LOCUS       NM_203487               6227 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens protocadherin 9 (PCDH9), transcript variant 1, mRNA.
ACCESSION   NM_203487
VERSION     NM_203487.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6227)
  AUTHORS   Kelam,J., Kelam,N., Filipovic,N., Komic,L., Racetin,A., Komic,D.,
            Kostic,S., Kuzmic Prusac,I. and Vukojevic,K.
  TITLE     Expression of Congenital Anomalies of the Kidney and Urinary Tract
            (CAKUT) Candidate Genes EDA2R, PCDH9, and TRAF7 in Normal Human
            Kidney Development and CAKUT
  JOURNAL   Genes (Basel) 15 (6), 702 (2024)
   PUBMED   38927638
  REMARK    GeneRIF: Expression of Congenital Anomalies of the Kidney and
            Urinary Tract (CAKUT) Candidate Genes EDA2R, PCDH9, and TRAF7 in
            Normal Human Kidney Development and CAKUT.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6227)
  AUTHORS   Zhou,K., Wang,L., Sun,Z., Liu,Y., Zhu,Y., Liu,Z., Zhang,B. and
            Shi,H.
  TITLE     COP1 Acts as a Ubiquitin Ligase for PCDH9 Ubiquitination and
            Degradation in Human Glioma
  JOURNAL   Mol Neurobiol 59 (4), 2378-2388 (2022)
   PUBMED   35084653
  REMARK    GeneRIF: COP1 Acts as a Ubiquitin Ligase for PCDH9 Ubiquitination
            and Degradation in Human Glioma.
            Erratum:[Mol Neurobiol. 2022 Jul;59(7):4647. doi:
            10.1007/s12035-022-02865-9.. PMID: 35579848]
REFERENCE   3  (bases 1 to 6227)
  AUTHORS   Izycka,N., Sterzynska,K., Januchowski,R. and Nowak-Markwitz,E.
  TITLE     Semaphorin 3A (SEMA3A), protocadherin 9 (PCdh9), and S100 calcium
            binding protein A3 (S100A3) as potential biomarkers of
            carcinogenesis and chemoresistance of different neoplasms,
            including ovarian cancer - review of literature
  JOURNAL   Ginekol Pol 90 (4), 223-227 (2019)
   PUBMED   31059116
  REMARK    GeneRIF: This review discusses the role and potential use as
            biomarkers of semaphorin 3A (SEMA3A), protocadherin 9 (PCDH9), and
            S100 calcium binding protein A3 (S100A3) in carcinogenesis and
            chemoresistance of various tumors, including ovarian cancer.
REFERENCE   4  (bases 1 to 6227)
  AUTHORS   Xiao,X., Zheng,F., Chang,H., Ma,Y., Yao,Y.G., Luo,X.J. and Li,M.
  TITLE     The Gene Encoding Protocadherin 9 (PCDH9), a Novel Risk Factor for
            Major Depressive Disorder
  JOURNAL   Neuropsychopharmacology 43 (5), 1128-1137 (2018)
   PUBMED   28990594
  REMARK    GeneRIF: convergent lines of evidence suggest that PCDH9 is likely
            a novel risk gene for MDD.
REFERENCE   5  (bases 1 to 6227)
  AUTHORS   Lv,J., Zhu,P., Zhang,X., Zhang,L., Chen,X., Lu,F., Yu,Z. and Liu,S.
  TITLE     PCDH9 acts as a tumor suppressor inducing tumor cell arrest at
            G0/G1 phase and is frequently methylated in hepatocellular
            carcinoma
  JOURNAL   Mol Med Rep 16 (4), 4475-4482 (2017)
   PUBMED   28791409
  REMARK    GeneRIF: PCDH9 acts as a potential tumor suppressor gene, and that
            the loss of PCDH9 expression appears be a driver in a significant
            fraction of hepatocarcinogenesis cases.
