LOCUS       NM_018935               3971 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens protocadherin beta 15 (PCDHB15), mRNA.
ACCESSION   NM_018935
VERSION     NM_018935.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3971)
  AUTHORS   Vanhalst,K., Kools,P., Vanden Eynde,E. and van Roy,F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   2  (bases 1 to 3971)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   3  (bases 1 to 3971)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   4  (bases 1 to 3971)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   5  (bases 1 to 3971)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   6  (bases 1 to 3971)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312794.1, BC038797.1,
            AF217742.1, AI473490.1 and AC244517.2.
            
            On Nov 23, 2018 this sequence version replaced NM_018935.3.
            
            Summary: This gene is a member of the protocadherin beta gene
            cluster, one of three related gene clusters tandemly linked on
            chromosome five. The gene clusters demonstrate an unusual genomic
            organization similar to that of B-cell and T-cell receptor gene
            clusters. The beta cluster contains 16 genes and 3 pseudogenes,
            each encoding 6 extracellular cadherin domains and a cytoplasmic
            tail that deviates from others in the cadherin superfamily. The
            extracellular domains interact in a homophilic manner to specify
            differential cell-cell connections. Unlike the alpha and gamma
            clusters, the transcripts from these genes are made up of only one
            large exon, not sharing common 3' exons as expected. These neural
            cadherin-like cell adhesion proteins are integral plasma membrane
            proteins. Their specific functions are unknown but they most likely
            play a critical role in the establishment and function of specific
            cell-cell neural connections. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1803616.131073.1,
                                        SRR1803615.178351.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000231173.6/ ENSP00000231173.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AK312794.1         48-65
            19-184              BC038797.1         1-166
            185-2625            AF217742.1         1-2441
            2626-2840           AI473490.1         6-220               c
            2841-3971           AC244517.2         174086-175216
FEATURES             Location/Qualifiers
     source          1..3971
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..3971
                     /gene="PCDHB15"
                     /gene_synonym="PCDH-BETA15"
                     /note="protocadherin beta 15"
                     /db_xref="GeneID:56121"
                     /db_xref="HGNC:HGNC:8686"
                     /db_xref="MIM:606341"
     exon            1..3971
                     /gene="PCDHB15"
                     /gene_synonym="PCDH-BETA15"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..2548
                     /gene="PCDHB15"
                     /gene_synonym="PCDH-BETA15"
                     /codon_start=1
                     /product="protocadherin beta-15 precursor"
                     /protein_id="NP_061758.1"
                     /db_xref="CCDS:CCDS4257.1"
                     /db_xref="GeneID:56121"
