LOCUS       NM_001384140            9366 bp    mRNA    linear   PRI 10-DEC-2024
DEFINITION  Homo sapiens protocadherin related 15 (PCDH15), transcript variant
            R, mRNA.
ACCESSION   NM_001384140
VERSION     NM_001384140.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9366)
  AUTHORS   Villasante,C.M., Deng,X., Cohen,J.E. and Hudspeth,A.J.
  TITLE     Nanomechanics of wild-type and mutant dimers of the inner-ear
            tip-link protein protocadherin 15
  JOURNAL   Proc Natl Acad Sci U S A 121 (40), e2404829121 (2024)
   PUBMED   39298473
  REMARK    GeneRIF: Nanomechanics of wild-type and mutant dimers of the
            inner-ear tip-link protein protocadherin 15.
REFERENCE   2  (bases 1 to 9366)
  AUTHORS   Yang,H., Zhang,Y.J., Zhu,L., Zheng,W.Y., Shi,M.Y., Zhao,W.R. and
            Zhao,H.C.
  TITLE     A novel compound heterozygous PCDH15 variants is associated with
            arRP in a Chinese pedigree
  JOURNAL   BMC Ophthalmol 24 (1), 373 (2024)
   PUBMED   39187782
  REMARK    GeneRIF: A novel compound heterozygous PCDH15 variants is
            associated with arRP in a Chinese pedigree.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9366)
  AUTHORS   Ahmed,Z.M., Riazuddin,S., Aye,S., Ali,R.A., Venselaar,H., Anwar,S.,
            Belyantseva,P.P., Qasim,M., Riazuddin,S. and Friedman,T.B.
  TITLE     Gene structure and mutant alleles of PCDH15: nonsyndromic deafness
            DFNB23 and type 1 Usher syndrome
  JOURNAL   Hum Genet 124 (3), 215-223 (2008)
   PUBMED   18719945
  REMARK    GeneRIF: study of PCDH15 mutations in nonsyndromic deafness DFNB23
            and type 1 Usher syndrome
REFERENCE   4  (bases 1 to 9366)
  AUTHORS   Baux,D., Faugere,V., Larrieu,L., Le Guedard-Mereuze,S., Hamroun,D.,
            Beroud,C., Malcolm,S., Claustres,M. and Roux,A.F.
  TITLE     UMD-USHbases: a comprehensive set of databases to record and
            analyse pathogenic mutations and unclassified variants in seven
            Usher syndrome causing genes
  JOURNAL   Hum Mutat 29 (8), E76-E87 (2008)
   PUBMED   18484607
REFERENCE   5  (bases 1 to 9366)
  AUTHORS   Alagramam,K.N., Miller,N.D., Adappa,N.D., Pitts,D.R., Heaphy,J.C.,
            Yuan,H. and Smith,R.J.
  TITLE     Promoter, alternative splice forms, and genomic structure of
            protocadherin 15
  JOURNAL   Genomics 90 (4), 482-492 (2007)
   PUBMED   17706913
  REMARK    GeneRIF: Both mouse and human protocadherin 15 genes have complex
            genomic structures and transcription control mechanisms.
REFERENCE   6  (bases 1 to 9366)
  AUTHORS   Alagramam,K.N., Yuan,H., Kuehn,M.H., Murcia,C.L., Wayne,S.,
            Srisailpathy,C.R., Lowry,R.B., Knaus,R., Van Laer,L., Bernier,F.P.,
            Schwartz,S., Lee,C., Morton,C.C., Mullins,R.F., Ramesh,A., Van
            Camp,G., Hageman,G.S., Woychik,R.P. and Smith,R.J.
  TITLE     Mutations in the novel protocadherin PCDH15 cause Usher syndrome
            type 1F
  JOURNAL   Hum Mol Genet 10 (16), 1709-1718 (2001)
   PUBMED   11487575
  REMARK    GeneRIF: Mutations cause Usher syndrome type 1F. Protocadherins are
            essential for maintenance of normal retinal and cochlear function.
