LOCUS       NM_032088               4782 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens protocadherin gamma subfamily A, 8 (PCDHGA8),
            transcript variant 1, mRNA.
ACCESSION   NM_032088
VERSION     NM_032088.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4782)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   2  (bases 1 to 4782)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   3  (bases 1 to 4782)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   4  (bases 1 to 4782)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   5  (bases 1 to 4782)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC152415.1 and AF152328.1.
            
            On Aug 11, 2020 this sequence version replaced NM_032088.1.
            
            Summary: This gene is a member of the protocadherin gamma gene
            cluster, one of three related clusters tandemly linked on
            chromosome five. These gene clusters have an immunoglobulin-like
            organization, suggesting that a novel mechanism may be involved in
            their regulation and expression. The gamma gene cluster includes 22
            genes divided into 3 subfamilies. Subfamily A contains 12 genes,
            subfamily B contains 7 genes and 2 pseudogenes, and the more
            distantly related subfamily C contains 3 genes. The tandem array of
            22 large, variable region exons are followed by a constant region,
            containing 3 exons shared by all genes in the cluster. Each
            variable region exon encodes the extracellular region, which
            includes 6 cadherin ectodomains and a transmembrane region. The
            constant region exons encode the common cytoplasmic region. These
            neural cadherin-like cell adhesion proteins most likely play a
            critical role in the establishment and function of specific
            cell-cell connections in the brain. Alternative splicing has been
            described for the gamma cluster genes. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) includes the constant region
            exons and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF152328.1, SRR14038197.80015.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398604.3/ ENSP00000381605.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               BC152415.1         2479-2659
            182-4782            AF152328.1         1-4601
FEATURES             Location/Qualifiers
     source          1..4782
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..4782
                     /gene="PCDHGA8"
                     /gene_synonym="PCDH-GAMMA-A8"
                     /note="protocadherin gamma subfamily A, 8"
                     /db_xref="GeneID:9708"
                     /db_xref="HGNC:HGNC:8706"
                     /db_xref="MIM:606295"
     exon            1..2605
                     /gene="PCDHGA8"
                     /gene_synonym="PCDH-GAMMA-A8"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..2980
                     /gene="PCDHGA8"
                     /gene_synonym="PCDH-GAMMA-A8"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protocadherin gamma-A8"
                     /codon_start=1
                     /product="protocadherin gamma-A8 isoform 1 precursor"
                     /protein_id="NP_114477.1"
                     /db_xref="CCDS:CCDS47291.1"
                     /db_xref="GeneID:9708"
                     /db_xref="HGNC:HGNC:8706"
                     /db_xref="MIM:606295"
                     /translation="MAAPQSRPRRGELILLCALLGTLWEIGRGQIRYSVPEETDKGSF
                     VGNISKDLGLDPRKLAKHGVRIVSRGRTQLFALNPRSGSLITAGRIDREELCAQSPRC
                     LININTLVEDKGKLFGVEIEIIDINDNNPKFQVEDLEVKINEIAVPGARYPLPEAVDP
                     DVGVNSLQSYQLSPNHHFSLDVQTGDNGAINPELVLERALDREEEAAHHLVLTASDGG
                     KPPRSSTVRIHVTVLDTNDNAPVFPHPIYRVKVLENMPPGTRLLTVTASDPDEGINGK
