LOCUS       NM_019035               5925 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens protocadherin 18 (PCDH18), transcript variant 1, mRNA.
ACCESSION   NM_019035
VERSION     NM_019035.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5925)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5925)
  AUTHORS   Zhou,D., Tang,W., Su,G., Cai,M., An,H.X. and Zhang,Y.
  TITLE     PCDH18 is frequently inactivated by promoter methylation in
            colorectal cancer
  JOURNAL   Sci Rep 7 (1), 2819 (2017)
   PUBMED   28588296
  REMARK    GeneRIF: Our results suggested that PCDH18 was a putative tumor
            suppressor with epigenetic silencing in colorectal cancer and a
            potential biomarker for colorectal cancer diagnosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5925)
  AUTHORS   Gao,L., Dang,X., Huang,L., Zhu,L., Fang,M., Zhang,J., Xu,X.,
            Zhu,L., Li,T., Zhao,L., Wei,J. and Zhou,J.
  TITLE     Search for the potential 'second-hit' mechanism underlying the
            onset of familial hemophagocytic lymphohistiocytosis type 2 by
            whole-exome sequencing analysis
  JOURNAL   Transl Res 170, 26-39 (2016)
   PUBMED   26739415
  REMARK    GeneRIF: A homozygous PCDH18 missense mutation (S1006L)from
            familial hemophagocytic lymphohistiocytosis type 2 patient
            destabilized the protein structure.
REFERENCE   4  (bases 1 to 5925)
  AUTHORS   Kerns,S.L., Stock,R.G., Stone,N.N., Blacksburg,S.R., Rath,L.,
            Vega,A., Fachal,L., Gomez-Caamano,A., De Ruysscher,D.,
            Lammering,G., Parliament,M., Blackshaw,M., Sia,M., Cesaretti,J.,
            Terk,M., Hixson,R., Rosenstein,B.S. and Ostrer,H.
  TITLE     Genome-wide association study identifies a region on chromosome
            11q14.3 associated with late rectal bleeding following radiation
            therapy for prostate cancer
  JOURNAL   Radiother Oncol 107 (3), 372-376 (2013)
   PUBMED   23719583
REFERENCE   5  (bases 1 to 5925)
  AUTHORS   Jensen,R.A., Sim,X., Li,X., Cotch,M.F., Ikram,M.K., Holliday,E.G.,
            Eiriksdottir,G., Harris,T.B., Jonasson,F., Klein,B.E., Launer,L.J.,
            Smith,A.V., Boerwinkle,E., Cheung,N., Hewitt,A.W., Liew,G.,
            Mitchell,P., Wang,J.J., Attia,J., Scott,R., Glazer,N.L., Lumley,T.,
            McKnight,B., Psaty,B.M., Taylor,K., Hofman,A., de Jong,P.T.,
            Rivadeneira,F., Uitterlinden,A.G., Tay,W.T., Teo,Y.Y.,
            Seielstad,M., Liu,J., Cheng,C.Y., Saw,S.M., Aung,T., Ganesh,S.K.,
            O'Donnell,C.J., Nalls,M.A., Wiggins,K.L., Kuo,J.Z., van Duijn,C.M.,
            Gudnason,V., Klein,R., Siscovick,D.S., Rotter,J.I., Tai,E.S.,
            Vingerling,J. and Wong,T.Y.
  CONSRTM   Blue Mountains Eye Study GWAS Team; CKDGen Consortium
  TITLE     Genome-wide association study of retinopathy in individuals without
            diabetes
  JOURNAL   PLoS One 8 (2), e54232 (2013)
   PUBMED   23393555
REFERENCE   6  (bases 1 to 5925)
  AUTHORS   Wolverton,T. and Lalande,M.
  TITLE     Identification and characterization of three members of a novel
            subclass of protocadherins
  JOURNAL   Genomics 76 (1-3), 66-72 (2001)
   PUBMED   11549318
REFERENCE   7  (bases 1 to 5925)
  AUTHORS   Suzuki,S.T.
  TITLE     Recent progress in protocadherin research
  JOURNAL   Exp Cell Res 261 (1), 13-18 (2000)
   PUBMED   11082270
  REMARK    Review article
REFERENCE   8  (bases 1 to 5925)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   9  (bases 1 to 5925)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   10 (bases 1 to 5925)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX647786.1, AB046782.1,
            BG541979.1, BX097655.1 and BQ017212.1.
