LOCUS       NM_018932               3853 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens protocadherin beta 12 (PCDHB12), mRNA.
ACCESSION   NM_018932
VERSION     NM_018932.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3853)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3853)
  AUTHORS   Vanhalst,K., Kools,P., Vanden Eynde,E. and van Roy,F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   3  (bases 1 to 3853)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   4  (bases 1 to 3853)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   5  (bases 1 to 3853)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   6  (bases 1 to 3853)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   7  (bases 1 to 3853)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC045637.1, AF217746.1 and
            AC244517.2.
            
            On May 17, 2019 this sequence version replaced NM_018932.3.
            
            Summary: This gene is a member of the protocadherin beta gene
            cluster, one of three related gene clusters tandemly linked on
            chromosome five. The gene clusters demonstrate an unusual genomic
            organization similar to that of B-cell and T-cell receptor gene
            clusters. The beta cluster contains 16 genes and 3 pseudogenes,
            each encoding 6 extracellular cadherin domains and a cytoplasmic
            tail that deviates from others in the cadherin superfamily. The
            extracellular domains interact in a homophilic manner to specify
            differential cell-cell connections. Unlike the alpha and gamma
            clusters, the transcripts from these genes are made up of only one
            large exon, not sharing common 3' exons as expected. These neural
            cadherin-like cell adhesion proteins are integral plasma membrane
            proteins. Their specific functions are unknown but they most likely
            play a critical role in the establishment and function of specific
            cell-cell neural connections. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC045637.1, SRR1660807.225080.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239450.4/ ENSP00000239450.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2260              BC045637.1         1-2260
            2261-3392           AF217746.1         2072-3203
            3393-3408           BC045637.1         3394-3409
            3409-3853           AC244517.2         137978-138422
FEATURES             Location/Qualifiers
     source          1..3853
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..3853
                     /gene="PCDHB12"
                     /gene_synonym="PCDH-BETA12"
                     /note="protocadherin beta 12"
                     /db_xref="GeneID:56124"
                     /db_xref="HGNC:HGNC:8683"
                     /db_xref="MIM:606338"
     exon            1..3853
                     /gene="PCDHB12"
                     /gene_synonym="PCDH-BETA12"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..2577
                     /gene="PCDHB12"
                     /gene_synonym="PCDH-BETA12"
                     /note="PCDH-beta-12"
                     /codon_start=1
                     /product="protocadherin beta-12 precursor"
                     /protein_id="NP_061755.1"
                     /db_xref="CCDS:CCDS4254.1"
                     /db_xref="GeneID:56124"
