LOCUS       NM_032968               9022 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens protocadherin 11 X-linked (PCDH11X), transcript
            variant c, mRNA.
ACCESSION   NM_032968
VERSION     NM_032968.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9022)
  AUTHORS   Veerappa,A.M., Saldanha,M., Padakannaya,P. and Ramachandra,N.B.
  TITLE     Genome-wide copy number scan identifies disruption of PCDH11X in
            developmental dyslexia
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 162B (8), 889-897 (2013)
   PUBMED   24591081
  REMARK    GeneRIF: PCDH11X, expressed in brain is implicated in cell-cell
            communication, verbal ability, cerebral asymmetry, and dendritic
            synaptic plasticity, may be regarded as a new candidate gene for
            dyslexia.
REFERENCE   2  (bases 1 to 9022)
  AUTHORS   Priddle,T.H. and Crow,T.J.
  TITLE     Protocadherin 11X/Y a human-specific gene pair: an
            immunohistochemical survey of fetal and adult brains
  JOURNAL   Cereb Cortex 23 (8), 1933-1941 (2013)
   PUBMED   22744706
  REMARK    GeneRIF: PCDH11X expression was detected in the fetal neocortex,
            ganglionic eminences, cerebellum, and inferior olive. In the adult
            brain, the cerebral cortex, hippocampal formation, and cerebellum
            and brain stem were immunoreactive.
REFERENCE   3  (bases 1 to 9022)
  AUTHORS   Priddle,T.H. and Crow,T.J.
  TITLE     The protocadherin 11X/Y (PCDH11X/Y) gene pair as determinant of
            cerebral asymmetry in modern Homo sapiens
  JOURNAL   Ann N Y Acad Sci 1288 (1), 36-47 (2013)
   PUBMED   23600975
  REMARK    GeneRIF: the PCDH11X/Y gene pair determines cerebral asymmetry by
            initiating the right shift in Homo sapiens
REFERENCE   4  (bases 1 to 9022)
  AUTHORS   Lyons,P.A., Rayner,T.F., Trivedi,S., Holle,J.U., Watts,R.A.,
            Jayne,D.R., Baslund,B., Brenchley,P., Bruchfeld,A., Chaudhry,A.N.,
            Cohen Tervaert,J.W., Deloukas,P., Feighery,C., Gross,W.L.,
            Guillevin,L., Gunnarsson,I., Harper,L., Hruskova,Z., Little,M.A.,
            Martorana,D., Neumann,T., Ohlsson,S., Padmanabhan,S., Pusey,C.D.,
            Salama,A.D., Sanders,J.S., Savage,C.O., Segelmark,M.,
            Stegeman,C.A., Tesar,V., Vaglio,A., Wieczorek,S., Wilde,B.,
            Zwerina,J., Rees,A.J., Clayton,D.G. and Smith,K.G.
  TITLE     Genetically distinct subsets within ANCA-associated vasculitis
  JOURNAL   N Engl J Med 367 (3), 214-223 (2012)
   PUBMED   22808956
REFERENCE   5  (bases 1 to 9022)
  AUTHORS   Miar,A., Alvarez,V., Corao,A.I., Alonso,B., Diaz,M., Menendez,M.,
            Martinez,C., Calatayud,M., Moris,G. and Coto,E.
  TITLE     Lack of association between protocadherin 11-X/Y (PCDH11X and
            PCDH11Y) polymorphisms and late onset Alzheimer's disease
  JOURNAL   Brain Res 1383, 252-256 (2011)
   PUBMED   21276771
  REMARK    GeneRIF: our data...failed to confirm the association between
            PCDH11X polymorphisms and late-onset Alzheimer's disease
REFERENCE   6  (bases 1 to 9022)
  AUTHORS   Blanco,P., Sargent,C.A., Boucher,C.A., Mitchell,M. and Affara,N.A.
  TITLE     Conservation of PCDHX in mammals; expression of human X/Y genes
            predominantly in brain
  JOURNAL   Mamm Genome 11 (10), 906-914 (2000)
   PUBMED   11003707
REFERENCE   7  (bases 1 to 9022)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   8  (bases 1 to 9022)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   9  (bases 1 to 9022)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 9022)
  AUTHORS   Yoshida,K. and Sugano,S.
