LOCUS       NM_013340               7973 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens protocadherin beta 1 (PCDHB1), mRNA.
ACCESSION   NM_013340
VERSION     NM_013340.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7973)
  AUTHORS   Vanhalst,K., Kools,P., Vanden Eynde,E. and van Roy,F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   2  (bases 1 to 7973)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   3  (bases 1 to 7973)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   4  (bases 1 to 7973)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   5  (bases 1 to 7973)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   6  (bases 1 to 7973)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010223.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 21, 2019 this sequence version replaced NM_013340.3.
            
            Summary: This gene is a member of the protocadherin beta gene
            cluster, one of three related gene clusters tandemly linked on
            chromosome five. The gene clusters demonstrate an unusual genomic
            organization similar to that of B-cell and T-cell receptor gene
            clusters. The beta cluster contains 16 genes and 3 pseudogenes,
            each encoding 6 extracellular cadherin domains and a cytoplasmic
            tail that deviates from others in the cadherin superfamily. The
            extracellular domains interact in a homophilic manner to specify
            differential cell-cell connections. Unlike the alpha and gamma
            clusters, the transcripts from these genes are made up of only one
            large exon, not sharing common 3' exons as expected. These neural
            cadherin-like cell adhesion proteins are integral plasma membrane
            proteins. Their specific functions are unknown but they most likely
            play a critical role in the establishment and function of specific
            cell-cell neural connections. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC112096.1, AF152488.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306549.6/ ENSP00000307234.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7973              AC010223.6         3267-11239          c
FEATURES             Location/Qualifiers
     source          1..7973
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..7973
                     /gene="PCDHB1"
                     /gene_synonym="PCDH-BETA1"
                     /note="protocadherin beta 1"
                     /db_xref="GeneID:29930"
                     /db_xref="HGNC:HGNC:8680"
                     /db_xref="MIM:606327"
     exon            1..7973
                     /gene="PCDHB1"
                     /gene_synonym="PCDH-BETA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..2554
                     /gene="PCDHB1"
                     /gene_synonym="PCDH-BETA1"
                     /note="PCDH-beta-1"
                     /codon_start=1
