LOCUS       NM_018927               4775 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens protocadherin gamma subfamily B, 7 (PCDHGB7),
            transcript variant 1, mRNA.
ACCESSION   NM_018927
VERSION     NM_018927.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4775)
  AUTHORS   Dong,S., Lu,Q., Xu,P., Chen,L., Duan,X., Mao,Z., Zhang,B., Sui,L.,
            Wang,Y. and Yu,W.
  TITLE     Hypermethylated PCDHGB7 as a universal cancer only marker and its
            application in early cervical cancer screening
  JOURNAL   Clin Transl Med 11 (6), e457 (2021)
   PUBMED   34185407
  REMARK    GeneRIF: Hypermethylated PCDHGB7 as a universal cancer only marker
            and its application in early cervical cancer screening.
REFERENCE   2  (bases 1 to 4775)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   3  (bases 1 to 4775)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   4  (bases 1 to 4775)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   5  (bases 1 to 4775)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   6  (bases 1 to 4775)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
REFERENCE   7  (bases 1 to 4775)
  AUTHORS   Matsuyoshi,N., Tanaka,T., Toda,K. and Imamura,S.
  TITLE     Identification of novel cadherins expressed in human melanoma cells
  JOURNAL   J Invest Dermatol 108 (6), 908-913 (1997)
   PUBMED   9182820
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005618.1 and AC008781.7.
            
            On Jun 2, 2019 this sequence version replaced NM_018927.3.
            
            Summary: This gene is a member of the protocadherin gamma gene
            cluster, one of three related clusters tandemly linked on
            chromosome five. These gene clusters have an immunoglobulin-like
            organization, suggesting that a novel mechanism may be involved in
            their regulation and expression. The gamma gene cluster includes 22
            genes divided into 3 subfamilies. Subfamily A contains 12 genes,
            subfamily B contains 7 genes and 2 pseudogenes, and the more
            distantly related subfamily C contains 3 genes. The tandem array of
            22 large, variable region exons are followed by a constant region,
            containing 3 exons shared by all genes in the cluster. Each
            variable region exon encodes the extracellular region, which
            includes 6 cadherin ectodomains and a transmembrane region. The
            constant region exons encode the common cytoplasmic region. These
            neural cadherin-like cell adhesion proteins most likely play a
            critical role in the establishment and function of specific
            cell-cell connections in the brain. Alternative splicing has been
            described for the gamma cluster genes. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) includes the constant region
            exons and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.162331.1, AF152336.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398594.4/ ENSP00000381594.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2598              AC005618.1         129189-131786
