LOCUS       NM_019120               2750 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens protocadherin beta 8 (PCDHB8), mRNA.
ACCESSION   NM_019120
VERSION     NM_019120.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2750)
  AUTHORS   Vanhalst,K., Kools,P., Vanden Eynde,E. and van Roy,F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   2  (bases 1 to 2750)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   3  (bases 1 to 2750)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   4  (bases 1 to 2750)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   5  (bases 1 to 2750)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   6  (bases 1 to 2750)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC136801.1 and AC244517.2.
            
            On May 17, 2019 this sequence version replaced NM_019120.4.
            
            Summary: This gene is a member of the protocadherin beta gene
            cluster, one of three related gene clusters tandemly linked on
            chromosome five. The gene clusters demonstrate an unusual genomic
            organization similar to that of B-cell and T-cell receptor gene
            clusters. The beta cluster contains 16 genes and 3 pseudogenes,
            each encoding 6 extracellular cadherin domains and a cytoplasmic
            tail that deviates from others in the cadherin superfamily. The
            extracellular domains interact in a homophilic manner to specify
            differential cell-cell connections. Unlike the alpha and gamma
            clusters, the transcripts from these genes are made up of only one
            large exon, not sharing common 3' exons as expected. These neural
            cadherin-like cell adhesion proteins are integral plasma membrane
            proteins. Their specific functions are unknown but they most likely
            play a critical role in the establishment and function of specific
            cell-cell neural connections. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC136801.1, SRR1803614.254952.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239444.4/ ENSP00000239444.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2711              BC136801.1         1-2711
            2712-2750           AC244517.2         106352-106390
FEATURES             Location/Qualifiers
     source          1..2750
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..2750
                     /gene="PCDHB8"
                     /gene_synonym="PCDH-BETA8; PCDH3I"
                     /note="protocadherin beta 8"
                     /db_xref="GeneID:56128"
                     /db_xref="HGNC:HGNC:8693"
                     /db_xref="MIM:606334"
     exon            1..2750
                     /gene="PCDHB8"
                     /gene_synonym="PCDH-BETA8; PCDH3I"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..2651
                     /gene="PCDHB8"
                     /gene_synonym="PCDH-BETA8; PCDH3I"
                     /note="protocadherin-3i"
                     /codon_start=1
                     /product="protocadherin beta-8 precursor"
                     /protein_id="NP_061993.3"
                     /db_xref="CCDS:CCDS4250.1"
                     /db_xref="GeneID:56128"
                     /db_xref="HGNC:HGNC:8693"
                     /db_xref="MIM:606334"
                     /translation="MEASGKLICRQRQVLFSFLLLGLSLAGAAEPRSYSVVEETEGSS
                     FVTNLAKDLGLEQREFSRRGVRVVSRGNKLHLQLNQETADLLLNEKLDREDLCGHTEP
                     CVLRFQVLLESPFEFFQAELQVIDINDHSPVFLDKQMLVKVSESSPPGTAFPLKNAED
                     LDIGQNNIENYIISPNSYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTALDG
                     GSPPRSGTAQVYIEVVDVNDNAPEFEQPFYRVQISEDSPISFLVVKVSATDVDTGVNG
                     EISYSLFQASDEISKTFKVDFLTGEIRLKKQLDFEKFQSYEVNIEARDAGGFSGKCTV
                     LIQVIDVNDHAPEVTMSAFTSPIPENAPETVVALFSVSDLDSGENGKISCSIQEDLPF
                     LLKSSVGNFYTLLTETPLDRESRAEYNVTITVTDLGTPRLTTHLNMTVLVSDVNDNAP
                     AFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSIN
                     TDNGHLFALRSLDYEALQAFEFRVGASDRGSPALSSEALVRVLVLDANDNSPFVLYPL
                     QNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGE
                     VRTARLLSERDAAKQRLVVLVKDNGEPPCSATATLHVLLVDGFSQPYLPLPEAAPAQG
