LOCUS       NM_018920               4759 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens protocadherin gamma subfamily A, 7 (PCDHGA7),
            transcript variant 1, mRNA.
ACCESSION   NM_018920
VERSION     NM_018920.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4759)
  AUTHORS   Liu,Y., Peng,K., Xie,R., Zheng,J., Guo,J., Wei,R., Yang,H., Cai,C.
            and Wei,Q.
  TITLE     Protocadherin gamma-A7 is down-regulated in colorectal cancer and
            associated with the prognosis in patients with wild-type KRAS
  JOURNAL   Hum Pathol 83, 14-21 (2019)
   PUBMED   30121367
  REMARK    GeneRIF: this study demonstrates that PCDHGA7 is down-regulated in
            colorectal cancer, and its expression level is correlated with
            clinical outcomes in patients with wild-type KRAS
REFERENCE   2  (bases 1 to 4759)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   3  (bases 1 to 4759)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   4  (bases 1 to 4759)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   5  (bases 1 to 4759)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   6  (bases 1 to 4759)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA287863.1 and AF152327.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018920.3.
            
            Summary: This gene is a member of the protocadherin gamma gene
            cluster, one of three related clusters tandemly linked on
            chromosome five. These gene clusters have an immunoglobulin-like
            organization, suggesting that a novel mechanism may be involved in
            their regulation and expression. The gamma gene cluster includes 22
            genes divided into 3 subfamilies. Subfamily A contains 12 genes,
            subfamily B contains 7 genes and 2 pseudogenes, and the more
            distantly related subfamily C contains 3 genes. The tandem array of
            22 large, variable region exons are followed by a constant region,
            containing 3 exons shared by all genes in the cluster. Each
            variable region exon encodes the extracellular region, which
            includes 6 cadherin ectodomains and a transmembrane region. The
            constant region exons encode the common cytoplasmic region. These
            neural cadherin-like cell adhesion proteins most likely play a
            critical role in the establishment and function of specific
            cell-cell connections in the brain. Alternative splicing has been
            described for the gamma cluster genes. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) includes the constant region
            exons and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.82626.1, AF152327.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000518325.2/ ENSP00000430024.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               DA287863.1         4-161
            159-4759            AF152327.1         1-4601
FEATURES             Location/Qualifiers
     source          1..4759
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..4759
                     /gene="PCDHGA7"
                     /gene_synonym="PCDH-GAMMA-A7"
                     /note="protocadherin gamma subfamily A, 7"
                     /db_xref="GeneID:56108"
                     /db_xref="HGNC:HGNC:8705"
                     /db_xref="MIM:606294"
     exon            1..2582
                     /gene="PCDHGA7"
                     /gene_synonym="PCDH-GAMMA-A7"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..2957
                     /gene="PCDHGA7"
                     /gene_synonym="PCDH-GAMMA-A7"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protocadherin gamma-A7"
                     /codon_start=1
                     /product="protocadherin gamma-A7 isoform 1 precursor"
                     /protein_id="NP_061743.1"
                     /db_xref="CCDS:CCDS54927.1"
                     /db_xref="GeneID:56108"
                     /db_xref="HGNC:HGNC:8705"
                     /db_xref="MIM:606294"