            2599-2657           AC008781.7         156232-156290       c
            2658-2746           AC008781.7         145616-145704       c
            2747-4775           AC008781.7         138122-140150       c
FEATURES             Location/Qualifiers
     source          1..4775
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..4775
                     /gene="PCDHGB7"
                     /gene_synonym="ME6; PCDH-GAMMA-B7"
                     /note="protocadherin gamma subfamily B, 7"
                     /db_xref="GeneID:56099"
                     /db_xref="HGNC:HGNC:8714"
                     /db_xref="MIM:606304"
     exon            1..2598
                     /gene="PCDHGB7"
                     /gene_synonym="ME6; PCDH-GAMMA-B7"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..2973
                     /gene="PCDHGB7"
                     /gene_synonym="ME6; PCDH-GAMMA-B7"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cadherin ME6; protocadherin gamma-B7"
                     /codon_start=1
                     /product="protocadherin gamma-B7 isoform 1 precursor"
                     /protein_id="NP_061750.1"
                     /db_xref="CCDS:CCDS47293.1"
                     /db_xref="GeneID:56099"
                     /db_xref="HGNC:HGNC:8714"
                     /db_xref="MIM:606304"
                     /translation="MGGSCAQRRRAGPRQVLFPLLLPLFYPTLCEPIRYSIPEELAKG
                     SVVGNLAKDLGLSVLDVSARELRVSAEKLHFSVDAQSGDLLVKDRIDREQICKERRRC
                     ELQLEAVVENPLNIFHVIVVIEDVNDHAPQFRKDEINLEISESVSLGMGTILESAEDP
                     DISMNSLSKYQLSPNEYFSLVEKDNPDGGKYPELVLQKTLDRETQSAHHLVLTALDGG
                     DPPRSGTAQIRILVIDANDNPPVFSQDVYRVSLREDVPPGTSILRVKATDQDEGINSE
                     ITYSFFGVADKAQHVFSLDYTTGNILTQQPLDFEEVERYTINIEAKDRGSLSTRCKVI
                     VEVVDENDNSPEIIITSLSDQIMEDSPPGVVVALFKTRDQDSGENGEVRCSLSRGVPF
                     KIHSSSNNYYKLVTDEALDREQTPEYNVTIAATDRGKPPLSSSKTITLHITDVNDNAP
                     VFGQSAYLVHVPENNQPGASIAQVSASDPDFGLNGRVSYSLIASDLESRTLSSYVSVS
                     AQSGVVFAQRAFDHEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPA
                     LGPDGSALFDTVPRAAQPGYLVTKVVAVDADSGHNAWLSYHVVQASEPGLFSLGLRTG
                     EVRMVRALGDKDSVRQRLLVAVRDGGQPPLSATATLHLVFADSLQEVLPDFSDHPTPS
                     DSQAEMQFYLVVALALISVLFLLAVILAIALRLRQSFSPTAGDCFESVLCSKSGPVGP
                     PNYSEGTLPYAYNFCVPGDQMNPEFNFFTSVDHCPATQDNLNKDSMLLASILTPSVEA
                     DKKILKQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEA
                     ADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPA
                     GGNGNKKKSGKKEKK"
     exon            2599..2657
                     /gene="PCDHGB7"
                     /gene_synonym="ME6; PCDH-GAMMA-B7"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2746
                     /gene="PCDHGB7"
                     /gene_synonym="ME6; PCDH-GAMMA-B7"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..4775
                     /gene="PCDHGB7"
                     /gene_synonym="ME6; PCDH-GAMMA-B7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4754..4759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHGB7"
