LOCUS       NM_001173523            8773 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens protocadherin 7 (PCDH7), transcript variant d, mRNA.
ACCESSION   NM_001173523
VERSION     NM_001173523.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8773)
  AUTHORS   Liu,Z., Xu,Y., Liu,X. and Wang,B.
  TITLE     PCDH7 knockdown potentiates colon cancer cells to chemotherapy via
            inducing ferroptosis and changes in autophagy through restraining
            MEK1/2/ERK/c-Fos axis
  JOURNAL   Biochem Cell Biol 100 (6), 445-457 (2022)
   PUBMED   35926236
  REMARK    GeneRIF: PCDH7 knockdown potentiates colon cancer cells to
            chemotherapy via inducing ferroptosis and changes in autophagy
            through restraining MEK1/2/ERK/c-Fos axis.
REFERENCE   2  (bases 1 to 8773)
  AUTHORS   Xu,S., Wu,X., Tao,Z., Li,H., Fan,C., Chen,S., Guo,J., Ning,Y. and
            Hu,X.
  TITLE     Effect of aberrantly methylated androgen receptor target gene PCDH7
            on the development of androgen-independent prostate cancer cells
  JOURNAL   Genes Genomics 42 (3), 299-307 (2020)
   PUBMED   31872382
  REMARK    GeneRIF: Effect of aberrantly methylated androgen receptor target
            gene PCDH7 on the development of androgen-independent prostate
            cancer cells.
REFERENCE   3  (bases 1 to 8773)
  AUTHORS   Zhou,X., Padanad,M.S., Evers,B.M., Smith,B., Novaresi,N.,
            Suresh,S., Richardson,J.A., Stein,E., Zhu,J., Hammer,R.E. and
            O'Donnell,K.A.
  TITLE     Modulation of Mutant KrasG12D -Driven Lung Tumorigenesis In Vivo by
            Gain or Loss of PCDH7 Function
  JOURNAL   Mol Cancer Res 17 (2), 594-603 (2019)
   PUBMED   30409919
  REMARK    GeneRIF: Authors demonstrated that enforced PCDH7 expression
            significantly accelerates Kras(G12D) -driven lung tumorigenesis and
            potentiates MAPK pathway activation.
REFERENCE   4  (bases 1 to 8773)
  AUTHORS   Chen,H.F., Ma,R.R., He,J.Y., Zhang,H., Liu,X.L., Guo,X.Y. and
            Gao,P.
  TITLE     Protocadherin 7 inhibits cell migration and invasion through
            E-cadherin in gastric cancer
  JOURNAL   Tumour Biol 39 (4), 1010428317697551 (2017)
   PUBMED   28381163
  REMARK    GeneRIF: protocadherin 7 may play important roles in the invasion
            and metastasis of gastric cancer.
REFERENCE   5  (bases 1 to 8773)
  AUTHORS   Zhou,X., Updegraff,B.L., Guo,Y., Peyton,M., Girard,L., Larsen,J.E.,
            Xie,X.J., Zhou,Y., Hwang,T.H., Xie,Y., Rodriguez-Canales,J.,
            Villalobos,P., Behrens,C., Wistuba,I.I., Minna,J.D. and
            O'Donnell,K.A.
  TITLE     PROTOCADHERIN 7 Acts through SET and PP2A to Potentiate MAPK
            Signaling by EGFR and KRAS during Lung Tumorigenesis
  JOURNAL   Cancer Res 77 (1), 187-197 (2017)
   PUBMED   27821484
  REMARK    GeneRIF: we report that the PROTOCADHERIN PCDH7 is overexpressed
            frequently in Non-small cell lung cancer tumors where this event is
            associated with poor clinical outcome
REFERENCE   6  (bases 1 to 8773)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   7  (bases 1 to 8773)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   8  (bases 1 to 8773)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   9  (bases 1 to 8773)
  AUTHORS   Yoshida,K., Watanabe,M., Kato,H., Dutta,A. and Sugano,S.
  TITLE     BH-protocadherin-c, a member of the cadherin superfamily, interacts
            with protein phosphatase 1 alpha through its intracellular domain
  JOURNAL   FEBS Lett 460 (1), 93-98 (1999)
   PUBMED   10571067
REFERENCE   10 (bases 1 to 8773)
  AUTHORS   Yoshida,K., Yoshitomo-Nakagawa,K., Seki,N., Sasaki,M. and Sugano,S.