                     /db_xref="HGNC:HGNC:8686"
                     /db_xref="MIM:606341"
                     /translation="MEPAGERFPEQRQVLILLLLLEVTLAGWEPRRYSVMEETERGSF
                     VANLANDLGLGVGELAERGARVVSEDNEQGLQLDLQTGQLILNEKLDREKLCGPTEPC
                     IMHFQVLLKKPLEVFRAELLVTDINDHSPEFPEREMTLKIPETSSLGTVFPLKKARDL
                     DVGSNNVQNYNISPNSHFHVSTRTRGDGRKYPELVLDTELDREEQAELRLTLTAVDGG
                     SPPRSGTVQILILVLDANDNAPEFVQALYEVQVPENSPVGSLVVKVSARDLDTGTNGE
                     ISYSLYYSSQEIDKPFELSSLSGEIRLIKKLDFETMSSYDLDIEASDGGGLSGKCSVS
                     VKVLDVNDNFPELSISSLTSPIPENSPETEVALFRIRDRDSGENGKMICSIQDDVPFK
                     LKPSVENFYRLVTEGALDRETRAEYNITITITDLGTPRLKTEQSITVLVSDVNDNAPA
                     FTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPRDPHLPLTSLVSINT
                     DNGHLFALQSLDYEALQAFEFRVGATDRGFPALSSEALVRVLVLDANDNSPFVLYPLQ
                     NGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEV
                     RTARLLSERDVAKHRLVVLVKDNGEPPRSATATLQVLLVDGFSQPYLPLPEAAPAQAQ
                     ADSLTVYLVVALASVSSLFLFSVFLFVAVRLCRRSRAASVGRCSVPEGPFPGHLVDVS
                     GTGTLSQSYQYEVCLTGGSESNDFKFLKPIFPNIVSQDSRRKSEFLE"
     regulatory      2816..2821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHB15"
                     /gene_synonym="PCDH-BETA15"
                     /note="hexamer: AATAAA"
     polyA_site      2840
                     /gene="PCDHB15"
                     /gene_synonym="PCDH-BETA15"
     regulatory      3952..3957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHB15"
                     /gene_synonym="PCDH-BETA15"
                     /note="hexamer: AATAAA"
     polyA_site      3971
                     /gene="PCDHB15"
                     /gene_synonym="PCDH-BETA15"
                     /note="major polyA site"
ORIGIN      
        1 agacctcttt cagcctaaga ggaaagcctg ttagcagagc acggaccagt gtctccggag
       61 aatgctattc tcctacattt ccgaacaggt tatcaacgca cagatcgatc actgcctctg
      121 tcccatcgct ccctgaagta gctctgactc cggttccttg aaaggggcgt gtacagaagt
      181 aaagatggag cctgcagggg agcgctttcc cgaacaaagg caagtcctga ttctccttct
      241 tttactggaa gtgactctgg caggctggga accccgtcgc tattctgtga tggaggaaac
      301 agagagaggt tcttttgtag ccaacctggc caatgaccta gggctgggag tgggggagct
      361 agccgagcgg ggagcccggg tagtttctga ggataacgaa caaggcttgc agcttgatct
      421 gcagaccggg cagttgatat taaatgagaa gctggaccgg gagaagctgt gtggccctac
      481 tgagccctgt ataatgcatt tccaagtgtt actgaaaaaa cctttggaag tatttcgagc
      541 tgaactacta gtgacagaca taaacgatca ttctcctgag tttcctgaaa gagaaatgac
      601 cctgaaaatc ccagaaacta gctcccttgg gactgtgttt cctctgaaaa aagctcggga
      661 cttggacgtg ggcagcaata atgttcaaaa ctacaatatt tctcccaatt ctcatttcca
      721 tgtttccact cgcacccgag gggatggcag gaaataccca gagctggtgc tggacacaga
      781 actggatcgc gaggagcagg ccgagctcag attaaccttg acagcggtgg acggtggctc
      841 tccaccccga tctggcaccg tccagatcct catcttggtc ttggacgcca atgacaatgc
      901 cccggagttt gtgcaggcgc tctacgaggt gcaggtccca gagaacagcc cagtaggctc
      961 cctagttgtc aaggtctctg ctagggattt agacactggg acaaatggag agatatcata
     1021 ctccctttat tacagctctc aggagataga caaacctttt gagctaagca gcctttcagg
     1081 agaaattcga ctaattaaaa aactagattt tgagacaatg tcttcgtatg atctagatat
     1141 agaggcatct gatggcgggg gactttctgg aaaatgctct gtctctgtta aggtgctgga
     1201 tgttaacgat aacttcccgg aactaagtat ttcatcactt accagcccta ttcccgagaa
