKVRSWTEIWRWATLLFLFYHLGYVCGQIRYPVPEESQEGTF
                     VGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNPIDREALCGLSASC
                     IVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDA
                     DVGSNSISSYRLSSNEHFALDVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGG
                     NPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGN
                     VTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHC
                     SLRVDLLDVNDNAPYITVTSELGTLPESAEPGTVVALISVQDPDSGSNGDVSLRIPDH
                     LPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVND
                     NPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSASSFI
                     SLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPAVL
                     RPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRY
                     AGEVRTAVPIPADLPPQKLVIVVKDSGSPPLSTSVTLLVSLEEDTHPVVPDLRESSAP
                     REGESRLTLYLAVSLVAICFVSFGSFVALLSKCLRGAACGVTCFPAGTCACLTRSRRR
                     EGLPPSNGILRIQLGSDDPIKFVDVGGHSHGCTPLASAPTRSDSFMMVKSPSAPMAGE
                     PVRPSCPPSDLLYGLEQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQA
                     MILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAA
                     GKRDGKAPAGGNGNKKKSGKKEKK"
     exon            2587..2645
                     /gene="PCDHGC4"
                     /gene_synonym="NEDGS; PCDH-GAMMA-C4"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2734
                     /gene="PCDHGC4"
                     /gene_synonym="NEDGS; PCDH-GAMMA-C4"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..4763
                     /gene="PCDHGC4"
                     /gene_synonym="NEDGS; PCDH-GAMMA-C4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4742..4747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHGC4"
                     /gene_synonym="NEDGS; PCDH-GAMMA-C4"
                     /note="hexamer: AATAAA"
     polyA_site      4763
                     /gene="PCDHGC4"
                     /gene_synonym="NEDGS; PCDH-GAMMA-C4"
                     /note="major polyA site"
ORIGIN      
        1 gcgtaaccct tgcggcgccg gccgaaccgc gccagagctg gcgcggggaa agggagatag
       61 gtgtctccag ctgctgtggc tgtttggggc gggtcggctt catccgcgtc tcaggagcaa
      121 gtagagaatt agcgggcggc agcaatgctc cgcaaggtga gaagctggac agaaatctgg
      181 cggtgggcta cccttttgtt cctcttttac cacctgggtt acgtttgtgg gcagatccgc
      241 tacccggtcc cagaggagtc acaggaaggg acttttgtag ggaatgtcgc tcaagatttc
      301 ctgctggata cggacagtct gtcagctcgc aggctgcagg tcgctggaga ggtgaaccaa
      361 agacacttcc gtgtggattt ggacagcgga gccctgctca tcaagaaccc aatcgaccga
      421 gaggcactgt gtgggctcag tgccagctgc atcgtgcccc tggagtttgt caccgaaggt
      481 cctttggaaa tgtaccgagc agaggtagag atcgtagatg tgaatgatca cgccccccgt
      541 tttccgcggc agcagctgga cttggaaatt ggggaggcag ctcctccagg acagcgtttc
      601 ccgttggaaa aggctcagga tgcagatgtg gggagcaatt cgattagcag ctataggctg
      661 agctccaatg aacactttgc actggatgtg aagaagcgca gcgacggcag cctggtccca
      721 gagctgctcc tggagaagcc tttggatcga gagaagcaat cggactaccg cctggtgctg
      781 actgctgtcg atggagggaa cccgccgaga tctggcaccg cagagctccg ggtatccgtg
      841 ctggacgtaa acgacaacgc cccagccttc cagcaatcca gctacaggat tagtgtgttg
      901 gagagcgcac cagcgggcat ggtgctcatc cagctcaatg cctcagaccc ggacctgggt
      961 cccagtggta acgtcacctt ttatttcagt ggtcataccc ctgatcgtgt aagaaacctc
     1021 tttagcctgc accccactac tggaaagctt actcttttgg ggcccctaga ctttgagagt
     1081 gagaattact atgaatttga tgtgcgggct cgcgatgggg gttctccagc catggagcaa
     1141 cattgcagcc ttcgagtgga tctgctggac gtaaatgaca atgcccctta catcacagtg
     1201 acctcagagc ttggaaccct ccccgagagt gcagaacctg gcactgtggt ggcacttatc
     1261 agtgtgcagg atccagactc agggtcaaac ggagatgtga gcctccgcat tcctgaccac
     1321 ttgccatttg ccctcaagtc tgccttcagg aaccagttct ccctggtgac tgctggaccc
     1381 ttggatcgag aggccaaatc tagctatgac atcatggtca ctgcttctga tgctgggaac
     1441 cctcctctca gtacccacag aactattttc ctcaatattt cagatgtgaa tgataatcca
