LOCUS       NM_002590               5088 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens protocadherin 8 (PCDH8), transcript variant 1, mRNA.
ACCESSION   NM_002590
VERSION     NM_002590.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5088)
  AUTHORS   Yang,R., Yang,N., Yin,P., Xue,Z., Sun,F., Fan,R., Liang,J., Lv,X.,
            Wu,S. and Sun,L.
  TITLE     PCDH8 is a novel prognostic biomarker in thyroid cancer and
            promotes cell proliferation and viability
  JOURNAL   Funct Integr Genomics 24 (2), 35 (2024)
   PUBMED   38368303
  REMARK    GeneRIF: PCDH8 is a novel prognostic biomarker in thyroid cancer
            and promotes cell proliferation and viability.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5088)
  AUTHORS   Wu,S., Li,X., Yang,J. and Yang,L.
  TITLE     PCDH8 participates in the growth process of colorectal cancer cells
            by regulating the AKT/GSK3beta/beta-catenin signaling pathway
  JOURNAL   Tissue Cell 78, 101864 (2022)
   PUBMED   35907345
  REMARK    GeneRIF: PCDH8 participates in the growth process of colorectal
            cancer cells by regulating the AKT/GSK3beta/beta-catenin signaling
            pathway.
REFERENCE   3  (bases 1 to 5088)
  AUTHORS   Yu,H., Jiang,X., Jiang,L., Zhou,H., Bao,J., Zhu,X., Liu,F. and
            Huang,J.
  TITLE     Protocadherin 8 (PCDH8) Inhibits Proliferation, Migration,
            Invasion, and Angiogenesis in Esophageal Squamous Cell Carcinoma
  JOURNAL   Med Sci Monit 26, e920665 (2020)
   PUBMED   32330123
  REMARK    GeneRIF: Protocadherin 8 (PCDH8) Inhibits Proliferation, Migration,
            Invasion, and Angiogenesis in Esophageal Squamous Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5088)
  AUTHORS   Lin,Y., Ge,X., Zhang,X., Wu,Z., Liu,K., Lin,F., Dai,C., Guo,W. and
            Li,J.
  TITLE     Protocadherin-8 promotes invasion and metastasis via laminin
            subunit gamma2 in gastric cancer
  JOURNAL   Cancer Sci 109 (3), 732-740 (2018)
   PUBMED   29325230
  REMARK    GeneRIF: Study showed that high expression of PCDH8 was
            significantly correlated with poorer prognosis in gastric cancer
            (GC). Its ectopic expression in GC cells promoted invasion,
            migration and, metastasis; on the contrary, its knockdown inhibited
            invasion and migration of GC cell lines through LAMC2 regulation.
REFERENCE   5  (bases 1 to 5088)
  AUTHORS   Li,Y., Liu,C., Wang,Z. and Hu,G.
  TITLE     Expression of protocadherin8: Function as a tumor suppressor in
            hypopharyngeal carcinoma
  JOURNAL   Cancer Biomark 22 (3), 495-502 (2018)
   PUBMED   29865037
  REMARK    GeneRIF: Serum downregulated miR-940 may serve as a reliable
            diagnostic and prognostic biomarker in breast cancer patients.
REFERENCE   6  (bases 1 to 5088)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   7  (bases 1 to 5088)
  AUTHORS   Yamagata,K., Andreasson,K.I., Sugiura,H., Maru,E., Dominique,M.,
            Irie,Y., Miki,N., Hayashi,Y., Yoshioka,M., Kaneko,K., Kato,H. and
            Worley,P.F.
  TITLE     Arcadlin is a neural activity-regulated cadherin involved in long
            term potentiation
  JOURNAL   J Biol Chem 274 (27), 19473-11979 (1999)
   PUBMED   10383464
REFERENCE   8  (bases 1 to 5088)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
REFERENCE   9  (bases 1 to 5088)
  AUTHORS   Strehl,S., Glatt,K., Liu,Q.M., Glatt,H. and Lalande,M.
  TITLE     Characterization of two novel protocadherins (PCDH8 and PCDH9)
            localized on human chromosome 13 and mouse chromosome 14
  JOURNAL   Genomics 53 (1), 81-89 (1998)
   PUBMED   9787079
REFERENCE   10 (bases 1 to 5088)
  AUTHORS   Strehl,S., LaSalle,J.M. and Lalande,M.
  TITLE     High-resolution analysis of DNA replication domain organization
            across an R/G-band boundary
  JOURNAL   Mol Cell Biol 17 (10), 6157-6166 (1997)
   PUBMED   9315676
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC036025.1, AF061573.2 and
            AL139085.13.