REFERENCE   6  (bases 1 to 6227)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 6227)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   8  (bases 1 to 6227)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   9  (bases 1 to 6227)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 6227)
  AUTHORS   Strehl,S., Glatt,K., Liu,Q.M., Glatt,H. and Lalande,M.
  TITLE     Characterization of two novel protocadherins (PCDH8 and PCDH9)
            localized on human chromosome 13 and mouse chromosome 14
  JOURNAL   Genomics 53 (1), 81-89 (1998)
   PUBMED   9787079
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK054661.1, BX537422.1,
            DA278856.1, AL834258.1 and AI300218.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_203487.2.
            
            Summary: This gene encodes a member of the protocadherin family,
            and cadherin superfamily, of transmembrane proteins containing
            cadherin domains. These proteins mediate cell adhesion in neural
            tissues in the presence of calcium. The encoded protein may be
            involved in signaling at neuronal synaptic junctions. Sharing a
            characteristic with other protocadherin genes, this gene has a
            notably large exon that encodes multiple cadherin domains and a
            transmembrane region. Alternatively spliced transcript variants
            encoding distinct isoforms have been found for this gene. [provided
            by RefSeq, Nov 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC136626.1, SRR1660803.75701.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377865.7/ ENSP00000367096.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               AK054661.1         1-233
            234-920             BX537422.1         232-918
            921-1149            DA278856.1         315-543
            1150-4800           AL834258.1         1-3651
            4801-6224           AL834258.1         3653-5076
            6225-6227           AI300218.1         8-10                c
FEATURES             Location/Qualifiers
     source          1..6227
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q21.32"
     gene            1..6227
                     /gene="PCDH9"
                     /note="protocadherin 9"
                     /db_xref="GeneID:5101"
                     /db_xref="HGNC:HGNC:8661"
                     /db_xref="MIM:603581"
     exon            1..557
                     /gene="PCDH9"
                     /inference="alignment:Splign:2.1.0"
     exon            558..3728
                     /gene="PCDH9"
                     /inference="alignment:Splign:2.1.0"
     CDS             693..4406
                     /gene="PCDH9"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cadherin superfamily protein VR4-11"
                     /codon_start=1
                     /product="protocadherin-9 isoform 1 precursor"
                     /protein_id="NP_982354.1"
                     /db_xref="CCDS:CCDS9444.1"
                     /db_xref="GeneID:5101"
                     /db_xref="HGNC:HGNC:8661"
                     /db_xref="MIM:603581"
                     /translation="MDLRDFYLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIP
                     KDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGAS
