LOCUS       NM_018940               3740 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens protocadherin beta 7 (PCDHB7), mRNA.
ACCESSION   NM_018940
VERSION     NM_018940.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3740)
  AUTHORS   Vanhalst,K., Kools,P., Vanden Eynde,E. and van Roy,F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   2  (bases 1 to 3740)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   3  (bases 1 to 3740)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   4  (bases 1 to 3740)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   5  (bases 1 to 3740)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   6  (bases 1 to 3740)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA779188.1, AF217750.1 and
            AC244517.2.
            
            On May 17, 2019 this sequence version replaced NM_018940.3.
            
            Summary: This gene is a member of the protocadherin beta gene
            cluster, one of three related gene clusters tandemly linked on
            chromosome five. The gene clusters demonstrate an unusual genomic
            organization similar to that of B-cell and T-cell receptor gene
            clusters. The beta cluster contains 16 genes and 3 pseudogenes,
            each encoding 6 extracellular cadherin domains and a cytoplasmic
            tail that deviates from others in the cadherin superfamily. The
            extracellular domains interact in a homophilic manner to specify
            differential cell-cell connections. Unlike the alpha and gamma
            clusters, the transcripts from these genes are made up of only one
            large exon, not sharing common 3' exons as expected. These neural
            cadherin-like cell adhesion proteins are integral plasma membrane
            proteins. Their specific functions are unknown but they most likely
            play a critical role in the establishment and function of specific
            cell-cell neural connections. The transcript for this particular
            family member uses more than one polyadenylation site. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1803616.27540.1, AF217750.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000231137.6/ ENSP00000231137.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               DA779188.1         25-216
            193-3733            AF217750.1         1-3541
            3734-3740           AC244517.2         102228-102234
FEATURES             Location/Qualifiers
     source          1..3740
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..3740
                     /gene="PCDHB7"
                     /gene_synonym="PCDH-BETA7"
                     /note="protocadherin beta 7"
                     /db_xref="GeneID:56129"
                     /db_xref="HGNC:HGNC:8692"
                     /db_xref="MIM:606333"
     exon            1..3740
                     /gene="PCDHB7"
                     /gene_synonym="PCDH-BETA7"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..2574
                     /gene="PCDHB7"
                     /gene_synonym="PCDH-BETA7"
                     /codon_start=1
                     /product="protocadherin beta-7 precursor"