            
            On Nov 23, 2018 this sequence version replaced NM_002590.3.
            
            Summary: This gene belongs to the protocadherin gene family, a
            subfamily of the cadherin superfamily. The gene encodes an integral
            membrane protein that is thought to function in cell adhesion in a
            CNS-specific manner. Unlike classical cadherins, which are
            generally encoded by 15-17 exons, this gene includes only 3 exons.
            Notable is the large first exon encoding the extracellular region,
            including 6 cadherin domains and a transmembrane region.
            Alternative splicing yields isoforms with unique cytoplasmic tails.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036025.1, AF061573.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377942.7/ ENSP00000367177.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               BC036025.1         1-365
            366-4003            AF061573.2         365-4002
            4004-5088           AL139085.13        131407-132491       c
FEATURES             Location/Qualifiers
     source          1..5088
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.3"
     gene            1..5088
                     /gene="PCDH8"
                     /gene_synonym="ARCADLIN; PAPC"
                     /note="protocadherin 8"
                     /db_xref="GeneID:5100"
                     /db_xref="HGNC:HGNC:8660"
                     /db_xref="MIM:603580"
     exon            1..2835
                     /gene="PCDH8"
                     /gene_synonym="ARCADLIN; PAPC"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..3417
                     /gene="PCDH8"
                     /gene_synonym="ARCADLIN; PAPC"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="protocadherin-8 isoform 1 precursor"
                     /protein_id="NP_002581.2"
                     /db_xref="CCDS:CCDS9438.1"
                     /db_xref="GeneID:5100"
                     /db_xref="HGNC:HGNC:8660"
                     /db_xref="MIM:603580"
                     /translation="MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGT
                     VIGTLAEDLHMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQC
                     VLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPV
                     DEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQ
                     DGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEG
                     PNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPR
                     AATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSPAGAGT
                     PEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVV
                     TAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVRE
                     NNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRS
                     FDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPAPANGSLEVAVP
                     GRTAKDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEILLTGDLSQEPP
                     GRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVS
                     GSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGG
                     ASAPGSPEEAARGAGPRPNMFDVLTFPGTGKAPFGSPAADAPPPAVAAAEVPGSEGGS
                     ATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAPPVAVWKGHSFNTISGREAEKFSG
                     KDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGHSDRCWSPSCSGP
                     NAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEKVLHRDYDRTV
                     TLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV"
     exon            2836..3043
                     /gene="PCDH8"
                     /gene_synonym="ARCADLIN; PAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..5088
                     /gene="PCDH8"