     1261 ttctccagag acagaagtgg ccctgtttag gattagagac cgagactctg gggaaaatgg
     1321 aaaaatgatt tgctcaattc aggatgatgt tccttttaag ctaaaacctt ctgttgagaa
     1381 tttctacagg ctggtaacag aaggggcgct ggacagagag accagagccg agtacaacat
     1441 caccatcacc atcacagact tggggactcc aaggctgaaa accgagcaga gcataaccgt
     1501 gctggtgtcg gacgtcaatg acaacgcccc cgccttcacc caaacctcct acaccctgtt
     1561 cgtccgcgag aacaacagcc ccgccctgca catcggcagt gtcagcgcca cagacagaga
     1621 ctcgggcacc aacgcccagg tcacctactc gctgctgccg ccccgggacc cgcacctgcc
     1681 cctcacctcc ctggtctcca ttaacacgga caacggccac ctgttcgctc tccagtcgct
     1741 ggactacgag gccctgcagg ctttcgagtt ccgcgtgggc gccacagacc gcggcttccc
     1801 ggcgctgagc agcgaggcgc tggtgcgagt gctggtgctg gacgccaacg acaactcgcc
     1861 cttcgtgctg tacccgctgc agaacggctc cgcgccctgc accgagctgg tgccccgggc
     1921 ggccgagccg ggctacctgg tgaccaaggt ggtggcggtg gacggcgact cgggccagaa
     1981 cgcctggctg tcgtaccagc tgctcaaggc cacggagccc gggctgttcg gcgtgtgggc
     2041 gcacaatggc gaggtgcgca ccgccaggct gctgagcgag cgcgacgtgg ccaagcacag
     2101 gctagtggtg ctggtcaagg acaatggcga gcctccgcgc tcggccaccg ccacgctgca
     2161 agtgctcctg gtggacggct tctctcagcc ctacctgccg ctcccagagg cggccccggc
     2221 ccaagcccag gccgactcgc ttaccgtcta cctggtggtg gcattggcct cggtgtcttc
     2281 gctcttcctc ttctcggtgt tcctgttcgt ggcagtgcgg ctgtgcagga ggagcagggc
     2341 ggcctcagtg ggtcgctgct cggtgcccga gggccccttt ccagggcatc tggtggacgt
     2401 gagcggcacc gggacccttt cccagagcta ccagtacgag gtgtgtctga cgggaggctc
     2461 tgaaagtaat gatttcaagt tcttgaagcc tatattccca aatattgtaa gccaggactc
     2521 taggaggaaa tcagaatttc tagaataatg taggtatctg tagctttccg accgtctgtt
     2581 aattttgtct tcctcacttt tcaccttagt tttttttaac cctttagtaa tcttgaattc
     2641 tacttttttt taaatttcta ctgttgtctt tagtaatgtt actcatttcc tttgtctgat
     2701 tgttagtttt caaattattg tattattata aatattttat atcaggaaag ttcatatttc
     2761 tgaataaatt aatagtattc attcctgaag ggtgatatga aagttaaccc cacctaataa
     2821 acataactct aattctgaaa ttacctttca cactatatga cactacataa gaatgtatga
     2881 tttttgaagt catattttaa gtttttttta tagtttttct tattcacaca gcttgacttt
     2941 ttgacaaaag tttggggtgt aatcatttca tatttatcca tgtgtaattt cttccaagct
     3001 tcatatttgg agttttgttt tttccaataa ggagcaacat ggataagttt aagctactct
     3061 tttcaaggtc acacttgtaa gcattagatt ttcattctaa aacacatatg tcatctcata
     3121 aaaatatatc tgcgtaatgt attctgtctc atgtaaatta acatagaaaa gactaatggg
     3181 ttcttcctta tctctatcta atgttatgat cctattgggg ggactggaca ggctttctaa
     3241 tacccagatt tactgtgttt aaggtgttcg tataaggcca atagacacta ggaccaagta
     3301 atgcatctcc tgcaatttcc tcttttcaca gcaggaaaat cttaacgagt tccaaattct
     3361 gggcttagag gagcttctga tggtacagta tgccaacatc tacttgtttt ggatggcaac
     3421 attgttctga ttcataagga atttgaaaga aaatacattg tagaattaat attagttaac
     3481 caaacaaaat ttattaaagg atatgttggt gaaggagttg aattatttga ggaaaaaaca
     3541 tctgctctct tgtcaggact tttctgtctc caggagcttc tcaactttgc agatactcta
     3601 gaatggtatt gcatgcaaaa taatgaccgc caagatgttc ctgccctaat ccccagaacc
     3661 tatgaatatg ttatattgca aagaaattaa ggttcaaaca gaattaaggt tgccaatcag
     3721 ctaaacttaa aatagggaga ctctcctaga taatctgggt gggtctattt caatcagtgg
     3781 aaaggccata aaagcagagt tgagtcttcc gtgagatgaa aataaatttt gtttaaggac
     3841 agcagcttca gcttatgccc cagaattcca gcctgcccct cctaactgcc tgctgtacag
     3901 attttggact tgtccagcca cgtttcaaaa ctgagtaagt cacttccttg caataaattg
     3961 attactacac a
//