                     YAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSR
                     FPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTY
                     VMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHA
                     TDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASD
                     GSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKD
                     TDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLN
                     QTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL
                     GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDEN
                     DNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYS
                     GVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNT
                     SFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEK
                     PAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTMETPLDR
                     NIGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVLVRCRHASRFKAAQRSKQGAEW
                     MSPNQENKQNKKKKRKKRKSPKSSLLNFVTIEESKPDDAVHEPINGTISLPAELEEQS
                     IGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKKHHVIQELPLDNT
                     FVGGCDTLSKRSSTSSDHFSASECSSQGGFKTKGPLHTRQCNSHSKSDNIPVTPQKCP
                     SSTGFHIQENEESHYESQRRVTFHLPDGSQESCSDSGLGDHEPVGSGTLISHPLPLVQ
                     PQDEFYDQASPDKRTEADGNSDPNSDGPLGPRGLAEATEMCTQECLVLGHSDNCWMPP
                     GLGPYQHPKSPLSTFAPQKEWVKKDKLVNGHTLTRAWKEDSNRNQFNDRKQYGSNEGH
                     FNNGSHMTDIPLANLKSYKQAGGATESPKEHQL"
     exon            3729..3830
                     /gene="PCDH9"
                     /inference="alignment:Splign:2.1.0"
     exon            3831..4032
                     /gene="PCDH9"
                     /inference="alignment:Splign:2.1.0"
     exon            4033..6227
                     /gene="PCDH9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6206..6211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDH9"
                     /note="hexamer: AATAAA"
     polyA_site      6227
                     /gene="PCDH9"
                     /note="major polyA site"
ORIGIN      
        1 agttcagaga gaggagaggg agaaggagag aggggcagag gggaagggag agagggagag
       61 cacgcgagac ggaaaggagc gcctcagagt ctctgaagca cgcaagagat aaccgattag
      121 gaatttttcg ggcaactgtc acccggatag ctgtcagaga atcatcatca ccgcaactct
      181 gacgtttcct acaagaagtt agagacttaa gcagtattgg catcggatgg aaatggtatg
      241 catgctgctg tggaaaatat ccctgagctg aagaagtgca actatgtgtt gtgtgtgcta
      301 aatgcccaga agaacccaga cccagtgggt aagagagacg aaatgtggag agaatgacta
      361 acgacaaatc cgtgaatttg ttctctggag ttgctaattt gccagcccga agcaacacat
      421 tttacaagga ggaaacattt tgctgcttct gatttctccc caaactggtg ctaccagatg
      481 catggctttc tatgtgttgg aacaaatcat tcctaactgc agcatactgg gaaaggggaa
      541 aggttgaggc aactaaccgg ctgtctccaa ataagtgatg agatataatg catcctccag
      601 tccatgcacg cttcctcttg caatttgtgc atcattcctc agtggaaacc tttaaaccct
      661 aaaatccagg aaaagaaaat aaatacatta tcatggacct gagggatttt tacctgttgg
      721 ctgctctgat tgcctgttta aggctggatt ccgcaatagc tcaagaactt atttacacta
      781 ttagagagga attgcctgaa aatgtgccca taggaaacat accaaaggat ctgaacattt
      841 ctcacatcaa tgctgccaca gggaccagcg ccagccttgt ctacagactg gtttctaaag