                     /gene_synonym="ME6; PCDH-GAMMA-B7"
                     /note="hexamer: AATAAA"
     polyA_site      4775
                     /gene="PCDHGB7"
                     /gene_synonym="ME6; PCDH-GAMMA-B7"
                     /note="major polyA site"
ORIGIN      
        1 aacagaaaag aaaaccagct cccacacaga ggctcccggc tgcgcagacc ttgcccagca
       61 caccagattg ccagctccga gacccgggac tcctcctgtc ctgggccgaa tgctctttta
      121 gcgcggtaga gtgcactttc tccaactgga aaagcgggga cccagcgaga acccgagcga
      181 acgatgggag ggagctgcgc gcagaggcgc cgggccggcc cgcggcaggt actatttcct
      241 ttgctgctgc ctttgttcta ccccacgctg tgtgagccga tccgctactc gattccggag
      301 gagctggcca agggctcggt ggtggggaac ctcgctaagg atctagggct tagtgtcctg
      361 gatgtgtcgg ctcgcgagct gcgagtgagc gcggagaagc tgcacttcag cgtagacgcg
      421 cagagcgggg acttacttgt gaaggaccga atagaccgtg agcaaatatg caaagagaga
      481 agaagatgtg agttgcaatt ggaagctgtg gtggaaaatc ctttaaatat ttttcatgtc
      541 attgtggtga ttgaggatgt taatgaccac gcccctcaat tccggaaaga tgaaataaac
      601 ttagaaatca gtgaatccgt cagcctgggg atgggaacaa ttcttgagtc tgcagaagat
      661 cctgatatta gtatgaattc gctgagcaaa taccaactaa gtcctaacga gtatttctca
      721 ttggtggaga aagacaatcc tgatggtggc aaatatccag aattagtatt gcagaagact
      781 ctggaccgag aaacgcagag cgctcaccac ttggtactga ccgccttaga tggtggggac
      841 cctccccgaa gcggtactgc tcagataaga atcctggtaa tagatgccaa tgacaacccc
      901 ccagtgttca gccaggacgt gtacagggtt agccttcggg aagacgtgcc tccaggcacc
      961 tccatcctga gagtgaaggc cactgaccag gacgagggca tcaactcaga gatcacttat
     1021 tccttctttg gtgtggctga caaagctcag cacgtgttct ctctggatta cactacagga
     1081 aacattctaa ctcagcagcc tttggatttt gaagaagtag aaagatatac gataaacata
     1141 gaagcaaaag accgaggatc tctctcaaca cggtgtaaag taattgtaga agttgtagac
     1201 gaaaacgaca acagcccaga aataatcatc acgtcactct ctgatcagat tatggaggat
     1261 tcccctccag gagtggttgt tgccctcttc aaaacacggg accaagactc aggggaaaat
     1321 ggggaagtca ggtgtagctt aagtagaggt gttccattta agattcattc ttcttctaat
     1381 aattactaca agctagtaac agatgaggcc ctggatcggg agcagacccc agagtacaac
     1441 gtcaccatcg cagccacaga caggggcaag cctccgttat cctccagcaa aaccataacc
     1501 ctgcacatta ctgacgtcaa tgacaacgcg ccggttttcg gacagtcagc ctacctggtc
     1561 cacgtgccag aaaacaacca gccgggtgcc tccatagcgc aagtcagtgc ctctgaccca
     1621 gacttcgggc tcaacggccg tgtctcctac tctctcattg ccagcgacct ggagtcacga
     1681 acgctgtcgt cctacgtgtc cgtgagcgcg cagagcgggg tggtgttcgc gcagcgcgcc
     1741 ttcgaccacg agcagctgcg caccttcgag ctcacgctgc aggcccgcga ccagggctcg
     1801 cccgcgctca gcgccaatgt gagcctgcgc gtgttggtgg gcgaccgtaa cgacaacgca
     1861 ccgcgggtgc tgtaccctgc gctgggtccc gacggctccg cgctcttcga cacagtgccg
     1921 cgggccgcgc agccaggcta cctggtgacc aaggtggtgg ccgtggacgc ggactcgggg
     1981 cacaatgcct ggctgtccta ccacgtggtg caggccagtg agcccgggct cttcagcctg
     2041 gggctgcgaa caggcgaggt gcgcatggtg cgtgctttgg gtgacaagga ctcggtccgc
     2101 cagcgcctgc tagtcgctgt aagagatgga ggacagccac ccctttcagc cactgccacg
     2161 ctgcacctgg tgttcgcaga tagcttgcaa gaggtactgc cggatttcag cgaccatccc
     2221 acaccctctg actcccaggc tgagatgcag ttttacctgg tggtggcctt ggccttgatt
