LOCUS       NM_018923               4740 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens protocadherin gamma subfamily B, 2 (PCDHGB2),
            transcript variant 1, mRNA.
ACCESSION   NM_018923
VERSION     NM_018923.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4740)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   2  (bases 1 to 4740)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   3  (bases 1 to 4740)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   4  (bases 1 to 4740)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   5  (bases 1 to 4740)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005618.1 and AF152331.1.
            
            On Sep 17, 2020 this sequence version replaced NM_018923.2.
            
            Summary: This gene is a member of the protocadherin gamma gene
            cluster, one of three related clusters tandemly linked on
            chromosome five. These gene clusters have an immunoglobulin-like
            organization, suggesting that a novel mechanism may be involved in
            their regulation and expression. The gamma gene cluster includes 22
            genes divided into 3 subfamilies. Subfamily A contains 12 genes,
            subfamily B contains 7 genes and 2 pseudogenes, and the more
            distantly related subfamily C contains 3 genes. The tandem array of
            22 large, variable region exons are followed by a constant region,
            containing 3 exons shared by all genes in the cluster. Each
            variable region exon encodes the extracellular region, which
            includes 6 cadherin ectodomains and a transmembrane region. The
            constant region exons encode the common cytoplasmic region. These
            neural cadherin-like cell adhesion proteins most likely play a
            critical role in the establishment and function of specific
            cell-cell connections in the brain. Alternative splicing has been
            described for the gamma cluster genes. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) includes the constant region
            exons and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF152331.1, SRR14038197.1269007.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000522605.2/ ENSP00000429018.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AC005618.1         71506-71647
            143-4740            AF152331.1         1-4598
FEATURES             Location/Qualifiers
     source          1..4740
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..4740
                     /gene="PCDHGB2"
                     /gene_synonym="PCDH-GAMMA-B2"
                     /note="protocadherin gamma subfamily B, 2"
                     /db_xref="GeneID:56103"
                     /db_xref="HGNC:HGNC:8709"
                     /db_xref="MIM:606300"
     exon            1..2563
                     /gene="PCDHGB2"
                     /gene_synonym="PCDH-GAMMA-B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..2938
                     /gene="PCDHGB2"
                     /gene_synonym="PCDH-GAMMA-B2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protocadherin gamma-B2"
                     /codon_start=1
                     /product="protocadherin gamma-B2 isoform 1 precursor"
                     /protein_id="NP_061746.1"
                     /db_xref="CCDS:CCDS54924.1"
                     /db_xref="GeneID:56103"
                     /db_xref="HGNC:HGNC:8709"
                     /db_xref="MIM:606300"
                     /translation="MKASSGRCGLVRWLQVLLPFLLSLFPGALPVQIRYSIPEELAKN
                     SVVGNLAKDLGLSVRDLPARKLRVSAEKEYFTVNPESGDLLVSDRIDREQICGKQPLC
                     VLDFDTVAENPLNIFYIAVIVQDINDNTPLFKQTKINLKIGESTKPGTTFPLDPALDS
                     DVGPNSLQRYHLNDNEYFDLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGG
                     DPPQSGTTQIRIKVTDANDNPPVFSQDVYRVTLREDVPPGFFVLQVTATDRDEGINAE
                     ITYSFHNVDEQVKHFFNLNEKTGEITTKDDLDFEIASSYTLSIEAKDPGDLAAHCSIQ
                     VEILDDNDCAPEVIVTSVSTPLPEDSPPGTVIALIKTRDRDSGENGEVYCQVLGNAKF
                     ILKSSSKNYYKLVTDGALDREEIPEYNLTITATDGGKPPLSSSIIVTLHISDVNDNAP
                     VFQQTSYMVHVAENNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREILSYVSVS
                     AQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPA
                     LGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTG
                     EVRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLIFADSLQEVLPDLSDRREPS
                     DPQAKLQFYLVVALALISVLFFLAVILAISLRLRLSSRSDAWDCFQPGLSSKPGPGVL
                     PNYSEGTLPYSYNLCVASQSAKTEFNFLNITPELVPAQDLVCDNASWEQNTNHGAAGV
                     PFASDTILKQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASAS
                     EAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKA
                     PAGGNGNKKKSGKKEKK"
     exon            2564..2622
                     /gene="PCDHGB2"
                     /gene_synonym="PCDH-GAMMA-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2711
                     /gene="PCDHGB2"
                     /gene_synonym="PCDH-GAMMA-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..4740
                     /gene="PCDHGB2"
                     /gene_synonym="PCDH-GAMMA-B2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4719..4724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHGB2"
                     /gene_synonym="PCDH-GAMMA-B2"
                     /note="hexamer: AATAAA"
     polyA_site      4740
                     /gene="PCDHGB2"
                     /gene_synonym="PCDH-GAMMA-B2"
                     /note="major polyA site"
ORIGIN      
        1 ctgcacaaac caaccacaca gagaaggcca gtatagattc ggaaacagaa aacaaaagca
       61 ggaaaagtga ccttagcccg gattctgcca tccccggaag gcttattcct cctatgggca
      121 aaggagcaaa gggagccaga agatgaaagc gagctcaggg aggtgcgggc tggtgcggtg
      181 gctgcaggta ctgttgccct tcctgttgtc tttgttcccc ggggctctcc cagtccagat
      241 ccgctattca attccagagg agctggccaa aaactcggtc gtaggaaacc tcgccaagga
      301 tctggggctc agcgtccggg acttgccagc ccggaagctg cgggttagcg cggagaagga
      361 atatttcaca gtaaacccag aaagcggaga cttacttgtg agtgacagaa tagaccgaga
      421 acagatatgc gggaagcagc ctctgtgtgt tctggatttc gatactgtcg ctgaaaatcc
      481 actaaatatt ttctacatag cagtaattgt gcaggatata aatgataata ccccgctatt
      541 caaacagact aagattaatt taaaaattgg cgaatccact aagccaggta caacatttcc
      601 acttgaccca gccctggatt cagatgttgg tcctaactca ctacaaagat accaccttaa
      661 tgacaacgag tactttgatc tcgctgagaa acagactcca gatggtcgta aatatcctga
      721 gttgattcta aaacactctc tggacagaga agagcacagt ttacatcaat tggtcctcac
      781 agctgtggat ggcggagacc cacctcaaag tggcacgacc caaatccgaa tcaaagtcac
      841 ggatgccaac gataaccctc cagtgttcag ccaggacgtg tacagggtca ccctgaggga
      901 ggacgtgccg ccgggcttct ttgtgcttca agtgacagcc accgaccggg atgaaggcat
      961 aaacgcagag atcacctact cctttcataa tgtggacgaa caagtgaaac actttttcaa
     1021 cttaaatgaa aaaacaggag aaatcacgac aaaggatgat ttggattttg agattgcaag
     1081 tagttacact ctgagtatcg aagcaaaaga tcctggagat ctagcagccc actgcagtat
     1141 ccaagttgaa attcttgatg acaacgattg tgcacctgaa gttattgtga cttcagtatc
     1201 tactccccta ccggaggatt cgccaccagg aacagtgatc gccttgataa aaacgagaga
     1261 cagagactct ggagaaaatg gagaagttta ctgccaagtg ttgggaaatg ccaagtttat
     1321 tttgaaatct tcctcaaaga actattacaa actagtgaca gacggcgctc tggaccggga
     1381 ggagatccca gaatacaatc tcaccatcac agccaccgac gggggcaagc cgcccctctc
     1441 ctccagcata attgtcaccc tgcacatctc cgacgtcaac gataatgccc cagttttcca
     1501 acagacttcc tacatggttc acgtggcaga gaacaatcct cctggcgcct ctatcgctca
     1561 aatcagtgcc tctgaccctg acttgggccc cagtggccaa gtttcctact ccatcgtagc
     1621 gagcgacctg aagccgcggg agattttatc ctacgtgtcc gtgagcgcgc agagcggggt
