LOCUS       NM_018936               4089 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens protocadherin beta 2 (PCDHB2), mRNA.
ACCESSION   NM_018936
VERSION     NM_018936.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4089)
  AUTHORS   Frank,M. and Kemler,R.
  TITLE     Protocadherins
  JOURNAL   Curr Opin Cell Biol 14 (5), 557-562 (2002)
   PUBMED   12231349
  REMARK    Review article
REFERENCE   2  (bases 1 to 4089)
  AUTHORS   Vanhalst,K., Kools,P., Vanden Eynde,E. and van Roy,F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   3  (bases 1 to 4089)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   4  (bases 1 to 4089)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   5  (bases 1 to 4089)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   6  (bases 1 to 4089)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   7  (bases 1 to 4089)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA703023.1, BC098575.1,
            AF217756.1, BE502304.1 and AC244517.2.
            
            On May 17, 2019 this sequence version replaced NM_018936.3.
            
            Summary: This gene is a member of the protocadherin beta gene
            cluster, one of three related gene clusters tandemly linked on
            chromosome five. The gene clusters demonstrate an unusual genomic
            organization similar to that of B-cell and T-cell receptor gene
            clusters. The beta cluster contains 16 genes and 3 pseudogenes,
            each encoding 6 extracellular cadherin domains and a cytoplasmic
            tail that deviates from others in the cadherin superfamily. The
            extracellular domains interact in a homophilic manner to specify
            differential cell-cell connections. Unlike the alpha and gamma
            clusters, the transcripts from these genes are made up of only one
            large exon, not sharing common 3' exons as expected. These neural
            cadherin-like cell adhesion proteins are integral plasma membrane
            proteins. Their specific functions are unknown but they most likely
            play a critical role in the establishment and function of specific
            cell-cell neural connections. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1660805.221139.1,
                                        SRR1803615.169890.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000194155.7/ ENSP00000194155.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                DA703023.1         9-36
            29-176              BC098575.1         1-148
            177-2300            AF217756.1         1-2124
            2301-2766           BE502304.1         6-471               c
            2767-4089           AC244517.2         23232-24554
FEATURES             Location/Qualifiers
     source          1..4089
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..4089
                     /gene="PCDHB2"
                     /gene_synonym="PCDH-BETA2"
                     /note="protocadherin beta 2"
                     /db_xref="GeneID:56133"
                     /db_xref="HGNC:HGNC:8687"
                     /db_xref="MIM:606328"
     exon            1..4089
                     /gene="PCDHB2"
                     /gene_synonym="PCDH-BETA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..2573
                     /gene="PCDHB2"
                     /gene_synonym="PCDH-BETA2"
                     /codon_start=1
                     /product="protocadherin beta-2 precursor"
                     /protein_id="NP_061759.1"
                     /db_xref="CCDS:CCDS4244.1"