                     VAYKFRKINEKQTPLFQLNENTGEISIAKSLDYEECSFYEMEIQAEDVGALLGRTKLL
                     ISVEDVNDNRPEVIITSLFSPVLENSLPGTVIAFLSVHDQDSGKNGQVVCYTRDNLPF
                     KLEKSIGNYYRLVTRKYLDRENVSIYNITVMASDLGTPPLSTETQIALHVADINDNPP
                     TFPHASYSAYILENNLRGASIFSLTAHDPDSQENAQVTYSVTEDTLQGAPLSSYISIN
                     SDTGVLYALQSFDYEQIRDLQLLVTASDSGDPPLSSNMSLSLFVLDQNDNAPEILYPA
                     LPTDGSTGVELAPRSAERGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTG
                     EVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPEVLTELGSLKPSV
                     DPNDSSLTLYLVVAVAAISCVFLAFVAVLLGLRLRRWHKSRLLQDSGGRLVGVPASHF
                     VGVEEVQAFLQTYSQEVSLTADSRKSHLIFPQPNYADMLISQEGCEKNDSLLTSVDFH
                     EYKNEADHGQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASA
                     SEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGK
                     APAGGNGNKKKSGKKEKK"
     exon            2606..2664
                     /gene="PCDHGA8"
                     /gene_synonym="PCDH-GAMMA-A8"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2753
                     /gene="PCDHGA8"
                     /gene_synonym="PCDH-GAMMA-A8"
                     /inference="alignment:Splign:2.1.0"
     exon            2754..4782
                     /gene="PCDHGA8"
                     /gene_synonym="PCDH-GAMMA-A8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4761..4766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHGA8"
                     /gene_synonym="PCDH-GAMMA-A8"
                     /note="hexamer: AATAAA"
     polyA_site      4782
                     /gene="PCDHGA8"
                     /gene_synonym="PCDH-GAMMA-A8"
                     /note="major polyA site"
ORIGIN      
        1 acacctcacg aagacccgca gatgccacaa actaactgct ggactgcagc gaaacccgac
       61 ccctgtttgg aggcactcca ggtttccgga ggattgtcat ctccatagct gcggcaagaa
      121 actaaataag acccatttat gcacagtgaa gattctgaga ggattctgca gcaaaacaac
      181 aatggccgct ccacagagtc gccccagacg cggcgagctg atcctgctgt gcgcgctgct
      241 gggaacgctg tgggaaatcg ggaggggaca gattcgctac tctgtgccag aagagacgga
      301 caaaggctcc ttcgtgggta atatctccaa ggacctgggg ctggaccccc ggaagctggc
      361 gaagcacgga gtccgtatcg tctccagagg taggacgcag ctctttgctc tgaacccgcg
      421 cagcggcagc ttgatcaccg cgggcaggat agatcgggag gagctctgcg ctcagagccc
      481 gcggtgtctg ataaatatta acaccctggt tgaggataaa ggaaaactct ttggggtaga
      541 aatagaaata attgatatta acgataataa cccaaaattc caggtcgaag atctagaagt
      601 aaaaattaac gaaatcgcgg ttcctggagc acgttatcca ctcccagaag ctgttgaccc
      661 ggatgtgggc gtgaactccc tccagagcta ccagctcagc cccaatcacc acttctccct
      721 ggacgtgcag actggagaca atggagccat aaacccagag ctggtgctgg agcgcgccct
      781 ggacagggag gaagaggctg ctcaccacct ggtcctcacg gcctcggatg gcggcaagcc
      841 gcctcgctct agcacagtgc gcatccacgt gacagtgttg gatacaaatg acaatgcccc
      901 ggtttttcct cacccgattt accgagtgaa agtccttgag aacatgcccc caggcacgcg
      961 gctgcttact gtaacagcca gcgacccgga tgagggaatc aacggaaaag tggcatacaa
     1021 attccggaaa attaatgaaa aacaaactcc gttattccag cttaatgaaa atactgggga
     1081 aatatcaata gcaaaaagtc tagattatga agaatgttca ttttatgaaa tggaaataca
     1141 agccgaagat gtgggggcac ttctggggag gaccaaattg ctcatttcgg tggaagatgt
     1201 aaatgacaat agaccagaag tgatcattac gtctttgttt agcccagtgt tagaaaattc
     1261 tcttcccggg acagtaattg ccttcttgag tgtgcatgac caagactctg gaaagaatgg
     1321 tcaagttgtc tgttacacac gtgataattt accttttaaa ttagaaaagt caataggtaa
     1381 ttattataga ttagtgacaa ggaaatattt ggaccgagaa aatgtctcta tctacaatat
     1441 cacagtgatg gcctcagatc taggaacacc acctctgtcc actgaaactc aaatcgctct
     1501 gcacgtggca gacattaacg acaaccctcc tactttccct catgcctcct actcagcgta
     1561 tatcctagag aacaacctga gaggagcctc catcttttcc ttgactgcac acgaccccga
     1621 cagccaggag aatgcccagg tcacttactc tgtgaccgag gacacgctgc agggggcgcc
