LOCUS       NM_001395587            8550 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens protocadherin 11 Y-linked (PCDH11Y), transcript
            variant e, mRNA.
ACCESSION   NM_001395587
VERSION     NM_001395587.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8550)
  AUTHORS   Anilkumar,T.R., Devi,A.N., Pillai,S.M., Jayakrishnan,K.,
            Oommen,O.V. and Kumar,P.G.
  TITLE     Expression of protocadherin 11Yb (PCDH11Yb) in seminal germ cells
            is correlated with fertility status in men
  JOURNAL   Reprod Fertil Dev 29 (11), 2100-2111 (2017)
   PUBMED   28241900
  REMARK    GeneRIF: In the present study, PCDH11Yb, but not PCDH11Ya or
            PCDH11Yc, was expressed in germ cells isolated from the semen of
            all 13 men with proven fertility. However, in several subjects from
            various infertility classes, there was complete absence or a
            significant reduction in the expression of PCDH11Yb. In conclusion,
            expression levels of PCDH11Yb in germ cells in the semen were
            correlated with the fertility status of men.
REFERENCE   2  (bases 1 to 8550)
  AUTHORS   Priddle,T.H. and Crow,T.J.
  TITLE     Protocadherin 11X/Y a human-specific gene pair: an
            immunohistochemical survey of fetal and adult brains
  JOURNAL   Cereb Cortex 23 (8), 1933-1941 (2013)
   PUBMED   22744706
  REMARK    GeneRIF: PCDH11Y expression was detected in the fetal neocortex,
            ganglionic eminences, cerebellum, and inferior olive. In the adult
            brain, the cerebral cortex, hippocampal formation, and cerebellum
            and brain stem were immunoreactive.
REFERENCE   3  (bases 1 to 8550)
  AUTHORS   Priddle,T.H. and Crow,T.J.
  TITLE     The protocadherin 11X/Y (PCDH11X/Y) gene pair as determinant of
            cerebral asymmetry in modern Homo sapiens
  JOURNAL   Ann N Y Acad Sci 1288 (1), 36-47 (2013)
   PUBMED   23600975
  REMARK    GeneRIF: the PCDH11X/Y gene pair determines cerebral asymmetry by
            initiating the right shift in Homo sapiens
REFERENCE   4  (bases 1 to 8550)
  AUTHORS   Ahn,K., Huh,J.W., Kim,D.S., Ha,H.S., Kim,Y.J., Lee,J.R. and
            Kim,H.S.
  TITLE     Quantitative analysis of alternative transcripts of human PCDH11X/Y
            genes
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 153B (3), 736-744 (2010)
   PUBMED   19859901
  REMARK    GeneRIF: The present article investigated the patterns of
            alternative splicing and expression of the PCDH11X/Y genes.
REFERENCE   5  (bases 1 to 8550)
  AUTHORS   Blanco-Arias,P., Sargent,C.A. and Affara,N.A.
  TITLE     Protocadherin X (PCDHX) and Y (PCDHY) genes; multiple mRNA isoforms
            encoding variant signal peptides and cytoplasmic domains
  JOURNAL   Mamm Genome 15 (1), 41-52 (2004)
   PUBMED   14727141
REFERENCE   6  (bases 1 to 8550)
  AUTHORS   Skaletsky,H., Kuroda-Kawaguchi,T., Minx,P.J., Cordum,H.S.,
            Hillier,L., Brown,L.G., Repping,S., Pyntikova,T., Ali,J., Bieri,T.,
            Chinwalla,A., Delehaunty,A., Delehaunty,K., Du,H., Fewell,G.,
            Fulton,L., Fulton,R., Graves,T., Hou,S.F., Latrielle,P.,
            Leonard,S., Mardis,E., Maupin,R., McPherson,J., Miner,T., Nash,W.,
            Nguyen,C., Ozersky,P., Pepin,K., Rock,S., Rohlfing,T., Scott,K.,
            Schultz,B., Strong,C., Tin-Wollam,A., Yang,S.P., Waterston,R.H.,
            Wilson,R.K., Rozen,S. and Page,D.C.
  TITLE     The male-specific region of the human Y chromosome is a mosaic of
            discrete sequence classes
  JOURNAL   Nature 423 (6942), 825-837 (2003)
   PUBMED   12815422
REFERENCE   7  (bases 1 to 8550)
  AUTHORS   Chen,M.W., Vacherot,F., De La Taille,A., Gil-Diez-De-Medina,S.,
            Shen,R., Friedman,R.A., Burchardt,M., Chopin,D.K. and Buttyan,R.
