LOCUS       NM_018913               4802 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens protocadherin gamma subfamily A, 10 (PCDHGA10),
            transcript variant 1, mRNA.
ACCESSION   NM_018913
VERSION     NM_018913.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4802)
  AUTHORS   Xu,Y., Zhang,Y., Lopez,I.A., Hilbers,J., Griswold,A.J.,
            Ishiyama,A., Blanton,S., Liu,X.Z. and Lundberg,Y.W.
  TITLE     Identification of a genetic variant underlying familial cases of
            recurrent benign paroxysmal positional vertigo
  JOURNAL   PLoS One 16 (5), e0251386 (2021)
   PUBMED   33956893
  REMARK    GeneRIF: Identification of a genetic variant underlying familial
            cases of recurrent benign paroxysmal positional vertigo.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4802)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   3  (bases 1 to 4802)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   4  (bases 1 to 4802)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   5  (bases 1 to 4802)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   6  (bases 1 to 4802)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005618.1 and AF152319.1.
            
            On Sep 17, 2020 this sequence version replaced NM_018913.2.
            
            Summary: This gene is a member of the protocadherin gamma gene
            cluster, one of three related clusters tandemly linked on
            chromosome five. These gene clusters have an immunoglobulin-like
            organization, suggesting that a novel mechanism may be involved in
            their regulation and expression. The gamma gene cluster includes 22
            genes divided into 3 subfamilies. Subfamily A contains 12 genes,
            subfamily B contains 7 genes and 2 pseudogenes, and the more
            distantly related subfamily C contains 3 genes. The tandem array of
            22 large, variable region exons are followed by a constant region,
            containing 3 exons shared by all genes in the cluster. Each
            variable region exon encodes the extracellular region, which
            includes 6 cadherin ectodomains and a transmembrane region. The
            constant region exons encode the common cytoplasmic region. These
            neural cadherin-like cell adhesion proteins most likely play a
            critical role in the establishment and function of specific
            cell-cell connections in the brain. Alternative splicing has been
            described for the gamma cluster genes. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) includes the constant region
            exons and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF152319.1, SRR11853565.23834.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398610.3/ ENSP00000381611.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AC005618.1         124499-124687
            190-4802            AF152319.1         1-4613
FEATURES             Location/Qualifiers
     source          1..4802
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..4802
                     /gene="PCDHGA10"
                     /gene_synonym="PCDH-GAMMA-A10"
                     /note="protocadherin gamma subfamily A, 10"
                     /db_xref="GeneID:56106"
                     /db_xref="HGNC:HGNC:8697"
                     /db_xref="MIM:606297"
     exon            1..2625
                     /gene="PCDHGA10"
                     /gene_synonym="PCDH-GAMMA-A10"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..3000
                     /gene="PCDHGA10"
                     /gene_synonym="PCDH-GAMMA-A10"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protocadherin gamma-A10"
                     /codon_start=1
                     /product="protocadherin gamma-A10 isoform 1 precursor"
                     /protein_id="NP_061736.1"
                     /db_xref="CCDS:CCDS47292.1"
                     /db_xref="GeneID:56106"
                     /db_xref="HGNC:HGNC:8697"
                     /db_xref="MIM:606297"
