LOCUS       NM_018933               5061 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens protocadherin beta 13 (PCDHB13), mRNA.
ACCESSION   NM_018933
VERSION     NM_018933.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5061)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   2  (bases 1 to 5061)
  AUTHORS   Frank,M. and Kemler,R.
  TITLE     Protocadherins
  JOURNAL   Curr Opin Cell Biol 14 (5), 557-562 (2002)
   PUBMED   12231349
  REMARK    Review article
REFERENCE   3  (bases 1 to 5061)
  AUTHORS   Vanhalst,K., Kools,P., Vanden Eynde,E. and van Roy,F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   4  (bases 1 to 5061)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   5  (bases 1 to 5061)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   6  (bases 1 to 5061)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   7  (bases 1 to 5061)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   8  (bases 1 to 5061)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC329454.1, AF217745.1 and
            AC244517.2.
            
            On May 17, 2019 this sequence version replaced NM_018933.3.
            
            Summary: This gene is a member of the protocadherin beta gene
            cluster, one of three related gene clusters tandemly linked on
            chromosome five. The gene clusters demonstrate an unusual genomic
            organization similar to that of B-cell and T-cell receptor gene
            clusters. The beta cluster contains 16 genes and 3 pseudogenes,
            each encoding 6 extracellular cadherin domains and a cytoplasmic
            tail that deviates from others in the cadherin superfamily. The
            extracellular domains interact in a homophilic manner to specify
            differential cell-cell connections. Unlike the alpha and gamma
            clusters, the transcripts from these genes are made up of only one
            large exon, not sharing common 3' exons as expected. These neural
            cadherin-like cell adhesion proteins are integral plasma membrane
            proteins. Their specific functions are unknown but they most likely
            play a critical role in the establishment and function of specific
            cell-cell neural connections. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF217745.1, SRR1660803.92405.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341948.6/ ENSP00000345491.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               DC329454.1         1-205
            206-3503            AF217745.1         1-3298
            3504-5061           AC244517.2         143273-144830
FEATURES             Location/Qualifiers
     source          1..5061
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..5061
                     /gene="PCDHB13"
                     /gene_synonym="PCDH-BETA13"
                     /note="protocadherin beta 13"
                     /db_xref="GeneID:56123"
                     /db_xref="HGNC:HGNC:8684"
                     /db_xref="MIM:606339"
     exon            1..5061
                     /gene="PCDHB13"
                     /gene_synonym="PCDH-BETA13"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..2602
                     /gene="PCDHB13"
                     /gene_synonym="PCDH-BETA13"
                     /codon_start=1
                     /product="protocadherin beta-13 precursor"
                     /protein_id="NP_061756.1"
                     /db_xref="CCDS:CCDS4255.1"
                     /db_xref="GeneID:56123"
                     /db_xref="HGNC:HGNC:8684"
                     /db_xref="MIM:606339"
                     /translation="MEASGKLICRQRQVLFSFLLLGLSLAGAAEPRSYSVVEETEGSS
                     FVTNLAKDLGLEQREFSRRGVRVVSRGNKLHLQLNQETADLLLNEKLDREDLCGHTEP
                     CVLRFQVLLESPFEFFQAELQVIDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAED
                     LDVGQNNIENYIISPNSYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTALDG
                     GSPPRSGTAQVYIEVLDVNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNG
                     EISYSLFQASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGTFSGKCTV
