LOCUS       NM_018939               3231 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens protocadherin beta 6 (PCDHB6), transcript variant 1,
            mRNA.
ACCESSION   NM_018939
VERSION     NM_018939.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3231)
  AUTHORS   Frank,M. and Kemler,R.
  TITLE     Protocadherins
  JOURNAL   Curr Opin Cell Biol 14 (5), 557-562 (2002)
   PUBMED   12231349
  REMARK    Review article
REFERENCE   2  (bases 1 to 3231)
  AUTHORS   Vanhalst,K., Kools,P., Vanden Eynde,E. and van Roy,F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   3  (bases 1 to 3231)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   4  (bases 1 to 3231)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   5  (bases 1 to 3231)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   6  (bases 1 to 3231)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   7  (bases 1 to 3231)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244517.2.
            
            On Jul 13, 2020 this sequence version replaced NM_018939.3.
            
            Summary: This gene is a member of the protocadherin beta gene
            cluster, one of three related gene clusters tandemly linked on
            chromosome five. The gene clusters demonstrate an unusual genomic
            organization similar to that of B-cell and T-cell receptor gene
            clusters. Unlike the alpha and gamma clusters, the transcripts from
            these genes do not share common 3' exons. These neural
            cadherin-like cell adhesion proteins are integral plasma membrane
            proteins that most likely play a critical role in the establishment
            and function of specific cell-cell neural connections. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF217752.1, AF152499.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000231136.4/ ENSP00000231136.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3231              AC244517.2         75908-79138
FEATURES             Location/Qualifiers
     source          1..3231
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..3231
                     /gene="PCDHB6"
                     /gene_synonym="PCDH-BETA6"
                     /note="protocadherin beta 6"
                     /db_xref="GeneID:56130"
                     /db_xref="HGNC:HGNC:8691"
                     /db_xref="MIM:606332"
     exon            1..3231
                     /gene="PCDHB6"
                     /gene_synonym="PCDH-BETA6"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..2586
                     /gene="PCDHB6"
                     /gene_synonym="PCDH-BETA6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="protocadherin beta-6 isoform 1 precursor"
                     /protein_id="NP_061762.2"
                     /db_xref="CCDS:CCDS4248.1"
                     /db_xref="GeneID:56130"
                     /db_xref="HGNC:HGNC:8691"
                     /db_xref="MIM:606332"
                     /translation="MMQTKVQNKKRQVAFFILLMLWGEVGSESIQYSVLEETESGTFV
                     ANLTKDLGLRVGELASRGARVVFKGNRQHLQFDPQTHDLLLNEKLDREELCGSTEPCV
                     LPFQVLLENPLQFFQASLRVRDINDHAPEFPAREMLLKISEITMPGKIFPLKMAHDLD
                     TGSNGLQRYTISSNPHFHVLTRNRSEGRKFPELVLDKPLDREEQPQLRLTLIALDGGS
                     PPRSGTSEIQIQVLDINDNVPEFAQELYEAQVPENNPLGSLVITVSARDLDAGSFGKV
                     SYALFQVDDVNQPFEINAITGEIRLRKALDFEEIQSYDVDVEATDGGGLSGKCSLVVR
                     VLDVNDNAPELTMSFFISLIPENLPEITVAVFSVSDADSGHNQQVICSIENNLPFLLR
                     PSVENFYTLVTEGALDRESRAEYNITITVTDLGTPRLKTQQSITVQVSDVNDNAPAFT
                     QTSYTLFVRENNSPALHIGSVSATDRDSGINAQVTYSLLPPQDPHLPLSSLVSINADN
                     GHLFALRSLDYEALQSFEFRVGATDRGSPALSSEALVRLLVLDANDNSPFVLYPLQNG
                     SAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAHNGEVRT
                     ARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPAQAQAD
                     SLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGRYSVPEGPFPGHLVDVSGT
                     GTLSQSYQYKVCLTGGSETNEFKFLKPIMPNFPPQGTEREMEETPTSRNSFPFS"
     regulatory      3206..3211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHB6"
                     /gene_synonym="PCDH-BETA6"
                     /note="hexamer: AATAAA"