            Erratum:[Hum Mol Genet 2001 Oct 15;10(22):2603. Hagemen GS
            [corrected to Hageman GS]]
REFERENCE   7  (bases 1 to 9366)
  AUTHORS   Ahmed,Z.M., Riazuddin,S., Bernstein,S.L., Ahmed,Z., Khan,S.,
            Griffith,A.J., Morell,R.J., Friedman,T.B., Riazuddin,S. and
            Wilcox,E.R.
  TITLE     Mutations of the protocadherin gene PCDH15 cause Usher syndrome
            type 1F
  JOURNAL   Am J Hum Genet 69 (1), 25-34 (2001)
   PUBMED   11398101
REFERENCE   8  (bases 1 to 9366)
  AUTHORS   Alagramam,K.N., Murcia,C.L., Kwon,H.Y., Pawlowski,K.S., Wright,C.G.
            and Woychik,R.P.
  TITLE     The mouse Ames waltzer hearing-loss mutant is caused by mutation of
            Pcdh15, a novel protocadherin gene
  JOURNAL   Nat Genet 27 (1), 99-102 (2001)
   PUBMED   11138007
REFERENCE   9  (bases 1 to 9366)
  AUTHORS   Shearer,A.E., Hildebrand,M.S., Odell,A.M. and Smith,R.J.H.
  TITLE     Genetic Hearing Loss Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301607
REFERENCE   10 (bases 1 to 9366)
  AUTHORS   Koenekoop,R.K., Arriaga,M.A., Trzupek,K.M. and Lentz,J.J.
  TITLE     Usher Syndrome Type I
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301442
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC051618.7, AL356114.12,
            AL353784.15, AL360214.19, AC013737.5, AC024073.7, AC027671.9,
            AC016817.6 and AL365496.15.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene is a member of the cadherin superfamily. Family
            members encode integral membrane proteins that mediate
            calcium-dependent cell-cell adhesion. It plays an essential role in
            maintenance of normal retinal and cochlear function. Mutations in
            this gene result in hearing loss and Usher Syndrome Type IF
            (USH1F). Extensive alternative splicing resulting in multiple
            isoforms has been observed in the mouse ortholog. Similar
            alternatively spliced transcripts are inferred to occur in human,
            and additional variants are likely to occur. [provided by RefSeq,
            Dec 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000644397.2/ ENSP00000495195.1
            RefSeq Select criteria    :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               AC051618.7         29803-30109         c
            308-426             AL356114.12        15906-16024         c
            427-492             AL353784.15        110703-110768       c
            493-653             AL360214.19        11300-11460         c
            654-809             AC013737.5         202897-203052       c
            810-929             AC013737.5         180142-180261       c
            930-1040            AC013737.5         163373-163483       c
            1041-1211           AC013737.5         151048-151218       c
            1212-1320           AC013737.5         70600-70708         c
            1321-1433           AC024073.7         158363-158475       c
            1434-1640           AC024073.7         140110-140316       c
            1641-1775           AC024073.7         129561-129695       c
            1776-1925           AC024073.7         127871-128020       c
            1926-2119           AC024073.7         97527-97720         c
            2120-2252           AC024073.7         77302-77434         c
