LOCUS       NM_001184880            9756 bp    mRNA    linear   PRI 17-NOV-2024
DEFINITION  Homo sapiens protocadherin 19 (PCDH19), transcript variant 3, mRNA.
ACCESSION   NM_001184880
VERSION     NM_001184880.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9756)
  AUTHORS   de Nys,R., Gardner,A., van Eyk,C., Mincheva-Tasheva,S., Thomas,P.,
            Bhattacharjee,R., Jolly,L., Martinez-Garay,I., Fox,I.W.J.,
            Kamath,K.S., Kumar,R. and Gecz,J.
  TITLE     Proteomic analysis of the developing mammalian brain links PCDH19
            to the Wnt/beta-catenin signalling pathway
  JOURNAL   Mol Psychiatry 29 (7), 2199-2210 (2024)
   PUBMED   38454084
  REMARK    GeneRIF: Proteomic analysis of the developing mammalian brain links
            PCDH19 to the Wnt/beta-catenin signalling pathway.
REFERENCE   2  (bases 1 to 9756)
  AUTHORS   Szalai,R., Hadzsiev,K., Till,A., Fogarasi,A., Bodo,T., Buki,G.,
            Banfai,Z. and Bene,J.
  TITLE     NGS-Based Identification of Two Novel PCDH19 Mutations in Female
            Patients with Early-Onset Epilepsy
  JOURNAL   Int J Mol Sci 25 (11), 5732 (2024)
   PUBMED   38891919
  REMARK    GeneRIF: NGS-Based Identification of Two Novel PCDH19 Mutations in
            Female Patients with Early-Onset Epilepsy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9756)
  AUTHORS   Lenge,M., Balestrini,S., Napolitano,A., Mei,D., Conti,V.,
            Baldassarri,G., Trivisano,M., Pellacani,S., Macconi,L., Longo,D.,
            Rossi Espagnet,M.C., Cappelletti,S., D'Incerti,L., Barba,C.,
            Specchio,N. and Guerrini,R.
  CONSRTM   PCDH19 Clinical Study Group
  TITLE     Morphometric network-based abnormalities correlate with psychiatric
            comorbidities and gene expression in PCDH19-related developmental
            and epileptic encephalopathy
  JOURNAL   Transl Psychiatry 14 (1), 35 (2024)
   PUBMED   38238304
  REMARK    GeneRIF: Morphometric network-based abnormalities correlate with
            psychiatric comorbidities and gene expression in PCDH19-related
            developmental and epileptic encephalopathy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9756)
  AUTHORS   Hynes,K., Tarpey,P., Dibbens,L.M., Bayly,M.A., Berkovic,S.F.,
            Smith,R., Raisi,Z.A., Turner,S.J., Brown,N.J., Desai,T.D., Haan,E.,
            Turner,G., Christodoulou,J., Leonard,H., Gill,D., Stratton,M.R.,
            Gecz,J. and Scheffer,I.E.
  TITLE     Epilepsy and mental retardation limited to females with PCDH19
            mutations can present de novo or in single generation families
  JOURNAL   J Med Genet 47 (3), 211-216 (2010)
   PUBMED   19752159
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 9756)
  AUTHORS   Depienne,C., Bouteiller,D., Keren,B., Cheuret,E., Poirier,K.,
            Trouillard,O., Benyahia,B., Quelin,C., Carpentier,W., Julia,S.,
            Afenjar,A., Gautier,A., Rivier,F., Meyer,S., Berquin,P., Helias,M.,
            Py,I., Rivera,S., Bahi-Buisson,N., Gourfinkel-An,I., Cazeneuve,C.,
            Ruberg,M., Brice,A., Nabbout,R. and Leguern,E.