                     /db_xref="GeneID:56133"
                     /db_xref="HGNC:HGNC:8687"
                     /db_xref="MIM:606328"
                     /translation="MEAGEGKERVPKQRQVLIFFVLLGIAQASCQPRHYSVAEETESG
                     SFVANLLKDLGLEIGELAVRGARVVSKGKKMHLQFDRQTGDLLLNEKLDREELCGPTE
                     PCVLPFQVLLENPLQFFQAELRIRDVNDHSPVFLDKEILLKIPESITPGTTFLIERAQ
                     DLDVGTNSLQNYTISPNFHFHLNLQDSLDGIILPQLVLNRALDREEQPEIRLTLTALD
                     GGSPPRSGTALVRIEVVDINDNVPEFAKLLYEVQIPEDSPVGSQVAIVSARDLDIGTN
                     GEISYAFSQASEDIRKTFRLSAKSGELLLRQKLDFESIQTYTVNIQATDGGGLSGTCV
                     VFVQVMDLNDNPPELTMSTLINQIPENLQDTLIAVFSVSDPDSGDNGRMVCSIQDDLP
                     FFLKPSVENFYTLVISTALDRETRSEYNITITVTDFGTPRLKTEHNITVLVSDVNDNA
                     PAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSI
                     NADNGHLFALQSLDYEALQAFEFRVGAADRGSPALSSEALVRVLVLDANDNSPFVLYP
                     LQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG
                     EVRTARLLRERDAAKQRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLLLPEAAPAQ
                     AQADLLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGRCSVPEGPFPGQMVD
                     VSGTGTLSQSYQYEVCLTGGSGTNEFKFLKPIIPNFVAQGAERVSEANPSFRKSFEFT
                     "
     regulatory      2738..2743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHB2"
                     /gene_synonym="PCDH-BETA2"
                     /note="hexamer: AATAAA"
     polyA_site      2766
                     /gene="PCDHB2"
                     /gene_synonym="PCDH-BETA2"
                     /note="major polyA site"
     regulatory      4064..4069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHB2"
                     /gene_synonym="PCDH-BETA2"
                     /note="hexamer: AATAAA"
     polyA_site      4089
                     /gene="PCDHB2"
                     /gene_synonym="PCDH-BETA2"
                     /note="major polyA site"
ORIGIN      
        1 agatactcag ctaaagaagc agcaagcagg aagaggaggc tttctaaggc ggtcgctccg
       61 ggaaatccgg gccctaggat tgtccactca tcccagtatc agcgagatac ggggagatag
      121 agttagcgac aacgtgagcc agagctggag cacgtttggt gagagaccag aaagcaatgg
      181 aggccggaga ggggaaggag cgcgttccga aacaaaggca agtcctgata ttctttgttt
      241 tgctgggcat agctcaggct agttgccagc ctaggcacta ttcagtggcc gaggaaacgg
      301 agagtggctc ctttgtggcc aatttgttaa aagacctggg gctggagata ggagaacttg
      361 ctgtgagggg ggccagggtc gtttccaaag gaaaaaaaat gcatttgcag ttcgataggc
      421 agaccgggga tttgttgtta aatgagaaat tggaccggga ggagctgtgc ggccccacag
      481 agccctgtgt cctacctttc caggtgttac tagaaaatcc cttgcagttt tttcaggcgg
      541 agctacggat tagggacgta aatgatcatt ccccagtttt cctagacaaa gaaatacttt
      601 tgaaaattcc agaaagtatc actcctggaa ctactttctt aatagaacgt gcccaggact
      661 tggatgtagg aaccaacagt ctccaaaatt acacaatcag tcccaatttc cactttcatc
      721 ttaatttaca agacagtctc gatggcataa tattaccaca gctggtgctg aacagagccc
      781 tggatcgcga ggagcagcct gagatcaggt taaccctcac agcgctagat ggcgggagtc
      841 cacccaggtc cggcacggcc ctggtacgga ttgaagttgt ggacatcaat gacaacgtcc
      901 cagagtttgc aaagctgctc tatgaggtgc agatcccgga ggacagcccc gttggatccc
      961 aggttgccat cgtctctgcc agggatttag acattggaac taatggagaa atatcttatg
     1021 cattttccca agcatctgaa gacattcgca aaacgtttcg attaagtgca aaatcgggag
     1081 aactgctttt aagacagaaa ctggatttcg aatccatcca gacatacaca gtaaatattc
     1141 aggcgacaga tggtgggggc ctatctggaa cttgtgtggt atttgtccaa gtgatggatt
     1201 tgaatgacaa tcctccggaa ctaactatgt cgacacttat caatcagatc ccagaaaact