                     /protein_id="NP_061763.1"
                     /db_xref="CCDS:CCDS4249.1"
                     /db_xref="GeneID:56129"
                     /db_xref="HGNC:HGNC:8692"
                     /db_xref="MIM:606333"
                     /translation="MEARVERAVQKRQVLFLCVFLGMSWAGAEPLRYFVAEETERGTF
                     LTNLAKDLGLGVGELRARGTRIVSDQNMQILLLSSLTGDLLLNEKLDREELCGPREPC
                     VLPFQLLLEKPFQIFRAELWVRDINDHAPVFLDREISLKILESTTPGAAFLLESAQDS
                     DVGTNSLSNYTISPNAYFHINVHDSGEGNIYPELVLNQVLDREEIPEFSLTLTALDGG
                     SPPRSGTALVRILVLDVNDNAPDFVRSLYKVQVPENSPVGSMVVSVSARDLDTGSNGE
                     IAYAFSYATERILKTFQINPTSGSLHLKAQLDYEAIQTYTLTIQAKDGGGLSGKCTVV
                     VDVTDINDNRPELLLSSLTSPIAENSPETVVAVFRIRDRDSGNNGKTVCSIQDDVPFI
                     LKPSVENFYTLVTEKPLDRERNTEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPA
                     FTQTSYTLFVRENNSPALPIGSVSATDRDSGTNAQVIYSLLPSQDPHLPLASLVSINA
                     DNGHLFALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQ
                     NSSAPCTEPLPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEV
                     RTARLLSERDAAKQRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLRLPEAAPDQAN
                     SLTVYLVVALASVSSLFLLSVLLFVAVRLCRRSRAAPVGRCSVPEGPFPRHLVDLSGT
                     GTLSQSYQYEVCLTGGSGTNEFKFLKPIIPNLLPQSTGREVEENRPFQNNLGF"
     regulatory      2807..2812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHB7"
                     /gene_synonym="PCDH-BETA7"
                     /note="hexamer: ATTAAA"
     polyA_site      2839
                     /gene="PCDHB7"
                     /gene_synonym="PCDH-BETA7"
                     /note="major polyA site"
ORIGIN      
        1 agagcaaaga ggcaatctga agagaaaagc ataggaaagg aaacagtggt aataggaatt
       61 ggggtaaaat gaggatcctt ccccacaaac attgctatta ttcagctcat ttcaaaggat
      121 tccgctgctg ccatttgtga gagccgctgg aggctgagtg aaagtcattt tgaaagactg
      181 atccaaagaa gaatggaggc cagagtggag cgtgctgtgc agaaaaggca agtcttattt
      241 ctttgtgtat ttctgggaat gtcttgggct ggcgccgaac cgcttcggta ttttgtggcg
      301 gaggaaaccg agagaggcac ctttcttacc aacttggcaa aagacctagg gttaggggta
      361 ggggaactga gagcccgggg aactagaatt gtttcagacc agaacatgca aattttactg
      421 ctcagttcgc ttactggtga tctacttcta aatgagaaat tggaccgaga ggaactgtgt
      481 ggccccagag agccctgtgt gctgcctttc cagttgttat tggaaaaacc ttttcagatt
      541 ttccgtgctg aactatgggt cagagacatc aatgatcacg ctccagtatt tctagacaga
      601 gagatttcct tgaaaatatt agaaagtacc actccagggg cggcatttct cctagagagt
      661 gcacaggatt cagatgttgg aaccaacagc ctgagtaact acaccatcag ccccaatgcc
      721 tatttccata ttaatgtcca tgatagcggg gaggggaata tctatcccga attggtgctg
      781 aatcaagtgc tggatcggga agagatacca gagttcagtt taaccctcac cgctttagac
      841 ggcggctctc ctccaagatc agggaccgcc ctcgtgcgca ttctggttct agacgtaaat
      901 gacaacgccc ctgattttgt gcggtcgctc tacaaggtgc aggtgcccga aaatagcccc
      961 gttggttcca tggttgtctc cgtgtcagcc agagatttag ataccggaag taatggggaa
     1021 atagcctatg cattttctta cgccactgaa agaattctca aaacgtttca aatcaatcca
     1081 acatctggca gtcttcatct taaagcgcaa ttggactatg aggcaattca aacttacaca
     1141 ttaactattc aggccaaaga cggcggcggg ctttctggaa aatgcactgt agtggttgat