                     /product="protocadherin beta-1 precursor"
                     /protein_id="NP_037472.2"
                     /db_xref="CCDS:CCDS4243.1"
                     /db_xref="GeneID:29930"
                     /db_xref="HGNC:HGNC:8680"
                     /db_xref="MIM:606327"
                     /translation="MAGTRRKSLQNRQVGSLLIFLCISVGDATTIRYSVAEEMESGSF
                     VANVAKDLGLEVGKLAARGARLVSEGNKMHFRLHRKTGDLFVKEKLDRESLCGKADPC
                     VLHFEVVLVEPLQSFRAEVRVFDINDNAPVFLNKEPLLKIPESTPLGSRFPLQSAQDL
                     DVGLNGLQNYTLSANGYFHLHTRFCSHGPKYAELVLNKPLDREEQPEVNLTITAVDGG
                     SPPKSGTAHIHVVVLDVNDHVPQFSRLVYRAQVSENSPNGSLVATVTAVDLDEGTNKA
                     ITYSLAQNPEAILKTFQIDPQNGEVRLRGPLDFEAIETYDIDIQATDGGGLSAHSKVL
                     VEVVDVNDNPPEVMVSSVSSPLPEDSPPQTVVALFTIRDRDIRVGGKVTCFLREDLPF
                     VIKPTFGNSYSLVTDRSLDREEVSGYNITIVAMDTGPPSLSAETMIEVLISDVNDNPP
                     IFREDSYILTVRENNSPAVFIGKVHAEDLDLGENAQITYSLLPPKNGDLSVFAYISIN
                     SGNGKLYALRTMDYEAIQDFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPL
                     QNGTLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLLKATDLGLFSVQRQNGE
                     IHTLRQISERDPMMQKLIILVQDHGQPALSTTVSLNILLVDGFSEPYLQFQDPTKHSR
                     KVNPSTKYLVISLVILSFLFLLSVIVIFIIHVYQKIKYREKFTIQEHFYDDCNFSNNL
                     VQGQGNGSLSRPCPYEMCSATGTGNSEFRFLKRFMPNFPFPHATGEIKMEAGSSLPPN
                     SDRNKSQRLEGHDQVSDDYM"
     regulatory      7952..7957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDHB1"
                     /gene_synonym="PCDH-BETA1"
                     /note="hexamer: AATAAA"
     polyA_site      7973
                     /gene="PCDHB1"
                     /gene_synonym="PCDH-BETA1"
                     /note="major polyA site"
ORIGIN      
        1 aagcggagag cagctgttgc agtaacctgt tgcagaaaag tgaaagtata tccgcaacag
       61 ttggctctga ttgcagagag cgcgcttgtg agaactgatg gcgggtacgc gcagaaaatc
      121 tttgcaaaac aggcaagtgg gatctcttct catttttctg tgcatatctg tgggggatgc
      181 gacaactatc cgctattcag tggcagagga aatggagagc ggctcgtttg tggccaacgt
      241 agctaaggac ctaggactgg aggtagggaa gctggctgcg cgcggggcgc ggctggtttc
      301 cgagggcaac aaaatgcatt tccggctcca ccgcaagacg ggagatttgt ttgtgaagga
      361 gaaactggat cgggagtcac tttgtggcaa agccgaccct tgtgttctgc actttgaagt
      421 agtcctggtg gagccgctgc agtccttccg ggccgaggtc agggtatttg atatcaatga
      481 caatgcccca gttttcctaa acaaggagcc gcttttaaag attccggaga gcaccccttt
      541 gggttcacgt tttcctctgc agagcgccca ggatctggac gtgggcctta acggtctcca
      601 gaactacacc ctgagtgcca atgggtattt ccacctgcac acccgcttct gcagccacgg
      661 gcctaaatat gctgagctgg tgctgaacaa acccctggac cgagaggagc agcctgaagt
      721 caacttgaca attacggcgg tggacggcgg gtccccgcct aagtctggca cagctcacat
      781 ccacgtggtg gttctggatg tcaacgacca cgtgccccag ttctcgcgac tggtgtacag
      841 agcccaggta tcagagaaca gccccaatgg ctctttggtg gccacggtga ctgccgtgga