                     /gene_synonym="ARCADLIN; PAPC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3975..3980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDH8"
                     /gene_synonym="ARCADLIN; PAPC"
                     /note="hexamer: AATAAA"
     polyA_site      4003
                     /gene="PCDH8"
                     /gene_synonym="ARCADLIN; PAPC"
                     /note="major polyA site"
     regulatory      4167..4172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDH8"
                     /gene_synonym="ARCADLIN; PAPC"
                     /note="hexamer: ATTAAA"
     polyA_site      4193
                     /gene="PCDH8"
                     /gene_synonym="ARCADLIN; PAPC"
     regulatory      4816..4821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDH8"
                     /gene_synonym="ARCADLIN; PAPC"
                     /note="hexamer: ATTAAA"
     polyA_site      4847
                     /gene="PCDH8"
                     /gene_synonym="ARCADLIN; PAPC"
     regulatory      5069..5074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDH8"
                     /gene_synonym="ARCADLIN; PAPC"
                     /note="hexamer: AATAAA"
     polyA_site      5088
                     /gene="PCDH8"
                     /gene_synonym="ARCADLIN; PAPC"
ORIGIN      
        1 agcttctgta agagacggag aggcgcagag tgagggcggg tccgcgcgtc ctcagagccc
       61 gctggaggct cggagctgct acccgcagac ttctcccgca cagggctcgc aaagagcgtg
      121 attccgagag cctgagactg acgcccgacc tggaaaccag agaagacttc cttagccttt
      181 cggatcgcac ttgaggctgg aggcatgagt cctgtgaggc gttggggcag cccctgcctt
      241 ttccccttgc agctcttcag cctctgctgg gtgctctcag tggcccagag caaaacagtc
      301 cgatacagca ccttcgagga ggatgccccc ggcacggtca tcgggaccct ggccgaggac
      361 ctgcatatga aagtatcggg tgacacaagc ttccgcctga tgaagcaatt caacagctct
      421 ctgctccggg tgcgcgaagg cgacgggcag ctgaccgtcg gggacgccgg cctggaccgc
      481 gagcggctgt gtggccaggc cccgcagtgc gtgctggcct tcgatgtggt cagcttctcg
      541 caggagcagt tccggctggt gcacgtggag gtagaggtga gggacgtcaa cgaccacgcg
      601 ccgcgcttcc ccagggccca gatcccggta gaggtgtccg agggtgcggc agtgggcacg
      661 cgcatcccct tggaggtgcc ggtggacgag gacgtgggcg ccaacgggct gcagaccgtg
      721 cgcctggccg agccgcacag cccctttcgc gtggagctgc agacgcgagc ggacggcgct
      781 cagtgcgcag acctggtgct gctgcaggag ctggaccgcg agagccaggc cgcctacagc
      841 ctggagctgg tggcccagga cggcggccgc ccgccgcgct ccgccacggc tgccctcagc
      901 gtgcgcgtcc tggatgcgaa tgaccacagc ccggccttcc cgcagggcgc cgtggccgaa
      961 gtggagctgg cggaagacgc gcccgtgggc tccctgcttc tcgacctgga cgcagccgac
     1021 cccgacgagg gacctaacgg cgacgtggtg ttcgcatttg gcgcccgcac cccgccggag
     1081 gcgcgccgcc tctttcggct tgacccgcga tcaggccgcc tcaccctggc cgggcccgtg
     1141 gactacgagc gtcaggacac ctacgagctg gacgtgcggg cgcaggaccg cggacccggg
     1201 ccccgcgctg ccacctgcaa ggtcatcgtg cgcatccgag acgtcaatga caacgcaccc
     1261 gacatcgcca tcaccccgct ggccgcccca ggcgcgccgg caacctcacc cttcgccgct
     1321 gccgccgccg ccgctgcact cgggggagcg gacgctagct cgccggcggg agccgggacg
     1381 ccggaggctg gtgccacttc gctggtgccg gagggggcgg cgcgcgagag cctggtggcc
     1441 ctggtcagca cctcggacag ggactcgggc gccaacgggc aagtgcgctg cgccctctat
     1501 gggcacgagc acttccggct gcagccggcc tacgcgggca gctacctggt ggtgaccgcg
     1561 gcgtcgctgg accgcgaacg catcgccgag tacaacttga cgctggtggc cgaggatcgc
     1621 ggcgcgcccc cgctgcgcac agtgcggccc tacacggtgc gtgtgggcga cgagaacgac
     1681 aacgcgccgc tcttcacgcg gccggtctat gaggtgtcgg tgcgcgagaa caacccgcca
     1741 ggcgcctacc tggccacggt ggccgcccgc gaccgggacc tgggccgcaa cggccaggtc
     1801 acctaccggc tgctggaggc cgaggtgggc cgcgccgggg gcgccgtgtc cacttatgtc
     1861 tcggtggacc cagctaccgg agccatctac gcgctgcgca gcttcgacta tgagacgctg
     1921 cgccaactcg acgttcgcat ccaagctagc gacggcggct cccctcagct ttccagcagc
     1981 gccctagtgc aagtgcgcgt gctggaccag aacgaccatg cgccagtcct ggtgcacccg