            
            On Jun 2, 2019 this sequence version replaced NM_019035.4.
            
            Summary: This gene belongs to the protocadherin gene family, a
            subfamily of the cadherin superfamily. This gene encodes a protein
            which contains 6 extracellular cadherin domains, a transmembrane
            domain and a cytoplasmic tail differing from those of the classical
            cadherins. Although its specific function is undetermined, the
            cadherin-related neuronal receptor is thought to play a role in the
            establishment and function of specific cell-cell connections in the
            brain. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB046782.1, SRR1803614.145166.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467147 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344876.9/ ENSP00000355082.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BX647786.1         6-24
            20-4875             AB046782.1         1-4856
            4876-5387           BG541979.1         21-532
            5388-5582           BX097655.1         310-504
            5583-5925           BQ017212.1         13-355              c
FEATURES             Location/Qualifiers
     source          1..5925
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q28.3"
     gene            1..5925
                     /gene="PCDH18"
                     /gene_synonym="PCDH68L"
                     /note="protocadherin 18"
                     /db_xref="GeneID:54510"
                     /db_xref="HGNC:HGNC:14268"
                     /db_xref="MIM:608287"
     exon            1..2893
                     /gene="PCDH18"
                     /gene_synonym="PCDH68L"
                     /inference="alignment:Splign:2.1.0"
     CDS             407..3814
                     /gene="PCDH18"
                     /gene_synonym="PCDH68L"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protocadherin 68-like protein"
                     /codon_start=1
                     /product="protocadherin-18 isoform 1 precursor"
                     /protein_id="NP_061908.1"
                     /db_xref="CCDS:CCDS34064.1"
                     /db_xref="GeneID:54510"
                     /db_xref="HGNC:HGNC:14268"
                     /db_xref="MIM:608287"
                     /translation="MHQMNAKMHFRFVFALLIVSFNHDVLGKNLKYRIYEEQRVGSVI
                     ARLSEDVADVLLKLPNPSTVRFRAMQRGNSPLLVVNEDNGEISIGATIDREQLCQKNL
                     NCSIEFDVITLPTEHLQLFHIEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDS
                     AFDPDVGENSLHTYSLSANDFFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTA
                     SDMGVPQRSGSSILKISISDSNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEG
                     ANGKIVYSFSSHVSPKIMETFKIDSERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSI
                     PAHCKIIIKVVDVNDNKPEININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLN
                     GEIVCKLHGHGHFKLQKTYENNYLILTNATLDREKRSEYSLTVIAEDRGTPSLSTVKH
                     FTVQINDINDNPPHFQRSRYEFVISENNSPGAYITTVTATDPDLGENGQVTYTILESF
                     ILGSSITTYVTIDPSNGAIYALRIFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTI
                     IDENDNVPVVIGPALRNNTAEITIPKGAESGFHVTRIRAIDRDSGVNAELSCAIVAGN