  TITLE     Sporadic infantile epileptic encephalopathy caused by mutations in
            PCDH19 resembles Dravet syndrome but mainly affects females
  JOURNAL   PLoS Genet 5 (2), e1000381 (2009)
   PUBMED   19214208
  REMARK    GeneRIF: Mutation of PCDH19 plays a major role in epileptic
            encephalopathies, mainly affects females.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[PLoS Genet. 2009 Apr;5(4). doi:
            10.1371/annotation/314060d5-06da-46e0-b9e4-57194e8ece3a]
REFERENCE   6  (bases 1 to 9756)
  AUTHORS   Dibbens,L.M., Tarpey,P.S., Hynes,K., Bayly,M.A., Scheffer,I.E.,
            Smith,R., Bomar,J., Sutton,E., Vandeleur,L., Shoubridge,C.,
            Edkins,S., Turner,S.J., Stevens,C., O'Meara,S., Tofts,C.,
            Barthorpe,S., Buck,G., Cole,J., Halliday,K., Jones,D., Lee,R.,
            Madison,M., Mironenko,T., Varian,J., West,S., Widaa,S., Wray,P.,
            Teague,J., Dicks,E., Butler,A., Menzies,A., Jenkinson,A.,
            Shepherd,R., Gusella,J.F., Afawi,Z., Mazarib,A., Neufeld,M.Y.,
            Kivity,S., Lev,D., Lerman-Sagie,T., Korczyn,A.D., Derry,C.P.,
            Sutherland,G.R., Friend,K., Shaw,M., Corbett,M., Kim,H.G.,
            Geschwind,D.H., Thomas,P., Haan,E., Ryan,S., McKee,S.,
            Berkovic,S.F., Futreal,P.A., Stratton,M.R., Mulley,J.C. and Gecz,J.
  TITLE     X-linked protocadherin 19 mutations cause female-limited epilepsy
            and cognitive impairment
  JOURNAL   Nat Genet 40 (6), 776-781 (2008)
   PUBMED   18469813
  REMARK    GeneRIF: X-linked protocadherin 19 mutations cause female-limited
            epilepsy and cognitive impairment
REFERENCE   7  (bases 1 to 9756)
  AUTHORS   Wolverton,T. and Lalande,M.
  TITLE     Identification and characterization of three members of a novel
            subclass of protocadherins
  JOURNAL   Genomics 76 (1-3), 66-72 (2001)
   PUBMED   11549318
REFERENCE   8  (bases 1 to 9756)
  AUTHORS   Ryan,S.G., Chance,P.F., Zou,C.H., Spinner,N.B., Golden,J.A. and
            Smietana,S.
  TITLE     Epilepsy and mental retardation limited to females: an X-linked
            dominant disorder with male sparing
  JOURNAL   Nat Genet 17 (1), 92-95 (1997)
   PUBMED   9288105
REFERENCE   9  (bases 1 to 9756)
  AUTHORS   Fabisiak,K. and Erickson,R.P.
  TITLE     A familial form of convulsive disorder with or without mental
            retardation limited to females: extension of a pedigree limits
            possible genetic mechanisms
  JOURNAL   Clin Genet 38 (5), 353-358 (1990)
   PUBMED   2126489
REFERENCE   10 (bases 1 to 9756)
  AUTHORS   Juberg,R.C. and Hellman,C.D.
  TITLE     A new familial form of convulsive disorder and mental retardation
            limited to females
  JOURNAL   J Pediatr 79 (5), 726-732 (1971)
   PUBMED   5116697
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from EF676096.1, AB037734.1 and
            BM975868.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001184880.1.
            
            Summary: The protein encoded by this gene is a member of the
            delta-2 protocadherin subclass of the cadherin superfamily. The
            encoded protein is thought to be a calcium-dependent cell-adhesion
            protein that is primarily expressed in the brain. Mutations in this
            gene on human chromosome X are associated with sporadic infantile
            epileptic encephalopathy and to a female-restricted form of
            epilepsy (EFMR; also known as PCDH19RE). Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2017].