     1681 cctgtcctcg tatatctcca tcaactctga caccggtgtc ctgtatgcgc tgcaatcttt
     1741 cgactatgag cagatccgag acctgcagct actggtaaca gccagcgaca gcggggaccc
     1801 gcccctcagc agcaacatgt cactgagcct gttcgtgctg gaccagaatg acaacgcgcc
     1861 cgagatcctg taccccgccc tccccacaga cggttccact ggcgtggagc tggcgccccg
     1921 ctccgcagag cgtggctacc tggtgaccaa ggtggtggcg gtggacagag actcgggcca
     1981 gaacgcctgg ctgtcctacc gcctgctcaa ggccagcgag ccgggactct tctcggtggg
     2041 tctgcacacg ggcgaggtgc gcacggcgcg agccctgctg gacagagatg cgctcaagca
     2101 gagcctcgtg gtggccgtcc aggaccatgg ccagccccct ctctccgcca ctgtcacgct
     2161 caccgtagcc gtggctgaca gcatccccga agtcctgacc gagttgggca gtctgaagcc
     2221 ttcggtcgac ccgaacgatt cgagccttac actctatctc gtggtggcag tggctgccat
     2281 ctcctgtgtc ttcctcgcct ttgtcgctgt gcttctgggg ctcaggctga ggcgctggca
     2341 caagtcacgc ctgctccagg attccggtgg cagattggta ggcgtgcctg cctcacattt
     2401 tgtgggtgtt gaggaggtac aggctttcct gcagacctat tcccaggaag tctccctcac
     2461 cgccgactcg cggaagagtc acctgatctt tccccagccc aactacgcag acatgctcat
     2521 cagtcaggag ggctgtgaga aaaatgattc tttgttaaca tccgtagatt ttcatgaata
     2581 taagaatgaa gctgatcatg gtcagcaagc cccgcccaac acggactggc gtttctctca
     2641 ggcccagaga cccggcacca gcggctccca aaatggcgat gacaccggca cctggcccaa
     2701 caaccagttt gacacagaga tgctgcaagc catgatcttg gcgtccgcca gtgaagctgc
     2761 tgatgggagc tccaccctgg gagggggtgc cggcaccatg ggattgagcg cccgctacgg
     2821 accccagttc accctgcagc acgtgcccga ctaccgccag aatgtctaca tcccaggcag
     2881 caatgccaca ctgaccaacg cagctggcaa gcgggatggc aaggccccag caggtggcaa
     2941 tggcaacaag aagaagtcgg gcaagaagga gaagaagtaa catggaggcc aggccaagag
     3001 ccacagggcg gcctctcccc aaccagccca gcttctcctt acctgcaccc aggcctcaga
     3061 gtttcagggc taacccccag aatactggta ggggccaagg ccatgctccc cttgggaaac
     3121 agaaacaagt gcccagtcag cacctacccc ttccccccca gggggttgaa tatgcaaaag
     3181 cagttccgct gggaaccccc atccaatcaa ctgctgtacc catgggggta gtggggttac
     3241 tgtagacacc aagaaccatt tgccacaccc cgtttagtta cagctgaact cctccatctt
     3301 ccaaatcaat caggcccatc catcccatgc ctccctcctc cccaccccac tccaacagtt
     3361 cctctttccc gagtaaggtg gttggggtgt tgaagtacca agtaacctac aagcctccta
     3421 gttctgaaaa gttggaaggg catcatgacc tcttggcctc tcctttgatt ctcaatcttc
     3481 ccccaaagca tggtttggtg ccagcccctt cacctccttc cagagcccaa gatcaatgct
     3541 caagttttgg aggacatgat caccatcccc atggtactga tgcttgctgg atttagggag
     3601 ggcattttgc taccaagcct cttcccaacg ccctggggac cagtcttctg ttttgttttt
     3661 cattgtttga cgtttccact gcatgccttg acttccccca cctcctcctc aaacaagaga
     3721 ctccactgca tgttccaaga cagtatgggg tggtaagata aggaagggaa gtgtgtggat
     3781 gtggatggtg ggggcatgga caaagcttga cacatcaagt tatcaaggcc ttggaggagg
     3841 ctctgtatgt cctcagggga ctgacaacat cctccagatt ccagccataa accaataact
     3901 aggctggacc cttcccacta cataataggg ctcagcccag gcagccagct ttgggctgag
     3961 ctaacaggac caatggatta aactggcatt tcagtccaag gaagctcgaa gcaggtttag
     4021 gaccaggtcc ccttgagagg tcagaggggc ctctgtgggt gctgggtact ccagaggtgc
     4081 cactggtgga agggtcagcg gagccccagc aggaagggtg ggccagccag gccattctta
     4141 gtccctgggt tggggaggca gggagctagg gcagggacca aatgaacaga aagtctcagc
     4201 ccaggatggg gcttcttcaa cagggcccct gccctcctga agcctcagtc cttcaccttg
     4261 ccaggtgccg tttctcttcc gtgaaggcca ctgcccaggt ccccagtgcg ccccctagtg
     4321 gccatagcct ggttaaagtt ccccagtgcc tccttgtgca tagaccttct tctcccaccc
     4381 ccttctgccc ctgggtcccc ggccatccag cggggctgcc agagaacccc agacctgccc
     4441 ttacagtagt gtagcgcccc ctccctcttt cggctggtgt agaatagcca gtagtgtagt
     4501 gcggtgtgct tttacgtgat ggcgggtggg cagcgggcgg cgggctccgc gcagccgtct
     4561 gtccttgatc tgcccgcggc ggcccgtgtt gtgttttgtg ctgtgtccac gcgctaaggc
     4621 gaccccctcc cccgtactga cttctcctat aagcgcttct cttcgcatag tcacgtagct
     4681 cccaccccac cctcttcctg tgtctcacgc aagttttata ctctaatatt tatatggctt
     4741 tttttcttcg acaaaaaaat aataaaacgt ttcttctgaa aa
//