            2253-2332           AC024073.7         34411-34490         c
            2333-2426           AC024073.7         23758-23851         c
            2427-2555           AC024073.7         11184-11312         c
            2556-2861           AC027671.9         67357-67662         c
            2862-3086           AC027671.9         64657-64881         c
            3087-3203           AC027671.9         40114-40230         c
            3204-3344           AC016817.6         150055-150195       c
            3345-3457           AC016817.6         148035-148147       c
            3458-3567           AC016817.6         129169-129278       c
            3568-3708           AC016817.6         127118-127258       c
            3709-3836           AC016817.6         91546-91673         c
            3837-4052           AC016817.6         54945-55160         c
            4053-4141           AC016817.6         45478-45566         c
            4142-4318           AC016817.6         28623-28799         c
            4319-4537           AC016817.6         19618-19836         c
            4538-4546           AC016817.6         16868-16876         c
            4547-4702           AC016817.6         15696-15851         c
            4703-4768           AL365496.15        166723-166788       c
            4769-4787           AL365496.15        164553-164571       c
            4788-4826           AL365496.15        162797-162835       c
            4827-4897           AL365496.15        158107-158177       c
            4898-5006           AL365496.15        157114-157222       c
            5007-9366           AL365496.15        149329-153688       c
FEATURES             Location/Qualifiers
     source          1..9366
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.1"
     gene            1..9366
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /note="protocadherin related 15"
                     /db_xref="GeneID:65217"
                     /db_xref="HGNC:HGNC:14674"
                     /db_xref="MIM:605514"
     exon            1..307
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            308..426
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            427..492
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            493..653
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            654..809
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            810..929
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1040
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1211
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1320
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1433
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1640
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1775
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1925
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2119
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2252
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2332
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2426
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2555
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2861
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..3086
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3203
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            3204..3344