      901 ctggggatgc ccctttggtg aaagtttcca gcagcactgg ggaaattttc acaacctcca
      961 acagaataga cagagaaaaa ctctgtgctg gcgcctcata tgctgaggag aatgagtgtt
     1021 tctttgaact tgaggtggtg atcctcccca atgatttctt caggctgatc aaaataaaaa
     1081 taattgtcaa ggataccaat gataatgccc ccatgtttcc atctcctgtc atcaatattt
     1141 ccattccaga aaacactttg atcaacagcc gctttccaat tccatcagca acagatcctg
     1201 acacaggctt caatggtgta cagcattatg aattgttaaa tgggcagagt gtttttggac
     1261 tggatatcgt ggaaactcca gagggagaga agtggccaca actgattgtt cagcaaaact
     1321 tggatagaga acagaaagat acctatgtga tgaaaatcaa agtagaggat ggaggcactc
     1381 cacagaaatc cagtacggcc atactgcagg tcacagtaag tgatgtaaat gacaacaggc
     1441 cagtgtttaa agagggtcaa gtggaggtgc atattccaga gaatgctccc gtaggtacct
     1501 ctgtaattca gctccatgcc actgatgcag atataggcag taatgctgaa atccggtaca
     1561 tttttggtgc ccaggtcgcc cctgcaacca aaagactctt tgctttaaat aatactactg
     1621 ggctgattac agttcagagg tccttagata gagaggagac agccattcac aaagtgacag
     1681 tgctggctag tgacggcagc tccactcctg ctcgagcaac ggttaccatc aatgtcaccg
     1741 atgtaaatga taaccctcct aatatagacc tcaggtacat tataagtccc atcaatggca
     1801 ccgtgtattt atctgagaaa gatcctgtca atacaaagat tgccctaatt acagtttcag
     1861 ataaggacac agatgtgaat ggcaaagtga tctgttttat tgaaagagag gtcccatttc
     1921 atttgaaggc ggtatatgac aaccaatatt tgttagagac ctcttctttg ttggactatg
     1981 agggcaccaa agaattcagc tttaaaattg ttgcctctga ttctgggaag cccagtttaa
     2041 atcagactgc cctggtaagg gttaagcttg aggatgaaaa tgacaaccca ccaattttca
     2101 accagcctgt aattgagctg tcagtttctg aaaacaaccg acgtgggtta tacttaacaa
     2161 ctattagtgc cacagatgaa gacagtggga aaaatgcaga cattgtttat cagcttggac
     2221 cgaatgcctc cttctttgat ctggaccgaa aaacaggagt tttgacagcc tccagagtat
     2281 ttgacagaga agaacaagaa cgattcattt ttacagtaac tgccagggac aatgggaccc
     2341 ctcccctcca aagccaagcg gctgtgattg ttactgttct ggatgagaat gacaatagcc
     2401 ccaagtttac tcataatcat tttcaatttt ttgtgtctga gaatctgcca aagtatagta
     2461 ctgtgggggt aatcacagtg acagatgcag atgctggaga gaataaagct gtgactcttt
     2521 ccattctaaa tgacaatgat aattttgtgt tggatcccta ttctggagtc ataaagtcaa
     2581 atgtctcatt tgatagagag cagcagagtt cctacacttt tgatgtcaaa gccactgatg
     2641 gaggacaacc acctcgttcc tctactgcaa aagtaactat caacgtcatg gatgtcaatg
     2701 acaacagccc agttgtcatt tctccaccgt ctaatacttc ctttaagttg gtgcccctct
     2761 cagccattcc tggctccgtg gtagcagaag tttttgcagt ggatgttgac actggaatga
     2821 acgctgaact aaagtatact atagtgagtg gaaacaataa aggcttattc cggattgatc
     2881 cagtaacagg taacattact ctggaagaaa aaccagcacc tactgatgtg ggattgcatc
     2941 gtttggtggt caacataagt gacctggggt accctaagtc tttgcacacg cttgtgcttg
     3001 tattccttta tgttaacgac actgctggaa atgcctccta tatctatgac ttgatccgca
     3061 ggactatgga gaccccgttg gacaggaaca taggggatag tagccaaccc tatcaaaatg
     3121 aggactatct aaccatcatg attgccatca tcgccggtgc catggtggtc attgttgtga
     3181 tcttcgtcac cgttctggtg cgctgtcgcc atgcatcaag gttcaaagca gctcagagga
     3241 gcaagcaagg tgccgaatgg atgtccccaa accaggagaa caagcaaaac aagaaaaaga
     3301 aaagaaagaa aaggaagtct cccaaaagct ctcttttgaa ctttgttact atcgaagagt
     3361 ccaaacccga tgatgcagtt catgaaccta tcaatgggac aataagcctg ccggctgaac
     3421 tggaggagca aagtatagga agatttgact ggggcccggc acctccaaca acattcaagc
     3481 ctaacagtcc tgacctggcc aagcactaca aatctgcttc tccacagcct gcttttcatc
     3541 tcaaaccaga cactccagtt tccgtgaaaa agcaccacgt gattcaggaa ctccctttgg
