LOCUS       NM_031865               2427 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens protocadherin alpha 13 (PCDHA13), transcript variant
            2, mRNA.
ACCESSION   NM_031865
VERSION     NM_031865.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2427)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   2  (bases 1 to 2427)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   3  (bases 1 to 2427)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   4  (bases 1 to 2427)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   5  (bases 1 to 2427)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   6  (bases 1 to 2427)
  AUTHORS   Sugino,H., Hamada,S., Yasuda,R., Tuji,A., Matsuda,Y., Fujita,M. and
            Yagi,T.
  TITLE     Genomic organization of the family of CNR cadherin genes in mice
            and humans
  JOURNAL   Genomics 63 (1), 75-87 (2000)
   PUBMED   10662547
REFERENCE   7  (bases 1 to 2427)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF152478.1.
            
            [WARNING] On Feb 5, 2025 this sequence was replaced by NM_031865.2.
            
            Summary: This gene is a member of the protocadherin alpha gene
            cluster, one of three related gene clusters tandemly linked on
            chromosome five that demonstrate an unusual genomic organization
            similar to that of B-cell and T-cell receptor gene clusters. The
            alpha gene cluster is composed of 15 cadherin superfamily genes
            related to the mouse CNR genes and consists of 13 highly similar
            and 2 more distantly related coding sequences. The tandem array of
            15 N-terminal exons, or variable exons, are followed by downstream
            C-terminal exons, or constant exons, which are shared by all genes
            in the cluster. The large, uninterrupted N-terminal exons each
            encode six cadherin ectodomains while the C-terminal exons encode
            the cytoplasmic domain. These neural cadherin-like cell adhesion
            proteins are integral plasma membrane proteins that most likely
            play a critical role in the establishment and function of specific
            cell-cell connections in the brain. Alternative splicing has been
            observed and additional variants have been suggested but their
            full-length nature has yet to be determined. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (2) utilizes the large, first exon
            then continues into the downstream intron 1 sequence before
            terminating. This one-exon transcript encodes a shorter isoform
            (2), compared to isoform 1. This short variant is represented based
            on data in PMID:10380929.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF152478.1 [ECO:0000345]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2427
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..2427
                     /gene="PCDHA13"
                     /gene_synonym="CNR5; CNRN5; CNRS5; CRNR5; PCDH-ALPHA13"
                     /note="protocadherin alpha 13"
                     /db_xref="GeneID:56136"
                     /db_xref="HGNC:HGNC:8667"
                     /db_xref="MIM:606319"
     exon            1..2427
                     /gene="PCDHA13"
                     /gene_synonym="CNR5; CNRN5; CNRS5; CRNR5; PCDH-ALPHA13"
                     /inference="alignment:Splign:2.1.0"
     CDS             1..2424
                     /gene="PCDHA13"
                     /gene_synonym="CNR5; CNRN5; CNRS5; CRNR5; PCDH-ALPHA13"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; KIAA0345-like 1; ortholog of mouse CNR5;
                     PCDH-alpha-13"
                     /codon_start=1
                     /product="protocadherin alpha-13 isoform 2 precursor"
                     /protein_id="NP_114071.1"
                     /db_xref="GeneID:56136"
                     /db_xref="HGNC:HGNC:8667"
                     /db_xref="MIM:606319"
                     /translation="MLSSWQGGPRPRQLLLWLLILAAWETGSGQLHYSVPEEAKHGTF
                     VGRIAQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAEC
                     SIHLEVIVDRPLQVFHVEVKVRDINDNPPIFPESKKRIIIAESRPPETRFPLDGASDA
                     DIGVNSALTYRLDPNDYFTLDAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGG
                     KPELTGTVQLLITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGD
                     IVYSFRRPVWPAVVYAFTINPNNGEIRTKGKLDFEEKKLYEISVEAVDKGNIPMAGHC
                     TLLVEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPH
                     VPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGVADVND
                     NAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERALSSYV
                     SVHAESGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALL
                     TPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFRV
                     GLYTGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTATATVLLSLVESGQAPQASSRA
                     SAGAVGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAPPTEGACAPGKPTLV
                     CSSAAGSWSYSQQRRPRVCSGEGPHKTDLMAFSPSLPPCLGSAEGTGQREEDSECLKE
                     VSLYFKKLS"
ORIGIN      
        1 atgctgtctt cctggcaagg aggcccaaga ccgcggcaac tactgctctg gcttctgatc
       61 ctcgcagcct gggagacggg tagtggccag ctccactact ccgtccccga ggaagcaaaa
      121 cacggcacct tcgtgggccg catcgctcag gacctggggc tggagctggc ggagctggtg
      181 ccgcgcctgt tccgggtggc gtccaaaaga cacggggacc ttctggaggt aaatctgcag
      241 aatggcattt tgtttgtgaa ttctcggatc gaccgcgagg agctgtgtgg gcggagcgcg
      301 gagtgcagca tccacctgga ggtgatcgtg gacaggcctc tgcaggtttt ccatgtggag
      361 gtgaaggtga gggacattaa cgacaacccg cccatattcc ctgaaagcaa gaaacgaata
      421 atcattgcag aatctagacc tccggaaact cgatttccac tagatggcgc atccgatgca
      481 gatattggag taaactcggc attgacctac cgactggatc ccaacgatta tttcactttg
      541 gacgcacaaa acagtcttga gcaaatgtct tcattatcac ttgtactgag gaaaacactg
      601 gacagagagg aaattcagga acatagttta ttactgacag ccagtgatgg aggtaaaccc
      661 gagctgactg gcacagttca gctgctcatc acgattctgg acgtgaatga caacgccccg
      721 gaattttacc aatccgttta taaagtgacg gtgttagaga acgccttcaa tggaacatta
      781 gtgatcaagc taaatgccac agatcctgat gatggtacaa atggagatat agtttactca
      841 tttagaaggc ctgtatggcc tgcagtggta tatgcattta ccataaatcc gaacaatgga
      901 gaaattagga caaaaggcaa actagatttc gaagaaaaga aattatatga aatatccgtg
      961 gaggcagttg acaaaggaaa tattccaatg gcgggtcatt gtaccctttt ggtggaagta
     1021 ctagatgtaa atgataacgc cccagaggtt accatcactt ctttgtcact ccccatcaga
     1081 gaagacactc agcctagcgc cattattgcc ctaatcagtg tgtccgatcg tgactctggc
     1141 tcaaatggac aggtcacctg caccttgacg ccgcatgtcc ccttcaagct ggtgtccacc
     1201 tacaagaact actactcatt agtgctggac agcgccctgg accgcgagag cgtatcagcc
     1261 tatgaactgg tggtgaccgc gcgggacggg ggctcgcctt cgctgtgggc cacggccagc
     1321 gtgtcggtgg gggtggccga cgtgaacgac aacgcgccgg cgttcgcgca gcccgagtac
     1381 acggtgttcg tgaaggaaaa caatccgccg ggctgccaca tcttcacggt gtctgctcag
     1441 gacgcggacg cacaggagaa cgcgctggtc tcctactcgc tggtggagcg gcgggtgggc
     1501 gagcgtgcgc tgtcgagcta cgtgtcggtg cacgcggaga gcggcaaggt gtacgcgctg
     1561 cagccgttgg accacgagga gctggagctg ttgcagttcc aggtgagcgc gcgcgactct
     1621 ggcgtgccgc ctctgggcag caacgtgacg ctgcaggtgt tcgtgctgga cgagaacgac
     1681 aacgctccgg cgctgctgac gcccggggct ggcagcgcgg gaggcacagt gagcgagctg
     1741 atgccgcggt cggtgggtgc aggccacgtg gtggcgaagg tgcgcgcggt ggacgccgat
     1801 tcgggctaca atgcgtggct ttcgtatgaa ttgcagctgg cggcggtcgg cgcgcgcatc
     1861 ccgttccgcg tggggctgta cactggcgag atcagcacga cgcgccctct ggacgaggtg
     1921 gacgcgccgc accaccgcct tctggtgctg gtgaaggacc acggtgagcc cgcgctgacg
     1981 gccacggcaa cggtgctgtt gtcgctggtg gagagcggcc aagcgccaca ggcttcgtcg
     2041 agggcgtcgg caggcgctgt gggtccagaa gcggcgctgg tggatgtcaa tgtttacttg
     2101 atcattgcca tctgcgcggt gtccagcctg ttggtgctca cgttgctgct gtatactgcg
     2161 ctgcggtgct cggcaccgcc caccgagggc gcgtgcgcgc cgggcaagcc cactctagtg
     2221 tgctccagcg cggcagggag ttggtcgtac tcgcagcaga ggcggccgag ggtgtgctct
     2281 ggggagggcc cgcataagac ggacctcatg gccttcagtc ccagccttcc tccttgtctg
     2341 ggttctgcag agggaacagg ccagagggag gaggactcag aatgcttgaa agaggtaagc
     2401 ttatatttta aaaaattgtc ttagtaa
//