      901 cctagacgag ggcaccaaca aagcgataac ttactcttta gctcaaaacc cagaagcaat
      961 tctcaagacg tttcagattg accctcaaaa tggagaagtt cgactaagag gacccctcga
     1021 ttttgaagcc attgaaacat acgacattga cattcaagct acagatggtg gaggcctctc
     1081 tgcccacagc aaagtcctgg tagaagtggt ggatgtgaat gacaatcctc ccgaagtgat
     1141 ggtctcctct gtgtccagcc cactccctga agactcacca ccacagacag tagtagccct
     1201 tttcactatc agagaccggg acattcgagt gggaggaaaa gtcacctgct tcctcagaga
     1261 agaccttccc tttgtaatca aacctacatt tgggaattct tactcactgg tcactgacag
     1321 aagcttggat cgggaggagg tctcaggcta taatatcacc attgttgcca tggatactgg
     1381 accacctagc ttgtctgccg agactatgat agaggtgcta atatccgacg ttaatgacaa
     1441 tcctccaata tttcgggaag attcctatat cttgactgtt cgagaaaaca acagtcctgc
     1501 ggtttttatt ggcaaagtcc atgctgagga tcttgatttg ggtgagaatg cccaaataac
     1561 atattctctg ttgcctccaa aaaacggaga tctttcagtc tttgcttaca tatccataaa
     1621 ttcaggcaat gggaagctct acgcgctgag aaccatggat tatgaggcca ttcaagattt
     1681 tcaatttgtg gtaaaggcaa ctgatggggg cttcctgtca ctgagtagcc aagttactgt
     1741 cagagtggtt gtcctagatg acaatgacaa tcgtccaatg atcttatacc cactgcagaa
     1801 cggcaccttg ccctgcaatg acctggtgcc caggtctgca gaggcaggct acctagtgac
     1861 caaagtggtg gctgtggatg gtgactcagg tcagaattct tggctttcat atcatctact
     1921 taaggccact gaccttgggt tattttctgt tcaaagacaa aatggagaaa tccatacatt
     1981 aaggcagata tctgagagag accccatgat gcagaaattg atcattcttg ttcaggatca
     2041 cggccaacca gctctttcca ctactgtctc actcaacatc ctgctggtag atggcttttc
     2101 agagccctac ctgcagttcc aggatccaac caagcattct agaaaggtaa atccatccac
     2161 taaatatttg gtcatttctc tggtcatcct ttcctttctc tttctcctct ctgtcatagt
     2221 gatcttcatt atacatgtct accaaaagat taaatataga gaaaagttca caattcaaga
     2281 gcatttctat gatgactgta atttctctaa caacctggta caaggacaag gcaatggatc
     2341 cttatctcgg ccttgtccat atgaaatgtg ttcagccact ggcactggta atagtgagtt
     2401 tcgctttctt aagcgtttta tgcccaactt ccctttccct catgccactg gggagataaa
     2461 aatggaggct ggctccagtt tgcccccaaa ttctgatagg aataagtctc agagattaga
     2521 gggccatgac caggtatctg atgactatat gtagctccta tttacaggct cagtgagaga
     2581 agagaagcaa aattttatac ttggtatgca aagatgttac atcctcatta aaacaaaaac
     2641 tggtagtaga ttgcagcttt agtaaagata agagtactta gtttggtgaa aatgggaaac
     2701 ctagagtgag gctaggctta ctcaatacaa agcagttatc ctgatcccca gatcatatat
     2761 ctataaccct ttctccagtt ggaattctgt ttaaagaaat gtcaccctct ataaatgcat
     2821 atgtggtagg aacttctgct tttccatctc tgtgctagca agtaatgaat aagccattat
     2881 tcacattttc cttagaagtt cattggtcct ggcccaggaa atacttagtt ccatagagag
     2941 atccttttat ttgcctctaa attattttcc agtagaaagt tatgcatgca tagggaagag
     3001 aactaccttc cctttttgat atattgggaa gtgattaggt ttgacaagca gagatatagt
     3061 ttattattca ggaatctcta aattcttgtc cctgatgagt gattatcttt gatcaatacc
     3121 ttgcctgcaa tcattcataa tcataatcat ggaaatgcct ggtaaatggt gatcttcaca
     3181 aataatcatg gtgggaggaa gggtggagaa agaaaaggat ttcacttatt tgcaaatgtg