     3601 acaacacctt tgttgggggt tgtgacaccc tttctaaacg ctcttccact agttcagatc
     3661 acttcagtgc ctcagagtgc agttcccaag gaggcttcaa gacaaagggc cccttacaca
     3721 ccagacagtg taactcacac agcaaaagtg acaatattcc tgtcactcct cagaaatgtc
     3781 ccagctccac gggtttccac attcaggaga atgaagaaag ccattacgag tcgcagcgcc
     3841 gtgttacgtt tcatctccct gatggctccc aggaaagctg cagtgacagt ggtctaggag
     3901 accatgagcc ggtgggtagt ggaaccctga tctcacaccc tcttcctctg gttcagccac
     3961 aggacgaatt ctatgaccag gcctctccgg acaagaggac tgaagcagat ggcaactctg
     4021 atcccaactc tgatgggcct ttgggtcccc gaggattagc tgaagctaca gagatgtgca
     4081 ctcaagagtg cttggttttg ggtcactctg ataattgctg gatgcctcct ggcttgggtc
     4141 catatcaaca ccccaaatct cctctctcaa cctttgcacc ccagaaagaa tgggtgaaga
     4201 aggacaagct tgtgaatggg cacaccctga ccagagcctg gaaagaagac agcaacagga
     4261 accagttcaa tgaccgtaag cagtatggct ccaatgaagg ccatttcaac aatggcagcc
     4321 acatgacaga cattcctctg gcaaatctga agtcttataa gcaagcagga ggtgctactg
     4381 agagtcctaa ggagcaccaa ctctaagaaa aggctatatg ggacctaata actttaaata
     4441 gacatgctaa taccgtgtgc gtcagagctt tatgtattca atagatctct acaactatgc
     4501 cccttctagc agggatacct ataactttgt gttagcacca tggagaatac aatgtttttg
     4561 caacatatga gagaagatag ttctagccat gcaattttgt ttactagaat tgattacact
     4621 ctccagagat ctctccattg tgcaaatttt ttttattatt gcattttatt ttgaccctgg
     4681 actgctgcta tgaacaatag aatatgcatt tggaaagtaa gaaagtttca tggattagag
     4741 tgactgaaaa acatatccag ttagaaaatt gtgctttttt tttttttttt tttttttttt
     4801 gtcattgatt tgtgctggga ctgctatact tgacattata ctgcaaacaa aacttaaaga
     4861 gataagcatt aaacctattg tgctgttaac aacgttagtg gacacttgta agtcaatcag
     4921 tgttaaagta tttgtaaata gaagcaagct attattaaca acttttgtgt acttataatg
     4981 ttcacctaaa aatgttgtag cataattctg tgttttatgg ttgcttctgt ccttcttttt
     5041 atttacctct ttgttgttat ttttgttgtt tctttcagtg aggtgtttct gtgttagtag
     5101 tctgtcttga cacacattgt tcaaacaatc tcaagcactt gtgtttaaaa aaggttctga
     5161 aatcttgctt ctcatatgat agcttatgat gccggaattc tgtaaacaat aaagatgaaa
     5221 gaaaaaatga aaactttata caaaaaagga cttctgcaaa agcttggaaa ttcagaacct
     5281 attttttatc atcttatttt caaagtaggc aaaagcaaaa tcacttaatt agtaccatta
     5341 agtgagagag taatggaaaa ctgttatcca tcaaaagtga tataatatcc tgtacttgtc
     5401 actcatgtaa aactaatgta tcaaaattag catatatgga agaaaaatca ctattcaaaa
     5461 atagtttcaa ttgggcaaat gtgtgtctac aactttgttg aaatggcaga gtctgtgttg
     5521 atcctcatat acaataatgt tgttgtaaca caagtgttat tagaccatag ccacaaaata
     5581 tttaatgtgt tgtgccttca tgatgtaaca gaacattctc caggtagggt agttggggga
     5641 aataaaggga taaatctcta attattgctg tttaactgtt tgttatcata gttggtcaat
     5701 gcctggcagg taccagcata ttgtcactta ggtcaaacca ataaagtgac aactaatgtt
     5761 aataagatct cagttgcacg tgcaaacaaa tccaaattcg aacattctta ggaggttttt
     5821 gttaaggcat gacagatgat ttaaacaaat aaatagcatg caacaaaatg tctttattga
     5881 aagaagtgga agttatctta atgccacggt tcaccatcaa tttaaaagta aaaaaaacaa
     5941 aaaaaaaaca aaaaatttaa aaaaaaggtt tgctaatctg atagttaatt tgttcttacc
     6001 aaaaaataaa attactttgt aaatagcagt tcacattttt ccacagtata atggaaaata
     6061 atgggtaggg gtgcattgct tattgaagta catttttgtc ggtttgtgag gggtgtttga
     6121 tgactttgac agaataaata tctaaacaat tatccttgtt actgctttgc cagttctacg
     6181 ttatttacaa ttattcagct cttgcaataa atgttctgaa ttcctga
//