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (c).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF676096.1, SRR14372080.210383.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373034.8/ ENSP00000362125.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5514              EF676096.1         1-5514
            5515-9754           AB037734.1         1579-5818
            9755-9756           BM975868.1         18-19               c
FEATURES             Location/Qualifiers
     source          1..9756
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..9756
                     /gene="PCDH19"
                     /gene_synonym="DEE9; EFMR; EIEE9"
                     /note="protocadherin 19"
                     /db_xref="GeneID:57526"
                     /db_xref="HGNC:HGNC:14270"
                     /db_xref="MIM:300460"
     exon            1..3823
                     /gene="PCDH19"
                     /gene_synonym="DEE9; EFMR; EIEE9"
                     /inference="alignment:Splign:2.1.0"
     CDS             1677..5123
                     /gene="PCDH19"
                     /gene_synonym="DEE9; EFMR; EIEE9"
                     /note="isoform c precursor is encoded by transcript
                     variant 3"
                     /codon_start=1
                     /product="protocadherin-19 isoform c precursor"
                     /protein_id="NP_001171809.1"
                     /db_xref="CCDS:CCDS55462.1"
                     /db_xref="GeneID:57526"
                     /db_xref="HGNC:HGNC:14270"
                     /db_xref="MIM:300460"
                     /translation="MESLLLPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAK
                     DAREAGFALDPRQASAFRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIIS
                     LEVMSSSMEICVIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGS
                     FGVQTYELTPNELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPR
                     LGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYS
                     FYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTV
                     SVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNV
                     PFRLQEYESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNH
                     PHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSI
                     NPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAP
                     PLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEGDRGFFEIDQVNGEV
                     RTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLIYLSPALDAQESMGSVNLSLIFI
                     IALGSIAGILFVTMIFVAIKCKRDNKEIRTYNCSNCLTITCLLGCFIKGQNSKCLHCI
                     SVSPISEEQDKKTEEKVSLRGKRIAEYSYGHQKKSSKKKKISKNDIRLVPRDVEETDK
                     MNVVSCSSLTSSLNYFDYHQQTLPLGCRRSESTFLNVENQNTRNTSANHIYHHSFNSQ
                     GPQQPDLIINGVPLPETENYSFDSNYVNSRAHLIKSSSTFKDLEGNSLKDSGHEESDQ
                     TDSEHDVQRSLYCDTAVNDVLNTSVTSMGSQMPDHDQNEGFHCREECRILGHSDRCWM
                     PRNPMPIRSKSPEHVRNIIALSIEATAADVEAYDDCGPTKRTFATFGKDVSDHPAEER
                     PTLKGKRTVDVTICSPKVNSVIREAGNGCEAISPVTSPLHLKSSLPTKPSVSYTIALA
                     PPARDLEQYVNNVNNGPTRPSEAEPRGADSEKVMHEVSPILKEGRNKESPGVKRLKDI
                     VL"
     exon            3824..3964
                     /gene="PCDH19"