  TITLE     Cloning, expression analysis, and chromosomal localization of
            BH-protocadherin (PCDH7), a novel member of the cadherin
            superfamily
  JOURNAL   Genomics 49 (3), 458-461 (1998)
   PUBMED   9615233
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC098595.2, AC110766.5 and
            AC107394.3.
            
            On Jun 2, 2019 this sequence version replaced NM_001173523.1.
            
            Summary: This gene belongs to the protocadherin gene family, a
            subfamily of the cadherin superfamily. The gene encodes a protein
            with an extracellular domain containing 7 cadherin repeats. The
            gene product is an integral membrane protein that is thought to
            function in cell-cell recognition and adhesion. Alternative
            splicing yields isoforms with unique cytoplasmic tails. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (d) represents the longest
            transcript and encodes the longest isoform (d).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.118347.1,
                                           SRR1803612.137810.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000695919.1/ ENSP00000512266.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4228              AC098595.2         133539-137766
            4229-4445           AC110766.5         49924-50140
            4446-8773           AC107394.3         75988-80315
FEATURES             Location/Qualifiers
     source          1..8773
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.1"
     gene            1..8773
                     /gene="PCDH7"
                     /gene_synonym="BH-Pcdh; BHPCDH; PPP1R120"
                     /note="protocadherin 7"
                     /db_xref="GeneID:5099"
                     /db_xref="HGNC:HGNC:8659"
                     /db_xref="MIM:602988"
     exon            1..4228
                     /gene="PCDH7"
                     /gene_synonym="BH-Pcdh; BHPCDH; PPP1R120"
                     /inference="alignment:Splign:2.1.0"
     CDS             1055..4822
                     /gene="PCDH7"
                     /gene_synonym="BH-Pcdh; BHPCDH; PPP1R120"
                     /note="isoform d precursor is encoded by transcript
                     variant d; brain-heart protocadherin; BH-protocadherin
                     (brain-heart); protein phosphatase 1, regulatory subunit
                     120"
                     /codon_start=1
                     /product="protocadherin-7 isoform d precursor"
                     /protein_id="NP_001166994.1"
                     /db_xref="GeneID:5099"
                     /db_xref="HGNC:HGNC:8659"
                     /db_xref="MIM:602988"
                     /translation="MLRMRTAGWARGWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPA
                     DVRIGNVASDLGIVTGSGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMI
                     FDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGT
                     LYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGG
                     SGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGALDREQRDSYEL
                     TLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAAD
                     LDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQ
                     PPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDR
                     DQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAV
                     DSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGK
                     NAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTT
                     VIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENN
                     NIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAP
                     TVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTS
                     GVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATAIDSQIARS
                     LHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKNKNGYEA
                     GKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPNGQRYDSVNEKLS
                     DSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTF
                     VGAGDNISIGSDHCSEYSCQTNNKYSKQPFRRVTFSVVSQPQDPHQGSLQSCYDSGLE
                     ESETPSSKSSSGPRLGALPLPEDNYERTTPDGSVGEAEHMENDSRPLPDVALTGKCTR
                     ECDEYGHSDSCWMPVRTSPERKKSQPKLSTFMPVDERGSQEKLANGEAAIMGDRNRNL
                     LNKKLTSSYETFSAASFSKNEEANPEDIPLTKTGEYKPSPVNTLTRREVYL"
     exon            4229..4445
                     /gene="PCDH7"
                     /gene_synonym="BH-Pcdh; BHPCDH; PPP1R120"
                     /inference="alignment:Splign:2.1.0"
     exon            4446..8773
                     /gene="PCDH7"
                     /gene_synonym="BH-Pcdh; BHPCDH; PPP1R120"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8302..8307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDH7"
                     /gene_synonym="BH-Pcdh; BHPCDH; PPP1R120"
                     /note="hexamer: AAGAAA"
     polyA_site      8326
                     /gene="PCDH7"
                     /gene_synonym="BH-Pcdh; BHPCDH; PPP1R120"
     regulatory      8752..8757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDH7"
                     /gene_synonym="BH-Pcdh; BHPCDH; PPP1R120"
                     /note="hexamer: AATATA"
     polyA_site      8773
                     /gene="PCDH7"
                     /gene_synonym="BH-Pcdh; BHPCDH; PPP1R120"
                     /note="major polyA site"
ORIGIN      
        1 gaatcgcgca cagcgctgca gatcccactg ctccgacatg cgggccgaat gcaggtgaga
       61 aaaggcacgg actctgcggc tgcgaaccca aacttgggca ccgcacggtg cgcactgctc
      121 agccttcgcc cccgtgggcg aaaggctgct gcggtttcag gcggctgctt cgtgactaat
      181 gaccttgcgc agagttgtta agaaaaaaga gaaacccgcg ctctccgggg tgagaaggga
      241 ctgactctgg gcgtctctga agatggctcg ggcttctctt tggcgcgccg gggggaccct
      301 gacactgacc gctctgtgac gcgagtagtc tcccctgcac cgtgcccgaa gcgacgtgcc
      361 gggggatttt tcattctcga tctgttgact ggctcccccg ctgcatgagc agagtcggag
      421 ttgagactgg cttgttgctg gccccagcgc ctggtgcagg aagcgactca cgtttgtctg
      481 ggtggccgga gccggagcag agcctgggtt tggagtgagt gcctggaacg tgaattggac
      541 tcaactcgag tagcagcaaa gaccagcggg ctggcaggcg ggggaggctg caggctcatt
      601 ccccacctct tcccagcccc actgcccgtc tgccggagcg gttctggccc cttccgacag
      661 agcggggact agagccgggg attctccgcc cgctgagggg atgactctgg gttgggggag
      721 cgccgaaccc gcggcgcgca gtgtcccgtg aactgtgagt actgcgactg aacggcggca
      781 ggcgagcggg cgattagcac ccattgcatg aattatgaaa caataacttt cggaagaagc