     1501 ccctctttct ttcagaggtc acatgaggtg tttgttcctg agaacaatcg cccaggggac
     1561 ctgctttgct cccttgcagc ctctgaccca gactctggct tgaatgcgct tatctcctac
     1621 tcactcctgg agcccaggaa tcgagatgta tcagcttcct ctttcatctc tctgaacccc
     1681 cagacaggag ctgttcatgc tactcgatcc tttgactatg agcaaaccca gacactgcag
     1741 tttgaggtgc aggcccggga tcggggcaac ccacccctta gcagcactgt aacagttcgt
     1801 ctatttgtgc tggacctcaa tgacaatgct ccagctgtgc tccgtcctcg ggcccggcct
     1861 ggttccttat gtccccaagc actgcctcca tcagttggtg ctggccacct aatcacaaag
     1921 gtgactgctg tggacttgga ttcaggttac aatgcttggg tttcctatca gctcctggag
     1981 gccccagatc ccagcctgtt tgcagtctct cgatatgctg gggaggtgcg gacggctgtt
     2041 cctatcccag ctgacctccc accacagaag ctggtcattg tggtaaagga tagtggtagt
     2101 ccaccactct ctacctctgt tactctctta gtgtccttag aggaagacac tcatccagtt
     2161 gtcccagatc ttcgagaatc ttcagctcca agggaaggag aatctcgtct aaccctctac
     2221 ttggctgtgt ccctagtggc aatttgcttt gtctcctttg gctcattcgt ggcactactc
     2281 tctaagtgtc ttcgtggggc agcctgtgga gtcacatgct ttcctgctgg cacctgtgcc
     2341 tgtctcacca gatctcgaag gagggagggg cttccccctt ccaatgggat cctccgaatc
     2401 cagctagggt cagatgaccc tatcaagttt gttgatgtgg gaggccactc tcatggctgt
     2461 acacccttgg cttctgcacc cactcggagt gatagcttca tgatggtgaa gtcacccagt
     2521 gcacctatgg caggggagcc tgttcgccca agctgcccac cctctgatct tctctatggg
     2581 ctagagcaag ccccgcccaa cacggactgg cgtttctctc aggcccagag acccggcacc
     2641 agcggctccc aaaatggcga tgacaccggc acctggccca acaaccagtt tgacacagag
     2701 atgctgcaag ccatgatctt ggcgtccgcc agtgaagctg ctgatgggag ctccaccctg
     2761 ggagggggtg ccggcaccat gggattgagc gcccgctacg gaccccagtt caccctgcag
     2821 cacgtgcccg actaccgcca gaatgtctac atcccaggca gcaatgccac actgaccaac
     2881 gcagctggca agcgggatgg caaggcccca gcaggtggca atggcaacaa gaagaagtcg
     2941 ggcaagaagg agaagaagta acatggaggc caggccaaga gccacagggc ggcctctccc
     3001 caaccagccc agcttctcct tacctgcacc caggcctcag agtttcaggg ctaaccccca
     3061 gaatactggt aggggccaag gccatgctcc ccttgggaaa cagaaacaag tgcccagtca
     3121 gcacctaccc cttccccccc agggggttga atatgcaaaa gcagttccgc tgggaacccc
     3181 catccaatca actgctgtac ccatgggggt agtggggtta ctgtagacac caagaaccat
     3241 ttgccacacc ccgtttagtt acagctgaac tcctccatct tccaaatcaa tcaggcccat
     3301 ccatcccatg cctccctcct ccccacccca ctccaacagt tcctctttcc cgagtaaggt
     3361 ggttggggtg ttgaagtacc aagtaaccta caagcctcct agttctgaaa agttggaagg
     3421 gcatcatgac ctcttggcct ctcctttgat tctcaatctt cccccaaagc atggtttggt
     3481 gccagcccct tcacctcctt ccagagccca agatcaatgc tcaagttttg gaggacatga
     3541 tcaccatccc catggtactg atgcttgctg gatttaggga gggcattttg ctaccaagcc
     3601 tcttcccaac gccctgggga ccagtcttct gttttgtttt tcattgtttg acgtttccac
     3661 tgcatgcctt gacttccccc acctcctcct caaacaagag actccactgc atgttccaag
     3721 acagtatggg gtggtaagat aaggaaggga agtgtgtgga tgtggatggt gggggcatgg
     3781 acaaagcttg acacatcaag ttatcaaggc cttggaggag gctctgtatg tcctcagggg
     3841 actgacaaca tcctccagat tccagccata aaccaataac taggctggac ccttcccact
     3901 acataatagg gctcagccca ggcagccagc tttgggctga gctaacagga ccaatggatt
     3961 aaactggcat ttcagtccaa ggaagctcga agcaggttta ggaccaggtc cccttgagag
     4021 gtcagagggg cctctgtggg tgctgggtac tccagaggtg ccactggtgg aagggtcagc
     4081 ggagccccag caggaagggt gggccagcca ggccattctt agtccctggg ttggggaggc
     4141 agggagctag ggcagggacc aaatgaacag aaagtctcag cccaggatgg ggcttcttca
     4201 acagggcccc tgccctcctg aagcctcagt ccttcacctt gccaggtgcc gtttctcttc
     4261 cgtgaaggcc actgcccagg tccccagtgc gccccctagt ggccatagcc tggttaaagt
     4321 tccccagtgc ctccttgtgc atagaccttc ttctcccacc cccttctgcc cctgggtccc
     4381 cggccatcca gcggggctgc cagagaaccc cagacctgcc cttacagtag tgtagcgccc
     4441 cctccctctt tcggctggtg tagaatagcc agtagtgtag tgcggtgtgc ttttacgtga
     4501 tggcgggtgg gcagcgggcg gcgggctccg cgcagccgtc tgtccttgat ctgcccgcgg
     4561 cggcccgtgt tgtgttttgt gctgtgtcca cgcgctaagg cgaccccctc ccccgtactg
     4621 acttctccta taagcgcttc tcttcgcata gtcacgtagc tcccacccca ccctcttcct
     4681 gtgtctcacg caagttttat actctaatat ttatatggct ttttttcttc gacaaaaaaa
     4741 taataaaacg tttcttctga aaa
//