                     /gene_synonym="DEE9; EFMR; EIEE9"
                     /inference="alignment:Splign:2.1.0"
     exon            3965..4292
                     /gene="PCDH19"
                     /gene_synonym="DEE9; EFMR; EIEE9"
                     /inference="alignment:Splign:2.1.0"
     exon            4293..4351
                     /gene="PCDH19"
                     /gene_synonym="DEE9; EFMR; EIEE9"
                     /inference="alignment:Splign:2.1.0"
     exon            4352..4524
                     /gene="PCDH19"
                     /gene_synonym="DEE9; EFMR; EIEE9"
                     /inference="alignment:Splign:2.1.0"
     exon            4525..9756
                     /gene="PCDH19"
                     /gene_synonym="DEE9; EFMR; EIEE9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9732..9737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDH19"
                     /gene_synonym="DEE9; EFMR; EIEE9"
                     /note="hexamer: ATTAAA"
     polyA_site      9756
                     /gene="PCDH19"
                     /gene_synonym="DEE9; EFMR; EIEE9"
                     /note="major polyA site"
ORIGIN      
        1 agtagtttgc ggcatccgga ggagcagcag cagcagtagc ggcggcggct ggcgcagcgc
       61 ggagacggac gagcgggcac agacggcagc acagctcccg tgcaccatgc ctggcttgcc
      121 cgggaggcac tggcacccgc gtccctagcc cggcgctggc ccttggcgcg ttgcgctccg
      181 cagcattccg gctgagcgat ttcatccgaa atcctaaacc tcctacccca aacccattgc
      241 ctcctgcttg ctcatactcc acactcacac tccccacacc acacactcac tcttcctctc
      301 tctctcacac attcacacac agcccgagac agacagagaa agcgagacag acctcccgag
      361 tgcgcgagcg cccgggagga agggagccca acgcagcgcg gccagcgcct ctccgggaag
      421 atgaaatcaa gacgctcctg caagtaaact tcggcggcga caaaatcgtc gactgtggca
      481 gctgctgagg cggaccccag cgacgtgcaa ctgagctagg agggcttcct cccgcggcgg
      541 cggcggcggc ggcggcggcg gcggaccttg gagcgacacc ccagcccaaa cggagagaag
      601 agaagcaccc ggtacccacg gcggcggccc cgcctctcct ggccggtact gttgttgcct
      661 ccccttccct cttccccatt ccccgccacc cccggccatt agaaagaccg gggctttgat
      721 tttcttggac aaattgccat ctccccgttt ccacaaactt gacgtggagg gtcggactgc
      781 gttgttaact ttgatttcct agacgaaaac gcccgcagac cctcaactgc tctgtggggg
      841 gaactccgct cccacctcgg atcctggaca gacgcgcccc caagcccttc gaagccagcc
      901 ttagcgcgag ggagcgcgct caagctctgg cagcctctct cccctccccc ttcctctgct
      961 ggccccggga ccgccatccg actcaaccct ataaccgggt gcccgcggcg cttgccagta
     1021 actgactccc gtctgcgaca ccccctttct cccgaacagg cctcgaagag gccagtgtgg
     1081 cccccccaga ccccggaggg cgcattccaa gcgggtactc tctccgcagt gaactgggag
     1141 cgctgggggg aggtctttgc gcatgccagg tgcacagaca gcgagttcgc cagcctcagt
     1201 gccggtgcac cgcggcgggc cgggcagtgc ctgaaaggct gcgcctcctc cgccctcttt
     1261 accttcgcct caagtactgt ccggactcag cggtgcgtcc tccaggccgc gcagacgccg
     1321 cccgacccgc agccctgggc ggctgccgac agtcgcgccc ggctaacttt gaaggggtaa
     1381 aactgagtag ccgggctgga gggagggggc tcggggccgc gcggcgctcc cttggcccct
     1441 cggagccccc ggggcccccg cgagcccccg ccgcgtccgc cgcaacctca gcattggagc
     1501 cgccgcgggt gtcccccgcg cgccgccggg ccgccctggg cgggacttct cccgcggcct
     1561 ccggggccac ggggcgcgcg caacaggcgg cccgagccgg cgggaagctg gagcgccgac
     1621 ggcgtcggtc tcggaggggt gtggagaggc gaggccaggc agagccccgt gcagccatgg
     1681 agtcgctcct gctgccggtg ctgctgctgc tggccatact gtggacgcag gctgccgccc