      841 aggaggaaaa aaagaagcat ctatcgctgc cctcccaccc ccattcccgg ccaactctcc
      901 acgccgcttt tgccccctcc ctcccctccc tctcgctcct tcctttccgg gagaggggag
      961 aggactcggg ggagggcagg cggccggccc cggaggaggg gggcgccgag ggggctgtgg
     1021 ttagaaggag cagtagcagc agcagcagga gaagatgctg aggatgcgga ccgcgggatg
     1081 ggcgcgcggc tggtgcttgg gctgctgcct cctcctgccg ctctcgctca gcctggcggc
     1141 cgccaagcag ctcctccggt accggctggc cgaggagggc cccgccgacg tccgcatcgg
     1201 caacgtggct tcagacctgg gcatcgtgac cggatcgggt gaggtgactt tcagcctgga
     1261 gtccggttcc gagtacctga agatcgacaa cctcactggc gagctgagca cgagcgagcg
     1321 gcgcatcgac cgcgagaagc tgccccagtg tcagatgatc ttcgacgaga acgagtgctt
     1381 cctggacttc gaggtgtcgg tgatcgggcc ctcgcagagc tgggtggacc tgtttgaggg
     1441 tcaggtcatc gtgcttgaca tcaacgacaa cacgcccacc ttcccgtcgc ccgtgctcac
     1501 gctcacggtg gaggagaatc ggccggtggg cacactttac ctgctgccca cagccaccga
     1561 ccgcgacttc ggccgcaacg gcatcgagcg ctacgagctg ctccaggagc ccggaggcgg
     1621 cggcagcggc ggcgagagcc ggcgcgccgg ggcggccgac agcgccccct accccggggg
     1681 cggcgggaac ggcgcgagcg gcggcggctc gggaggctcc aagcggcggc tggacgcatc
     1741 agagggcggc ggcggcacca accccggcgg ccgcagcagc gtgttcgagc tgcaggtggc
     1801 ggacaccccg gacggcgaga agcagccgca gctgatcgtg aagggggcgc tggaccgcga
     1861 gcagcgcgac tcctacgagc tgaccctgcg agtgcgcgac ggcggcgacc cgcctcgctc
     1921 ctcgcaggcc atcctacggg tcctcatcac cgacgtgaac gacaacagcc cccgcttcga
     1981 gaagagcgtg tacgaggccg acttggctga gaacagcgcc ccggggaccc ccatcctgca
     2041 actgcgcgca gccgacttgg acgtgggggt caacgggcag atcgaatacg tgttcggggc
     2101 ggccaccgag tcggtgaggc ggctgctgcg ccttgacgag acgtccggct ggctcagcgt
     2161 cctgcaccgg atcgaccgcg aggaggtgaa ccagctgcgc ttcacggtca tggcccgcga
     2221 ccgcgggcag ccccccaaga ccgacaaggc caccgtggtc cttaacatca aagacgagaa
     2281 cgacaacgtg ccgtccattg aaatccgcaa gattgggcgc atccccctca aggacggggt
     2341 ggccaacgtg gccgaggacg ttctggtcga cacccccatc gctctggtgc aggtgtccga
     2401 ccgagaccaa ggcgagaacg gggtggtcac ctgcaccgtg gtgggcgacg tgcccttcca
     2461 gctcaagcca gccagcgaca ccgagggcga ccagaacaag aaaaagtact tcttgcacac
     2521 ctcgacccct ctggactatg aggccacccg ggagttcaac gtggtcatcg tggcggtgga
     2581 ctcaggcagc cccagcctct cgagcaacaa ctccctgatt gtcaaggtgg gagacaccaa
     2641 cgacaacccg cccatgttcg gccagtcggt ggtggaggtt tacttccctg agaacaacat
     2701 cccgggcgag agggtggcca cggtgctggc gacagacgca gacagcggta agaacgccga
     2761 gatcgcctac tcgctggact cctctgtgat ggggatcttt gccatcgatc ccgattctgg
     2821 ggacatcctg gtcaataccg tgctggaccg cgagcagact gacaggtatg agtttaaagt
     2881 taacgccaaa gacaaaggca tccccgtgct gcagggcagc actacggtga ttgtgcaggt
     2941 ggctgataaa aatgacaatg accctaagtt tatgcaggac gtcttcacct tttatgtgaa
     3001 agaaaacttg cagcccaaca gccctgtggg gatggtcacc gtgatggatg ctgacaaggg
     3061 gcggaatgca gagatgagcc tgtacataga ggagaacaat aacatttttt ctattgaaaa
     3121 tgacacgggg accatttact ccacaatgtc ttttgaccgg gaacatcaga ccacatacac
     3181 tttcagagtc aaggctgtgg atgggggaga tcctcccaga tctgccacag ctacagtctc
     3241 gctttttgtg atggatgaaa atgacaatgc tcccacagtt acccttccca aaaacatttc
     3301 ctacacttta ctgccacctt cgagtaatgt caggacagta gtagctacag tgttggcaac
     3361 agacagtgat gatggcatca atgcagacct gaactacagc attgtgggag gaaatccctt
     3421 caagctgttt gaaattgatc ccactagtgg tgtggtttcc ttagtgggaa aactcaccca