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..3457
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            3458..3567
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            3568..3708
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            3709..3836
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            3837..4052
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            4053..4141
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            4142..4318
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            4319..4537
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            4538..4546
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            4547..4702
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            4703..4768
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            4769..4787
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            4788..4826
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            4827..4897
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            4898..5006
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     exon            5007..9366
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5842..5847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /note="hexamer: AAGAAA"
     polyA_site      5858
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /note="major polyA site"
     regulatory      9347..9352
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
                     /note="hexamer: AATAAA"
     polyA_site      9366
                     /gene="PCDH15"
                     /gene_synonym="CDHR15; DFNB23; USH1F"
ORIGIN      
        1 gttagttgct tgtggtaact aaggcaggtg gcatacatct cagaacgtgg agaatgatgg
       61 tatgctttct gagttaacat gttgaactgt tttgcttttc taaaaatttt cctagtaaca
      121 ttttcttgat gatatgagag tggatatcaa tgcctcacag aaacaagagg tggaacatgt
      181 gaatgaatcg tcttggaact agattatgag cactggttct ttttaaaggg atgtgcaaga
      241 ggcagccttg gcaagaaaac ttgctgcata atcttacatg gactaaagat gaaactttaa
      301 accgcaaatc agctttgagt gaactttgac agaagatgtt tcgacagttt tatctctgga
      361 catgtttagc ttcagggatc atcctgggct ctctctttga aatctgcttg ggccagtatg
      421 atgatgattg caaactagct aggggaggac caccagctac catagttgct attgatgaag
      481 aaagtcggaa tggtacaatt ctggtggaca acatgctgat caaagggact gctggaggac
      541 cagaccccac catagaactt tctttaaagg ataatgtgga ttactgggtg ttgatggatc
      601 ctgttaagca aatgcttttc ctgaacagca ccggaagagt tctggataga gatccaccga
      661 tgaacataca ctccattgtg gtgcaggtcc agtgcatcaa caaaaaagtg ggcactatta
      721 tctaccatga agtgcgaata gtggtgagag acaggaatga caactcaccc actttcaagc
      781 atgaaagcta ctatgccaca gtgaatgagc tcactccagt tggtaccaca atattcacag
      841 gattttcagg agacaatgga gctacagata tagatgatgg accaaatgga cagatagagt
      901 atgttattca gtataatcca gatgatccga catccaatga cacctttgaa attcccctaa
      961 tgttgactgg aaatatagtg ttaaggaaga ggctcaacta tgaagataag actcgctact
     1021 ttgtcataat ccaagctaat gaccgtgccc aaaatctgaa tgagaggcga accaccacca
     1081 ccactctcac agtggatgtt ctggatggag atgacttggg tccaatgttt cttccttgtg
     1141 tccttgtgcc aaacactcgt gattgccgtc cactcactta tcaagctgcc atacctgagt
     1201 tgagaactcc ggaagaactg aaccccatta ttgttacgcc accaatccaa gccattgatc
     1261 aggaccggaa tattcaaccg ccatcagata ggccaggaat cctctattcc atccttgttg
