LOCUS       NM_018915               4813 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens protocadherin gamma subfamily A, 2 (PCDHGA2),
            transcript variant 1, mRNA.
ACCESSION   NM_018915
VERSION     NM_018915.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4813)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   2  (bases 1 to 4813)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   3  (bases 1 to 4813)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   4  (bases 1 to 4813)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   5  (bases 1 to 4813)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA314472.1 and AF152322.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018915.3.
            
            Summary: This gene is a member of the protocadherin gamma gene
            cluster, one of three related clusters tandemly linked on
            chromosome five. These gene clusters have an immunoglobulin-like
            organization, suggesting that a novel mechanism may be involved in
            their regulation and expression. The gamma gene cluster includes 22
            genes divided into 3 subfamilies. Subfamily A contains 12 genes,
            subfamily B contains 7 genes and 2 pseudogenes, and the more
            distantly related subfamily C contains 3 genes. The tandem array of
            22 large, variable region exons are followed by a constant region,
            containing 3 exons shared by all genes in the cluster. Each
            variable region exon encodes the extracellular region, which
            includes 6 cadherin ectodomains and a transmembrane region. The
            constant region exons encode the common cytoplasmic region. These
            neural cadherin-like cell adhesion proteins most likely play a
            critical role in the establishment and function of specific
            cell-cell connections in the brain. Alternative splicing has been
            described for the gamma cluster genes. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) includes the constant region
            exons and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.100293.1,
                                           SRR1803617.137662.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394576.3/ ENSP00000378077.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               DA314472.1         1-212
            213-4813            AF152322.1         1-4601
FEATURES             Location/Qualifiers
     source          1..4813
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..4813
                     /gene="PCDHGA2"
                     /gene_synonym="PCDH-GAMMA-A2"
                     /note="protocadherin gamma subfamily A, 2"
                     /db_xref="GeneID:56113"
                     /db_xref="HGNC:HGNC:8700"
                     /db_xref="MIM:606289"
     exon            1..2636
                     /gene="PCDHGA2"
                     /gene_synonym="PCDH-GAMMA-A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..3011
                     /gene="PCDHGA2"
                     /gene_synonym="PCDH-GAMMA-A2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protocadherin gamma-A2"
                     /codon_start=1
                     /product="protocadherin gamma-A2 isoform 1 precursor"
                     /protein_id="NP_061738.1"
                     /db_xref="CCDS:CCDS47289.1"
                     /db_xref="GeneID:56113"
                     /db_xref="HGNC:HGNC:8700"
                     /db_xref="MIM:606289"
                     /translation="MAALQKLPHCRKLVLLCFLLATLWEARAGQIRYSVREEIDRGSF
                     VGNIAKDLGLEPLALAEQGVRIVSRGRSQLFALNPRSGSLVTANRIDREELCAQSAPC
                     LLNFNILLEDKLTIYSVEVEITDINDNAPRFGVEELELKISETTTPGFRIPLKNAHDA
                     DVGENALQKYALNPNDHFSLDVRRGADGNKYPELVLERSLDREEEAVHHLVLVASDGG
                     DPVLSGTSRICVKVLDANDNAPVFTQPEYRISIPENTLVGTRILTVTATDADEGYYAQ