                     /translation="MAAQPRGGDYRGFFLLSILLGTPWEAWAGRILYSVSEETDKGSF
                     VGDIAKDLGLEPRELAERGVRIISRGRTQLFALNQRSGSLVTAGRIDREEICAQSARC
                     LVNFNILMEDKMNLYPIDVEIIDINDNVPRFLTEEINVKIMENTAPGVRFPLSEAGDP
                     DVGTNSLQSYQLSPNRHFSLAVQSGDDETKYPELVLERVLDREEERVHHLVLTASDGG
                     DPPRSSTAHIQVTVVDVNDHTPVFSLPQYQVTVPENVPVGTRLLTVHAIDLDEGVNGE
                     VTYSFRKITPKLPKMFHLNSLTGEISTLEGLDYEETAFYEMEVQAQDGPGSLTKAKVL
                     ITVLDVNDNAPEVTMTSLSSSIPEDTPLGTVIALFYLQDRDSGKNGEVTCTIPENLPF
                     KLEKSIDNYYRLVTTKNLDRETLSLYNITLKATDGGTPPLSRETHIFMQVADTNDNPP
                     TFPHSSYSVYIAENNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPVSSYVSIN
                     SDTGVLYALQSFDYEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPEILYPA
                     LPTDGSTGMELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYLLLKASEPGLFAVGLYTG
                     EVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPEVLADLGSLEPSD
                     GPYNYDLTLYLVVAVATVSCVFLAFVLVLLALRLRRWHKSRLLQASEGGLANVPTSHF
                     VGMDGVQAFLQTYSHEVSLTADSRKSHLIFPQPNYVDMLISQESCEKNDSLLTSVDFQ
                     ECKENLPSIQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASA
                     SEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGK
                     APAGGNGNKKKSGKKEKK"
     exon            2583..2641
                     /gene="PCDHGA7"
                     /gene_synonym="PCDH-GAMMA-A7"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2730
                     /gene="PCDHGA7"
                     /gene_synonym="PCDH-GAMMA-A7"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..4759
                     /gene="PCDHGA7"
                     /gene_synonym="PCDH-GAMMA-A7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4738..4743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHGA7"
                     /gene_synonym="PCDH-GAMMA-A7"
                     /note="hexamer: AATAAA"
     polyA_site      4759
                     /gene="PCDHGA7"
                     /gene_synonym="PCDH-GAMMA-A7"
                     /note="major polyA site"
ORIGIN      
        1 agattgcgat aagccctctt ccaggctgca ctaaactcaa gcctctatcc tgctggattc
       61 tgagctcccc ttcctaagac agaggggtcc acccggatac acccgcattc tgaagcactt
      121 cccgagatcg gcgcctaagc aagagaagca ggacgactat ggcggctcag ccgaggggcg
      181 gggactacag aggattcttc ctgctctcca tcctcctggg gaccccctgg gaagcctggg
      241 caggacgtat tctctactcc gtgtcggagg agacggacaa agggtccttt gtgggagaca
      301 tcgccaagga cctggggctg gagccccggg agctggcgga gcgcggagtc cgcatcatct
      361 ccagaggtag gacgcagctt ttcgccctga accagcgcag cggcagcttg gtcactgcgg
      421 gcaggataga ccgggaagag atctgcgctc agagtgcgcg gtgtctggta aactttaaca
      481 tcctgatgga agataaaatg aatctttacc ctatagacgt ggaaataata gatattaatg
      541 acaacgttcc aagattcttg acggaagaaa taaatgtaaa aataatggag aatacagctc
      601 ctggggttcg gtttccgtta agcgaggctg gggatccaga tgtgggcacg aactccctcc
      661 agagttacca gctcagcccc aatcgccact tctccctggc tgtgcaaagt ggagacgatg
      721 aaactaagta cccggaactg gtgctggagc gggtgctgga ccgggaggaa gagcgggttc
      781 accacctggt cctcacagcc tctgatggcg gcgacccgcc ccgatccagc accgcccaca
      841 tccaggtgac agtggtggat gtgaatgacc acacgcctgt cttctctctg cctcagtacc
      901 aagtaactgt ccccgagaat gtgccagtgg gtacaagact gctcacggta catgctatcg
      961 acctggacga gggagtcaat ggggaagtga catattcttt tcggaaaata actcctaaac
     1021 ttccaaagat gtttcatctg aactcgctta caggagaaat atcaacttta gaaggattag
     1081 attatgaaga aactgccttc tatgaaatgg aggttcaggc tcaagatggt cctggtagtc
     1141 tgacaaaggc aaaagtactg atcacagttt tagatgtaaa tgataatgct ccagaagtga
     1201 ctatgacgtc tttaagtagc tcaatccctg aagacacacc tcttgggaca gtcattgctc
     1261 ttttctacct acaagacaga gattctggaa agaatggtga ggtgacctgc accattccag
     1321 aaaacctacc ttttaaatta gaaaaatcaa tagataatta ttatagattg gtcacaacca
     1381 aaaacttgga ccgggaaaca ctctctttgt ataacatcac actgaaagcc acagatggtg
     1441 gaactcctcc cttgtccagg gaaactcaca tattcatgca ggtggcagac accaacgata