     1321 ggactcctga ggattaccca cgatttttcc atatgcatcc taggacagca gaacttagtc
     1381 tcctggagcc agtaaacaga gactttcacc agaaatttga tttggttatt aaggctgaac
     1441 aagacaatgg tcatcctctt cctgcctttg ccggtctaca cattgaaata ctggatgaaa
     1501 acaatcaaag tccatatttt acaatgccca gttatcaagg ctatatcctg gaatctgccc
     1561 cagtgggagc aaccatttcg gacagtctca atttgacttc acctttaaga atagtagctc
     1621 tggacaagga catagaagat acaaaagacc cagagcttca cctttttctg aatgactaca
     1681 cctcagtctt caccgtcaca cagactggta ttactcgcta cctcacctta cttcaaccag
     1741 tggacaggga agaacagcaa acttacacct tttcgataac agcatttgat ggtgtacaag
     1801 aaagtgagcc agtcatcgtc aatattcaag tgatggatgc aaatgataac acgccaacct
     1861 tccctgaaat atcctatgat gtgtatgttt atacagacat gagacctggg gacagtgtca
     1921 tacagctcac tgcagtcgac gcagacgaag ggtcaaatgg ggagatcaca tatgaaatcc
     1981 ttgttggggc tcagggagac ttcatcatca ataaaacaac agggcttatc accatcgctc
     2041 caggggtgga aatgatagtc gggcggactt acgcactcac ggtccaagca gcggataatg
     2101 ctcctcctgc agagcgaagg aactccatct gcactgtgta tattgaagtg cttccaccaa
     2161 ataatcaaag ccctcctcgc ttcccacagc tgatgtatag ccttgaaatt agtgaagcca
     2221 tgagggttgg tgctgtttta ttaaatctac aggcaactga tcgagaggga gactcaataa
     2281 catatgccat tgagaatgga gatcctcaga gagtttttaa tctttcagaa accacgggga
     2341 ttctaacctt agggaaagca ctggacaggg aaagcactga tcgctacatt ctgatcatca
     2401 cagcttcaga tggcaggcca gatgggacct caactgccac agtaaacata gtggtgacag
     2461 atgtcaatga caatgctcca gtgtttgatc cttatctgcc aagaaattta tctgtggtgg
     2521 aagaagaagc caatgccttt gtgggtcaag taaaagcaac agaccctgat gctggaataa
     2581 atggtcaagt gcactacagt ttgggtaact ttaataatct ttttcgtatc acatccaatg
     2641 ggagcattta cacagcagtg aagcttaaca gagaagtcag ggactactat gaacttgttg
     2701 ttgtggcaac agatggagca gtacaccctc gtcattcaac tctaaccttg gccatcaagg
     2761 ttttggacat tgatgataac agtcctgtgt tcaccaattc aacatacact gtccttgttg
     2821 aagagaattt gccagctggg actaccatcc ttcaaataga ggccaaagat gtcgaccttg
     2881 gagcaaatgt gtcttaccgg ataagaagcc cagaagtgaa gcactttttt gcactacatc
     2941 catttacagg agaactatcg cttttaagga gtttagatta tgaggcattt ccagaccaag
     3001 aagcaagtat cacttttctg gtagaggcct ttgatattta tggaacaatg ccacctggta
     3061 ttgctactgt cacagtgatt gtaaaggata tgaatgatta tcctcctgtc tttagtaaac
     3121 gaatatacaa agggatggtg gctccggatg cagtcaaggg tacacctatc acaacagttt
     3181 atgctgaaga tgcagaccct cctggattac ctgcaagtcg tgtgaggtat agagtagatg
     3241 atgtacagtt tccttaccct gccagtattt ttgaagtgga agaagattct ggaagagtaa
     3301 taacacgagt caatcttaat gaagaaccta caacaatttt taagttggtg gtggttgctt
     3361 ttgatgatgg ggagcctgtg atgtccagca gtgccacagt gaagattctt gtcttacatc
     3421 ctggtgagat cccacgcttc acacaggagg aatatagacc tcctccagta agtgaacttg
     3481 ccaccaaagg gaccatggtt ggtgtaattt ctgctgctgc cattaatcaa agtattgtgt
     3541 actccattgt ttcaggaaat gaagaagata catttggaat taataacatc acaggtgtta
     3601 tctatgtgaa tggacctctg gattatgaga ccaggacaag ctatgtactt cgagtccaag
     3661 ctgattccct ggaagtggtc cttgccaatc tccgagttcc ttcaaaaagc aatacagcta
     3721 aagtatacat tgagattcag gatgaaaata atcatccccc agtgtttcag aaaaaattct
     3781 acatcggagg tgtatctgaa gatgcaagaa tgtttacttc tgtactcaga gtgaaggcta
     3841 ctgataaaga tactggcaat tatagtgtca tggcctacag actcataata ccaccaatta
     3901 aagagggaaa agaaggattt gtagtggaaa catatacagg gcttatcaaa actgctatgc
     3961 tcttccataa tatgaggaga tcctacttca agtttcaagt tattgcaact gacgactatg