                     /db_xref="HGNC:HGNC:8683"
                     /db_xref="MIM:606338"
                     /translation="MENGGAGTLQIRQVLLFFVLLGMSQAGSETGNFLVMEELQSGSF
                     VGNLAKTLGLEVSELSSRGARVVSNDNKECLQLDTNTGDLLLREMLDREELCGSNEPC
                     VLYFQVLMKNPTQFLQIELQVRDINDHSPVFLEKEMLLEIPENSPVGAVFLLESAKDL
                     DVGINAVKSYTINPNSHFHVKIRVNPDNRKYPELVLDKALDYEERPELSFILTALDGG
                     SPPRSGTALVRVVVVDINDNSPEFEQAFYEVKILENSILGSLVVTVSAWDLDSGTNSE
                     LSYTFSHASEDIRKTFEINQKSGDITLTAPLDFEAIESYSIIIQATDGGGLFGKSTVR
                     IQVMDVNDNAPEITVSSITSPIPENTPETVVMVFRIRDRDSGDNGKMVCSIPEDIPFV
                     LKSSVNNYYTLETERPLDRESRAEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPA
                     FTQTSYALFVRENNSPALHIGSISATDRDSGTNAQVNYSLLPSQDPHLPLASLVSINA
                     DNGHLFALRSLDYEALQGFQFRVGATDHGSPALSSEALVRVLVLDANDNSPFVLYPLQ
                     NGSAPCTELVPWAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEV
                     RTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPAQAQ
                     ADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAAPVGRCSVPEGPFPGHLVDVS
                     GTGTLSQSYHYEVCVTGGSRSNKFKFLKPIIPNFLPQSTGSEVEENPPFQNNLGF"
     regulatory      2800..2805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHB12"
                     /gene_synonym="PCDH-BETA12"
                     /note="hexamer: TATAAA"
     polyA_site      2821
                     /gene="PCDHB12"
                     /gene_synonym="PCDH-BETA12"
                     /note="major polyA site"
     regulatory      3390..3395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHB12"
                     /gene_synonym="PCDH-BETA12"
                     /note="hexamer: AACAAA"
     polyA_site      3408
                     /gene="PCDHB12"
                     /gene_synonym="PCDH-BETA12"
                     /note="major polyA site"
ORIGIN      
        1 agtacacgcg gagaactggg aagacagaaa gaacaatcct ttaagggaga acctagaagc
       61 cattcaacaa ggttaaaatc ttcaggcttc cgaggatttg gtagacagat cagaggcacg
      121 tttcccacaa ctgcgaagag gcgctgaggc aattctgcaa gaagattttg gggttttgga
      181 aaagaagcta tggaaaacgg aggggcaggc actctgcaga taaggcaagt cctgcttttc
      241 tttgttttgc tgggaatgtc tcaggcgggc tctgaaactg ggaacttttt ggtgatggag
      301 gaattgcaga gcgggagctt tgtaggaaat ttggcaaaga ccctgggact cgaggtgagt
      361 gagctgtctt cgcggggggc tcgggtggtt tctaatgata acaaagagtg tttgcagctg
      421 gacacaaaca ctggggattt gctcctgaga gaaatgctag acagggagga gctctgtggc
      481 tccaatgagc cttgtgtgct gtatttccaa gtgttaatga aaaaccccac gcagttttta
      541 caaattgagc tccaggtcag ggatataaat gatcactctc ccgtcttctt ggaaaaagaa
      601 atgctcttag aaatcccaga gaacagtcct gttggtgctg tgttcttgct tgaaagtgca
      661 aaggatttag atgtaggaat caatgctgta aaaagctaca caataaatcc gaactctcat
      721 ttccacgtta aaataagagt caatccagac aataggaaat accctgagtt agttctggac
      781 aaggcgctgg attatgaaga gcgcccggag ctcagtttca tcctcactgc tctggatggc
      841 gggtcccctc ccaggtctgg aactgccttg gtcagggtgg tggttgtaga tattaatgac
      901 aactcccctg agtttgagca ggctttttat gaggtgaaga ttctggagaa tagcatcctt
      961 ggctccctgg ttgtgaccgt ctcagcctgg gatttagact ctggaacaaa cagtgaacta
     1021 tcctatacct tttcccatgc ctcagaagat attcgcaaga catttgaaat taatcaaaag
     1081 tctggtgaca ttactttaac agcacctttg gattttgaag caattgagtc atactcaata