     1741 tcattaatct caagtactcg gtagaagagg agcagcgcgc cgggacggtg attgccaacg
     1801 tggccaaaga cgcgcgagag gcgggcttcg cgctggaccc ccggcaggct tcagcctttc
     1861 gcgtggtgtc caactcggct ccacacctag tggacatcaa tcccagctct ggcctgctgg
     1921 tcaccaagca gaagattgac cgtgatctgc tgtgccgcca gagccccaag tgcatcatct
     1981 cgctcgaggt catgtccagc tcaatggaaa tctgcgtgat aaaggtggag atcaaggacc
     2041 tgaacgacaa tgcgcccagt ttcccggcag cacagatcga gctggagatc tcggaggcag
     2101 ccagccctgg cacgcgcatc ccgctggaca gcgcttacga tccagactca ggaagctttg
     2161 gcgtgcagac ttacgagctc acgcccaacg agctgttcgg cctggagatc aagacgcgcg
     2221 gcgacggctc ccgctttgcc gaactcgtgg tggaaaagag cctggaccgc gagacgcagt
     2281 cgcactacag cttccgaatc actgcgctag acggtggcga cccgccgcgc ctgggcaccg
     2341 ttggccttag tatcaaggtg accgactcca atgacaacaa cccggtgttt agcgagtcca
     2401 cctacgcggt gagcgtgcca gaaaactcgc ctcccaacac acccgtcatc cgcctcaacg
     2461 ccagcgatcc agacgagggc accaacggcc aggtggtcta ctccttctat ggctacgtca
     2521 acgaccgcac gcgcgagctc tttcagatcg acccgcacag tggcctggtc actgtcactg
     2581 gcgctttaga ctacgaagag gggcacgtgt acgaactgga cgtgcaggct aaggacttgg
     2641 ggcccaattc catcccggca cactgcaagg tcaccgtcag cgtgctggac accaatgaca
     2701 atccgccggt catcaacctg ctgtcagtca acagtgagct tgtggaggtc agcgagagcg
     2761 cccccccggg ctacgtgatc gccttggtgc gggtgtctga tcgcgactca ggcctcaatg
     2821 gacgtgtgca gtgccgtttg ctgggcaatg tgccctttcg actgcaggaa tatgagagct
     2881 tctccactat tctggtggac ggacggctgg accgcgagca gcacgaccaa tacaacctca
     2941 caattcaggc acgcgacggc ggcgtgccca tgctgcagag tgccaagtcc tttaccgtgc
     3001 tcatcactga cgaaaatgac aaccacccgc acttttccaa gccctactac caggtcattg
     3061 tgcaggagaa caacacgcct ggcgcctatc tgctctctgt gtctgctcgc gaccccgacc
     3121 tgggtctcaa cggcagtgtc tcctaccaga tcgtgccgtc gcaggtgcgg gacatgcctg
     3181 tcttcaccta tgtctccatc aatcccaact caggcgacat ctacgcgctg cgatccttta
     3241 accacgagca gaccaaggcg ttcgaattca aggtgctggc caaggacggc ggccttccct
     3301 cactgcaaag caacgctacg gtgcgggtca tcatcctcga cgtcaacgac aacaccccgg
     3361 tcatcacagc cccacctctg attaacggca ctgccgaggt ctacataccc cgcaactctg
     3421 gcataggcta cctggtgact gttgtcaagg cagaagacta cgatgagggc gaaaatggcc
     3481 gagtcaccta cgacatgacc gagggcgacc gcggcttctt tgaaatagac caggtcaatg
     3541 gcgaagtcag aaccacccgc accttcgggg agagctccaa gtcctcctat gagcttatcg
     3601 tggtggctca cgaccacggc aagacatctc tctctgcctc tgctctcgtc ctaatctact
     3661 tgtcccctgc tctcgatgcc caagagtcaa tgggctctgt gaacttgtcc ttgattttca
     3721 ttattgccct gggctccatt gcgggcatcc tctttgtaac tatgatcttc gtggcaatca
     3781 agtgcaagcg agacaacaaa gagatccgga cctacaactg cagtaattgt ttaaccatca
     3841 cttgtctcct cggctgtttt ataaaaggac aaaacagcaa gtgtctgcat tgcatctcgg
     3901 tttctcccat tagcgaggag caagacaaaa agacagagga gaaagtgagc ctaaggggaa
     3961 agagaattgc tgagtactcc tatgggcatc aaaagaaatc aagcaagaag aaaaaaatca
     4021 gtaagaatga catccgcctg gtaccccggg atgtggagga gacagacaag atgaacgttg
     4081 tcagttgctc ttccctgacc tcctccctca actattttga ctaccaccag cagacgctgc
     4141 ccctgggctg ccgccgctct gagagcactt tcctgaatgt ggagaaccag aatacccgca
     4201 acaccagtgc taaccacatc taccatcact ctttcaacag ccaggggccc cagcagcctg
     4261 acctgattat caacggtgtg cctctgcctg agactgaaaa ctattctttt gactccaact
     4321 acgtgaatag ccgagcccat ttaatcaaga gcagctccac cttcaaggac ttagagggca
     4381 acagcctgaa ggatagtgga catgaggaga gtgaccaaac tgacagtgag catgatgtcc
