LOCUS       NM_018938               3806 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens protocadherin beta 4 (PCDHB4), mRNA.
ACCESSION   NM_018938
VERSION     NM_018938.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3806)
  AUTHORS   Frank,M. and Kemler,R.
  TITLE     Protocadherins
  JOURNAL   Curr Opin Cell Biol 14 (5), 557-562 (2002)
   PUBMED   12231349
  REMARK    Review article
REFERENCE   2  (bases 1 to 3806)
  AUTHORS   Vanhalst,K., Kools,P., Vanden Eynde,E. and van Roy,F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   3  (bases 1 to 3806)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   4  (bases 1 to 3806)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   5  (bases 1 to 3806)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   6  (bases 1 to 3806)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   7  (bases 1 to 3806)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA409037.1, AF217754.1 and
            AW135510.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_018938.3.
            
            Summary: This gene is a member of the protocadherin beta gene
            cluster, one of three related gene clusters tandemly linked on
            chromosome five. The gene clusters demonstrate an unusual genomic
            organization similar to that of B-cell and T-cell receptor gene
            clusters. The beta cluster contains 16 genes and 3 pseudogenes,
            each encoding 6 extracellular cadherin domains and a cytoplasmic
            tail that deviates from others in the cadherin superfamily. The
            extracellular domains interact in a homophilic manner to specify
            differential cell-cell connections. Unlike the alpha and gamma
            clusters, the transcripts from these genes are made up of only one
            large exon, not sharing common 3' exons as expected. These neural
            cadherin-like cell adhesion proteins are integral plasma membrane
            proteins. Their specific functions are unknown but they most likely
            play a critical role in the establishment and function of specific
            cell-cell neural connections. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1660809.19460.1, SRR1660805.174070.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000194152.4/ ENSP00000194152.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               DA409037.1         8-188
            182-3565            AF217754.1         1-3384
            3566-3806           AW135510.1         14-254              c
FEATURES             Location/Qualifiers
     source          1..3806
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..3806
                     /gene="PCDHB4"
                     /gene_synonym="PCDH-BETA4"
                     /note="protocadherin beta 4"
                     /db_xref="GeneID:56131"
                     /db_xref="HGNC:HGNC:8689"
                     /db_xref="MIM:606330"
     exon            1..3806
                     /gene="PCDHB4"
                     /gene_synonym="PCDH-BETA4"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..2569
                     /gene="PCDHB4"
                     /gene_synonym="PCDH-BETA4"
                     /codon_start=1