     1681 ggtgttcgcg cagcgcgcct tcgatcatga gcagctgcgc gccttcgagc tcacactgca
     1741 ggcccgcgac cagggctcgc ccgcgctcag cgccaacgtg agcctgcgcg tgttagtggg
     1801 cgacctcaat gacaatgcgc cacgggtgct gtaccccgcg ctggggcctg atggctccgc
     1861 cctcttcgat atggtgccac gcgccgcaga gcccggctac ctggtgacca aggtggtggc
     1921 ggtggacgca gactcaggac acaacgcttg gctgtcctac cacgtgctgc aggccagcga
     1981 gcccgggctc ttcagcctgg ggttgcgcac gggtgaggtg cgcacagcgc gtgccttggg
     2041 cgacagggac gcggcccgcc agcgcctgct ggtcgctgtg cgtgatggag gacagccgcc
     2101 actctccgct acggccacgc tgcacctaat cttcgcggat agcctgcaag aggtattgcc
     2161 agacctcagc gaccgccggg agccctctga cccccaggca aaactgcagt tttacctggt
     2221 tgtggccttg gccttgatct cagtgctctt cttcctcgcg gtgattctgg caatctccct
     2281 gcgcctgcga ctctcttcca ggtcagatgc ttgggactgt tttcagcctg gtctcagctc
     2341 caagcctgga cctggggttc tccccaatta cagtgagggt acattgccct attcctacaa
     2401 cctgtgtgtt gcctcacaat cagccaagac agagttcaat tttctgaaca taaccccgga
     2461 attggttccc gcgcaagatc tcgtctgtga caatgcctct tgggaacaaa atacaaatca
     2521 tggagccgct ggggtccctt ttgcctcaga tactattttg aagcaagccc cgcccaacac
     2581 ggactggcgt ttctctcagg cccagagacc cggcaccagc ggctcccaaa atggcgatga
     2641 caccggcacc tggcccaaca accagtttga cacagagatg ctgcaagcca tgatcttggc
     2701 gtccgccagt gaagctgctg atgggagctc caccctggga gggggtgccg gcaccatggg
     2761 attgagcgcc cgctacggac cccagttcac cctgcagcac gtgcccgact accgccagaa
     2821 tgtctacatc ccaggcagca atgccacact gaccaacgca gctggcaagc gggatggcaa
     2881 ggccccagca ggtggcaatg gcaacaagaa gaagtcgggc aagaaggaga agaagtaaca
     2941 tggaggccag gccaagagcc acagggcggc ctctccccaa ccagcccagc ttctccttac
     3001 ctgcacccag gcctcagagt ttcagggcta acccccagaa tactggtagg ggccaaggcc
     3061 atgctcccct tgggaaacag aaacaagtgc ccagtcagca cctacccctt cccccccagg
     3121 gggttgaata tgcaaaagca gttccgctgg gaacccccat ccaatcaact gctgtaccca
     3181 tgggggtagt ggggttactg tagacaccaa gaaccatttg ccacaccccg tttagttaca
     3241 gctgaactcc tccatcttcc aaatcaatca ggcccatcca tcccatgcct ccctcctccc
     3301 caccccactc caacagttcc tctttcccga gtaaggtggt tggggtgttg aagtaccaag
     3361 taacctacaa gcctcctagt tctgaaaagt tggaagggca tcatgacctc ttggcctctc
     3421 ctttgattct caatcttccc ccaaagcatg gtttggtgcc agccccttca cctccttcca
     3481 gagcccaaga tcaatgctca agttttggag gacatgatca ccatccccat ggtactgatg
     3541 cttgctggat ttagggaggg cattttgcta ccaagcctct tcccaacgcc ctggggacca
     3601 gtcttctgtt ttgtttttca ttgtttgacg tttccactgc atgccttgac ttcccccacc
     3661 tcctcctcaa acaagagact ccactgcatg ttccaagaca gtatggggtg gtaagataag
     3721 gaagggaagt gtgtggatgt ggatggtggg ggcatggaca aagcttgaca catcaagtta
     3781 tcaaggcctt ggaggaggct ctgtatgtcc tcaggggact gacaacatcc tccagattcc
     3841 agccataaac caataactag gctggaccct tcccactaca taatagggct cagcccaggc
     3901 agccagcttt gggctgagct aacaggacca atggattaaa ctggcatttc agtccaagga
     3961 agctcgaagc aggtttagga ccaggtcccc ttgagaggtc agaggggcct ctgtgggtgc
     4021 tgggtactcc agaggtgcca ctggtggaag ggtcagcgga gccccagcag gaagggtggg
     4081 ccagccaggc cattcttagt ccctgggttg gggaggcagg gagctagggc agggaccaaa
     4141 tgaacagaaa gtctcagccc aggatggggc ttcttcaaca gggcccctgc cctcctgaag
     4201 cctcagtcct tcaccttgcc aggtgccgtt tctcttccgt gaaggccact gcccaggtcc
     4261 ccagtgcgcc ccctagtggc catagcctgg ttaaagttcc ccagtgcctc cttgtgcata
     4321 gaccttcttc tcccaccccc ttctgcccct gggtccccgg ccatccagcg gggctgccag
     4381 agaaccccag acctgccctt acagtagtgt agcgccccct ccctctttcg gctggtgtag
     4441 aatagccagt agtgtagtgc ggtgtgcttt tacgtgatgg cgggtgggca gcgggcggcg
     4501 ggctccgcgc agccgtctgt ccttgatctg cccgcggcgg cccgtgttgt gttttgtgct
     4561 gtgtccacgc gctaaggcga ccccctcccc cgtactgact tctcctataa gcgcttctct
     4621 tcgcatagtc acgtagctcc caccccaccc tcttcctgtg tctcacgcaa gttttatact
     4681 ctaatattta tatggctttt tttcttcgac aaaaaaataa taaaacgttt cttctgaaaa
//
