LOCUS       NM_018930               3295 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens protocadherin beta 10 (PCDHB10), mRNA.
ACCESSION   NM_018930
VERSION     NM_018930.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3295)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   2  (bases 1 to 3295)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   3  (bases 1 to 3295)
  AUTHORS   Frank,M. and Kemler,R.
  TITLE     Protocadherins
  JOURNAL   Curr Opin Cell Biol 14 (5), 557-562 (2002)
   PUBMED   12231349
  REMARK    Review article
REFERENCE   4  (bases 1 to 3295)
  AUTHORS   Vanhalst,K., Kools,P., Vanden Eynde,E. and van Roy,F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   5  (bases 1 to 3295)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   6  (bases 1 to 3295)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   7  (bases 1 to 3295)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   8  (bases 1 to 3295)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   9  (bases 1 to 3295)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244517.2, BC031837.1 and
            AY358720.1.
            
            On May 17, 2019 this sequence version replaced NM_018930.3.
            
            Summary: This gene is a member of the protocadherin beta gene
            cluster, one of three related gene clusters tandemly linked on
            chromosome five. The gene clusters demonstrate an unusual genomic
            organization similar to that of B-cell and T-cell receptor gene
            clusters. The beta cluster contains 16 genes and 3 pseudogenes,
            each encoding 6 extracellular cadherin domains and a cytoplasmic
            tail that deviates from others in the cadherin superfamily. The
            extracellular domains interact in a homophilic manner to specify
            differential cell-cell connections. Unlike the alpha and gamma
            clusters, the transcripts from these genes are made up of only one
            large exon, not sharing common 3' exons as expected. These neural
            cadherin-like cell adhesion proteins are integral plasma membrane
            proteins. Their specific functions are unknown but they most likely
            play a critical role in the establishment and function of specific
            cell-cell neural connections. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1660805.27693.1, AK315583.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239446.6/ ENSP00000239446.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC244517.2         118204-118229
            27-3284             BC031837.1         1-3258
            3285-3288           AY358720.1         3263-3266
            3289-3295           AC244517.2         121492-121498
FEATURES             Location/Qualifiers
     source          1..3295
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..3295
                     /gene="PCDHB10"
                     /gene_synonym="PCDH-BETA10; PCHB10"
                     /note="protocadherin beta 10"
                     /db_xref="GeneID:56126"
                     /db_xref="HGNC:HGNC:8681"
                     /db_xref="MIM:606336"
     exon            1..3295
                     /gene="PCDHB10"
                     /gene_synonym="PCDH-BETA10; PCHB10"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..2603
                     /gene="PCDHB10"
                     /gene_synonym="PCDH-BETA10; PCHB10"
                     /note="PCDH-beta-10"
                     /codon_start=1
                     /product="protocadherin beta-10 precursor"
                     /protein_id="NP_061753.1"
                     /db_xref="CCDS:CCDS4252.1"
                     /db_xref="GeneID:56126"
                     /db_xref="HGNC:HGNC:8681"
                     /db_xref="MIM:606336"
                     /translation="MAVRELCFPRQRQVLFLFLFWGVSLAGSGFGRYSVTEETEKGSF
                     VVNLAKDLGLAEGELAARGTRVVSDDNKQYLLLDSHTGNLLTNEKLDREKLCGPKEPC
                     MLYFQILMDDPFQIYRAELRVRDINDHAPVFQDKETVLKISENTAEGTAFRLERAQDP
                     DGGLNGIQNYTISPNSFFHINISGGDEGMIYPELVLDKALDREEQGELSLTLTALDGG
                     SPSRSGTSTVRIVVLDVNDNAPQFAQALYETQAPENSPIGFLIVKVWAEDVDSGVNAE
                     VSYSFFDASENIRTTFQINPFSGEIFLRELLDYELVNSYKINIQAMDGGGLSARCRVL
                     VEVLDTNDNPPELIVSSFSNSVAENSPETPLAVFKINDRDSGENGKMVCYIQENLPFL
                     LKPSVENFYILITEGALDREIRAEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPA
                     FTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINA
                     DNGHLFALRSLDYEALQAFEFRVGATDRGSPALSREALVRVLVLDANDNSPFVLYPLQ
                     NGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEV
                     RTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHLLLVDGFSQPYLPLPEAAPAQAQ
                     AEADLLTVYLVVALASVSSLFLLSVLLFVAVRLCRRSRAASVGRCSVPEGPFPGHLVD
                     VRGAETLSQSYQYEVCLTGGPGTSEFKFLKPVISDIQAQGPGRKGEENSTFRNSFGFN
                     IQ"
     regulatory      3268..3273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHB10"
                     /gene_synonym="PCDH-BETA10; PCHB10"
                     /note="hexamer: AATAAA"
     polyA_site      3295
                     /gene="PCDHB10"
                     /gene_synonym="PCDH-BETA10; PCHB10"
                     /note="major polyA site"
ORIGIN      
        1 ggatgctatg caagtcacta ataaaggaag acacggacag atgaacttaa aagagaagct
       61 ttagctgcca aagattggga aagggaaagg acaaaaaaga cccctgggct acacggcgta
      121 ggtgcagggt ttcctactgc tgttctttta tgctgggagc tgtggctgta accaactagg
      181 aaataacgta tgcagcagct atggctgtca gagagttgtg cttcccaaga caaaggcaag
      241 tcctgtttct ttttcttttt tggggagtgt ccttggcagg ttctgggttt ggacgttatt
      301 cggtgactga ggaaacagag aaaggatcct ttgtggtcaa tctggcaaag gatctgggac
      361 tagcagaggg ggagctggct gcaaggggaa ccagggtggt ttccgatgat aacaaacaat
      421 acctgctcct ggattcacat accgggaatt tgctcacaaa tgagaaactg gaccgagaga
      481 agctgtgtgg ccctaaagag ccctgtatgc tgtatttcca aattttaatg gatgatccct
      541 ttcagattta ccgggctgag ctgagagtca gggatataaa tgatcacgcg ccagtatttc
      601 aggacaaaga aacagtctta aaaatatcag aaaatacagc tgaagggaca gcatttagac
      661 tagaaagagc acaggatcca gatggaggac ttaacggtat ccaaaactac acgatcagcc
      721 ccaactcttt tttccatatt aacattagtg gcggtgatga aggcatgata tatccagagc
      781 tagtgttgga caaagcactg gatcgggagg agcagggaga gctcagctta accctcacag
      841 cgctggatgg tgggtctcca tccaggtctg ggacctctac tgtacgcatc gttgtcttgg
      901 acgtcaatga caatgcccca cagtttgccc aggctctgta tgagacccag gctccagaaa
      961 acagccccat tgggttcctt attgttaagg tatgggcaga agatgtagac tctggagtca
     1021 acgcggaagt atcctattca ttttttgatg cctcagaaaa tattcgaaca acctttcaaa
     1081 tcaatccttt ttctggggaa atctttctca gagaattgct tgattatgag ttagtaaatt
     1141 cttacaaaat aaatatacag gcaatggacg gtggaggcct ttctgcaaga tgtagggttt
     1201 tagtggaagt attggacacc aatgacaatc cccctgaact gatcgtatca tcattttcca
     1261 actctgttgc tgagaattct cctgagacgc cgctggctgt ttttaagatt aatgacagag
     1321 actctggaga aaatggaaag atggtttgct acattcaaga gaatctgcca ttcctactaa
     1381 aaccttctgt ggagaatttt tacatcctaa ttacagaagg cgcgctggac agagagatca
     1441 gagccgagta caacatcact atcaccgtca ctgacttggg gacacccagg ctgaaaaccg
     1501 agcacaacat aacggtcctg gtctccgacg tcaatgacaa cgcccccgcc ttcacccaaa
     1561 cctcctacac cctgttcgtc cgcgagaaca acagccccgc cctgcacatc ggcagcgtca
     1621 gcgccacaga cagagactcg ggcaccaacg cccaggtcac ctactcgctg ctgccgcccc
     1681 aagacccgca cctgcccctc gcctccctgg tctccatcaa cgcggacaac ggccacctgt
     1741 tcgccctcag gtcgctggac tacgaggccc tgcaggcttt cgagttccgc gtgggcgcca
     1801 cagaccgcgg ctcccccgcg ctgagcagag aggcgctggt gcgcgtgctg gtgctggacg
     1861 ccaacgacaa ctcgcccttc gtgctgtacc cgctgcagaa cggctccgcg ccctgcaccg
     1921 agctggtgcc ccgggcggcc gagccgggct acctggtgac caaggtggtg gcggtggacg
     1981 gcgactcggg ccagaacgcc tggctgtcgt accagctgct caaggccacg gagcccgggc
     2041 tgttcggtgt gtgggcgcac aatggggagg tgcgcaccgc caggctgctg agcgagcgcg
     2101 acgcagccaa gcacaggctc gtggtgcttg tcaaggacaa tggcgagcct cctcgctcgg
     2161 ccaccgccac gctgcacttg ctcctggtgg acggcttctc ccagccctac ctgcctctcc
     2221 cggaggcggc cccggcccag gcccaggccg aggccgactt gctcaccgtc tacctggtgg
     2281 tggcgttggc ctcggtgtct tcgctcttcc tcctctcggt gctcctgttc gtggcggtgc
     2341 ggctgtgcag gaggagcagg gcggcctcgg tgggtcgctg ctcggtgccc gagggtcctt
     2401 ttccagggca tctggtggac gtgaggggcg ctgagaccct gtcccagagc taccagtatg
     2461 aggtgtgtct gacgggaggc cccgggacca gtgagttcaa gttcttgaaa ccagttattt
     2521 cggatattca ggcacagggc cctgggagga agggtgaaga aaattccacc ttccgaaata
     2581 gctttggatt taatattcag taaagtctgt ttttagtttc atatactttt ggtgtgttac
     2641 atagccatgt ttctattagt ttacttttaa atctcaaatt taagttatta tgcaacttca
     2701 agcattattt tcaagtagta tacccctgtg gttttacaat gtttcatcat ttttttgcat
     2761 taataacaac tgggtttaat ttaatgagta tttttttcta aatgatagtg ttaaggtttt
     2821 aattctttcc aactgcccaa ggaattaatt actattatat ctcattacag aaatctgagg
     2881 ttttgattca tttcagagct tgcatctcat gattctaatc acttctgtct atagtgtact
     2941 tgctctattt aagaaggcat atctacattt ccaaactcat tctaacattc tatatattcg
     3001 tgtttgaaaa ccatgtcatt tatttctaca tcatgtattt aaaaagaaat atttctctac
     3061 tactatgctc atgacaaaat gaaacaaagc atattgtgag caatactgaa catcaataat
     3121 acccttagtt tatatactta ttattttatc tttaagcatg ctacttttac ttggccaata
     3181 ttttcttatg ttaacttttg ctgatgtata aaacagacta tgccttataa ttgaaataaa
     3241 attataatct gcctgaaaat gaataaaaat aaaacatttt gaaatgtgtg gttga
//