                     /product="protocadherin beta-4 precursor"
                     /protein_id="NP_061761.1"
                     /db_xref="CCDS:CCDS4246.1"
                     /db_xref="GeneID:56131"
                     /db_xref="HGNC:HGNC:8689"
                     /db_xref="MIM:606330"
                     /translation="MKKLGRIHPNRQVLAFILMVFLSQVRLEPIRYSVLEETESGSFV
                     AHLAKDLGLGIGELASRSARVLSDDDKQRLQLDRQTGDLLLREKLDREELCGPIEPCV
                     LHFQVFLEMPVQFFQGELLIQDINDHSPIFPEREVLLKILENSQPGTLFPLLIAEDLD
                     VGSNGLQKYTISPNSHFHILTRNHSEGKKYPDLVQDKPLDREEQPEFSLTLVALDGGS
                     PPRSGTVMVRILIMDINDNAPEFVHTPYGVQVLENSPLDSPIVRVLARDIDAGNFGSV
                     SYGLFQASDEIKQTFSINEVTGEILLKKKLDFEKIKSYHVEIEATDGGGLSGKGTVVI
                     EVVDVNDNPPELIISSLTSSIPENAPETVVSIFRIRDRDSGENGKMICSIPDNLPFIL
                     KPTLKNFYTLVTERPLDRETSAEYNITIAVTDLGTPRLKTQQNITVQVSDVNDNAPAF
                     TQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINAD
                     NGHLFALRSLDYEALQAFEFRVGASDRGSPALSSEALVRVLVLDTNDNSPFVLYPLQN
                     GSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVR
                     TARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPAQAQA
                     DSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGRCSVPEGPFPGHLVDVSG
                     TGTLSQSYQYEVCLTGDSGTGEFKFLKPIFPNLLVQDTGREVKENPKFRNSLVFS"
     regulatory      3785..3790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHB4"
                     /gene_synonym="PCDH-BETA4"
                     /note="hexamer: AATAAA"
     polyA_site      3806
                     /gene="PCDHB4"
                     /gene_synonym="PCDH-BETA4"
                     /note="major polyA site"
ORIGIN      
        1 acacggaaga agcgttacaa gcagtgcagg tttaccaacg gcttggggca gcgatatact
       61 aaacaaattt aatattaaaa gcaactgtgt gacgattcct ccaagcaaga aattggaatt
      121 gaatgtctca agtctcgttg cggttgctga ggggattgga tatagggacc tggactccaa
      181 catgaagaag ctagggagaa ttcatccaaa caggcaagtg ttggccttta ttttgatggt
      241 gttcttgtct caggttcgcc tcgagcctat tcgttattct gtgttggagg aaacagagag
      301 cggctccttt gtagcccatc tggccaagga tctgggcctg ggaattgggg aactggcctc
      361 ccggtcagcc cgggtgctgt ctgacgatga caagcagcgt ttgcagctgg atcgtcagac
      421 tggagatttg cttctgaggg agaaactaga ccgggaagag ctctgtggtc ctattgaacc
      481 gtgtgtactg catttccaag tgttcctgga aatgccggtg caattttttc aaggagaatt
      541 attgatccag gacataaatg atcactctcc aatattccct gaaagggaag tgctcttgaa
      601 aatactagaa aatagccagc cgggtactct atttccgttg ctaatagctg aggatttgga
      661 tgtgggcagc aatggtcttc aaaaatacac aatcagcccc aattctcatt ttcacattct
      721 cactcgaaat catagtgagg gcaagaaata cccagatttg gtgcaggaca aaccactgga
      781 tcgagaggag cagcctgagt tcagcttaac cctcgtggcg ctggatggtg ggtcaccacc
      841 taggtctggc acggtcatgg ttcgaatcct gatcatggac atcaatgaca atgctcctga
      901 gtttgtgcac actccatatg gggtgcaggt cctggaaaac agccccctag actctccaat
      961 tgttagggtc ttagctagag atatagatgc tggaaacttc gggagtgttt cttatggctt
     1021 attccaagca tcagatgaaa ttaaacaaac tttctcaata aatgaagtca cgggagaaat
     1081 actgttgaaa aaaaaattgg atttcgaaaa aattaaatct taccatgtag aaattgaggc
     1141 cacagatgga ggaggccttt ctggaaaagg cactgtagtc atagaggtgg tggatgtgaa