                     EENIFIIDPRSCDIHTNVSMDSVPYTEWELSVIIQDKGNPQLHTKVLLKCMIFEYAES
                     VTSTAMTSVSQASLDVSMIIIISLGAICAVLLVIMVLFATRCNREKKDTRSYNCRVAE
                     STYQHHPKRPSRQIHKGDITLVPTINGTLPIRSHHRSSPSSSPTLERGQMGSRQSHNS
                     HQSLNSLVTISSNHVPENFSLELTHATPAVEQVSQLLSMLHQGQYQPRPSFRGNKYSR
                     SYRYALQDMDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEGFSDLFLTDGRIPAA
                     MRLCTEECRVLGHSDQCWMPPLPSPSSDYRSNMFIPGEEFPTQPQQQHPHQSLEDDAQ
                     PADSGEKKKSFSTFGKDSPNDEDTGDTSTSSLLSEMSSVFQRLLPPSLDTYSECSEVD
                     RSNSLERRKGPLPAKTVGYPQGVAAWAASTHFQNPTTNCGPPLGTHSSVQPSSKWLPA
                     MEEIPENYEEDDFDNVLNHLNDGKHELMDASELVAEINKLLQDVRQS"
     exon            2894..2982
                     /gene="PCDH18"
                     /gene_synonym="PCDH68L"
                     /inference="alignment:Splign:2.1.0"
     exon            2983..3146
                     /gene="PCDH18"
                     /gene_synonym="PCDH68L"
                     /inference="alignment:Splign:2.1.0"
     exon            3147..5925
                     /gene="PCDH18"
                     /gene_synonym="PCDH68L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3946..3951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDH18"
                     /gene_synonym="PCDH68L"
                     /note="hexamer: ATTAAA"
     polyA_site      3975
                     /gene="PCDH18"
                     /gene_synonym="PCDH68L"
                     /note="major polyA site"
     regulatory      5130..5135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDH18"
                     /gene_synonym="PCDH68L"
                     /note="hexamer: ATTAAA"
     regulatory      5135..5140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDH18"
                     /gene_synonym="PCDH68L"
                     /note="hexamer: AGTAAA"
     polyA_site      5145
                     /gene="PCDH18"
                     /gene_synonym="PCDH68L"
                     /note="major polyA site"
     polyA_site      5159
                     /gene="PCDH18"
                     /gene_synonym="PCDH68L"
                     /note="major polyA site"
     regulatory      5895..5900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDH18"
                     /gene_synonym="PCDH68L"
                     /note="hexamer: AATAAA"
     polyA_site      5925
                     /gene="PCDH18"
                     /gene_synonym="PCDH68L"
                     /note="major polyA site"
ORIGIN      
        1 agattttaga ctggagtcag caatcacggg tgtttagtct gcagccgagc agctaaaggg
       61 agaaagaatc gctcaggaaa gacacactgc agactccacc ggcaccctgc aatagatgga
      121 ttccgactac acaagggaga aaacgcggag gtgacactct cctgcctgga aagaggacga
      181 acgaccaaac aaacgcaagg actggactcc atgccgaagg tatctggaag tcgtgacacg
      241 gtgtgtataa aacaaaagtt tgcgagctgt taattgctgt gctgtgttat taagagacgc
      301 tttcaagttt caagtaccaa atgtagcttt acgttgccaa aggaagttga ggcaattgct
      361 ttgctgtttt aacttgctct gtgagggaaa tctcataaac tgaccaatgc accaaatgaa
      421 tgctaaaatg cactttaggt ttgtttttgc acttctgata gtatctttca accacgatgt
      481 actgggcaag aatttgaaat acaggattta tgaggaacag agggttggat cagtaattgc
      541 aagactatca gaggatgtgg ctgatgtttt attgaagctt cctaatcctt ctactgttcg
      601 atttcgagcc atgcagaggg gaaattctcc tctacttgta gtaaacgagg ataatgggga