                     /translation="MAAQRNRSKESKDCSGLVLLCLFFGIPWEAGARQISYSIPEELE
                     KGSFVGNISKDLGLAPRELAERGVRIVSRGRTQLFSLNPRSGSLITAGRIDREELCAQ
                     SARCVVSFNILVEDRVKLFGIEIEVTDINDNAPKFQAENLDVKINENVAAGMRFPLPE
                     AIDPDVGVNSLQSYQLSPNKHFSLRVQSRANGVKYPELVLEHSLDREEEAIHHLVLTA
                     SDGGDPLRSGTVLVSVTVFDANDNAPVFTLPEYRVSVPENLPVGTQLLTVTATDRDEG
                     ANGEVTYSFRKLPDTQLLKFQLNKYTGEIKISENLDYEETGFYEIEIQAEDGGAYLAT
                     AKVLITVEDVNDNSPELTITSLFSPVTEDSPLGTVVALLNVHDLDSEQNGQVTCSILA
                     YLPFKLEKSIDSYYRLVIHRALDREQVSSYNITVTATDGGSPPLSTEAHFMLQVADIN
                     DNPPTFSQVSYFTYIPENNARGASIFSVTALDPDSKENAQIIYSLAEDTIQGVPLSSY
                     ISINSDTGVLYALRSFDYEQFHELQMQVTASDSGDPPLSSNVSLSLFVLDQNDNAPEI
                     LYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFAVG
                     EHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPQVLADLGSF
                     ESPANSETSDLTLYLVVAVAAVSCVFLAFVIVLLAHRLRRWHKSRLLQASGGGLTGVS
                     GSHFVGVDGVRAFLQTYSHEVSLTADSRKSHLIFPQPNYADTLISQESCEKNDPLSLL
                     DDSKFPIEDTPLVPQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMI
                     LASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGK
                     RDGKAPAGGNGNKKKSGKKEKK"
     exon            2626..2684
                     /gene="PCDHGA10"
                     /gene_synonym="PCDH-GAMMA-A10"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2773
                     /gene="PCDHGA10"
                     /gene_synonym="PCDH-GAMMA-A10"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..4802
                     /gene="PCDHGA10"
                     /gene_synonym="PCDH-GAMMA-A10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4781..4786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHGA10"
                     /gene_synonym="PCDH-GAMMA-A10"
                     /note="hexamer: AATAAA"
     polyA_site      4802
                     /gene="PCDHGA10"
                     /gene_synonym="PCDH-GAMMA-A10"
                     /note="major polyA site"
ORIGIN      
        1 aatccggatt ctcagggctt caactacaca agccccacaa accggctgct gggctgcagg
       61 gaagctcact ccagaattta aagtgcccag gctacagaga caccctgaag ccacagaaag
      121 acaaaggaac cggttgaaac acacaacgtg tccagtgagg actttgcaga attctgtaac
      181 cagactacaa tggccgctca aaggaatcgc tcaaaggaat caaaggattg cagcgggctg
      241 gtcctgctct gccttttctt cgggattcca tgggaggctg gagcccggca gatctcctac
      301 tcaattcctg aggaattaga gaaaggctct ttcgtgggca acatctccaa ggacttgggt
      361 ctggcgcccc gggagctggc ggagcgcgga gtccgcatag tctccagagg taggacgcag
      421 cttttctctc tgaacccgcg cagcggcagc ttgatcaccg cgggcaggat agaccgggag
      481 gagctctgcg ctcagagcgc gcggtgcgtg gtgagtttta atatccttgt ggaagacagg
      541 gtgaaacttt ttgggataga aatagaagta actgatatca atgacaatgc tccaaaattc
      601 caagcagaaa atctagacgt aaaaattaat gaaaatgtcg ctgcgggaat gcgttttcct
      661 ctcccggaag ctattgatcc ggatgtgggc gtgaactccc tgcagagcta tcagctcagc
      721 cccaataagc acttctccct aagagttcag agccgtgcca atggcgtcaa gtacccggag
      781 ctggtactgg agcactccct agatcgcgag gaagaggcca ttcaccacct ggtcctcacc
      841 gcctccgacg ggggtgaccc tctccgatct ggcactgtcc ttgtcagtgt gactgtcttc
      901 gatgcaaatg acaacgcgcc ggtcttcacc ttgccagaat accgagtgag tgttcctgag
      961 aatttgcctg tgggcactca gctgctgaca gtcacagcca ccgacaggga cgaaggtgcc
     1021 aatggagaag tgacatattc attccgaaaa ttacctgaca cgcaattgtt gaagttccaa
     1081 ctaaacaaat atactggaga aataaaaata tcagaaaatc tagattatga agaaaccggt
     1141 ttctatgaaa tagaaataca agcagaagat ggaggagcat atcttgcaac tgcaaaagtg
     1201 ttgattacag tagaagatgt aaatgacaac agtccagagc tgaccatcac gtctctattt
     1261 agtccagtga ctgaagattc acctctggga acagtcgtag cccttttaaa tgtgcatgat
     1321 ttagactctg agcagaatgg acaggtaacc tgttccattt tggcgtatct accatttaaa
     1381 ttagaaaagt ccattgacag ttattacaga ttggtgatac acagagccct tgacagggaa
     1441 caggtatcct cttacaatat cacagtgaca gccacagatg ggggaagtcc tcctctatca
     1501 acggaagctc actttatgct acaagtggca gatatcaatg acaacccacc taccttctct