     3241 aataagggca gacataagga taaagagatt cagtttagga atgttctcca aaattaaatt
     3301 agatgtagtt gttttttttt tttttttttt tttttttgag acggagtttt tctcttgttg
     3361 cccagactgg agtgcaatgg cacgatctcg gctcactgca acctctgcct cctgggttca
     3421 agcgattctc ctgcctcagc ctcctgagta gctaggatta caggcatgcg ccaccatgcc
     3481 cagctaattt tttggtattt ttagtagaga cggggtttca ccatgttggc caggctggtc
     3541 atgaacttct gacctcaggt gatccaccag cctcggaaac ccaaagcact gggattacag
     3601 gcataagcca ccacgcccag ccagatttga tttcttgatt gtttggagcc ataggcaagt
     3661 ctcaaatctc cctcttttat atccagatgt ctatccttgc agtcccagag aaaatctatt
     3721 tgaaaaaacg gaaatggagg gtgggtgagg aaaaaaataa agtatgacgg ctgggcaccg
     3781 tggctcatgg ctgtaatctc agcactctgg gagacggagg gaggcagatc acctgaggtc
     3841 aggagttcga gatcaccctg gctaacatgg caaaacccta tctctactaa aaatacaaaa
     3901 attagtcagt cgtggtggca cgcacctgta atcccaggta ctcaagaggc tgaggctgga
     3961 gaatcgcttg aacctgggag gtggaggttg cagtgagctg agattgtgcc actgcactcc
     4021 agcctgggca acagagtgag acgctgtctc aaaaacataa aaataaatac ataaatacat
     4081 aaatacataa ggcctgctgt agttaataag tgttacagaa cactctaaac tattttgtgc
     4141 cattaagtgt acacaacatt tattgtaaac cattttgtag tttgtagagc aaatataaaa
     4201 taaaaagaca ttaaaattaa aaagttcatt aatactaatt aagtggcatt aaggaaagac
     4261 acattttcag gtagtactag atttgattgt aagccatttt cctctctgag tattctgaag
     4321 ttaacacatg caaactgaga aaaagtggca tttttagtaa atcattcata aaatgaaatg
     4381 gagtggggag acaacttaag cttctctttg atcaccactg tttgatttca taagctattc
     4441 tgagccctct cattctaaaa taagccaatg ttaaaacatt aacatatttc agggattctc
     4501 ccaacactgc taactgtgcc ttgaaagtca aaagtttgct ttagagaagg gcatggtggc
     4561 tcatacctgt agtcccagct actcaggagt ctgaaggagg aggattgctc aagcccagga
     4621 gttcaggggt gcagtaagct atgattgcac ttctgcactc cagcctgggc aaaagagtga
     4681 aacctcatct caaaaaaaaa aaaagtgtgc tttaatgagg ctttaattat attccttatt
     4741 ttataaaaat gtgtgtaaat tcagactcac tagaatacat cctcttggta ttttaagggt
     4801 agagcattat cttttaaaat acttcttaaa tataccaaat catgtttatt gatacaaact
     4861 tcattcttgg acttaatgac tgatacctaa tggcaccacc tggctgttta cctgttggcc
     4921 aggaatacac taaaatttag tgctgttatt ttttagatgt tagagatgct tagggcagaa
     4981 ctggtgtaac ctatggctgc cttcaatgtt aaaatgttaa agaacagatg aagcaaatgc
     5041 actatatcaa tgaattgctt ttatttttaa tattaaatat tttacataca ttgagttatg
     5101 attccgattt agagtaaagg ttttcttgca caaaacatag aataagtgtt ccagtgtatt
     5161 tgtgttccaa ttggtgaagg catgctgaaa tttctatttc ctttaaatga aaaaggagat
     5221 agaattttta tttatttatt tattttttgg agacaaagtc ttgctctgtc acccaggctg
     5281 gagtacagtg gcatgatctc ggctcactgc aaactccgtc tcctgggttc aagtgatctt
     5341 cctgcctcag cctcctgagt agctgggact acaggtatac attaccacgc ccagctaaat
     5401 tttgtgtttt tagtagagac ggggcttcgc catgttggca tttcgctatg ttggccaggc
     5461 tggtctcgag ctcctgatct caggtgatcc acccgccttg gcctcccaaa gtgctaggat
     5521 tacagcacca tgcccagcct agaattaatt tttatgggta agcaataatt agttaataaa
     5581 acatgcttaa gtaaaagcta ctgtattaac tgtgtttcat tacacttaat gatgtgaaca