     1201 gtaacagata taaacgataa tcgacccgag ctgctcctgt cttcacttac tagcccaatt
     1261 gcagaaaact cacccgagac agtcgtggct gtttttagga ttagagacag agattccggg
     1321 aacaatggaa agacagtgtg ctccatccag gacgatgtcc ccttcatcct gaagccatct
     1381 gtcgaaaact tctatactct ggtaacagag aaacctttgg atcgagagag gaacactgag
     1441 tacaacatca ccatcaccgt caccgacttg gggacaccca ggctgaaaac cgagcacaac
     1501 ataaccgtgc tggtctccga cgtcaatgac aacgctcccg ccttcaccca aacctcctac
     1561 accctgtttg tccgtgagaa caacagcccc gccctgccca tcggcagtgt cagcgccaca
     1621 gacagagact cgggcaccaa cgcccaggtc atctactccc tgctgccgtc ccaggacccg
     1681 cacctgcccc tcgcctccct ggtctccatc aacgcggaca acggccacct gtttgccctc
     1741 aggtccctgg actacgaggc cctgcaggcg ttcgagttcc gcgtgggcgc cacagaccgc
     1801 ggctcccccg cgctgagcag cgaggcgctg gtgcgcgtgc tggtgctgga cgccaacgac
     1861 aactcgccct tcgtgctgta cccgctgcag aacagctccg cgccctgcac cgagccgttg
     1921 ccccgggcgg ccgagccggg ctacctggtg accaaggtgg tggcggtgga cggcgactcg
     1981 ggccagaacg cctggctgtc gtaccagctg ctcaaggcca cggagcccgg gctattcggc
     2041 gtgtgggcgc acaatggcga ggtgcgtacc gccaggctgc tgagcgagcg cgacgcagcc
     2101 aagcagaggc tggtggtgct ggtcaaggac aatggcgagc ctccgcgctc ggccaccgcc
     2161 acgctgcacg tgctcctggt ggacggcttc tcccagccct acctgcggct cccggaggcg
     2221 gccccggacc aggccaactc gctcaccgtc tacctggtgg tggcgttggc ctcggtgtct
     2281 tcgctcttcc tcctctcggt gctcctgttc gtggcggtgc ggctgtgcag gaggagcagg
     2341 gcggccccgg tgggtcgctg ctcggtgcct gagggcccct ttccacgaca tctggtggac
     2401 ttgagcggca ccgggaccct atcccagagc taccagtatg aggtgtgcct gactggaggc
     2461 tccgggacaa atgagttcaa gtttctgaaa ccaattatcc ccaacctgct accccagagc
     2521 acaggcaggg aagtggaaga aaatcgccca tttcagaata atttgggttt ctgataaaga
     2581 atgtaaacta aatccgcgtc tgtgaatacg tttctgatta ggaacttatt gcgaggttcc
     2641 cttaagggag tgtctttaca tcatttcaaa tatgtactct tgaagtcaag caataaattt
     2701 ctatacataa aataggatcc tgatttagta tcaagaaccc ttcacaaagc atgaaatgta
     2761 tatgtgtaat gttttatgtc aaacaattat gcttaatata cagtctatta aatgtaagtc
     2821 ttgtttgaga tattttaaat tgctttccat tgttttcaat ctctactgag acttcctgag
     2881 ttgattagaa agctgtatga gtgtacctac cctagtctca gaagcataga ctgtagagta
     2941 tctttttaag catttttaaa aaatgctttt aatgcatcat acactatttt aacactttta
     3001 atctgagaag aagcatatga ggcatggtat tttaggaatg aacaaataga tggtcttaga
     3061 gattcagtaa gttcactaag ttccactaac taataagtga caaaactgag catccatccc
     3121 agatctgtct gactctgggt cagtgaccct gctccgattc catactgttt tctgtcatta
     3181 gatatcacct ggcaagtttc tgcctaatta aggagaagtc ttttatcata tttatactgc
     3241 tgtccaatct tttctatatt tagaaataat aatgtacata tttatctatg gttttatttt
     3301 cttatacacc aaaagtcctg cttttctggg tcaattttca actattatta ctaatgctct
     3361 gatctgtcca aactcaagcg gaaaacaaaa ttgaaagggc aacctgtgcc ttctcctttc
     3421 ttcagaacat atgactttca tttcccagaa aaaagattaa tggtcctgag taggaatatt
     3481 acataatttt gattgcatca ttagttaatt attttcttca tattgtagat tttctgcagt
     3541 cacccatact taacatttgt aatacatttt cctgatttga aagtttgttt ttaaaagttt
     3601 tctattaatt atagtgcact attgaatcag gaaaatttaa gaaaaagaat agttagtttt
     3661 aaatgcataa tatcaaagag aatcatagat gatcattaaa tttttagaaa ttctcggaag
     3721 ttaaggagaa gcactgtttt
//