     1261 tgcaggacac cctcattgct gtattcagcg tttcagatcc tgactccgga gacaacggaa
     1321 ggatggtgtg ctccatccaa gatgatcttc cttttttctt gaaaccttct gttgagaact
     1381 tttacactct ggtgataagc acggccctgg accgggagac cagatccgaa tacaacatca
     1441 ccatcaccgt caccgacttc gggacaccca ggctgaaaac cgagcacaac ataaccgtgc
     1501 tggtctccga cgtcaatgac aacgcccccg ccttcaccca aacctcctac accctgttcg
     1561 tccgcgagaa caacagcccc gccctgcaca tcggcagcgt cagcgccaca gacagagact
     1621 cgggcaccaa cgcccaggtc acctactcgc tgctgccgcc ccaggacccg cacctgcccc
     1681 tcgcctccct ggtctccatc aacgcggaca acggccacct gttcgctctc cagtcgctgg
     1741 actacgaggc cctgcaggcg ttcgagttcc gcgtgggcgc cgcagaccgc ggctccccgg
     1801 cgttgagcag cgaggcgctg gtgcgcgtgc tggtgctgga cgccaacgac aactcgccct
     1861 tcgtgctgta cccgctgcag aacggctccg cgccctgcac cgagctggtg ccccgggcgg
     1921 ccgagccggg ctacctggtg accaaggtgg tggcggtgga cggcgactcg ggccagaacg
     1981 cctggctgtc gtaccagctg ctcaaggcca cggagcccgg gctgttcggc gtgtgggcgc
     2041 acaatggcga ggtgcgcacc gccaggctgc tgagggagcg cgacgctgcc aagcagaggc
     2101 tggtggtgct ggtcaaggac aatggcgagc ctccgcgctc ggccaccgcc acgctgcacg
     2161 tgctcctggt ggacggcttc tcccagccct acctgctgct cccggaggcg gcaccggccc
     2221 aggcccaggc cgacttgctc accgtctacc tggtggtggc gttggcctcg gtgtcttcgc
     2281 tcttcctctt ctcggtgctc ctgttcgtgg cggtgcggct gtgcaggagg agcagggcgg
     2341 cctcggtggg tcgctgctcg gtgcccgagg gcccctttcc agggcagatg gtggacgtga
     2401 gcggcaccgg gaccctgtcc cagagctacc agtacgaggt gtgtctgact ggaggctccg
     2461 ggacaaatga gttcaagttc ctgaagccaa ttatccccaa cttcgttgct cagggtgcag
     2521 agagggttag cgaggcaaat cccagtttca ggaagagctt tgaattcact taagtgttaa
     2581 taaggatcta ctgaggctag tctcgtttaa tttgtggaaa gtcctttttt actgctttgc
     2641 ccattggagg tgtctccttt tattagaaag taaccatctt attccaattc tatgcatgtt
     2701 actggtattt ataaatgtat gagttttttt gcggtataat aaatgtaaat tttctttgta
     2761 ttctaattgt tggttagttt cattgcaatt taattgcatt taaagtgtaa aagtaaattt
     2821 tgtattttca gaaatcttta agttagagca tcttttccag acctcacagt ctatggtcct
     2881 agataatttt gaagtcctac atttgaaaat atttgttatc attacatgag ttatattttc
     2941 cagcccagaa tatttgtgtt ttttatatcc tcttaggcta gtgtaaattc tatcctgtga
     3001 attcacattg gctaaccctt taaataggta tatttatgaa taatatagca agcaccgtcc
     3061 ttacgttttt caatatatgt aatttttttt tttttttgag atggagtttt gcacttgttg
     3121 ctcaggctgt agtggagtgc aatggcgcaa tctcggctcg ccgcaacctc tgcctcccgg
     3181 gttcaagcga ttctcctgcc tcagcctccc aagtagctgg gattacaggc atgcatcatt
     3241 atgcccggct aattttgtat ttttagtaga gacagggtgt ctccatgttg gtcaggttgg
     3301 tcttgaactc ctgaccttag gtgatctgcc cacctcagcc tcccaaagtg ctgggattac
     3361 aggcgtgagc caccgccccc cagtccaata tgtatacttc tttcaagtgt tgacatatga
     3421 aaagtattag tctttagaga ttgtaagaat tttaactgtt ggattctaca aggcactaac
     3481 atcataagtg ctctaataaa tttttgtcaa aagtcaatca ttaatattca aaaatgtaga
     3541 taaataatac atgtctagca attttcaaag gcatgctaat tcatcatgct ttctctttca
     3601 aatagttttt ttaagagccc tctgcttatt ccagtccccc cctttaaaat cttttaaaat
     3661 tattaataac ctattaactt tgagcacttc attaaaatcc aaaaaatttg agggagtaca
     3721 tgtctttgtc ctttaccttt agaaccctca aacatagctt ggtattgctg tttttaaaat
     3781 tttctggagc atttaggatt cacttagaaa caagccttta gggagaaaaa tttatctagc
     3841 accactcact ctattttttt gcactgacta cttctatttt tccccctttc atttccctag
     3901 acttttcaat gcttttttat aaaggtgctt gagttctgtt tctcaacagc tccctcattt
     3961 attgaatgat tcacacagtc actggaatat tataggctct taataaaatt tttgaatgat
     4021 tgaaagagag aaaagtattt tacctgtgat atattgatat ttaaataaac tagaacactt
     4081 aaaggaaaa
//