     5641 taatcaatgg aaactggctt aatgtcaagg ataggaaaag aaaatggtgt agattcatga
     5701 ttttaagact ttgatattca aatagcagtg aaattcatga atacatatat acacacatac
     5761 acaatggaca gaagatgtag atttgtcaac tttttatttt ttcacattaa atgagataaa
     5821 atctaccact tcacgccacc attattccat aaacgaaatg gcattttaat ataaaaatgg
     5881 ttaagatagg ctgggcatgg tggctcacac ctgtaatacc agtactttgg gaggctgagg
     5941 cagatggatc acaaggtcaa gagatggaga ccatcctggc caacatggtg aaaccatgtc
     6001 tctattaaaa atacaaaaat tagctgggtg tggtggtatg tgcctgtagt cccagctact
     6061 tgggaggctg aggcaggaga attgcttgca cccaggaggt ggaggttgca gtgagctgag
     6121 atcatgccac tgcactccag cctggcgaca aagcaagact ctgtctcaaa aaaaaaaaaa
     6181 aaaaagaaaa aaagaaaaaa gaaaaaaaaa ggtaagataa caatctcata aaagaaacca
     6241 tcctttaaat ttaaaaaatg tatcgattta ataaaaaatt attttgccac catttttctt
     6301 atttttgcct taggtgaaaa ttttgtcact ctaattttat tcagacttca agttcccaag
     6361 aaaattccaa tcctacctga taacttaaaa taagaatata tcaattcact gaatgtgaag
     6421 taggccactt gtttttggag agaactctgt acaccagctg agattaagtc caggtctcta
     6481 tcagcaaatt aagacaaaga atggaaataa ttagggcaat tactctctcc aaagtgtcaa
     6541 gtgatattat aactatttct atgtattcaa agctataacc taagaacctt gaaaagtgtc
     6601 ttgtacaaaa aggcttttta ttaggaaata attctagact cataaaattg caaaaatact
     6661 atagatagtt cctgtatatc cttcacctaa cttcccggaa tgctaacatc ttatataacc
     6721 atagtagtta tcaaaattaa gaaattaacc ttggtataat tctatgaagt aaactacaga
     6781 tcttattcaa atttaacagt tttcccccaa tgtccttttt ctattcaagg atccaatcca
     6841 ggatcctgca aagcatttgt tatggctcct tagtctctac cacctgtgac agttccttac
     6901 tcttaccttg tctatcatga cttgagattt ttgaagagta ctagccagtt atttgtagaa
     6961 tgcccctcag tttgggattc tttgttttct cattattaaa ctgaggtaat gcattattgg
     7021 gaaaaatact gcagaaatga tattgtatcc ttttcagtgc atcacgtcag caggtatgtg
     7081 atgccaatgt cacactactg gtgatattaa tcttttttct tttattgtgg taaagaactt
     7141 ataaaatgta ccatgttagc catttttaag tatgttagcc atttttaagt aatgttaagg
     7201 tgatgttaat tttgatcgct tggttaacat aatgtctgcc acgtttctct actataaagt
     7261 tacttttttc tctttgtaat taataaacac ttgggggata tgctttgaaa ctatgcaaat
     7321 atgatgtttc tgcttaaacc aattttagta tccattgcta gatatttcct gtggcaatta
     7381 atattgtggc attctaatgg tgattttcta tttctctatt tccttttaca ttaattaaaa
     7441 ttcttctgga aggaaaactt gttactttcc cccccactta tttagttagt tatttcttta
     7501 cataaggata cctggatatc tcctctatta tttgggttac aaactaatcc tatcatttac
     7561 tttgttgttc agcaaactct tttatctgag atgaagagca gatttttaag actggaatta
     7621 tccatataga atacattttt atcaaaatta gtatttcttt gtaactctac atgttagatt
     7681 attttaaaca atcataaagt aaccccatta aggttcatgc ataaagtttt aactttaaat
     7741 gaaaattata ctaacataat tttaaattag tcatacattt taaaatagat ataaactgaa
     7801 aattttaaaa tttgttgtgc agacatgttt atatagttta agctatatat acctgagata
     7861 ctatttaaaa atagacttat atgctgaaat tagacttaca gatatacaaa aaatggaatt
     7921 ggtctgtctg atattatgta attctcctaa aaataaagaa tttctttatc atg
//