     3481 aaagcattat ggcttgcaca ggttggtggt gcaagtgaat gacagtgggc agccttccca
     3541 gtccaccacg actctggtgc acgtgtttgt caatgaaagt gtttctaatg caactgcgat
     3601 tgactcccag atagctagaa gtttgcacat cccactcacc caggatatag ctggtgaccc
     3661 aagctatgaa attagcaaac agagactcag tattgtcatt ggcgtggttg ctggcattat
     3721 gacggtgatt ctaatcatct taattgtagt gatggcaagg tactgcaggt ccaaaaataa
     3781 aaatggctat gaagccggca aaaaagatca cgaagacttt tttacacccc aacagcatga
     3841 caaatctaaa aagcctaaaa aggacaagaa aaacaaaaaa tctaagcagc ctctctacag
     3901 cagcattgtc actgtggagg cttctaagcc aaatggacag aggtatgata gtgtcaatga
     3961 gaagctgtca gacagcccaa gcatggggcg atacaggtcc gttaatggtg ggcccggcag
     4021 tcctgacctg gcaaggcatt acaaatctag ttccccattg cctactgttc agcttcatcc
     4081 ccagtcacca actgcaggaa aaaaacacca ggccgtacaa gatctaccac cagccaacac
     4141 atttgtggga gcaggagaca acatttcaat tggatcagat cactgctctg agtacagctg
     4201 tcaaaccaat aacaagtaca gcaaacagcc atttcgtaga gtgacgtttt ctgttgtgag
     4261 tcagcctcag gacccacatc aggggtcact gcagagttgc tatgacagcg ggctggagga
     4321 gtcagaaaca ccaagcagta agagttcatc agggccaaga ctgggtgcgc ttccactccc
     4381 agaggacaac tatgaaagga ccacgccgga tggcagtgtt ggtgaggcag agcatatgga
     4441 aaatgattca aggcctcttc cagatgtagc cctgactggg aagtgcactc gtgagtgtga
     4501 tgagtatggc cactcagact cctgctggat gccggtccgc acttctccgg agaggaagaa
     4561 gagccagcct aaactgtcca ctttcatgcc tgttgatgaa cgaggaagcc aggaaaagct
     4621 ggccaatggg gaggccgcca tcatgggtga ccgcaacaga aacctcctga acaaaaagtt
     4681 gacctcatcc tatgagacct tcagtgcagc tagtttcagc aaaaatgagg aagccaaccc
     4741 tgaggatatt ccccttacaa aaacagggga atataagcca tctcctgtca atactctcac
     4801 tagaagagaa gtttacctgt aggctataaa ggagcaacag caaagttctt tacatgtatg
     4861 aaaaggagaa taaggggcaa aaaccttaca aagcaaaacg tttaatcaca aagagggggc
     4921 taccaaagag acaaagcttt gcctgccact tctgcctcca gatcaggcct ttagtgatac
     4981 tgttagcctg attctactgt acaatgtaga aaccatcctt gttacttgca tgtctaaccc
     5041 cttcactgat tcccaacact cactttctct tccccacccc tctccaaaaa aaaaaaaaca
     5101 aaaagaaaag aaaaaaaaag ggggatagtt gcaagtttct ttcacagtaa ctgtacgaag
     5161 cctgattagc agaacacaac acaccctcat tatccctaag ctgaagcatg attttagtca
     5221 ctttgatttt gttcgagtgt catctggctg gtcaaaaata agcaggacag ataaaatgta
     5281 tttcagacat accatcagaa aatggtttat caccatcaaa ggcaatcctt tgaaagtgat
     5341 agagtccctc taaaggtaca gtccttagaa agagggactg tattaaaaag tattttggga
     5401 atatcaaagc tttaatattc caacaaagac taagagaaaa acaatactca gtgggtgatt
     5461 gcagtcctaa attgtcatat gttgttattt tcaggtcaag agcatcaact tcaattccat
     5521 acattcacca aatattctca gtatacacac agtcttgatt acatgtatca atttcaccag
     5581 ttatgacttc taaaaattat atatattttt tcagaacaag accactatta ttaactaact
     5641 tgaacaattg tatcatccaa aggccaaaga tcatatggca gatcagggaa gtcatgaagt
     5701 tgatttggtc ttgacgtgga aaaccattaa acaacaaaag caactgaacc catgtatgca
     5761 cagaaacaat caaacactag ttcattttat agtgcccagg aaaatgttcc ttcttttaaa
     5821 atggatttta tttgaaagcg cagaaaatga aaactagtga gatatatttt tggtattata
     5881 ataggcaatt ggttgaggtt caagtttagt ttcaggtaat attatcaggg aagattccat
     5941 gttttaaaat agtatttatg gatcatgggt aggttaagaa agatgcattg gcatatagtc
     6001 ttgatagtta agtccacgat tatcatttta gaatccaggc tatgcttgct gctcttttta
     6061 tccacatttt aaattacaat tgcatttttt acttgttcag tgcacacttt gatgcaccac