     1501 acccacccac cttcccccac tcatcctact cagtctacat cgctgagaac aaccccagag
     1561 gggcctccat tttcttagtg actgcacagg accacgacag tgaggataat gcccagatca
     1621 cttattcctt ggccgaagac accatccagg gggctccagt gtcctcctat gtctccataa
     1681 actctgacac tggagtcctg tacgcgctgc aatcctttga ttatgagcag ttgagagaac
     1741 tacaactaag agtgactgca catgacagcg gggacccgcc tctcagcagc aacatgtcac
     1801 tgagcctgtt cgtgctggac cagaatgaca acccgcccga gatcctgtac ccggccctcc
     1861 ccacagatgg ttctactggc atggagctgg caccccgctc cgcagagccc ggctacctgg
     1921 tgaccaaggt ggtggcggtg gacaaagatt caggccagaa cgcctggctg tcatacctcc
     1981 tgcttaaggc cagcgagcca ggactctttg cggttgggct gtacacgggc gaggtgcgca
     2041 cggctcgggc cctgctggac agagatgccc tcaagcagag cctcgtggtg gccgtccagg
     2101 accacggtca gcctcctctg tcagccaccg tcacactcac cgtggctgtg gctgacagca
     2161 tccccgaagt cttggccgac ctgggcagcc ttgagccctc cgacggtcct tacaactatg
     2221 acctcacgtt gtacctggtg gtggcggtgg ccacagtctc ctgcgtcttc ctagccttcg
     2281 tcctcgtact gctggcgctc aggctgcggc gctggcacaa gtcacgcctg ctgcaggctt
     2341 cagaaggtgg cttggcgaac gtgcccacct cgcactttgt gggcatggac ggggtgcagg
     2401 ctttcctgca gacctattcc catgaggtct ccctcaccgc ggactctcgg aagagtcacc
     2461 tgatcttccc ccagcccaac tatgtagaca tgctcatcag ccaggagagc tgtgagaaaa
     2521 atgattcttt gctaacatcc gtagattttc aggaatgtaa agaaaacctg ccaagtattc
     2581 agcaagcccc gcccaacacg gactggcgtt tctctcaggc ccagagaccc ggcaccagcg
     2641 gctcccaaaa tggcgatgac accggcacct ggcccaacaa ccagtttgac acagagatgc
     2701 tgcaagccat gatcttggcg tccgccagtg aagctgctga tgggagctcc accctgggag
     2761 ggggtgccgg caccatggga ttgagcgccc gctacggacc ccagttcacc ctgcagcacg
     2821 tgcccgacta ccgccagaat gtctacatcc caggcagcaa tgccacactg accaacgcag
     2881 ctggcaagcg ggatggcaag gccccagcag gtggcaatgg caacaagaag aagtcgggca
     2941 agaaggagaa gaagtaacat ggaggccagg ccaagagcca cagggcggcc tctccccaac
     3001 cagcccagct tctccttacc tgcacccagg cctcagagtt tcagggctaa cccccagaat
     3061 actggtaggg gccaaggcca tgctcccctt gggaaacaga aacaagtgcc cagtcagcac
     3121 ctaccccttc ccccccaggg ggttgaatat gcaaaagcag ttccgctggg aacccccatc
     3181 caatcaactg ctgtacccat gggggtagtg gggttactgt agacaccaag aaccatttgc
     3241 cacaccccgt ttagttacag ctgaactcct ccatcttcca aatcaatcag gcccatccat
     3301 cccatgcctc cctcctcccc accccactcc aacagttcct ctttcccgag taaggtggtt
     3361 ggggtgttga agtaccaagt aacctacaag cctcctagtt ctgaaaagtt ggaagggcat
     3421 catgacctct tggcctctcc tttgattctc aatcttcccc caaagcatgg tttggtgcca
     3481 gccccttcac ctccttccag agcccaagat caatgctcaa gttttggagg acatgatcac
     3541 catccccatg gtactgatgc ttgctggatt tagggagggc attttgctac caagcctctt
     3601 cccaacgccc tggggaccag tcttctgttt tgtttttcat tgtttgacgt ttccactgca
     3661 tgccttgact tcccccacct cctcctcaaa caagagactc cactgcatgt tccaagacag
     3721 tatggggtgg taagataagg aagggaagtg tgtggatgtg gatggtgggg gcatggacaa
     3781 agcttgacac atcaagttat caaggccttg gaggaggctc tgtatgtcct caggggactg
     3841 acaacatcct ccagattcca gccataaacc aataactagg ctggaccctt cccactacat
     3901 aatagggctc agcccaggca gccagctttg ggctgagcta acaggaccaa tggattaaac
     3961 tggcatttca gtccaaggaa gctcgaagca ggtttaggac caggtcccct tgagaggtca
     4021 gaggggcctc tgtgggtgct gggtactcca gaggtgccac tggtggaagg gtcagcggag
     4081 ccccagcagg aagggtgggc cagccaggcc attcttagtc cctgggttgg ggaggcaggg
     4141 agctagggca gggaccaaat gaacagaaag tctcagccca ggatggggct tcttcaacag
     4201 ggcccctgcc ctcctgaagc ctcagtcctt caccttgcca ggtgccgttt ctcttccgtg
     4261 aaggccactg cccaggtccc cagtgcgccc cctagtggcc atagcctggt taaagttccc
     4321 cagtgcctcc ttgtgcatag accttcttct cccaccccct tctgcccctg ggtccccggc
     4381 catccagcgg ggctgccaga gaaccccaga cctgccctta cagtagtgta gcgccccctc
     4441 cctctttcgg ctggtgtaga atagccagta gtgtagtgcg gtgtgctttt acgtgatggc
     4501 gggtgggcag cgggcggcgg gctccgcgca gccgtctgtc cttgatctgc ccgcggcggc
     4561 ccgtgttgtg ttttgtgctg tgtccacgcg ctaaggcgac cccctccccc gtactgactt
     4621 ctcctataag cgcttctctt cgcatagtca cgtagctccc accccaccct cttcctgtgt
     4681 ctcacgcaag ttttatactc taatatttat atggcttttt ttcttcgaca aaaaaataat
     4741 aaaacgtttc ttctgaaaa
//