                     LIQVIDVNDHAPEVTMSAFTSPIPENAPETVVALFSVSDLDSGENGKISCSIQEDLPF
                     LLKSAENFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIADVNDNAPA
                     FTQTSYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSLVSINA
                     DNGHLFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSPFVLYPLQ
                     NGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAHNGEV
                     RTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPTQAQ
                     ADLLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGRCLVPEGPLPGHLVDMS
                     GTRTLSQSYQYEVCLAGGSGTNEFKFLKPIIPNFPPQCPGKEIQGNSTFPNNFGFNIQ
                     "
     regulatory      2917..2922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHB13"
                     /gene_synonym="PCDH-BETA13"
                     /note="hexamer: AATAGA"
     polyA_site      2937
                     /gene="PCDHB13"
                     /gene_synonym="PCDH-BETA13"
                     /note="major polyA site"
     regulatory      3078..3083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHB13"
                     /gene_synonym="PCDH-BETA13"
                     /note="hexamer: AATAAA"
     polyA_site      3102
                     /gene="PCDHB13"
                     /gene_synonym="PCDH-BETA13"
                     /note="major polyA site"
     regulatory      3312..3317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHB13"
                     /gene_synonym="PCDH-BETA13"
                     /note="hexamer: AATAAT"
     polyA_site      3331
                     /gene="PCDHB13"
                     /gene_synonym="PCDH-BETA13"
     regulatory      3483..3488
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHB13"
                     /gene_synonym="PCDH-BETA13"
                     /note="hexamer: AATAAA"
     polyA_site      3503
                     /gene="PCDHB13"
                     /gene_synonym="PCDH-BETA13"
ORIGIN      
        1 gcagctccat taaccggcaa aaagcagcag aacctggaag tccacgggga gcttggatgc
       61 caaagggagg acggctgggt cctctggaga ggactactca ctggcatatt tctgaggtat
      121 ctgtagaata accacagcct cagatactgg ggactttaca gtcccacaga accgtcctcc
      181 caggaagctg aatccagcaa gaacaatgga ggccagcggg aagctcattt gcagacaaag
      241 gcaagtcctt ttttcctttc tccttttggg cttatctctg gcgggcgcgg cggaacctag
      301 aagctattct gtggtggagg aaactgaggg cagctccttt gtcaccaatt tagcaaagga
      361 cctgggtctg gagcagaggg aattctccag gcggggggtt agggttgttt ccagagggaa
      421 caaactacat ttgcagctca atcaggagac cgcggatttg ttgctaaatg agaaattgga
      481 ccgtgaggat ctgtgcggtc acacagagcc ctgtgtgcta cgtttccaag tgttgctaga
      541 gagtcccttc gagttttttc aagctgagct gcaagtaata gacataaacg accactctcc
      601 agtatttctg gacaaacaaa tgttggtgaa agtatcagag agcagtcctc ctgggactac
      661 gtttcctctg aagaatgccg aagacttaga tgtaggccaa aacaatattg agaactatat
      721 aatcagcccc aactcctatt ttcgggtcct cacccgcaaa cgcagtgatg gcaggaaata
      781 cccagagctg gtgctggaca aagcgctgga ccgagaggaa gaagctgagc tcaggttaac
      841 actcacagca ctggatggtg gctctccgcc cagatctggc actgctcagg tctacatcga
      901 agtcctggat gtcaacgata atgcccctga atttgagcag cctttctata gagtgcagat
      961 ctctgaggac agtccggtag gcttcctggt tgtgaaggtc tctgccacgg atgtagacac
     1021 aggagtcaac ggagagattt cctattcact tttccaagct tcagaagaga ttggcaaaac
     1081 ctttaagatc aatcccttga caggagaaat tgaactaaaa aaacaactcg atttcgaaaa
     1141 acttcagtcc tatgaagtca atattgaggc aagagatgct ggaacctttt ctggaaaatg
     1201 caccgttctg attcaagtga tagatgtgaa cgaccatgcc ccagaagtta ccatgtctgc
     1261 atttaccagc ccaatacctg agaacgcgcc tgaaactgtg gttgcacttt tcagtgtttc
     1321 agatcttgat tcaggagaaa atgggaaaat tagttgctcc attcaggagg atctaccctt
     1381 cctcctgaaa tccgcggaaa acttttacac cctactaacg gagagaccac tagacagaga
     1441 aagcagagcg gaatacaaca tcactatcac tgtcactgac ttggggaccc ctatgctgat
     1501 aacacagctc aatatgaccg tgctgatcgc cgatgtcaat gacaacgctc ccgccttcac
     1561 ccaaacctcc tacaccctgt tcgtccgcga gaacaacagc cccgccctgc acatccgcag
     1621 cgtcagcgct acagacagag actcaggcac caacgcccag gtcacctact cgctgctgcc
     1681 gccccaggac ccgcacctgc ccctcacatc cctggtctcc atcaacgcgg acaacggcca