     4021 ggaagggact gagcggcaaa gccgatgtac tcgtctccgt ggtcaatcag ctggatatgc
     4081 aagtcattgt ttccaatgtg cctcctactc tagtggaaaa aaagatagaa gatcttacag
     4141 agatcttgga tcgctatgtt caggaacaaa ttcctggtgc caaggtcgta gtggagtcca
     4201 ttggagctcg ccggcatgga gatgcctttt ccctagaaga ttacaccaaa tgtgacttga
     4261 ctgtctatgc aattgacccc caaaccaaca gagccatcga tagaaatgag ctttttaaat
     4321 ttttggatgg caaactactt gatatcaata aagactttca gccgtattat ggggaaggag
     4381 gacgcattct ggagatccgg actccagagg cagtgaccag cattaaaaag agaggagaaa
     4441 gtctaggata cacagaaggg gccttgttgg ctctggcctt catcatcatc ctctgctgca
     4501 ttcctgccat cttggtggtt ttggtcagct acagacagtt taaagtacgt caagctgagt
     4561 gtacaaagac tgcacgaatt caggccgcat tacccgcggc taaaccagca gtgccggctc
     4621 ctgcaccagt ggcagcgccc ccgccgccgc cgccgcctcc gccaggtgcg catctctatg
     4681 aagaacttgg agacagctca atttggagtt tttgttggca gctggtcata tgcatgagaa
     4741 cttgtgctat ttggcggact ctgacaagga gaggttatgg atcagagcaa cagcaactgc
     4801 tgaggccctc tcttcttaaa ccagaggaat tatccatgga gtctggaatt gatcctggcc
     4861 aggaatatgg acaagattat tacagttatg agcatgggta tgaaatgcct caatatggga
     4921 gtcgccgtcg attgttacca ccagctggac aggaggaata tggtgaggtg gttggtgaag
     4981 ctgaggaaga atatgaggag gaagagtggg caagaaaaag aatgatcaag ttagttgttg
     5041 atcgagagta tgaaaccagc tcaactggag aagacagtgc tcctgaatgt cagagaaacc
     5101 gtcttcacca tcctagtatc cacagtaata tcaacggcaa tatatatatt gcacagaatg
     5161 gttctgtggt gagaacccgc cgtgcctgcc tcacggacaa cttaaaagtt gcttcccctg
     5221 ttcgactggg agggcccttt aagaaactag acaagttggc agtgacacat gaggagaatg
     5281 tacctctgaa cacattatca aaggggccat tttctactga aaaaatgaat gcaagaccaa
     5341 ctctggttac atttgcccct tgccctgtgg ggactgacaa tacagcggtg aagccactaa
     5401 ggaacaggct gaaaagcaca gttgaacagg agtccatgat tgacagtaag aacatcaagg
     5461 aggctttgga atttcatagt gaccacacac agtctgatga tgaagagctt tggatgggcc
     5521 cctggaacaa cctccatata ccaatgacaa aactgtgacc aattttttaa aagatatttt
     5581 aattaatttt tacttacatt tttaataaac tgtgcttttt attgtcactg agaaaacaat
     5641 gtatggaatt tatatcatgc acacaagcta aaactttgaa caatatgctt taaaatttta
     5701 agagacagat ttgcactcac attgttatca attaatcgtt tttcccagaa aatccttttg
     5761 gacatacttt cactaaataa cctatcgttt aaacatttag ctgttttgtt gggtcttgaa
     5821 tttttgttca ttttaataaa caagaaataa ttactaaata atcatttata ttttattgat
     5881 taacatagat tatgctttat ttctagctcc acaaaacatt tttagtacat gtaattttat
     5941 tttccatagc caaaagggca aaaaagaagt aagaggatat ttacaggcaa tgagtttata
     6001 cagctgctgt ctatactgcc ctaattttta aaatgaaagc tagaattgca aagtaaagta
     6061 aatgagggaa tcacctgtaa ataattaatt attttaaatc atgagcttgt tttctttctt
     6121 tattgtcctg tataaaggtt ttcacatttt accataaata catttatatc ttgacccttt
     6181 aggaaaccac ttgaagtcgt atgtcttttt atcaatatta tttacaatat tctcttgtcc
     6241 cttcatctca tatcaaatat ggtagatact ttagtttagt ttaatcactt gaggttaaat
     6301 aattgtttgg agcaacatgg aaatctcacc cttagcaaaa gcttttaggg aagtgagaaa
     6361 ggttcgagta agcagtaatg catctagaac gacaatttca taatggaaga catggtgagg
     6421 ttagggaagt ctcacattaa tgtcactaga ctttaatagt ttgtaaaccc agcatatcag
     6481 agtaaaggaa tttggcaggg ttgaaatgta tataatatat aaagcttata aaggctatga
     6541 attcataact tcaaatgttg tgtttaactt cttccatttt caggttattt atagaatatt
     6601 ttaatgcaca tatttatgtg cctaaaatcc agaaccagga aatcattgcc tgggcatttt
     6661 ttaaaatcaa agaacatggt cttgattttt taccattgaa caaagcacag tgtttcatca
