LOCUS       NM_018934               4417 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens protocadherin beta 14 (PCDHB14), mRNA.
ACCESSION   NM_018934
VERSION     NM_018934.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4417)
  AUTHORS   Liu,Y., Ouyang,L., Mao,C., Chen,Y., Li,T., Liu,N., Wang,Z., Lai,W.,
            Zhou,Y., Cao,Y., Liu,S., Liang,Y., Wang,M., Liu,S., Chen,L.,
            Shi,Y., Xiao,D. and Tao,Y.
  TITLE     PCDHB14 promotes ferroptosis and is a novel tumor suppressor in
            hepatocellular carcinoma
  JOURNAL   Oncogene 41 (27), 3570-3583 (2022)
   PUBMED   35688944
  REMARK    GeneRIF: PCDHB14 promotes ferroptosis and is a novel tumor
            suppressor in hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 4417)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4417)
  AUTHORS   Halder,D., Mandal,C., Lee,B.H., Lee,J.S., Choi,M.R., Chai,J.C.,
            Lee,Y.S., Jung,K.H. and Chai,Y.G.
  TITLE     PCDHB14- and GABRB1-like nervous system developmental genes are
            altered during early neuronal differentiation of NCCIT cells
            treated with ethanol
  JOURNAL   Hum Exp Toxicol 34 (10), 1017-1027 (2015)
   PUBMED   25566775
  REMARK    GeneRIF: PCDHB14- and GABRB1-like nervous system developmental
            genes are altered during early neuronal differentiation of NCCIT
            cells treated with ethanol
REFERENCE   4  (bases 1 to 4417)
  AUTHORS   Frank,M. and Kemler,R.
  TITLE     Protocadherins
  JOURNAL   Curr Opin Cell Biol 14 (5), 557-562 (2002)
   PUBMED   12231349
  REMARK    Review article
REFERENCE   5  (bases 1 to 4417)
  AUTHORS   Vanhalst,K., Kools,P., Vanden Eynde,E. and van Roy,F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   6  (bases 1 to 4417)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   7  (bases 1 to 4417)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   8  (bases 1 to 4417)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   9  (bases 1 to 4417)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
REFERENCE   10 (bases 1 to 4417)
  AUTHORS   Matsuyoshi,N., Tanaka,T., Toda,K. and Imamura,S.
  TITLE     Identification of novel cadherins expressed in human melanoma cells
  JOURNAL   J Invest Dermatol 108 (6), 908-913 (1997)
   PUBMED   9182820
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC050417.1, AF217744.1,
            AI206913.1 and AC244517.2.
            
            On Aug 11, 2020 this sequence version replaced NM_018934.3.
            
            Summary: This gene is a member of the protocadherin beta gene
            cluster, one of three related gene clusters tandemly linked on
            chromosome five. The gene clusters demonstrate an unusual genomic
            organization similar to that of B-cell and T-cell receptor gene
            clusters. The beta cluster contains 16 genes and 3 pseudogenes,
            each encoding 6 extracellular cadherin domains and a cytoplasmic
            tail that deviates from others in the cadherin superfamily. The
            extracellular domains interact in a homophilic manner to specify
            differential cell-cell connections. Unlike the alpha and gamma
            clusters, the transcripts from these genes are made up of only one
            large exon, not sharing common 3' exons as expected. These neural
            cadherin-like cell adhesion proteins are integral plasma membrane
            proteins. Their specific functions are unknown but they most likely
            play a critical role in the establishment and function of specific
            cell-cell neural connections. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF217744.1, AK074555.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239449.7/ ENSP00000239449.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               BC050417.1         412-574
            164-2907            AF217744.1         1-2744
            2908-2946           AI206913.1         11-49               c
            2947-4417           AC244517.2         152140-153610
FEATURES             Location/Qualifiers
     source          1..4417
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..4417
                     /gene="PCDHB14"