     6121 aagtgcatta attttgaatc gtgtgcaata tagaaatatt ttgagactca caacattgaa
     6181 acaaggtgac accctagttg actttatcac taatgtgatt tgaacattat ttaaacaaat
     6241 ctagactgaa catgaaagaa aggagttttg ggcagtgaca tttttcacag aatgtatatc
     6301 tcaaaggtga aagcagagtt tttccagtgc aataaaaaga aacagaatat gcagattttg
     6361 agctactcac tctatagagg ataacctaac acggctgaaa attgagctgg gacattcaga
     6421 cgaaagtgac aatccatgga cagaataggg aataacaggt gtgaagagaa caaacttatc
     6481 actgaatgtt tgcaagctgg ttaaggcata gccttgatgg ctctctagca aactgtagaa
     6541 acaatgtagc tttgggtagt ttcatgcttt gcagaatttc ttagactata aagtgacaca
     6601 gcctggaata taggttgata attcactata ggtcttcaaa atacttatct ttgaaaaccg
     6661 cttctctgtt tggtggggta caatttgggg gtcatttcct tatgctcttt cttaaatgga
     6721 gttttcattt tgatgttagt ttatgtataa taggtaggat gcaaaaagat atgtaattga
     6781 aacaaaaaac attggactaa aatatcagta attgaacatg tttatgtttg attattattt
     6841 acactatgga aagatgcaat tctagtactt tgttaggaaa ctgcattaaa gcagttctgc
     6901 cttgtataat ctgtaagtac ctattaagac aaaatacttc taaagatact tatgaaatgt
     6961 atacacattt tttcttgcac gttacaaaga aaatactcaa ttgcataaca cggatgtttg
     7021 acaaactttt ttttttttaa tgcatttctt tctttcatga gacattgaaa ccactgatag
     7081 ctcatttcac cctatcttaa acccttctct tgtctataaa actaatacgg gtcacaccgg
     7141 accttcggat taattggatc cacattcccc aatgatgttt gcaccccatt caagatagcc
     7201 atgccattgt catttaactc gtgaacctct ctttaaaact aaaatggatg tgaaagaata
     7261 aaattcagtg tactgtaagt attcacagta attctagtag aattagctgt cataacatgt
     7321 ttattatata atgagctggc atgacacaga aatatatttt gtgtttgtat gacttttatt
     7381 ttaaataggt taaatctggt gccactccat atatagagtg cttttgaaaa aaaatcaata
     7441 aaaagaaaca aaaaaaataa atgagtgaat gcaaaataag caactgtgcc ttttatacct
     7501 gttgttacgg taaaaaaacg gttgttgggt ttggacaatg aggggaaatg ggctattccc
     7561 aacttttttg atcctgtata tttgtccatg tttattttct gaacataata aataatatat
     7621 taaaaatttg ccttctgaca aactcagata atggaccagt cttaaatatt gttatgtcat
     7681 aaagcaaagt taaggcatta atatgggctg cttaaatctg actagaagat gaaagcgttt
     7741 attgtaagtg taacacagag atactatcag gagtgaaatc agtccatttg gcaaggtaaa
     7801 atactgattt agagttttat tctttatttc ttttttgttg tgtttctttc agctatggtt
     7861 tcattttggt tgtacagtat ataaaccata tttgttttct gtacacaaga ctctcaagtg
     7921 aattttgcat gcattataca ttaggacaca tttataaatt aatgagtaac tatataaatt
     7981 tatgtgtatt aaaacgtctg tagcttcaat ctaaaatcta ctgctctttc tgaatctcca
     8041 gatatcattt ctgtatggtt tctgactggc ctgctgcctg agtttcagaa aacaagggag
     8101 gcattatttt tatgggagga ggaactaaga tggtactgag gatgtctgac tgaaacacta
     8161 ccctaggaag ctgtcttgta ggaaaataga ataaaacaca cagaccagaa gaaattgtca
     8221 agaagcaaac agccatccaa aaacagtcat gagaaatcta aagacctaaa taatcttagg
     8281 tatatgctct cagtgagaaa taagaaaatg tgtccttaag caaaaataaa taaataaata
     8341 aataaataaa taaataataa aaagtgagca tgatcatgaa tatagtaaat cttgtgagtt
     8401 gtgacctagg tgaaggtgta atgataacat ctggaggaag catcatttgt tcagctacct
     8461 agggtttact ttcagacttt tcctacagtt taaagcactt gcgttcagtg tggtacgatc
     8521 tgtttgtaat gttaatcatt gactattgtt ctgctacttg gatgttgata gtgaagcaga
     8581 gaacaattta tcatcgttta ttatgagtca ctatgcacgc aactatgctt aacatggcga
     8641 aatgtattaa acactcgtcc aactatttat gaaatacttt gcataattta atttgctttt
     8701 gtacagtttt atgtaaataa attgcttgtc atttttgtct ctgcaaatta aaatataaca
     8761 tggtcaaatg gtt
//