     1741 cctgttcgcc ctcaggtctc tggactacga ggccctgcag gggttccagt tccgcgtggg
     1801 cgcttcagac cacggctccc cggcgctgag cagcgaggcg ctggtgcgcg tggtggtgct
     1861 ggacgccaac gacaactcgc ccttcgtgct gtacccgctg cagaacggct ccgcgccctg
     1921 caccgagctg gtgccccggg cggccgagcc gggctacctg gtgaccaagg tggtggcggt
     1981 ggacggcgac tcgggccaga acgcctggct gtcgtaccag ctgctcaagg ccacggagct
     2041 cggtctgttc ggcgtgtggg cgcacaatgg cgaggtgcgc accgccaggc tgctgagcga
     2101 gcgcgacgcg gccaagcaca ggctggtggt gctggtcaag gacaatggcg agcctccgcg
     2161 ctcggccacc gccacgctgc acgtgctcct ggtggacggc ttctcccagc cctacctgcc
     2221 tctcccggag gcggccccga cccaggccca ggccgacttg ctcaccgtct acctggtggt
     2281 ggcgttggcc tcggtgtctt cgctcttcct cttttcggtg ctcctgttcg tggcggtgcg
     2341 gctgtgtagg aggagcaggg cggcctcggt gggtcgctgc ttggtgcccg agggccccct
     2401 tccagggcat cttgtggaca tgagcggcac caggacccta tcccagagct accagtatga
     2461 ggtgtgtctg gcaggaggct cagggaccaa tgagttcaag ttcctgaagc cgattatccc
     2521 caacttccct ccccagtgcc ctgggaaaga aatacaagga aattctacct tccccaataa
     2581 ctttgggttc aatattcagt gaccatagtt gacttttaca ttccataggt attttatttt
     2641 gtggcatttc catgccaatg tttatttccc ccaatttgtg tgtatgtaat attgtacgga
     2701 tttactcttg atttttctca tgttctttct ccctttgttt taaagtgaac atttaccttt
     2761 attcctggtt cttaaaaggt gacaattcat tctttaaccc agatggtctt aatttgtaat
     2821 taatttgcct ccctaaagag caataccaaa tcacattttt ttcatgcccc tatctttagc
     2881 tgaacttcac ccactattat gcttatggta aaattaaata gagcaatttg gaagtgattc
     2941 caattttcca gcatttcttc atttgattct ctttttttag tcttaaaata atgactccta
     3001 ttcagacata tcatttttct tttttgtaaa tccagtgcgt ttttagttaa cctttaaata
     3061 tgctttttgc tttcaaaaat aaaccagaaa acctatatcc tatgatacaa ctctaagtgt
     3121 tatcacttga ttcgaaaggg tcagaagacc agttttttag tatcctttcc tcattcatcc
     3181 tggagaggat tgtgcaggca cattaatatt gtgaccaatc acagaatctg ggaatatgaa
     3241 gctataattt tttaattaat gtcacaaagc tctagtgcaa tctagttgaa tgcagatgcc
     3301 tgtgcccaaa taataattca tatagcataa attggagttg tgtgttaatg tgtaaaaatt
     3361 tttgcctgta ctatcatata atttaatgta tatacaccag aaactatttt tcaaactttt
     3421 tttactgcaa ccaatagtta agattatatt ttacatattt tgaaacacac aagcttaata
     3481 gaaataaatg cttgtgaaca atgcttagtc tttttatgac ataatttgaa attacctata
     3541 tatttcattc tattcaattt tcaaatgtgg tcatgatcca ctaaatttat ttcatggtat
     3601 actagtgggt agtaacccaa agtttgaaaa ccacttttct cagacatata aaagcatacc
     3661 agatgttgaa cattgatagt atcaaaagat agtcccttag ggttctaatt ttaaaaaaat
     3721 tttcaaagca ttgtagggga gtagctttgt ctcatgttaa atcactctta cctttaagga
     3781 tctgacacac tatgtaagaa aaagacttca aggttggagg aggagatttt ccatgacttt
     3841 tatcaaagtc tacagtctat gttgtgggag aaaaatgtag aataacaaaa tgagtaaaag
     3901 tatagaggca aaacaagcat gtgtatgaga gagagagaga aagcatggaa aagaggaaat
     3961 tcatggggat gagcaaaatg actacttcca gtgccacaga ctagactcag ttgcttctct
     4021 tatgttattt tttgagacaa ggtcctgttc tgtcacccag gctggagtgc agtggtgtga
     4081 tctccactca ctgtgatctc cactcactgc aacctccacc tcctgggctc aagtgatcct
     4141 cccacctcag cctccctagt acccaggact acaggcccag gccaccacac ccactaattt
     4201 ttgcatattt agtagagacg aggtttcatc atattgccca gactggtctc gaattcctga
     4261 gctcaagcag tctgcctgcc tcagcctccc aaagtgctat gattacaggt atgagcacct
     4321 ggcctcaact acttcttgaa gatattttaa aactttatct taacattgta gagggactgg
     4381 gtattagtca gttgataatg ccaagaagtg caatctcttt taatagcata tctaagacaa
     4441 cctaatgttt atacttctga ctcagatttc actactggtt ctgttgagct ttgtcaactg
     4501 agtaattatt cttttctttt ttctttcttt gtttatgttt tagagacagg gtcttagtca
     4561 cctaggctgg agtgcagtgg tgcaatcata gctcactgaa gccttgacct cctgggctca
     4621 agcaatcctc ctgacgcagc atcccaagta gccgggacca caggcacatg ccacccccca
     4681 cagctatttt tgtttgtttg tttgtttttt gttttgtttt gtttttgagg cagagtctca
     4741 ctctgtcacc caggctggag tgcagtggcg cgatctcggc tcactgcaag ctccgcctcc
     4801 tgggttcccg ccattctcct gcctcagtct cccgagtagc acccccagct attttaaaaa
     4861 aaatttttgt agagatgggt tctcatcatg tcgcccaggc tgttgaactt ctggcctcca
     4921 aaggtgggag ttattctagc agcttccctg tgatcttctc atatctactg gtggagtggg
     4981 aaagagtagt tcaaacaact cagacagaaa atctcgctgg tgcaacagtg gagagaaggg
     5041 ccaagtactt gtcctgttac t
//