     2281 tctgtgctct ttctcctcgc ggtgattcta gctattgctc tacgcctgcg acagtctttc
     2341 agccctactg caggagactg ctttgagtca gttctctgct ccaagtccgg acctgtgggt
     2401 ccccccaact acagtgaggg aacgttgccc tatgcctata atttttgtgt gcctggggat
     2461 caaatgaatc cagaatttaa ttttttcaca tctgttgatc attgtccagc cacacaagat
     2521 aacctcaaca aagatagcat gctactggct agcattttaa ctcccagcgt tgaagcagat
     2581 aagaagattc ttaaacagca agccccgccc aacacggact ggcgtttctc tcaggcccag
     2641 agacccggca ccagcggctc ccaaaatggc gatgacaccg gcacctggcc caacaaccag
     2701 tttgacacag agatgctgca agccatgatc ttggcgtccg ccagtgaagc tgctgatggg
     2761 agctccaccc tgggaggggg tgccggcacc atgggattga gcgcccgcta cggaccccag
     2821 ttcaccctgc agcacgtgcc cgactaccgc cagaatgtct acatcccagg cagcaatgcc
     2881 acactgacca acgcagctgg caagcgggat ggcaaggccc cagcaggtgg caatggcaac
     2941 aagaagaagt cgggcaagaa ggagaagaag taacatggag gccaggccaa gagccacagg
     3001 gcggcctctc cccaaccagc ccagcttctc cttacctgca cccaggcctc agagtttcag
     3061 ggctaacccc cagaatactg gtaggggcca aggccatgct ccccttggga aacagaaaca
     3121 agtgcccagt cagcacctac cccttccccc ccagggggtt gaatatgcaa aagcagttcc
     3181 gctgggaacc cccatccaat caactgctgt acccatgggg gtagtggggt tactgtagac
     3241 accaagaacc atttgccaca ccccgtttag ttacagctga actcctccat cttccaaatc
     3301 aatcaggccc atccatccca tgcctccctc ctccccaccc cactccaaca gttcctcttt
     3361 cccgagtaag gtggttgggg tgttgaagta ccaagtaacc tacaagcctc ctagttctga
     3421 aaagttggaa gggcatcatg acctcttggc ctctcctttg attctcaatc ttcccccaaa
     3481 gcatggtttg gtgccagccc cttcacctcc ttccagagcc caagatcaat gctcaagttt
     3541 tggaggacat gatcaccatc cccatggtac tgatgcttgc tggatttagg gagggcattt
     3601 tgctaccaag cctcttccca acgccctggg gaccagtctt ctgttttgtt tttcattgtt
     3661 tgacgtttcc actgcatgcc ttgacttccc ccacctcctc ctcaaacaag agactccact
     3721 gcatgttcca agacagtatg gggtggtaag ataaggaagg gaagtgtgtg gatgtggatg
     3781 gtgggggcat ggacaaagct tgacacatca agttatcaag gccttggagg aggctctgta
     3841 tgtcctcagg ggactgacaa catcctccag attccagcca taaaccaata actaggctgg
     3901 acccttccca ctacataata gggctcagcc caggcagcca gctttgggct gagctaacag
     3961 gaccaatgga ttaaactggc atttcagtcc aaggaagctc gaagcaggtt taggaccagg
     4021 tccccttgag aggtcagagg ggcctctgtg ggtgctgggt actccagagg tgccactggt
     4081 ggaagggtca gcggagcccc agcaggaagg gtgggccagc caggccattc ttagtccctg
     4141 ggttggggag gcagggagct agggcaggga ccaaatgaac agaaagtctc agcccaggat
     4201 ggggcttctt caacagggcc cctgccctcc tgaagcctca gtccttcacc ttgccaggtg
     4261 ccgtttctct tccgtgaagg ccactgccca ggtccccagt gcgcccccta gtggccatag
     4321 cctggttaaa gttccccagt gcctccttgt gcatagacct tcttctccca cccccttctg
     4381 cccctgggtc cccggccatc cagcggggct gccagagaac cccagacctg cccttacagt
     4441 agtgtagcgc cccctccctc tttcggctgg tgtagaatag ccagtagtgt agtgcggtgt
     4501 gcttttacgt gatggcgggt gggcagcggg cggcgggctc cgcgcagccg tctgtccttg
     4561 atctgcccgc ggcggcccgt gttgtgtttt gtgctgtgtc cacgcgctaa ggcgaccccc
     4621 tcccccgtac tgacttctcc tataagcgct tctcttcgca tagtcacgta gctcccaccc
     4681 caccctcttc ctgtgtctca cgcaagtttt atactctaat atttatatgg ctttttttct
     4741 tcgacaaaaa aataataaaa cgtttcttct gaaaa
//