     1561 caagtctcct actttaccta tatcccagag aacaacgcca ggggtgcctc catcttctca
     1621 gtgacagcgc tggacccgga cagcaaagag aatgcccaga ttatttactc cctggctgaa
     1681 gacaccatcc agggggtacc tctgtcctca tacatatcca tcaactcaga cactggcgtc
     1741 ctgtatgcac tcagatcctt cgactatgag cagtttcatg agctacagat gcaggtgaca
     1801 gccagcgaca gcggggatcc tccactcagc agcaacgtgt cgttgagcct gtttgtgctg
     1861 gaccagaacg acaatgcgcc cgagatcctg taccccgccc tccccacaga cggttccaca
     1921 ggcgtggagc tggcgccccg ctccgcagag cccggctacc tggtgaccaa ggtggtggcg
     1981 gtggacagag actccggcca gaacgcctgg ctgtcctacc gtctgctcaa ggccagcgag
     2041 ccgggactct tcgcggtggg ggagcacacg ggcgaggtgc gcacggcgcg agccctgctg
     2101 gacagagacg cgctcaagca aagcctcgta gtggccgtcc aggaccacgg ccagccccct
     2161 ctctccgcca ctgtcacgct caccgtggcc gtggccgaca gcatccccca agtcctggcg
     2221 gacctcggca gcttcgagtc tccagctaac tctgaaacct cagacctcac tctgtacctg
     2281 gtggtagcgg tggccgcggt ctcctgcgtc ttcctggcct tcgtcatcgt gctgctggcg
     2341 cacaggctgc ggcgctggca caagtcacgc ctgctgcagg cttcaggagg cggcttgaca
     2401 ggtgtgtccg gctcgcactt tgtgggcgtg gacggggttc gggctttcct gcagacctat
     2461 tcccacgagg tctctctcac cgcggactcg cgaaagagtc acctgatctt cccccagccc
     2521 aattatgcgg acacgctcat cagccaggag agctgtgaga aaaacgatcc tttgtctttg
     2581 ttagatgatt cgaagtttcc tatagaggat accccattgg ttccacaagc cccgcccaac
     2641 acggactggc gtttctctca ggcccagaga cccggcacca gcggctccca aaatggcgat
     2701 gacaccggca cctggcccaa caaccagttt gacacagaga tgctgcaagc catgatcttg
     2761 gcgtccgcca gtgaagctgc tgatgggagc tccaccctgg gagggggtgc cggcaccatg
     2821 ggattgagcg cccgctacgg accccagttc accctgcagc acgtgcccga ctaccgccag
     2881 aatgtctaca tcccaggcag caatgccaca ctgaccaacg cagctggcaa gcgggatggc
     2941 aaggccccag caggtggcaa tggcaacaag aagaagtcgg gcaagaagga gaagaagtaa
     3001 catggaggcc aggccaagag ccacagggcg gcctctcccc aaccagccca gcttctcctt
     3061 acctgcaccc aggcctcaga gtttcagggc taacccccag aatactggta ggggccaagg
     3121 ccatgctccc cttgggaaac agaaacaagt gcccagtcag cacctacccc ttccccccca
     3181 gggggttgaa tatgcaaaag cagttccgct gggaaccccc atccaatcaa ctgctgtacc
     3241 catgggggta gtggggttac tgtagacacc aagaaccatt tgccacaccc cgtttagtta
     3301 cagctgaact cctccatctt ccaaatcaat caggcccatc catcccatgc ctccctcctc
     3361 cccaccccac tccaacagtt cctctttccc gagtaaggtg gttggggtgt tgaagtacca
     3421 agtaacctac aagcctccta gttctgaaaa gttggaaggg catcatgacc tcttggcctc
     3481 tcctttgatt ctcaatcttc ccccaaagca tggtttggtg ccagcccctt cacctccttc
     3541 cagagcccaa gatcaatgct caagttttgg aggacatgat caccatcccc atggtactga
     3601 tgcttgctgg atttagggag ggcattttgc taccaagcct cttcccaacg ccctggggac
     3661 cagtcttctg ttttgttttt cattgtttga cgtttccact gcatgccttg acttccccca
     3721 cctcctcctc aaacaagaga ctccactgca tgttccaaga cagtatgggg tggtaagata
     3781 aggaagggaa gtgtgtggat gtggatggtg ggggcatgga caaagcttga cacatcaagt
     3841 tatcaaggcc ttggaggagg ctctgtatgt cctcagggga ctgacaacat cctccagatt
     3901 ccagccataa accaataact aggctggacc cttcccacta cataataggg ctcagcccag
     3961 gcagccagct ttgggctgag ctaacaggac caatggatta aactggcatt tcagtccaag
     4021 gaagctcgaa gcaggtttag gaccaggtcc ccttgagagg tcagaggggc ctctgtgggt
     4081 gctgggtact ccagaggtgc cactggtgga agggtcagcg gagccccagc aggaagggtg
     4141 ggccagccag gccattctta gtccctgggt tggggaggca gggagctagg gcagggacca
     4201 aatgaacaga aagtctcagc ccaggatggg gcttcttcaa cagggcccct gccctcctga
     4261 agcctcagtc cttcaccttg ccaggtgccg tttctcttcc gtgaaggcca ctgcccaggt
     4321 ccccagtgcg ccccctagtg gccatagcct ggttaaagtt ccccagtgcc tccttgtgca
     4381 tagaccttct tctcccaccc ccttctgccc ctgggtcccc ggccatccag cggggctgcc
     4441 agagaacccc agacctgccc ttacagtagt gtagcgcccc ctccctcttt cggctggtgt
     4501 agaatagcca gtagtgtagt gcggtgtgct tttacgtgat ggcgggtggg cagcgggcgg
     4561 cgggctccgc gcagccgtct gtccttgatc tgcccgcggc ggcccgtgtt gtgttttgtg
     4621 ctgtgtccac gcgctaaggc gaccccctcc cccgtactga cttctcctat aagcgcttct
     4681 cttcgcatag tcacgtagct cccaccccac cctcttcctg tgtctcacgc aagttttata
     4741 ctctaatatt tatatggctt tttttcttcg acaaaaaaat aataaaacgt ttcttctgaa
     4801 aa
//