     1201 tgacaatccc ccagaactta tcatatcttc actcaccagc tccatcccag aaaatgctcc
     1261 tgagacggta gtctctatct tccgaattcg agatagagat tccggagaaa atggaaagat
     1321 gatttgctct attccagata atctaccgtt tattctaaaa ccaactttga agaattttta
     1381 caccctggta acagagagac cactggaccg agagaccagc gctgagtaca acatcaccat
     1441 cgccgtcact gacttgggga cacccaggct gaaaacccag cagaacataa ccgtgcaggt
     1501 ctccgacgtc aatgacaacg cccccgcctt cacccaaacc tcctacaccc tgttcgtccg
     1561 cgagaacaac agccccgccc tgcacatcgg cagtgtcagc gccacagaca gagactcggg
     1621 caccaacgcc caggtcacct actcgctgct gccgccccag gacccgcacc tgcccctcgc
     1681 ctccctggtc tccatcaacg cagacaacgg ccacctgttc gccctcaggt cgctggacta
     1741 cgaggccctg caggcgttcg agttccgcgt gggcgcctca gaccgcggtt ctccggcttt
     1801 gagcagcgag gcgctggtgc gcgtgctggt gctggacacc aacgacaact cgcccttcgt
     1861 gctgtacccg ctgcagaatg gctccgcgcc ctgcaccgag ctggtgcccc gggcggccga
     1921 gccgggctac ctggtgacca aggtggtggc ggtggacggc gactcgggcc agaacgcctg
     1981 gctgtcgtac cagctgctca aggccacgga gcctgggctg ttcggcgtgt gggcgcacaa
     2041 tggcgaggtg cgcaccgcca ggctgctgag cgagcgcgac gcagccaagc acaggctcgt
     2101 ggtgcttgtc aaggacaatg gcgagcctcc gcgctcggcc accgccacgc tgcacgtgct
     2161 cctggtggat ggcttctccc agccctacct gcctctccct gaggcggccc cggcccaggc
     2221 ccaggccgac tctctcaccg tctacctggt ggtggcgttg gcctcggtgt cgtcgctctt
     2281 cctcttctcg gtgctcctgt tcgtggcggt gcggctgtgc aggaggagca gggcggcctc
     2341 ggtgggtcgc tgctcggtgc ccgagggccc ctttccaggg catctggtgg acgtaagcgg
     2401 caccgggacc ctgtcccaga gctaccagta cgaggtgtgt ctgacaggag actctgggac
     2461 tggtgagttc aagttcctga agccaatatt tcctaatctc ttggttcagg acaccgggag
     2521 ggaagttaag gaaaacccca agttcagaaa tagcttggta ttcagttaag tattgtattt
     2581 agttcagtga accgcccgtt agttttgtca aacttcccac tgcaatgcct ttatttaaaa
     2641 aaattgtcta cttatctaaa tattcatacc acaatttcaa acctactcat gtccctgata
     2701 aagctaaatt tgtccctttt ttattgttat taattgcact taacattttt agttatactg
     2761 gatattgagt atggattttc tctatatttg atctattggt gattaatctt tttgtaatca
     2821 taaattactc aattaggata aaaataaatt atgttttaat gaaattctta aattaacatc
     2881 tttttaatgg aacatttaag tgaatatatg aatattgaat ttctaaatat ttgttgtgcc
     2941 tgtctttacc atgtaactta atgtttgcaa ggccagagtg tttgaaagtt ttgtatttaa
     3001 ctttataatt accttgtcct ttctggttga ctatactagg ctaagccctc ttaatagcca
     3061 tgagtgtaaa atttagttta ctcatttttc acaaattgta tataaacatg cacttcacta
     3121 cattggtaat acactaaaat tgtggtcctt ttcctcttgt gaccaccaca tgtctagtga
     3181 ttattttgtt tatttggttg ctacttacct agcacattgt aatgttccat gaatgctaat
     3241 attaaatttt gtaaaaataa cttatttata aataattttt aaagagaaaa atctcatata
     3301 atttgtcata acctttcaat aaataaaact gttaaatcat ggcctgatat catcttaaaa
     3361 aaaaatctca gaatctgaaa taagccctaa atttctcccc aaaatcaaga ctcttgagag
     3421 catcataggt ctccttgtgc taccttttac tccctataaa tagaaatcca agtatacttt
     3481 aatatgtgta tattttttgg ttttcctaca gcttctcccc atctttcaaa agaatcacga
     3541 aatttcttct gcaccttggc tattctgttt aaatctgata atcagttgat ctcaggtttt
     3601 tcactgtaca ttactttgca gatatggaca gcctttacaa aaataatttt taaatgctta
     3661 attattttaa tttgttcttt aaggtaacct tcagttattt tgaattaatt taacttctca
     3721 attatgccaa agttgcactt gcatgaaata aatattattt tgtccttgta tagactggaa
     3781 cagtaataaa tttatctgaa ttaaaa
//