      661 aatcagcata ggggctacaa ttgaccgtga acaactgtgc cagaaaaact tgaactgttc
      721 catagagttt gatgtgatca ctctacccac agagcatctg cagcttttcc atattgaagt
      781 tgaagtgctg gatattaatg acaattctcc ccagttttca agatctctca tacctattga
      841 gatatctgag agtgcagcag ttgggactcg cattcccctg gacagtgcat ttgatccaga
      901 tgttggggaa aattccctcc acacatactc gctctctgcc aatgattttt ttaatatcga
      961 ggttcggacc aggactgatg gagccaagta tgcagaactc atagtggtca gagagttaga
     1021 tcgggagctg aagtcaagct acgagcttca gctcactgcc tcagacatgg gagtacctca
     1081 gaggtctggc tcatccatac taaaaataag catttcagac tccaatgaca acagccctgc
     1141 ttttgagcag caatcttata taatacaact cttagaaaac tccccggttg gcactttgct
     1201 cttagatctg aatgccacgg atccagatga gggcgctaat gggaaaattg tatattcctt
     1261 cagcagtcat gtgtctccca aaattatgga gacttttaaa attgattctg aaagaggaca
     1321 tttgactctt ttcaagcaag tggattatga aatcaccaaa tcctatgaga ttgatgttca
     1381 ggctcaagat ttgggtccaa attcaatccc agcccattgc aaaattataa ttaaggttgt
     1441 ggatgttaat gacaataaac ctgaaattaa catcaacctc atgtcccctg gaaaagaaga
     1501 aatatcttat atttttgaag gggatcctat tgatacattt gttgctttgg tcagagttca
     1561 ggacaaggat tctgggctga atggagaaat agtttgtaag cttcatggac atggtcactt
     1621 taaacttcag aagacatatg aaaacaatta tttaatctta actaatgcca cactggatag
     1681 agaaaagaga tctgagtata gtttgactgt aatcgctgag gacaggggga cacccagtct
     1741 ctctacagtg aaacatttta cagttcaaat caatgatatc aatgacaatc caccccactt
     1801 ccagagaagc cgatatgaat ttgtaatttc agaaaataac tcaccagggg catatatcac
     1861 cactgttaca gccacagatc ctgatcttgg agaaaatggg caagtgacat acaccatctt
     1921 ggagagtttt attctaggaa gttccataac tacatatgta accattgacc catctaatgg
     1981 agccatctat gccctcagaa tctttgatca tgaagaagtg agtcagatca cttttgtggt
     2041 agaagcaaga gatggaggaa gcccgaagca actggtaagc aataccacag ttgtgctcac
     2101 catcattgac gaaaatgaca acgttcctgt ggttataggg cctgcattgc gtaataatac
     2161 ggcagaaatc accattccca aaggggctga aagtggcttt catgtcacaa gaataagggc
     2221 aattgacaga gactctggtg tgaatgctga actcagctgc gccatagtag caggtaatga
     2281 ggagaatatc ttcataattg atccacgatc atgtgacatc cataccaacg ttagcatgga
     2341 ttctgttccc tacacagaat gggagctgtc agttatcatt caggacaaag gcaatcctca
     2401 gctacatacc aaagtccttc tgaagtgcat gatctttgaa tatgcagagt cggtgacaag
     2461 tacagcaatg acttcagtaa gccaggcatc cttggatgtc tccatgataa taattatttc
     2521 cttaggagca atttgtgcag tgttgctggt tattatggtg ctatttgcaa ctaggtgtaa
     2581 ccgcgagaag aaagacacta gatcctataa ctgcagggtg gccgaatcaa cttaccagca
     2641 ccacccaaaa aggccatccc ggcagattca caaaggggac atcacattgg tgcctaccat
     2701 aaatggcact ctgcccatca gatctcatca cagatcgtct ccatcttcat ctcctacctt
     2761 agaaagaggg cagatgggca gccggcagag tcacaacagt caccagtcac tcaacagttt
     2821 ggtgacaatc tcatcaaacc acgtgccaga gaatttctca ttagaactca cccacgccac
     2881 tcctgctgtt gagcaggtct ctcagcttct ttcaatgctt caccaggggc aatatcagcc
     2941 aagaccaagt tttcgaggaa acaaatattc caggagctac agatatgccc ttcaagacat
     3001 ggacaaattt agcttgaaag acagtggccg tggtgacagt gaggcaggag acagtgatta
     3061 tgatttgggg cgagattctc caatagatag gctgttgggt gaaggattca gcgacctgtt
     3121 tctcacagat ggaagaattc cagcagctat gagactctgc acggaggagt gcagggtcct
     3181 gggacactct gaccagtgct ggatgccacc actgccctca ccgtcttctg attataggag
     3241 taacatgttc attccagggg aagaattccc aacgcaaccc cagcagcagc atccacatca