  TITLE     The emergence of protocadherin-PC expression during the acquisition
            of apoptosis-resistance by prostate cancer cells
  JOURNAL   Oncogene 21 (51), 7861-7871 (2002)
   PUBMED   12420223
  REMARK    GeneRIF: A 4.8 kb cDNA was cloned from TPA-resistance LNCaP
            prostate cancer cells. It is an unusual protocadherin family gene
            with 2 large overlapping ORFs encoding homologous polypeptides, one
            with and one without a signal sequence. [protocadherin-PC]
REFERENCE   8  (bases 1 to 8550)
  AUTHORS   Blanco,P., Sargent,C.A., Boucher,C.A., Mitchell,M. and Affara,N.A.
  TITLE     Conservation of PCDHX in mammals; expression of human X/Y genes
            predominantly in brain
  JOURNAL   Mamm Genome 11 (10), 906-914 (2000)
   PUBMED   11003707
REFERENCE   9  (bases 1 to 8550)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   10 (bases 1 to 8550)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010722.2, AC012067.2,
            AC012667.2 and AC010081.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene belongs to the protocadherin family, a subfamily
            of the cadherin superfamily. The encoded protein consists of an
            extracellular domain containing seven cadherin repeats, a
            transmembrane domain, and a cytoplasmic tail that differs from
            those of the classical cadherins. This gene is located on the Y
            chromosome in a block of X/Y homology and is very closely related
            to its paralog on the X chromosome. The protein is thought to play
            a role in cell-cell recognition during development of the central
            nervous system. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Jul
            2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.9549.1,
                                           SRR1803614.266348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000698851.1/ ENSP00000513983.1
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-310               AC010722.2         11257-11566
            311-881             AC010722.2         67850-68420
            882-3374            AC010722.2         109176-111668
            3375-3573           AC012067.2         147448-147646
            3574-3597           AC012667.2         63859-63882
            3598-8550           AC010081.4         144552-149504
FEATURES             Location/Qualifiers
     source          1..8550
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /map="Yp11.2"
     gene            1..8550
                     /gene="PCDH11Y"
                     /gene_synonym="PCDH-PC; PCDH22; PCDHX; PCDHY"
                     /note="protocadherin 11 Y-linked"
                     /db_xref="GeneID:83259"
                     /db_xref="HGNC:HGNC:15813"
                     /db_xref="MIM:400022"
     exon            1..310
                     /gene="PCDH11Y"
                     /gene_synonym="PCDH-PC; PCDH22; PCDHX; PCDHY"
                     /inference="alignment:Splign:2.1.0"
     exon            311..881
                     /gene="PCDH11Y"
                     /gene_synonym="PCDH-PC; PCDH22; PCDHX; PCDHY"
                     /inference="alignment:Splign:2.1.0"
     CDS             522..4268
                     /gene="PCDH11Y"
                     /gene_synonym="PCDH-PC; PCDH22; PCDHX; PCDHY"
                     /note="isoform d is encoded by transcript variant e;