                     /gene_synonym="PCDH-BETA14"
                     /note="protocadherin beta 14"
                     /db_xref="GeneID:56122"
                     /db_xref="HGNC:HGNC:8685"
                     /db_xref="MIM:606340"
     exon            1..4417
                     /gene="PCDHB14"
                     /gene_synonym="PCDH-BETA14"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..2560
                     /gene="PCDHB14"
                     /gene_synonym="PCDH-BETA14"
                     /codon_start=1
                     /product="protocadherin beta-14 precursor"
                     /protein_id="NP_061757.1"
                     /db_xref="CCDS:CCDS4256.1"
                     /db_xref="GeneID:56122"
                     /db_xref="HGNC:HGNC:8685"
                     /db_xref="MIM:606340"
                     /translation="MEIRGALDLRKRQVLIFLVLLGLSRAGTESAHYSVAEETEIGSF
                     VANLARDLGLGVEELSSREARVVSDDNKKYLHLDLLTGNLLLNEKLDRDELCGSTEPC
                     VLHFQVVLENPLQFFRFELCVKDINDHSPTFLDKEILIKISEGTTVGATFLMESAQDL
                     DVGSNSLQNYTISPNSHFYIKIPDSSDRKIYPELVLDRALDYEQEAELRLTLTAVDGG
                     SPPKSGTTLVLIKVLDINDNAPEFPQSLYEVQVPEDRPLGSWIATISAKDLDAGNYGK
                     ISYTFFHASEDIRKTFEINPISGEVNLRSPLDFEVIQSYTINIQATDGGGLSGKCTLL
                     VKVMDINDNPPEVTISSITKRIPENASETLVALFSILDQDSGDNGRMICSIQDNLPFF
                     LKPTFKNFFTLVSEKALDRESQAEYNITITVTDLGTPRLKTEYNITVLLSDVNDNAPT
                     FTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVNYSLLPPQDRHLPLASLVSINA
                     DNGHLFALRSLDYEALQEFEFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQ
                     NGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEV
                     RTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPAQAQ
                     ADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGRCSVPEGPFPGHLVDVS
                     GTGTLSQSYQYEVCLTGGSGTNEFKFLKPIIPNFQVHDTGRNMGEIENFRNSFGLNIQ
                     "
     regulatory      2928..2933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHB14"
                     /gene_synonym="PCDH-BETA14"
                     /note="hexamer: AATAAA"
     polyA_site      2959
                     /gene="PCDHB14"
                     /gene_synonym="PCDH-BETA14"
                     /note="major polyA site"
     regulatory      4399..4404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHB14"
                     /gene_synonym="PCDH-BETA14"
                     /note="hexamer: AATAAA"
     polyA_site      4414
                     /gene="PCDHB14"
                     /gene_synonym="PCDH-BETA14"
     polyA_site      4417
                     /gene="PCDHB14"
                     /gene_synonym="PCDH-BETA14"
                     /note="major polyA site"
ORIGIN      
        1 agaaagcatc caacccactg aaaagacagg cattaaagga gcttcgccta cagagctgct
       61 ggaggataca ctctccaggg ggttcctgtt aaaaaccaga gcttcagctt ccaaaattac
      121 ggctgagctt cagtttttcc acaagagatt gcctaaagga accatggaga tcagaggggc
      181 actcgatctg cgaaaaaggc aagttctaat attccttgtt ttgctgggat tgtctcgggc
      241 aggtactgaa tctgcacact attctgtggc agaggaaaca gaaattggct cttttgtggc
      301 taatctagcg agggacctag ggctgggggt ggaggagctg tcttcacgtg aagcccgggt
      361 agtgtctgat gataataaaa agtatttgca ccttgatttg ctgactggga atttgctcct
      421 aaatgagaaa ctagaccgag acgagctgtg tggctccacc gagccctgtg tgctgcattt
      481 tcaggtggtt ttggaaaacc ctttacagtt ttttcggttt gagctgtgtg tcaaagacat
      541 aaatgatcac tcccctacat ttctagacaa ggaaatactt attaaaatat cagaaggtac
      601 cactgttgga gctacctttc taatggagag tgctcaagat ttggatgtcg gaagcaacag
      661 tctccaaaac tacacaatta gccccaattc tcacttctac attaaaattc ccgacagtag
      721 tgacagaaag atatacccag agctggtcct agatagagct ttagattatg aacaggaagc
      781 tgaactcaga ttaacactca cagcagtgga tggtggatcc ccgcccaagt ctgggacaac
      841 tttggttctc atcaaggtgt tggacatcaa tgataatgcc cctgagtttc ctcagagtct
      901 ctatgaggtg caagtccccg aggacagacc ccttggctcc tggattgcca ccatctcagc
      961 taaggatctg gatgcaggaa actatggaaa aatatcttac acatttttcc atgcatcaga
     1021 agatattcgt aaaacatttg aaattaatcc aatatctggg gaagttaatt tgagatcacc