     polyA_site      3231
                     /gene="PCDHB6"
                     /gene_synonym="PCDH-BETA6"
                     /note="major polyA site"
ORIGIN      
        1 gtttcatcca gaagccaagt aaaaatacag accacgttta cagctaaagc tgagatagat
       61 gtgtccggga aggcagtcgt cgccagacaa gttgtaagaa cgaatttaaa aatctctgca
      121 aagacatccg agagggtcga cggtagatgt ggtgattggg agctgaaaag gatttttctt
      181 ccgtattcag acataataga catgatgcaa actaaagtac agaacaagaa aaggcaagtg
      241 gctttcttca ttttattgat gctttgggga gaggtgggtt ctgaatcgat tcagtattcc
      301 gtattggagg agacagaaag tggcacgttt gtggccaact tgacaaagga cctgggactg
      361 agggtggggg agctggcttc gcggggcgct cgggttgttt tcaaagggaa cagacaacat
      421 ttgcagtttg atccacagac ccatgattta ctgctaaatg aaaaactgga ccgggaggag
      481 ctgtgtggct ccactgagcc gtgtgtgcta cctttccaag tgttactgga aaaccccttg
      541 cagttttttc aggcttcctt gcgagtcaga gatataaatg accacgcccc ggaattccct
      601 gccagagaaa tgctcctgaa aatatcagaa attactatgc caggaaagat atttcctttg
      661 aaaatggcac acgatttaga caccggcagc aacggccttc agaggtacac aatcagctcc
      721 aaccctcact tccacgttct cacccgcaat cgcagcgaag gcaggaagtt cccggagctg
      781 gtgctagaca aaccgttgga ccgcgaggag cagccccaac tcaggctaac gctgatcgcg
      841 ctggatggcg ggtctccgcc ccggtcaggg acctccgaga ttcagatcca ggttttggac
      901 atcaatgaca acgtccccga gtttgctcag gagctctatg aagcacaagt ccctgagaac
      961 aaccccctcg gctctctggt tattaccgtc tcagccagag atttagatgc aggatcgttt
     1021 gggaaggtat cttacgccct gtttcaagtc gatgacgtca accaaccctt cgaaataaac
     1081 gcaatcacag gagaaattcg gctgagaaag gctttggatt ttgaggaaat tcagtcttat
     1141 gacgtggatg ttgaggctac agatggtgga ggcctatcag gaaaatgctc tttagtcgtc
     1201 agggtcctgg acgtgaatga caatgcccct gaactcacca tgtcgttctt catcagcctc
     1261 atcccagaaa acttaccaga gatcacagtg gcagttttca gtgtttcaga tgcagactct
     1321 ggacataacc aacaggttat ttgttcaata gagaacaatc tcccctttct actaagacct
     1381 tccgtggaga atttctacac cctggtaaca gaaggcgcgc tggacagaga gagcagagcc
     1441 gagtacaaca tcactatcac ggtcactgat ttggggacac caaggctgaa aacccagcag
     1501 agcataactg tgcaggtctc cgacgtcaat gacaacgccc ccgccttcac ccaaacctcc
     1561 tacaccctgt tcgtccgcga gaacaacagc cccgccctgc acatcggcag cgtcagcgcc
     1621 acagacagag actcaggcat caacgcccag gtcacctact cgctgctgcc gccccaggac
     1681 ccgcacctgc ccctctcttc cctggtctcc atcaacgcgg acaacggcca cctgtttgcc
     1741 ctcaggtcgc tggactacga ggccctgcag tctttcgagt tccgcgtggg cgccacagac
     1801 cgcggctccc cggcgttgag cagcgaggcg ctggtgcgct tgctggtgct ggacgccaac
     1861 gacaactcgc ccttcgtgtt gtacccgctg cagaacggct ccgcgccctg caccgagctg
     1921 gtgccccggg cggccgagcc gggctacctg gtgaccaagg tggtggcggt ggacggcgac
     1981 tcgggccaga acgcctggct gtcgtaccag ctgctcaagg ccacggagct cggtctgttc
     2041 ggcgtgtggg cgcacaatgg cgaggtgcgc accgccaggc tgctgagcga gcgagacgca
     2101 gccaagcaca ggctggtggt gcttgtcaag gacaatggcg agcctccgcg ctcggccacc
     2161 gccacgctgc acgtgctcct ggtggacggc ttctcccagc cctacctgcc tctccctgag
     2221 gcggccccgg cccaagccca ggccgactct ctcaccgtct acctggtggt ggcgttggcc
     2281 tcggtgtcgt cgctcttcct cttttcggtg ctcctgttcg tggcggtgcg gctgtgcagg
     2341 aggagcaggg cggcctcggt gggtcgctac tcggtgcccg agggtccctt tccagggcat
     2401 ctggtggatg tgagcggcac cgggacccta tcccagagct accagtacaa ggtgtgtctg
     2461 acgggaggct cagaaacaaa tgagttcaag ttcctgaagc cgattatgcc caacttccct
     2521 cctcagggca ctgagagaga aatggaagaa acccccacct ctcggaatag cttcccgttc
     2581 agttaagtgt gggattattt tactaaatct tacttatgtt tggagatctc ttttaactta
     2641 aagttacatg gtctgtttct tgtttatttt acctctattc tttaggttga aattttatat
     2701 aaagtaagat actggtatct tagtatttcc tgttcatgct tagtagttta ttacttcact
     2761 tgagggtact tgacaatatg aacaaaaagt aaatttttat ttgcataatt ttaagctttt
     2821 gaaattaaat tatctattct tccccccccc aaaaaaaagt attgtaaatc cttaagtaaa
     2881 attgtatttc tagctattgg taagagttgt ttcactattg ctatgtagga ctgtttaaaa
     2941 tgtgagtatc tgatattatt taatcctcca atgtctcatt ttgcagtaac tcctacagtg
     3001 tgtaacacta aaaataagaa ctaatgatgg ctaaacacta aagtagccat tcatacttat
     3061 gcatatttta gtatcccata atagtcaatc caaaattttt gtgactatag actttactga
     3121 agtgtcaaca cattagtttg tgagcctcat gtaagaacat gatggtcttt ttttaaaaaa
     3181 aaagtcgtgc caattataag tgcttaataa atatttgctg aatgttacta a
//