     6721 taagtagaaa tgaaaacaga atatccttta aaaaacttgc cttgtgtgtt gcttattttc
     6781 cagatgatgt aaaaagaatg aaacaatata gattaagaga attcagaatt ctattgaata
     6841 ttacttagta tgatatagat gtagctcact tcaaattttg cacagtattg accaagttca
     6901 ggttttaatg aaatttcctc atgcatgctt aatatatggt tgaaggactg aataatgcac
     6961 tattatttat tcccctctta catgtttcgc gtcttaaaaa ttgtttatta ttatgctatt
     7021 tcctcatttc caaagtgaat gaattgtact gacataaact tgccgacttg taagagtagt
     7081 atgtttttac ttcagatttc caagaaaata tttgagatca aatacagtaa catctcatct
     7141 accttatttt attgagaatt aatgcattcc atacccttgc caaaaaaaca aaacaaaaca
     7201 aacaaacaaa aaaaaaccta gtggcattag ctagattaga aacgtagaat catgaccaca
     7261 cctcctggcc tgccaaacaa gcatccacat tttcaaaaga tcctaaggtg gtttatatgc
     7321 acattaaatt ttggaagcaa tgaagtccgg ggcttattcc ttcaggcacc aaagcaatgg
     7381 tttttagtat aggatacttt gtataggaat tagattaagc atatatttcc ctactaattc
     7441 aatcagaggt catcgaatat aatttaatat tatcttgata cccccagatc atctcagtca
     7501 gcatcccttg atattctctc tatatacagc ttcatggctg cgtttttgtc ctttgatttc
     7561 tggctgtgac atttaactta ttctgttgtt gtgcctttct cacatttttt tctttcagtt
     7621 tatagcttct agtatcctga tgggaaagtt tgtgtttttt gtttgttttc ttaatgttga
     7681 aaaatcatga agcttaagat gggaattagg tacacggatt caaccaaatg ttttgcgact
     7741 cttagacgct ttctttggtt accagtagat ttggaaatat gatgttggca gaagtctagt
     7801 ggcctgacat atgagatgtc actgtatttt aaactacatt ttttatgaga aaatatgcaa
     7861 aattttacaa gccacttagc agacacattt cagtaattta aacttgatca tttcagtaaa
     7921 aacaatcatg aggtcaatca tctgttactt aatggagata gtataaagag aagcagaatt
     7981 tacacagagc aaccaaacca aatatttggt cagtatattt ttgggtaacg tagagcagca
     8041 aaattattac taactaaata aatctggatc aattaaatag ttactttcat agaactttca
     8101 ctagtctata aatccctgac tcaggattaa aactgtggaa cccagaggaa atacccaggt
     8161 atgtttaatc ttaagaatac ttcatataaa taacgtttca atgtaaatat ttataaagaa
     8221 attggttgtt atttttccta ggaaggtgta ggaaggtttt cttgttgttc tcaatcagca
     8281 ctagcttcaa tcaggcagaa gaaacagcag gtcttggcta atcgaggtga gaacagaatg
     8341 atgtaatgac taatattgca acccgttgat tttagaaggt cttgtgggca ttaagggaaa
     8401 gcagaggaag aatgagaaaa tatggtcaga gtgacatagg acatttgtga cttaatgacc
     8461 atcgaatcac aggtgttaat ctccctctct caatttgtct ttctcattaa ttacagactc
     8521 tgagagttgt catagaattg caaccgtagg ttggccaaaa ccatcttttt aaaatacaga
     8581 agaaagtttg ccttgaattt tatatgtgat atgtcattca tgttatttta ccacattgtt
     8641 cacagggatg ttaaagacta ttatttactt aagtggttgt tccaaaggtg attcagtagt
     8701 taccattaaa atattattta aaaacatttt tatatcatag agccagaagt aattgaatat
     8761 tgactctcga gggaagacat tttctgtctt ttatttcatg agctttgatt tttctctttc
     8821 tctgcttcac cttctgcact ttatacctta agtgggattt atataccact tgaatttaat
     8881 tagcaaaata ggcaaaaagt gctaataatc tattctcagg gcagatgcct attggtgcct
     8941 gcaaattaca cagcgataag gctgaaggat aggttcaaaa taatgttgag gacttacaca
     9001 ttttatagat agtttctttc tattcccaaa tggtatgtga aatttttgtt ctattttttt
     9061 tattggtttt caatagttaa ttttgatctt tatcataaga agctttagtt atagactggt
     9121 atttttttca ttgcaatcta ctttaaattt atggtcagtt aagcacatgt atggaagatt
     9181 cgaacattgt ctatagtttg aaaaatctat caacaccttc actgctttcc caatttcttt
     9241 atccaaatac ctgttcttcc ttaacaaata ttatgttact gtataagaat ctgaattaga
     9301 agttttaagt taaaatgcat tgttattcac tacacaatgt ttcaaaaata aattttcatt
     9361 tgaaaa
//