                     protocadherin 22; protocadherin-PC; protocadherin prostate
                     cancer; protocadherin on the Y chromosome"
                     /codon_start=1
                     /product="protocadherin-11 Y-linked isoform d"
                     /protein_id="NP_001382516.1"
                     /db_xref="CCDS:CCDS94706.1"
                     /db_xref="GeneID:83259"
                     /db_xref="HGNC:HGNC:15813"
                     /db_xref="MIM:400022"
                     /translation="MQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIPRDE
                     HCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPA
                     AVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVK
                     VEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADI
                     GENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP
                     ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG
                     RVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAML
                     FIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAP
                     PEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSP
                     VFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIR
                     PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYEL
                     VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVT
                     DLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEI
                     ADVSSPTSDYVKILVAAVAGTITVVVVIFITAVVRCRQAPHLKAAQKNMQNSEWATPN
                     PENRQMIMMKKKKKKKKHSPKNLLLNVVTIEETKADDVDSDGNRVTLDLPIDLEEQTM
                     GKYNWVTTPTTFKPDSPDLARHYKSASPQPAFQIQPETPLNLKHHIIQELPLDNTFVA
                     CDSISNCSSSSSDPYSVSDCGYPVTTFEVPVSVHTRPSQRRVTFHLPEGSQESSSDGG
                     LGDHDAGSLTSTSHGLPLGYPQEEYFDRATPSNRTEGDGNSDPESTFIPGLKKEITVQ
                     PTVEEASDNCTQECLIYGHSDACWMPASLDHSSSSQAQASALCHSPPLSQASTQHHSP
                     PVTQTIVLCHSPPVTQTIALCHSPPPIQVSALHHSPPLVQGTALHHSPPSAQASALCY
                     SPPLAQAAAISHSSSLPQVIALHRSQAQSSVSLQQGWVQGANGLCSVDQGVQGSATSQ
                     FYTMSERLHPSDDSIKVIPLTTFAPRQQARPSRGDSPIMETHPL"
     exon            882..3374
                     /gene="PCDH11Y"
                     /gene_synonym="PCDH-PC; PCDH22; PCDHX; PCDHY"
                     /inference="alignment:Splign:2.1.0"
     exon            3375..3573
                     /gene="PCDH11Y"
                     /gene_synonym="PCDH-PC; PCDH22; PCDHX; PCDHY"
                     /inference="alignment:Splign:2.1.0"
     exon            3574..3597
                     /gene="PCDH11Y"
                     /gene_synonym="PCDH-PC; PCDH22; PCDHX; PCDHY"
                     /inference="alignment:Splign:2.1.0"
     exon            3598..8550
                     /gene="PCDH11Y"
                     /gene_synonym="PCDH-PC; PCDH22; PCDHX; PCDHY"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagtcggcg aactgtctgg gcgggaggag ccgtgagcag tagctgcact cagctgcccg
       61 cgcggcaaag aggaaggcaa gccaaacaga gtgcgcagag tggcagtgcc agcggcgaca
      121 caggcagcac aggcagcccg ggctgcctga atagcctcag aaacaacctc agcgactccg
      181 gctgctctgc ggactgcgag ctgtggcggt agagcccgct acagcagtcg cagtctccgt
      241 ggagcgggcg gaagcctttt ttctcccttt cgtttacctc ttcattctac tctaaaggca
      301 tcgttattag tgttgtgcgg gttaatacaa caaactgtca caagtgtttg ttgtccggga