     4441 agcggagcct gtattgtgat actgctgtca acgatgtgct gaacaccagt gtgacctcca
     4501 tgggatctca gatgcctgat catgatcaga atgaaggatt tcattgccgg gaagaatgcc
     4561 ggattcttgg ccactctgac aggtgctgga tgccccggaa ccccatgccc atccgttcca
     4621 agtcccctga gcatgtgagg aacatcatcg cgctgtctat tgaagctact gctgctgatg
     4681 tcgaggctta tgacgactgc ggccccacca aacggacttt cgcaaccttt gggaaagatg
     4741 tcagcgacca cccggctgag gagaggccta ccctgaaagg caagaggact gtcgatgtga
     4801 ccatctgcag ccccaaggtc aacagcgtta tccgggaggc aggcaatggc tgtgaggcga
     4861 ttagccctgt cacctccccc ctccacctca agagctctct gcccaccaag ccttccgtgt
     4921 cttacaccat tgccctggct cccccagccc gtgatctgga gcagtatgtc aacaatgtca
     4981 acaatggccc tactcgtccc tctgaagctg agccccgtgg agctgatagc gagaaagtca
     5041 tgcatgaggt cagccccatt ctgaaggaag gtcgcaacaa agagtcccct ggtgtgaagc
     5101 gtctgaagga tatcgttctc taaaccagtc tccaggaaga agagaaagaa accacactgg
     5161 ctagtgaaga agcaggagct tcttgtttta attgctcacc aatggttggt tcttgagtgg
     5221 ctatatttca gagcttttcc taaatgtatt gtttataggt gattatcatt ctgtgacagt
     5281 cccttgtttc aacaggcagc aggggtgttc agttggagca aattagcttt ggcttgagtt
     5341 gttcatgggg ccttgatgtt ggggaaacag agacaaattc agttgtgaaa agtattatgt
     5401 attaagtgtt tgaatttata tatttttcta tgtcaaaatt ataatataaa ttaccattgt
     5461 ttgtggagga ttacatttaa aaaagcaaaa agtgaaaaaa aaaagctctg gacaccttta
     5521 ataagctcgc cactgttttt tgtagtgtag acaagttaat ggtcatttat tgtgtactat
     5581 tcattgattc agtgatgtga aattgagccc ccaaaaggtt gtttctgaag ctcgagtact
     5641 tcccaatgcc gctactttgc tgtggacacc cctgctttaa aaaccctttt gctagctgtg
     5701 ctattgttgt atttgatatt gcaaattgct atgtgtgtgg tgatggcaaa aggcttttaa
     5761 aagttggtgt tttctttttc ttaaaaaaat aataaaacta cagacaaaaa caaagtgcaa
     5821 acaactgaga cagcaaatga atgagcaaca ccatgcatat agattgagta cttggagaat
     5881 actcacgttt tttaactcat gtagtgattg ctcaccactt tgcaaagtat ttttcctgcc
     5941 tttcagtggt ctgcccaggt ccatgataga tcattgcaga aagtcatttt tggataggct
     6001 gctatctaat ttgcagttgt cagaaatact gtgctgaaag ttttatgaca tccatctttt
     6061 aaattttcag gccctgaaca ggaaagttgc tcctgaagtt atgtttccag gcttagaaat
     6121 tccctctctc caatcatcta aaattgaaga tgactgaatc tattttaaga tctaaattag
     6181 catctcttca gacacacact tcctgattca gtgtttccca atcatgatta gaattagact
     6241 gcaaagcacg tcatgggctg ggattgagaa ctccatgttg ctctgtatct taggcttata
     6301 tacgtaggga tagagtaagc agtacaaagt gtatattttg gaaaagacag gtaacaggta
     6361 acagcatcgc taatccaatt actgtgcctt ctaaacggag acactcagac acttgaactc
     6421 atctttttat gactaatagt tttttgatta aaaatgtgaa caagaaaata ctaaaataaa
     6481 aatcctttcg atttagccaa ctctttttgc tgtaggctag gaatacaccc tttttaaatt
     6541 aacacactgt agatcctttt tttctgtttt aacattcctc taactccccc atttatcttt
     6601 tgtctattaa tattcactag ccaacatagt atttttgcag cctaagagtt cattatttaa
     6661 aaataaacta aagaaatatg tcacctttgt tctgccttgg tcttaagaga gttgtttcta
     6721 gagaaacaag ttttatggtt ctgttttcat ttgtttcatt ttttgaaatt caggaataca
     6781 cagagagaag gcctagaggt tagagcacta gaatgcaaaa gaggatttat tttcttaagt
     6841 ttaggtagat aagtcagctc ttttgaatgt tttacttatt tttgcctgag ttcctagctt
     6901 tacgcattac taggaatatt ttcttttaca ggagggagaa gggttttgag ggagggggtg
     6961 ggtaaggcag tagggatggg gttaggtagg ggagaacatt tctgaaaaag aacttataat
     7021 gaagctacaa atccatcctt atttcttatt cagtgctgaa tactacctca tgcaaaatat