     1141 atcattcaag ccacagatgg gggaggactt tttggaaaat ctacagtcag aattcaggtg
     1201 atggatgtaa acgacaacgc tcctgaaatc actgtgtcat caattaccag tccaatccca
     1261 gaaaacactc cagagactgt ggttatggtt ttcaggatac gagacagaga ctctggggac
     1321 aacggaaaga tggtttgttc tatcccggag gacatcccat tcgtgctaaa atcttcggta
     1381 aataattact acactttgga aacagagaga ccgctggaca gagagagcag agccgagtac
     1441 aacatcacca tcaccgtcac cgacttgggg acccccaggc taaaaaccga gcacaacata
     1501 accgtgctgg tctccgacgt caatgacaac gcccccgcct tcacccaaac ttcctacgcc
     1561 ctgttcgtcc gcgagaacaa cagccccgcc ctgcacatcg gcagcatcag cgccacagac
     1621 agagactcgg gcaccaacgc ccaggtcaac tactcgctgc tgccgtccca ggacccgcac
     1681 ctgcccctcg cctccctggt ctccatcaac gcggacaacg gccacctgtt tgccctcagg
     1741 tcgctggact acgaggccct gcaggggttc cagttccgcg tgggcgccac agaccacggc
     1801 tccccggctt tgagcagcga ggcgctggtg cgcgtgctgg tgctggacgc caacgacaac
     1861 tcgcccttcg tgctgtaccc gctgcagaac ggctccgcgc cctgcaccga gctggtgccc
     1921 tgggcggccg agccgggcta cctggtgacc aaggtggtgg cggtggacgg tgactcgggc
     1981 cagaacgcct ggctgtcgta ccagctgctc aaggccacgg agcccgggct attcggcgtg
     2041 tgggcgcaca atggcgaggt gcgcaccgcc aggctgctga gcgagcgcga cgcggccaag
     2101 cacaggctgg tggtgctggt caaggacaat ggcgagcctc cgcgctcggc caccgccacg
     2161 ctgcacgtgc tcctggtgga cggcttctcc cagccctacc tgcctctccc ggaggcggcc
     2221 ccggcccagg cccaggccga ctcgctcact gtctacctgg tggtggcgtt ggcctcagtg
     2281 tcgtcgctct tcctcttctc ggtgctcctg ttcgtggcgg tgcggctgtg caggaggagc
     2341 agggcggccc cggtcggtcg ctgctcggtg cctgagggcc cctttccagg acatctggtg
     2401 gacgtgagtg gcaccgggac cctgtcccag agctaccact atgaggtgtg tgtgactgga
     2461 ggctccaggt caaataagtt caaatttctg aaaccaatta tccccaactt cctaccccag
     2521 agcacaggta gtgaagtcga agaaaatccc ccatttcaga ataatttggg tttctgataa
     2581 agaatgaaaa ataaaacctg tgtttatgaa tacatttata attaggaact tatcgtgagg
     2641 tgcctgtaaa gtagtatttt tgatcacttc aaatacatac tcttcaagtc aagaaataaa
     2701 tttctttaca tagaaaagga tacagattta gtaccaagaa cacttcacaa agcaggaaat
     2761 gtgcatgtgt aatggtttat gtcaaacaat tatgcttaat ataaagtcta ttaagtggta
     2821 agtcttgttt gagatatttt aaattgcttt ccattgtttt caatatttac tgtgactttt
     2881 gttttctgag ttgattagaa tgctgttcga gtatacctac cctagtttca gaagcataga
     2941 ttgtagtgta cctttttaaa ctttattttt ttaaaaaaag ttgttttatg aatcatacac
     3001 tattttcaca cttttaatct cagaagaaac atatgtgaca tggtatttta gtaatgacca
     3061 aatagacggt cttagagatt cagtaagttc actaaggtcc actaactaat aagtgacaaa
     3121 actgagcatc catcctagat ctgcctgact ctaagtcagt gactttgctc ccattccata
     3181 ctgtttttgt cattggatat cacctggcaa gtttctgcct aactaaagag aagaaaagtt
     3241 tttatcgtat tcatactact gttcaatctt tatttagaaa taaactttat ctatgatttc
     3301 attttcttat aaaccagtaa tcttgctttt ctgggtaaat tttcagctat tattactaat
     3361 gctctgatct gcccaaatct taagtaaaaa acaaaattga aagagcaacc tatgccttct
     3421 cattgtctcc tgaacatata actatcattt cacagaaaag attaatggtc ctgattagga
     3481 atagtacata attttgatgg cattattagt taattatttt ctttacattg tagtatattt
     3541 ccagagtcac ccatgcttac atttgtaata tattttcctg atttgagagt ttgtttttag
     3601 cagtttttct tacctatact gcactgctga atcaggaaaa tttaagaaaa agaatagatt
     3661 taaatgtgta atatcaaaga gaaatataga tgatcattaa atttttagaa attttgggga
     3721 gttaaggaga agcattgttt gttaaaaata tataaccgat tcttatattt aaaataggta
     3781 atttttgcat agttgtgttc taaatatatt ataaactagt gccagtaact ctaataaagc
     3841 tagtattact gca
//