     2041 gcgccagcca atggctccct agaagtggcg gtgcctgggc gcaccgcaaa ggacacggtt
     2101 gtggcccgtg tgcaggcccg ggatgcagac gagggagcca acggggagct ggcgttcgag
     2161 ctgcagcagc aggagccgcg cgaagccttc gccatcggcc gccgcacggg ggagatactg
     2221 ctcaccggcg acctctcgca ggagccaccc ggtcgcgtgt tcagggcgct cctggtcata
     2281 tccgacggcg gccgtccccc gctcaccacc accgcaactg tcagcttcgt ggtaacagca
     2341 gggggcgggc gtgggccggc tgcgcctgcc agtgcaggaa gcccggagcg ttcccgcccg
     2401 cctggctctc ggctcggggt gtccgggtcg gtgctgcaat gggacacgcc gctgatcgtc
     2461 atcatcgtgc tggccgggag ctgcacgctg ctgctggccg ccatcatcgc catcgccacc
     2521 acctgcaacc gccgcaagaa ggaggtgcgc aaaggggggg ccctccggga agagcggccc
     2581 ggggcggcgg gcggcggagc ctcggctccc ggctccccgg aggaggccgc ccggggagcc
     2641 gggcccaggc ccaacatgtt cgacgtgctc accttccctg gcaccggcaa agcgcccttt
     2701 ggcagccccg cggcggacgc gcctccgcct gcggtcgccg cggccgaagt gccgggctca
     2761 gagggcggca gcgccactgg ggaaagcgcc tgtcacttcg aggggcagca gcggctccgc
     2821 ggcgcgcacg ccgagcccta cggtgcctcc ccgggttttg gaaaggagcc ggcgccccct
     2881 gtggcggtgt ggaaaggaca ctccttcaac accatttctg gcagagaagc agagaagttc
     2941 agcggcaaag acagcggtaa aggggacagt gatttcaacg acagcgattc cgacatcagc
     3001 ggggacgctc tgaaaaagga tctcatcaac cacatgcaga gtggactgtg ggcgtgcacc
     3061 gctgagtgta agatcctggg ccactctgac cgctgctgga gcccatcctg cagcgggccc
     3121 aacgcacatc catcgcctca cccaccagcc cagatgtcaa ccttctgtaa gagcacgtca
     3181 ctgcctcggg atcctctgcg cagggacaat tactaccagg cccagctgcc caagacagtg
     3241 gggctgcaga gcgtctatga gaaagtactg cacagagact atgacaggac agtcactctg
     3301 ctctcccctc cccgtccagg gaggctccca gacctgcagg agattggagt acccctctac
     3361 cagtcccctc ctggcaggta cctgtccccg aagaagggag ccaatgaaaa tgtgtaatcc
     3421 catgctgcat gtcttcacac atatacaggt cactccgaga agcccctaag ttattgaccg
     3481 gtttcagtgt tgtatatata aatatgcaag atgtgcctta caatgaagtt gttggaagct
     3541 atttccaatc acattggtac tgtttggtat ttgcaaacaa aaatgtagtt aatgtaattt
     3601 ttatgaaatg tgtgcagtat ttaatttttc ttatgctatt gactttgatt tcaattgcgg
     3661 cttgccattt tcttagtgtt tttaacctgt acattgtgta atgtaatgtt tgtatataat
     3721 gaaattttgt tatattttta tataataaaa gctaaagtgg aagttattgc caaaggaact
     3781 gtctgtaaga caaaaaacaa aacatgttgg aattacttaa ttgaaattta tctttcacct
     3841 gaaacaacct agtgtttgag aaattttgcc ttgccaagta taacttgtat atcttgactc
     3901 tgtggtagat ttcaagttca atgttattta attacatttg gttttccgta aaccgtgtca
     3961 cttataagca cagtaataaa agatttgtca tgtgtttgaa gaatctgcca attgcttttc
     4021 atgaagctgc ctatagtcag acattcacaa ataatttgag tatcagaatg aaaccttctt
     4081 tcaagtgcta attatttggg cattattaat gttcatgaca atattaaacc tgtaggattt
     4141 caagtattgc aaaatgtcac ccaagtatta aaaacgtgtg ttgatttcat aaattatgtg
     4201 catctccata tgtattagtc tataaaatcc ctgctctcat ttattcacta ggtaaatatt
     4261 cattgagcag ccaccaaaaa gtgaagaaag ctaagtttgg gttgttcatt cactaattaa
     4321 acaagcatct gtagaacttt tactagctgc tggtacctcc tcctcaagct ggagtttgag
     4381 gtgaagaaga cgtagtccca aagagccctc agcttattcg gggtgttagt atcaaaaaga
     4441 ctaacatctt agtcttttgg aatataatag gttcccacta cattctgtcc tacttcctct
     4501 ttccttgcct tcctctggag ccagtctcca aagtaactat cagctctatt ccactcaaat
     4561 ttatgggcaa aatgacatga tgtttgggat tcgctttaaa atgttctaga aaaaaacaca
     4621 gggagctatg tgaaacaaga tcgatttgat aagatattga taattgtcaa tgctagcata
     4681 ggtgcatgtg aggtagggaa atttcagcag tatctctaaa tgtttgtgtt tgaaaatgta
     4741 cataatggaa agtcttaaaa aaagacactc aagagtacta tgcctatgtc ttatactcta
     4801 tggatttcat ttgaaattaa aatgatgata agcataatga gacctaacat ttactgagca
     4861 agtcttctgt gagcagagct ccttaccaag cattctgcat gaattatctc atttaatcag
     4921 caaactaccc ccaggatatg ggaagtatca ttaactccat tttgcaatta aagaaaccga
     4981 ggcacaagaa ggttagataa aatgccaaaa atcacacagc taataagtat ccagggtgag
     5041 attcaaacct aggttattca gtgcaaaaaa taaaacaaag taatgaaa
//