      361 cgtacatttt cgcggtcctg ctagtatgcg tggtgttcca ctctggcgcc caggagaaaa
      421 actacaccat ccgagaagaa attccagaaa acgtcctgat aggcaacttg ttgaaagacc
      481 ttaacttgtc gctgattcca aacaagtcct tgacaactac tatgcagttc aagctagtgt
      541 acaagaccgg agatgtgcca ctgattcgaa ttgaagagga tactggtgag atcttcacta
      601 ccggcgctcg cattgatcgt gagaaattat gtgctggtat cccaagggat gagcattgct
      661 tttatgaagt ggaggttgcc attttgccgg atgaaatatt tagactggtt aagatacgtt
      721 ttctgataga agatataaat gataatgcac cattgttccc agcaacagtt atcaacatat
      781 caattccaga gaactcggct ataaactcta aatatactct cccagcggct gttgatcctg
      841 acgtaggcat aaacggagtt caaaactacg aactaattaa gagtcaaaac atttttggcc
      901 tcgatgtcat tgaaacacca gaaggagaca agatgccaca actgattgtt caaaaggagt
      961 tagataggga agagaaggat acctatgtga tgaaagtaaa ggttgaagat ggtggctttc
     1021 ctcaaagatc cagtactgct attttgcaag taagtgttac tgatacaaat gacaaccacc
     1081 cagtctttaa ggagacagag attgaagtca gtataccaga aaatgctcct gtaggcactt
     1141 cagtgacaca gctccatgcc acagatgctg acataggtga aaatgccaag atccacttct
     1201 ctttcagcaa tctagtctcc aacattgcca ggagattatt tcacctcaat gccaccactg
     1261 gacttatcac aatcaaagaa ccactggata gggaagaaac accaaaccac aagttactgg
     1321 ttttggcaag tgatggtgga ttgatgccag caagagcaat ggtgctggta aatgttacag
     1381 atgtcaatga taatgtccca tccattgaca taagatacat cgtcaatcct gtcaatgaca
     1441 cagttgttct ttcagaaaat attccactca acaccaaaat tgctctcata actgtgacgg
     1501 ataaggatgc ggaccataat ggcagggtga catgcttcac agatcatgaa attcctttca
     1561 gattaaggcc agtattcagt aatcagttcc tcctggagaa tgcagcatat cttgactatg
     1621 agtccacaaa agaatatgcc attaaattac tggctgcaga tgctggcaaa cctcctttga
     1681 atcagtcagc aatgctcttc atcaaagtga aagatgaaaa tgacaatgct ccagttttca
     1741 cccagtcttt cgtaactgtt tctattcctg agaataactc tcctggcatc cagttgatga
     1801 aagtaagtgc aacggatgca gacagtgggc ctaatgctga gatcaattac ctgctaggcc
     1861 ctgatgctcc acctgaattc agcctggatc gtcgtacagg catgctgact gtagtgaaga
     1921 aactagatag agaaaaagag gataaatatt tattcacaat tctggcaaaa gataatgggg
     1981 taccaccctt aaccagcaat gtcacagtct ttgtaagcat tattgatcag aatgacaata
     2041 gcccagtttt cactcacaat gaatacaaat tctatgtccc agaaaacctt ccaaggcatg
     2101 gtacagtagg actaatcact gtaactgatc ctgattatgg agacaattct gcagttacgc
     2161 tctccatttt agatgagaat gatgacttca ccattgattc acaaactggt gtcatccgac
     2221 caaatatttc atttgataga gaaaaacaag aatcttacac tttctatgta aaggctgagg
     2281 atggtggtag agtatcacgt tcttcaagtg ccaaagtaac cataaatgtg gttgatgtca
     2341 atgacaacaa accagttttc attgtccctc cttacaacta ttcttatgaa ttggttctac
     2401 cgtccactaa tccaggcaca gtggtctttc aggtaattgc tgttgacaat gacactggca
     2461 tgaatgcaga ggttcgttac agcattgtag gaggaaacac aagagatctg tttgcaatcg
     2521 accaagaaac aggcaacata acattgatgg agaaatgtga tgttacagac cttggtttac
     2581 acagagtgtt ggtcaaagct aatgacttag gacagcctga ttctctcttc agtgttgtaa
     2641 ttgtcaatct gttcgtgaat gagtcagtga ccaatgctac actgattaat gaactggtgc
     2701 gcaaaagcat tgaagcacca gtgaccccaa atactgagat agctgatgta tcctcaccaa
     2761 ctagtgacta tgtcaagatc ctggttgcag ctgttgctgg caccataact gtcgttgtag
     2821 ttattttcat cactgctgta gtaagatgtc gccaggcacc acaccttaag gctgctcaga
     2881 aaaacatgca gaattctgaa tgggctaccc caaacccaga aaacaggcag atgataatga
     2941 tgaagaaaaa gaaaaagaag aagaagcatt cccctaagaa cctgctgctt aatgttgtca
     3001 ctattgaaga aactaaggca gatgatgttg acagtgatgg aaacagagtc acactagacc
     3061 ttcctattga tctagaagag caaacaatgg gaaagtacaa ttgggtaact acacctacta