                     VVYFLEKSPGETSEVFELKSTSGELTIIKDLDYEDATFHEIDIEAQDGPGLLTRAKVI
                     VTVLDVNDNAPEFYMTSATSSVSEDSLPGTIIGLFNVHDRDSGQNAFTTCSLPEDLPF
                     KLEKSVDNYYRLVTTRALDREQFSFYNITLTAKDGGNPSLSTDAHILLQVADINDNAP
                     AFSRTSYSTYIPENNPRGASVFSVTAHDPDSNDNAHVTYSFAEDTVQGAPLSSYISIN
                     SDTGVLYALRSFDYEQLRDLQVWVIARDSGNPPLSSNVSLSLFVLDQNDNAPEILYPA
                     FPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYHLLKASEPGLFSVGLHTG
                     EVRTARALLDRDALKQSLVVAIQDHGQPPLSATVTLTVAVADRIPDILADLGSLEPSA
                     IPNDSDLTLYLVVAVAAVSCVFLAFVIVLLAHRLRRWHKSRLLQASGGSLTGMQSSHF
                     VGVDGVRAFLQTYSHEVSLTADSRKSHLIFPQPNYADTLISQESCEKKDFLSAPQSLL
                     EEEREETFSQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASA
                     SEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGK
                     APAGGNGNKKKSGKKEKK"
     exon            2637..2695
                     /gene="PCDHGA2"
                     /gene_synonym="PCDH-GAMMA-A2"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..2784
                     /gene="PCDHGA2"
                     /gene_synonym="PCDH-GAMMA-A2"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..4813
                     /gene="PCDHGA2"
                     /gene_synonym="PCDH-GAMMA-A2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4792..4797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHGA2"
                     /gene_synonym="PCDH-GAMMA-A2"
                     /note="hexamer: AATAAA"
     polyA_site      4813
                     /gene="PCDHGA2"
                     /gene_synonym="PCDH-GAMMA-A2"
                     /note="major polyA site"
ORIGIN      
        1 aatccagcaa tacggctccc acagcacaag ggggtggagg tttggcccta aagcttcagg
       61 acaccaaaga aattcagtcg aacagcccac cagttctctc catagggacc tgggtcccgt
      121 gaatgctggt tatctcacac cctgaggaat aaagattgga atccgcactg gatgctggaa
      181 gttgactcgg agaaaattgc gacaggaggg aaatggcggc tctgcaaaag ttgccacact
      241 gcagaaagct ggtcctgctg tgcttccttt tggcgaccct gtgggaggcc agggccgggc
      301 agattcgcta ttctgtgcgg gaagagatcg acagaggctc cttcgtaggc aacatcgcca
      361 aggacttggg tttggagccc ctggcactgg cagagcaggg agtccgcatc gtctccagag
      421 gtaggtccca gctctttgct ctgaacccgc gaagcggcag cttggtcact gcgaacagga
      481 tagaccggga ggagctctgc gctcagagcg caccctgtct gttgaatttt aacattctgc
      541 tggaggataa attgactatt tattcagtag aggtggaaat aacagatatt aacgataatg
      601 cccctcgctt tggagtagag gaactggagc taaaaatcag tgaaaccact acgccaggat
      661 tccggattcc tcttaagaat gcgcatgatg cagacgtagg tgagaacgcc cttcagaagt
      721 acgcactcaa cccaaatgac cacttctccc tggacgtgcg aaggggagct gatgggaaca
      781 agtacccaga actggtgctg gagcgctctc tggaccgcga ggaagaggct gttcaccacc
      841 tcgttctcgt ggcttctgat gggggtgacc cagtgctatc tggcacctcc cgcatctgcg
      901 tgaaggtcct ggatgcgaac gacaatgcgc ctgtttttac acagcccgag taccgcataa
      961 gcattccgga gaatacgctc gtgggcaccc ggatactcac ggtgaccgcc actgacgcag
     1021 atgagggcta ctacgctcaa gtggtatatt ttctagagaa aagccctgga gaaacctcag
     1081 aggtatttga gcttaagtca acatctggag aactgacaat cataaaagat ctagattatg
     1141 aggatgctac attccatgaa attgatattg aagctcagga tggtccgggc cttctaacca
     1201 gagcgaaggt tatcgtcacg gttctggatg tgaatgacaa tgccccagaa ttttacatga
     1261 catctgctac tagctcagtt tctgaagact ctcttccagg aaccataatt gggcttttta
     1321 atgtacatga tagagactct gggcagaacg cattcaccac ctgttcactc cccgaggatc
     1381 ttccttttaa gttagaaaag tcagtagaca attactaccg actggttaca accagagccc
     1441 ttgacaggga acagttttcc ttttacaaca tcactctaac cgctaaagat ggagggaacc
     1501 cctccctgtc cacggatgct cacattttgc tccaggtggc agacatcaac gacaacgcac
     1561 ccgccttctc ccgcacatcc tactccacct acattcccga aaacaacccc agaggagcct
     1621 ctgtcttctc agtgacggcc catgaccccg acagcaacga caatgctcat gtaacttact
     1681 ctttcgcgga ggacactgtt cagggggcac ccttatcctc ttacatctct atcaactccg