     1081 cctggatttt gaagtaatac agtcctacac tataaatatt caggcaacag atggtggggg
     1141 tctttcagga aaatgcaccc ttctagttaa agttatggat ataaacgaca acccaccaga
     1201 agtgaccata tcgtcgatta caaagagaat tccagagaat gcctcagaga ccctagtagc
     1261 tctttttagt atcctagacc aagactctgg agacaatggg aggatgattt gctctattca
     1321 agataacctc ccttttttcc tgaaaccgac cttcaagaac tttttcactc tagtttctga
     1381 aaaagcactg gacagagaga gccaagccga gtacaacatc acgatcaccg tcacagactt
     1441 ggggacaccc aggctgaaaa ccgagtacaa cataaccgtg ctgctctctg acgtcaatga
     1501 caacgccccc accttcaccc aaacctccta caccctgttc gtccgcgaga acaacagccc
     1561 cgccctgcac atcggcagcg tcagcgccac agacagagac tcaggcacca acgcccaggt
     1621 caactactcg ctgctgccgc cccaggaccg gcacctgccc ctcgcctcct tggtctccat
     1681 caacgcggac aatggccacc tgtttgccct caggtcgctg gactacgagg ccctacagga
     1741 gttcgagttt cgcgtgggcg ccacagaccg cgggtccccg gcgttgagca gcgaggcgct
     1801 ggtgcgcgtg ctggtgctgg acgccaacga caactcgccc ttcgtgctgt acccgctgca
     1861 gaacggctcc gcgccctgca ccgagctggt gccccgggcg gccgagccgg gctacctggt
     1921 gaccaaggtg gtggcggtgg acggcgactc gggccagaac gcctggctgt cgtaccagct
     1981 gctcaaggcc acggagcccg ggctgttcgg cgtgtgggcg cacaatggcg aggtgcgcac
     2041 cgccaggctg ctgagcgagc gcgacgcggc caagcacagg ctggtggtgc tggtcaagga
     2101 caatggcgag cctcctcgct cggccaccgc cacgctgcac gtgctcctgg tggacggctt
     2161 ctcccagccc tacctgccgc tccctgaggc ggccccggcc caggcccagg ccgactccct
     2221 caccgtctac ctggtggtgg cattggcctc ggtgtcgtcg ctcttcctct tctcggtgct
     2281 cctgttcgtg gcggtgcggc tgtgcaggag gagcagggcg gcctcggtgg gtcgctgctc
     2341 ggtgcccgag ggtccctttc cagggcatct ggtggacgtg agcggcaccg ggaccctgtc
     2401 ccagagctac caatacgagg tgtgtctgac aggaggttcc gggacaaatg agttcaaatt
     2461 tctgaagccg attatcccca attttcaagt tcatgacact ggtaggaata tgggggaaat
     2521 cgagaacttt cgaaatagct ttggacttaa cattcaataa aacaatttat tttaaatgtc
     2581 taatttttgg ttattcttgg caagctgatg gtactttttg cataatcttt tgtggattct
     2641 tggttgtact gtagttgcat gcatgattat agctcttgtt tttctcacag tttctttaaa
     2701 aatctttatt agtggctata atgacgtgga aatgtaatct gtgttttctg gtttttcatt
     2761 tatttggcca aaatgttata ttaatggagt tattgctatt tttgctgtga taatggtatt
     2821 atgcaagacc atattctcaa ttatttggat atgcaaacta aagtattaag agctaatgtc
     2881 attatatatg taacttaaat ctagacacca tcaaagcata aaataaaaat aaaaagcgtt
     2941 gctgaatctg ggtcgaaaat gtagtgcgtt tatcccacta ttctctctga aaatgttctt
     3001 tagaaagggt aacaaagatg ctatccctcc attttcagtt ctggagaacc ttattagttt
     3061 ttcaaatatt tactttatga tgaaacttaa gtggtcacat tggaaattat taatttctta
     3121 agtaattttt tctgtaactg cttttgttga taatcctgtt gtggaggaag agtcttataa
     3181 tgctctgggc tttgctgtca ctctttggtt ttcttaattt aattctattt atttatgttt
     3241 tttgagacag ggtctcattc cattgacctg gctggaatgc agtggcacca tcatggctca
     3301 ctgccgcctt gacttcctgg gttcaggtga ttctcctgcc tcagcctcct gagtagctgg
     3361 atcaccagca caggccacta cggcctggct aattcttttg tatttttttt gtacagatgg
     3421 aatcttgcca tgtttcccag tctggtctgg aactccttgg ctcaagcgat ctgcccgcct
     3481 tagctagttt tttgtttttg ttttttgaga caaagtctca ctttgttgtc caggctagag
     3541 agtagtggca ggatcttggc tcactgcagc ctcgacatcc tgggctcagg caatcctcct
     3601 gcttcggcct attaaatagc tcaaactaca ggcacccgcc acgatgccta gctaaatttt
     3661 tgtatatgtg gtagagatgg agttttgcca tgtggcccag gctagtctcg aactcctgaa
     3721 ctcaagtgat ccacctgctt tggcctccca acgtgctagg attacaggca tgagccatta
     3781 cgtctggcct agttttcttt aaatacaccg tgtttactag cttaaatttt gtgttgttta
     3841 ttactaaagc agaaaataat ttagggtctt atcctgggta aaatagcctt ccatcagatg
     3901 agtacaaagc aagaacttca taagaaattg aaatgaagat tcaaactgtt aaagaaatga
     3961 tttagtttca ctttcctatt aattattgag taaatataaa acatcattaa cactttgtgg
     4021 cctctctcag atgcctacaa agaaggaatg ggtaggcatt tatggtttat agttgcctca
     4081 tcatgtaaca tattatatct cagctctaaa agaaagttct atagaagatt atagatagag
     4141 attttgataa ctggaatgta gtatggatat agggctggtg tacatataca ttttgaaatt
     4201 gctcttacaa gattaaatac tattatagac cagatgatgt agtaaaatgg aatttcactt
     4261 gccattgtga aataggtgaa acaaattcca gtttccttag atttcttccc tctactttat
     4321 gcaattatca ctgattttat ttttcgttgt aacaagtagt tatttgttgt gtggatttct
     4381 taaaattgac atttaaacaa taaaatcctg aaaagaa
//