     3121 ctttcaagcc tgacagccct gatttggccc gacactacaa atctgcctct ccacagcctg
     3181 ccttccaaat tcagcctgaa actcccctga atttgaagca ccacatcatc caagaactgc
     3241 ctctcgataa cacctttgtg gcctgtgact ctatctccaa ttgttcctca agcagttcag
     3301 atccctacag cgtttctgac tgtggctatc cagtgacaac cttcgaggta cctgtgtccg
     3361 tacacaccag accgtcccag cggcgtgtca catttcacct gccagaaggc tctcaggaaa
     3421 gcagcagtga tggtggactg ggagaccatg atgcaggcag ccttaccagc acatcccatg
     3481 gcctgcccct tggctatcct caggaggagt actttgatcg tgctacaccc agcaatcgca
     3541 ctgaagggga tggcaactcc gatcctgaat ctactttcat acctggacta aagaaagaaa
     3601 taactgttca accaactgtg gaagaggcct ctgacaactg cactcaagaa tgtctcatct
     3661 atggccattc tgatgcctgc tggatgccgg catctctgga tcattccagc tcttcacaag
     3721 cacaggcctc tgctctatgc cacagcccac cactgtcaca ggcctctact cagcaccaca
     3781 gcccaccagt gacacagacc attgttctct gccacagccc tccagtgaca cagaccatcg
     3841 cattgtgcca cagcccacca ccgatacagg tgtctgctct ccaccacagt cctcctctag
     3901 tgcagggtac tgcacttcac cacagcccac catcagcaca ggcctcagcc ctctgctaca
     3961 gccctccttt agcacaggct gctgcaatca gccacagctc ttctctgcca caggttattg
     4021 ccctccatcg tagtcaggcc caatcatcag tcagtttgca gcaaggttgg gtgcaaggtg
     4081 ctaatggact atgctctgtt gatcagggag tgcaaggtag tgcaacatct cagttttaca
     4141 ccatgtctga aagacttcat cccagtgatg attcaattaa agtcattcct ttgacaacct
     4201 tcgctccacg ccaacaggcc agaccgtcca gaggtgattc ccccattatg gaaacacatc
     4261 ccttgtaaag ctaaaatagt tacttcaaat tttcagaaaa gatgtatata gtcaaaattt
     4321 aagatacaat tccaatgagt attctgatta tcagatttgt aaataactat gtaaatagaa
     4381 acagatacca gaataaatct acagctagac ccttagtcaa tagttaacca aaaaattgca
     4441 atttgtttaa ttcagaatgt gtatttaaaa agaaaaggaa tttaacaatt tgcatcccct
     4501 tgtacagtaa ggcttatcat gacagagcgt actatttctg atgtacagta ttttttgttg
     4561 tttttatcat catgtgcaat attactgatt tgtttccatg ctgattgtgt ggaaccagta
     4621 tgtagcaaat ggaaagccta gaaatatctt attttctaag tttaccttta gtttacctaa
     4681 acttttgttc agataatgtt aaaaggtata cgtactctag ccttttttgg ggctttcttt
     4741 ttgatttttg tttgtggttt tcagtttttt tgttgttgtt agtgagtctc ccttcaaaat
     4801 acacagtagg tagtgtaaat actgcttgtt tgtgtctctc tgctgtcatg ttttctacct
     4861 tattccaata ctatattgtt gataaaattt gtatatacat tttcaataaa gaatatgtat
     4921 aaactgtaca gatctagatc tacaacctat ttctctactc tttagtagag ttcgagacac
     4981 agaagtgcaa taactgccct aattaagcaa ctatttgtta aaaagggccc ctttttactt
     5041 taatagttta gtgtaaagta catcagaaat aaaactgtat ctgacatttt aagcctgtag
     5101 tccattatta cttgggtctt tacttctggg aatttgtatg taacagccta gaaaattaaa
     5161 aggaggtgga tgcatccaaa gcacgagtca cttaaaatat cgacggtaaa ctactatttt
     5221 gtagagaaac tcaggaagat ttaaatgttg atttgacagc tcaataggct gttaccaaag
     5281 ggtgttcagt aaaaataaca aatacatgta actgtagata aaaccacata ctaaatctat
     5341 aagactaagg gatttttgtt attctagctc aacttactga agaaaaccac taataacaac
     5401 aagaatatca ggaaggaact tttcaagaaa tgtaattata aatctacatc aaacagaatt
     5461 ttaaggaaaa atgcagaggg agaaataagg cacatgactg cttcttgcag tcaagaagaa
     5521 ataccaataa cacacacaga acaaaaacca tcaaaatctc atatatgaaa taaaatatat
     5581 tcttctaagc aaagaaacag tactattcat agaaaacatt agttttctcc tgttgtctgt
     5641 tatttccttc ttttatcctc ttaactggcc attatcttgt atgtgcacat tttataaatg
     5701 tacagaaaca tcaccaactt gattttcttc catagcaaaa ctgagaaaat accttgtttc
     5761 agtataacac taaaccaaga gacaattgat gtttaatggg ggcggttggg gttggggggg