     3301 gagtcttgag gatgacgctc agcctgcaga ttccggtgaa aagaagaaga gtttttccac
     3361 ctttggaaag gactccccaa acgatgagga cactggggat accagcacat catctctgct
     3421 ctcggaaatg agcagtgtgt tccagcgtct cttaccgcct tccctggaca cctattctga
     3481 atgcagtgag gtggatcggt ccaactccct ggagcgcagg aagggaccct tgccagccaa
     3541 aactgtgggt tacccacagg gggtagcggc atgggcagcc agtacgcatt ttcaaaatcc
     3601 caccaccaac tgtgggccgc cacttggaac tcactccagt gtgcagcctt cttcaaaatg
     3661 gctgccagcc atggaggaga tccctgaaaa ttatgaggaa gatgattttg acaatgtgct
     3721 caaccacctc aatgatggga aacacgaact catggatgcc agtgaactgg tggcagagat
     3781 taacaaactg cttcaagatg tccgccagag ctaggagatt ttagcgaagc atttttgttt
     3841 ccatgtatat ggaaataggg aacaacaaca acaacaaaaa accctgaaag aactggcatt
     3901 gccaaatagt tgcatttatc ataaatgtgt ctgtgtatat tgaatattaa atactgtatt
     3961 ttcgtatgta cacaatgcaa gtgtgattat tttaatctgt attttaaaaa tacatttgta
     4021 ccttatattt atgtgtaatt taacaaacaa attttatttt tttactccca tgacagacat
     4081 gtttttccta gtcgtgtaga aactagccac tgttcaaatc tgatacacta ttcaaccaca
     4141 aagtgtaaag gcactgctta gattagtttt gttggggaag aattattatg ttgtatgaac
     4201 aaccccactg aagcattata caattcttaa ttccattaag tgatcccact ttttttcaat
     4261 aactttttag aaattaagaa tcattaaaat tgttaagcta ttttattgtt attttctcta
     4321 ctttctacta gccccaatag ttgaactctt ataggaaaat cgaaagataa agtgaaagtt
     4381 tatttcagga ctgagaaata tcttgaaggt tatttattag atgactatct caaatgaact
     4441 ttttatagac aatgatgaaa acagaattaa agtcaatgtt tcctgactcc caggccccta
     4501 ctattccagg ccatcacact ggcctgttcc ggagaatatt tctctcacaa tattattatc
     4561 tacttataat tatggtaaac aataaatttt attccatcct tgtagtatga aacatgctcc
     4621 aaggaaatgg aatctgtcct ttaaatggat aacagtatgt gttctaatgg cataaaatat
     4681 tactggataa aaacagttgt gtcagtgtct ctcctaaggt agtaaatata attgacttat
     4741 tctgaaccca ttctattttg aatctcccct ttcctctcac aatacttgaa cattttaatc
     4801 ttttggaata ttgtctttct ttgttataac tattcatttt tagcttttgt ctccagtgca
     4861 tgatctcata tttttgcttt tatttttagt ataagaacat ttataaaatc atatttttgt
     4921 tactgcaatt gttttatttg ttgtgtggca aatgagaaat cctttattta ttgtgctgtg
     4981 atctctctgt gtggaatgcc ttggtgagag agatgcttat tatgactatt atcatttctg
     5041 accaagcttc tattaatgtt atttctaata atacactatc ttgattgtac tctccagaaa
     5101 atttttctgt cagtgaaaat aaaagaaaaa ttaaagtaaa gctaaggaac tgtctataag
     5161 tcagagtcct gttcctacat atttgttcaa aagcttggca tgcagcaggc ccttcctgag
     5221 cgggtgattc agtgttgagt ttcaaataat aaacaggcag cattcagttg gctgggcgaa
     5281 caagaaaaac acaatggaaa aggaatgagt ttgagacttg taatgggaat gaaagtagta
     5341 agccatattc cagctaaata agttaaatgc atttggggaa taaagaaaaa agagtaagca
     5401 agcaataatt gcttgaatat ttttcaaatt acaacaaaaa aaaatacttt cttaggacat
     5461 tttgtattaa attgtgcagg ataaaaaggt atccttacaa tgtttccagg aggcaagaat
     5521 attatcgtcc ctggcttgct agtcaggaat tgaaacactg ggaaagttaa gtaactgaaa
     5581 agtgactaaa attcagatat ttgaattctc aaatgagtac cacattaaat agaatatatt
     5641 acctctttca acaggcacat tttcctttat aggagagatt gcaattacaa gtgaaatttc
     5701 agtatatttt tcagtagatt acacacacaa acgctaacca tatttaaatg cattctgcct
     5761 ttcaacttca cttcctttca gtatatatta ccattaagaa aaagactttt atatcctcac
     5821 tgttcttaat ttaaagcacc agcagtaata tgggaagcta tgctgaaaac cgctattttg
     5881 aataatgtga aataaataaa atgcaatatt tcattcaaca caaaa
//