     7081 tggtgtggct gcaaatttcc ctctgaagct gacacaatta aggatgaatt accataacat
     7141 cttcattttt cctcatttca ttgcctctca tacagttttc tccctctgat ttatttcatt
     7201 ttggtagtgg attttgaatt aagtatttat ttctctttgc aagtgactat ttgattaaca
     7261 cattaaaaat tttttaaaaa tttccccttt aagttatgat ggctgcctat agaatttaga
     7321 ctgtttctca ccctgatcca tcctgatatt atgttattag ctacgatttc aaggtcactt
     7381 tgaagtcaga cttcacagtt ttctacaggt gtatttcttg ctatgctcag tgggaaccag
     7441 ggagcagaaa agattgtgga aagtgggaac attaattgtc acgtggctgt tgagccagag
     7501 aggccactgg ctgccatgcc tcttaccagc caagttttaa atggttagag tggcattggc
     7561 attgattttg cttttctctt gggttttctt catttctttt cataattcat cttcaagcta
     7621 tagatccatc cttcttccct atccaaatac tttgttctca gtgggcagtc agattttttt
     7681 ggcttccaaa cctcactgag catgttcaga gaattcctct cattaaggaa atatttttcc
     7741 ccacaattgt ctgatgtatg agtcctctca gaagcacaag tgcatactag gaaggctttg
     7801 taaactggtt ttgtaggcag gctgtacctg caaataggca ttctgagcaa ggatcctaaa
     7861 tttccctttg gctcatgtcc cccccgcccc accccacctt ctcctttttg gcatgtctgg
     7921 tgaaaagcta caaggttcac agggccaaat attctccctt ttgttctcta aacatgttgc
     7981 acacataaac tcaagggagt gatttcggtt cctaagtcct agggagttct attccattta
     8041 ttctgatgtc ccttttaagg aggagttggt gttgaagtgt gacatgcttt aatgataact
     8101 gctttggcaa ttccccagac aggtatactt cttcatccaa aattgcacct aaggtgttca
     8161 tttagacaaa attgttcgct tagtgatcca ctgatctcta atcagaaata tttttaaaaa
     8221 atacaattta gatctctgaa aattggaacc actcaagagt atcatcttga tagtgttact
     8281 tcagcatatg actgactgat tttatgaagg gagtttagct gacttttccc tgtagcccta
     8341 tcatattaaa aacaaaaagt ggtccacttg aagcagcaag gacaaagggc agtttaggga
     8401 gaggcagggt gaaggggata gctcgattgg gcatccagag tggaaaagga ttattattgt
     8461 acataatagc agttctggct ggaattccaa tccactttct ggggatcatt ttgatgttga
     8521 atgttccccc aaagcattct gacaagtttg gtccacttgg ctctttaccc cgggtaataa
     8581 gacccttatt gactttgaaa aactggcata aatgagctta agaaatccat tgtatacagt
     8641 cctagtgttt gccttcttgg taaaattaca tttaaggatg tcatttcatg agtcaaattg
     8701 tatctgctga cactgaagtg tattgagatg ttgttcttta gtttaagtat gtaacaaagt
     8761 aatattcaaa ggggatgttt gggggtgggg ctgggaccgg gtggctttat attgataatg
     8821 aaatattcca gagcaaaaca cattgtccta atgaagttgt tgcagctctc ttcgttttct
     8881 tgtgccgctg gaattggctt gtgggtcact tgttgtgcaa aagtgaatta atttcaaata
     8941 ggaatcatat tgcttttgtg aaacaaagaa aatttaccac cttgtctgat acatagattg
     9001 gaaggcgctc ttggtaaaga ataacccaca aacacctgat cttgattgga aagcattgta
     9061 ggtcattagg gaaaactgat gatgctgact gttgctccag ctgtgttggc aattcaagat
     9121 gaccttgtta ctaactgaaa gttgctgtca accttagcaa acaaaccagc taacaccatt
     9181 acagcactgg ttaagtagat ttttactggc actggctggc gttcagctga ggaaggctag
     9241 gatacagact ttaatgacca agagccagac tagctcgagc tagaaatcag caacaaatac
     9301 ctccttgtgc tatttgaatg ctaaggtatt agttgcaata ggcttacgcc ttcgctcctc
     9361 tagtgagggg aatgagcctg atgacactat tactgtttac ctgtcaaacc agggtggaaa
     9421 tttagaggga tgcaagtaca gtatgtctca ttaagcagtc tctgttgctg attatatgaa
     9481 gataaaattg ttgtatatgc tgatctgtat gttatgtaca ttttcacagt gattgaatca
     9541 ttgtaaaaag aaaaaagaca aaaaagaatc accactgtct attttatgaa gatgataaag
     9601 cagctttatt aaattattac agttatgttt caaatggtgt tatctgccac attgtttcct
     9661 tttatctggt ggttctctgt ttcccccttt aaatgtgttt tctctgcttc aaaaatttaa
     9721 tgcattttag tattaaaggc tattatggaa aaagta
//