     5821 agtcaatatc tcctattgat taacttagac atagattttg taatgtataa cttgatattt
     5881 aatttatgat taaactgtaa ttttgtaaca taaactgtgg taattgcata atttcattgg
     5941 tgaggatttc ctttgaatat tgagaaagtt tcttttcatg tgcccagcag gttaagtagc
     6001 gttttcagaa tatacattat tcccatccat tgtaaagttc cttaagtcat atttgactgg
     6061 gcgtgcagaa taacttctta actattaact atcagagttt gattaataaa attaattaat
     6121 tttttttctc cttcgtgttg ttaatgttcc aagggatttg gagcatactg gttttccagg
     6181 tgcatgtgaa tcccgaagga ctgatgatat ttgaatgttt attaaattat tatcacacaa
     6241 atgtgttgat attgtggcta ttgttgatgt tgaaaattgt aaacttgggg aagattaaga
     6301 aaagaaccaa tagtgacaaa aatcagtgct tccagtagat tttagaacat tctttgcctc
     6361 aaaaaacctg caaagatgat gtgagatttt ttcttgtgtt ttaattattt tcacattttc
     6421 tctctgcaaa cctttagttt tctgatgatc tacacacaca catacacaca cacacacaca
     6481 cacgtgcaca cacacacatt taaaggatat aaaaagaaga ggttgaaaga ttattaaata
     6541 acttatcagg catctcaatg gttactatct atgttagtga aaatcaaata ggactcaaag
     6601 ttggatattt gggatttttc ttctgacagt ataatttatt gagttactag ggaggttctt
     6661 aaatcctcat atctggaaac ttgtgaagtt ttgacacctt tcctatagat ataggaatga
     6721 accaatacgc ttttattacc ctttctaact ctgattttat aatcagactt agattgtgtt
     6781 tagaatatta aatgactggg caccctcttc ttggttttta ccagagaggc tttgaatgga
     6841 agcaggctga gagtagccaa agaggcaagg ggtattagcc cagttattct cccctatgcc
     6901 ttctcttcct aagcgtccac taggtctggc cttggaaatc tgttacttct acggcttcag
     6961 atctgatgat atctttttca tcacattaca agttatttct ttgactgaat agacagtggt
     7021 ataggttgac acagcacaca agtggctatt gtgatgtatg atgtatgtag tcccacaact
     7081 gcaaaacgtc ttactgaagc aacaatcgaa aaatggttct gttttaaaaa ggattttgtt
     7141 tgatttgaaa ttaaaacttc aaactgaatg acttatatga gaataatatg ttcaatcaaa
     7201 gtagttattc tattttgtgt ccatattcca ttagattgtg attattaatt ttctagctat
     7261 ggtattacta tatcacactt gtgagtatgt attcaaatac taagtatctt atatgctacg
     7321 tgcatacaca ttcttttctt aaactttacc tgtgttttaa ctaatattgt gtcagtgtat
     7381 taaaaattag cttttacata tgatatctac aatgtaataa atttagagag taattttgtg
     7441 tattcttatt tacttaacat tttactttta attatgtaaa tttggttaga aaataataat
     7501 aaatggttag tgctattgtg taatggtagc agttacaaag agcctctgcc ttcccaaact
     7561 aatatttatc acacatggtc attaaatggg aaaaaaatag actaaacaaa tcacaaattg
     7621 ttcagttctt aaaatgtaat tatgtcacac acacaaaaaa atccttttca atcctgagaa
     7681 aattaaaggt gttttactca catggatatt tcaacattag ttttttttgt ttgtttcttt
     7741 ttcatggtat tactgaaggt gtgtatactc cctaatacac atttatgaaa atctacttgt
     7801 ttagactttt atttatactc ttctgattta tattttttat tataattatt atttcttatc
     7861 ttcttttata ttttttggaa accaaattta tagttagttt aggtaaactt tttattatga
     7921 ccattagaaa ctattttgaa tgtttccaac tggctcaatt ggctgggaaa acatgggaac
     7981 aagagaagct gaaatatatt tctgcaagaa cctttctata ttatgtgcca attaccacac
     8041 cagatcaatt ttatgcagag gccttaaaat attctttcac agtagctttc ttacactaac
     8101 cgtcatgtgc ttttagtaaa tatgattttt aaaagcagtt caagttgaca acagcagaaa
     8161 cagtaacaaa aaaatctgct cagaaaaatg tatgtgcaca aataaaaaaa attaatggca
     8221 attgtttagt gactgtaagt gatacttttt aaagagtaaa ctgtgtgaaa tttatactat
     8281 ccctgcttaa aatattaaga tttttatgaa atatgtattt atgtttgtat tgtgggaaga
     8341 ttcctcctct gtgatatcat acagcatctg aaagtgaaca gtatcccaaa gcagttccaa
     8401 gcatgctttg gaagtaagaa ggttgactat tgtatggcca aggatggcag tatgtaatcc
     8461 agaagcaaac ttgtattaat tgttctattt caggttctgt attgcatgtt ttcttattaa
     8521 tatatattaa taaaagttat gagaaataaa
//