     1741 acactggagt actctatgca ctgcgctcct ttgattatga gcagttgcga gacttgcaag
     1801 tgtgggtgat agcgcgggac agcgggaacc ctccactcag tagcaatgta tcattaagcc
     1861 tgttcgtgct ggaccagaac gacaacgcgc ccgagatcct gtaccctgcc ttccccacag
     1921 acggttccac tggcgtggag ctggcgcccc gctccgcaga gcccggctac ctggtgacca
     1981 aggtggtggc ggtggacaga gactcgggcc agaacgcctg gctgtcttac cacctgctca
     2041 aggccagcga gccgggactc ttctcggtgg gtctgcacac gggcgaggtg cgcacggcgc
     2101 gagccctgct ggacagagac gcgctcaagc agagcctcgt ggtggccatc caggaccacg
     2161 gccagccccc tctctccgcc actgtcacgc tcaccgtggc cgtggccgac aggatccccg
     2221 acatcctggc cgacctgggc agcctcgagc cctccgccat acccaacgat tcggacctca
     2281 ctctgtacct ggtggtggcg gtggccgcgg tctcctgcgt cttcctggcc ttcgtcatcg
     2341 tgttgctggc gcacaggctg cggcgctggc acaagtcacg cctgctgcag gcttcaggag
     2401 gcagcttgac aggcatgcag agctcgcact ttgtgggcgt ggacggggtt cgggctttcc
     2461 tgcagaccta ttcccacgag gtctccctca ctgcggactc gcggaagagc cacctgattt
     2521 tcccccagcc caactatgcg gacacgctca tcagccagga gagctgtgag aaaaaggatt
     2581 ttttatcagc gcctcaatct ctactcgaag aagaaagaga agaaacgttt tctcagcaag
     2641 ccccgcccaa cacggactgg cgtttctctc aggcccagag acccggcacc agcggctccc
     2701 aaaatggcga tgacaccggc acctggccca acaaccagtt tgacacagag atgctgcaag
     2761 ccatgatctt ggcgtccgcc agtgaagctg ctgatgggag ctccaccctg ggagggggtg
     2821 ccggcaccat gggattgagc gcccgctacg gaccccagtt caccctgcag cacgtgcccg
     2881 actaccgcca gaatgtctac atcccaggca gcaatgccac actgaccaac gcagctggca
     2941 agcgggatgg caaggcccca gcaggtggca atggcaacaa gaagaagtcg ggcaagaagg
     3001 agaagaagta acatggaggc caggccaaga gccacagggc ggcctctccc caaccagccc
     3061 agcttctcct tacctgcacc caggcctcag agtttcaggg ctaaccccca gaatactggt
     3121 aggggccaag gccatgctcc ccttgggaaa cagaaacaag tgcccagtca gcacctaccc
     3181 cttccccccc agggggttga atatgcaaaa gcagttccgc tgggaacccc catccaatca
     3241 actgctgtac ccatgggggt agtggggtta ctgtagacac caagaaccat ttgccacacc
     3301 ccgtttagtt acagctgaac tcctccatct tccaaatcaa tcaggcccat ccatcccatg
     3361 cctccctcct ccccacccca ctccaacagt tcctctttcc cgagtaaggt ggttggggtg
     3421 ttgaagtacc aagtaaccta caagcctcct agttctgaaa agttggaagg gcatcatgac
     3481 ctcttggcct ctcctttgat tctcaatctt cccccaaagc atggtttggt gccagcccct
     3541 tcacctcctt ccagagccca agatcaatgc tcaagttttg gaggacatga tcaccatccc
     3601 catggtactg atgcttgctg gatttaggga gggcattttg ctaccaagcc tcttcccaac
     3661 gccctgggga ccagtcttct gttttgtttt tcattgtttg acgtttccac tgcatgcctt
     3721 gacttccccc acctcctcct caaacaagag actccactgc atgttccaag acagtatggg
     3781 gtggtaagat aaggaaggga agtgtgtgga tgtggatggt gggggcatgg acaaagcttg
     3841 acacatcaag ttatcaaggc cttggaggag gctctgtatg tcctcagggg actgacaaca
     3901 tcctccagat tccagccata aaccaataac taggctggac ccttcccact acataatagg
     3961 gctcagccca ggcagccagc tttgggctga gctaacagga ccaatggatt aaactggcat
     4021 ttcagtccaa ggaagctcga agcaggttta ggaccaggtc cccttgagag gtcagagggg
     4081 cctctgtggg tgctgggtac tccagaggtg ccactggtgg aagggtcagc ggagccccag
     4141 caggaagggt gggccagcca ggccattctt agtccctggg ttggggaggc agggagctag
     4201 ggcagggacc aaatgaacag aaagtctcag cccaggatgg ggcttcttca acagggcccc
     4261 tgccctcctg aagcctcagt ccttcacctt gccaggtgcc gtttctcttc cgtgaaggcc
     4321 actgcccagg tccccagtgc gccccctagt ggccatagcc tggttaaagt tccccagtgc
     4381 ctccttgtgc atagaccttc ttctcccacc cccttctgcc cctgggtccc cggccatcca
     4441 gcggggctgc cagagaaccc cagacctgcc cttacagtag tgtagcgccc cctccctctt
     4501 tcggctggtg tagaatagcc agtagtgtag tgcggtgtgc ttttacgtga tggcgggtgg
     4561 gcagcgggcg gcgggctccg cgcagccgtc tgtccttgat ctgcccgcgg cggcccgtgt
     4621 tgtgttttgt gctgtgtcca cgcgctaagg cgaccccctc ccccgtactg acttctccta
     4681 taagcgcttc tcttcgcata gtcacgtagc tcccacccca ccctcttcct gtgtctcacg
     4741 caagttttat actctaatat ttatatggct ttttttcttc gacaaaaaaa taataaaacg
     4801 tttcttctga aaa
//