                     QADSLTVYLVVALASVSSLFLFSVLLFVAVLLCRRSRAASVGRCSVPEGPFPGHLVDV
                     RGTGSLSQNYQYEVCLAGGSGTNEFQLLKPVLPNIQGHSFGPEMEQNSNFRNGFGFSL
                     QLK"
     regulatory      2718..2723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHB8"
                     /gene_synonym="PCDH-BETA8; PCDH3I"
                     /note="hexamer: CATAAA"
     regulatory      2730..2735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHB8"
                     /gene_synonym="PCDH-BETA8; PCDH3I"
                     /note="hexamer: ATTACA"
     polyA_site      2740
                     /gene="PCDHB8"
                     /gene_synonym="PCDH-BETA8; PCDH3I"
     polyA_site      2750
                     /gene="PCDHB8"
                     /gene_synonym="PCDH-BETA8; PCDH3I"
                     /note="major polyA site"
ORIGIN      
        1 tggcgctgca ggataagaag gcacaaacca gaaccgcagc tgcagctcca ttaaccggca
       61 aaaagcagca gaacctggaa gtccacgggg agcttggatg ccaaagggag gacggctggg
      121 tcctctggag aggactactc actggcatat ttctgaggta tctgtagaaa accacagcct
      181 cagatactgg ggactttaca gtcccacaga accgtcctcc caggaagctg aattcagcaa
      241 gaacaatgga ggccagcggg aagctcattt gcagacaaag gcaagtcctt ttttcctttc
      301 tccttttggg cttatctctg gcgggcgcgg cggaacctag aagctattct gtggtggagg
      361 aaactgaggg cagctccttt gtcaccaatt tagcaaagga cctgggtctg gagcagaggg
      421 aattctccag gcggggggtt agggttgttt ccagagggaa caaactacat ttgcagctca
      481 atcaggagac cgcggatttg ttgctaaatg agaaattgga ccgtgaggat ctgtgcggtc
      541 acacagagcc ctgtgtgcta cgtttccaag tgttgctaga gagtcccttc gagttttttc
      601 aagctgagct gcaagtaata gacataaacg accactctcc agtatttctg gacaaacaaa
      661 tgttggtgaa agtatcagag agcagtcctc ctgggactgc gtttcctctg aagaatgctg
      721 aagacttaga tataggccaa aacaatattg agaactatat aatcagcccc aactcctatt
      781 ttcgggtcct cacccgcaaa cgcagtgatg gcaggaaata cccagagctg gtgctggaca
      841 aagcgctgga ccgagaggaa gaagctgagc tcaggttaac actcacagca ctggatggtg
      901 gctctccgcc cagatctggc actgctcagg tctacattga agttgtcgat gtcaatgata
      961 atgcccctga atttgagcag cctttctata gggtgcagat ctctgaggac agtccaataa
     1021 gcttcctggt tgtgaaggtc tctgccacgg atgtagacac aggagtcaac ggagagattt
     1081 cctattcact tttccaagct tcagatgaga taagcaaaac ttttaaggtc gatttcttga
     1141 caggagaaat tcgactaaag aaacaacttg atttcgaaaa atttcagtcc tatgaagtca
     1201 atatcgaggc gagagatgct ggaggctttt ctggaaaatg caccgttctg attcaagtga
     1261 tagatgtgaa cgaccatgcc ccagaagtta ccatgtctgc atttaccagc ccaatacctg
     1321 agaatgcgcc tgaaactgtg gttgcacttt tcagtgtttc agaccttgat tcaggagaaa
     1381 atgggaaaat aagttgctcc attcaggagg atctaccctt cctcctgaaa tcttctgtgg
     1441 ggaactttta caccctacta acagagacac cactagacag agaaagcaga gccgagtaca
     1501 acgtcactat caccgtcact gacttaggga cacccaggct gacaacacat ctcaatatga
     1561 ccgtgctggt gtcggacgtc aatgacaacg cccccgcctt cacccaaacc tcctacaccc
     1621 tgttcgtccg cgagaacaac agccccgccc tgcacatcgg cagcgtcagc gccacagaca
     1681 gagactcggg caccaacgcc caggtcacct actcgctgct gccgccccag gatccgcacc
     1741 tgcccctcgc ctccctggtc tccatcaaca cagacaacgg ccacctgttc gccctcaggt
     1801 cgctggacta cgaggccctg caggcgttcg agttccgggt gggcgcttca gaccgcggct
     1861 ccccggcttt gagcagcgag gcgctggtgc gcgtgctggt gctggacgcc aacgacaact
     1921 cgcccttcgt gctgtacccg ctgcagaatg gctccgcgcc ctgcaccgag ctggtgcccc
     1981 gggcggccga gccgggctac ctggtgacca aggtggtggc ggtggacggc gactcgggcc
     2041 agaacgcctg gctgtcgtac cagctgctca aggccacgga gcccgggctg ttcggtgtgt
     2101 gggcgcacaa tggcgaggtg cgcaccgcca ggctgctgag cgagcgcgac gcggccaagc
     2161 agaggctggt ggtgctggtc aaggacaatg gcgagcctcc gtgctcggcc accgccacgc
     2221 tgcacgtgct cctggtggac ggcttctccc agccctacct gccgcttccg gaggctgccc
     2281 cagcccaggg ccaggccgac tctctcaccg tctacctggt ggtggcgttg gcctcggtgt
     2341 cttcgctctt cctcttctcg gtgctcctgt tcgtggcggt gctgctgtgt aggaggagca
     2401 gggcggcctc ggtgggtcgc tgctcagtgc ctgagggccc ctttccaggg catctggtgg
     2461 acgtgagggg caccgggagc ctgtctcaga actatcagta cgaggtgtgc ctggcaggag
     2521 gctcagggac gaatgagttc cagctcctga aaccagtatt acctaatatt cagggccatt
     2581 cttttgggcc agaaatggaa caaaactcta actttaggaa tggctttggt ttcagccttc
     2641 agttaaagta attgatttca tattatatat tttaattttt atgatcaatt caaaggaatg
     2701 gttttctgtc aacttagcat aaattttaaa ttacactaca tttgcccata
//