  TITLE     Identification of a novel protocadherin gene (PCDH11) on the human
            XY homology region in Xq21.3
  JOURNAL   Genomics 62 (3), 540-543 (1999)
   PUBMED   10644456
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004388.1, AL133321.11,
            AL133274.8 and AL121869.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 15, 2020 this sequence version replaced NM_032968.4.
            
            Summary: This gene belongs to the protocadherin gene family, a
            subfamily of the cadherin superfamily. The encoded protein consists
            of an extracellular domain containing 7 cadherin repeats, a
            transmembrane domain and a cytoplasmic tail that differs from those
            of the classical cadherins. The gene is located in a major X/Y
            block of homology and its Y homolog, despite divergence leading to
            coding region changes, is the most closely related cadherin family
            member. The protein is thought to play a fundamental role in
            cell-cell recognition essential for the segmental development and
            function of the central nervous system. Disruption of this gene may
            be associated with developmental dyslexia. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jun
            2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1803616.213448.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN03465404 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000682573.1/
                                                ENSP00000507225.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-310               AC004388.1         61388-61697
            311-479             AC004388.1         91479-91647
            480-585             AC004388.1         92486-92591
            586-644             AC004388.1         93250-93308
            645-1228            AC004388.1         117474-118057
            1229-3721           AC004388.1         158794-161286
            3722-3802           AL133321.11        16010-16090
            3803-3832           AL133321.11        77749-77778
            3833-4031           AL133274.8         31665-31863
            4032-4055           AL121869.19        16267-16290
            4056-9022           AL121869.19        166232-171198
FEATURES             Location/Qualifiers
     source          1..9022
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.31"
     gene            1..9022
                     /gene="PCDH11X"
                     /gene_synonym="PCDH-X; PCDH-Y; PCDH11; PCDH11Y; PCDH22;
                     PCDHX; PPP1R119"
                     /note="protocadherin 11 X-linked"
                     /db_xref="GeneID:27328"
                     /db_xref="HGNC:HGNC:8656"
                     /db_xref="MIM:300246"
     exon            1..310
                     /gene="PCDH11X"
                     /gene_synonym="PCDH-X; PCDH-Y; PCDH11; PCDH11Y; PCDH22;
                     PCDHX; PPP1R119"
                     /inference="alignment:Splign:2.1.0"
     exon            311..479
                     /gene="PCDH11X"
                     /gene_synonym="PCDH-X; PCDH-Y; PCDH11; PCDH11Y; PCDH22;
                     PCDHX; PPP1R119"
                     /inference="alignment:Splign:2.1.0"
     exon            480..585
                     /gene="PCDH11X"
                     /gene_synonym="PCDH-X; PCDH-Y; PCDH11; PCDH11Y; PCDH22;
                     PCDHX; PPP1R119"
                     /inference="alignment:Splign:2.1.0"
     exon            586..644
                     /gene="PCDH11X"
                     /gene_synonym="PCDH-X; PCDH-Y; PCDH11; PCDH11Y; PCDH22;
                     PCDHX; PPP1R119"
                     /inference="alignment:Splign:2.1.0"
     exon            645..1228
                     /gene="PCDH11X"
                     /gene_synonym="PCDH-X; PCDH-Y; PCDH11; PCDH11Y; PCDH22;
                     PCDHX; PPP1R119"
                     /inference="alignment:Splign:2.1.0"
     CDS             689..4732
                     /gene="PCDH11X"
                     /gene_synonym="PCDH-X; PCDH-Y; PCDH11; PCDH11Y; PCDH22;
                     PCDHX; PPP1R119"
                     /note="isoform c precursor is encoded by transcript
                     variant c; protocadherin-S; protocadherin 11X;
                     protocadherin on the X chromosome; protein phosphatase 1,
                     regulatory subunit 119; Protocadherin-11 Y-linked;
                     Protocadherin on the Y chromosome; Protocadherin prostate
                     cancer; Protocadherin-22; Protocadherin-PC"
                     /codon_start=1
                     /product="protocadherin-11 X-linked isoform c precursor"
                     /protein_id="NP_116750.1"
                     /db_xref="CCDS:CCDS14461.1"
                     /db_xref="GeneID:27328"
                     /db_xref="HGNC:HGNC:8656"
                     /db_xref="MIM:300246"
                     /translation="MDLLSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLL
                     KDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIPR
                     DEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTL
                     PAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMK
                     VKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDA
                     DIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGL
                     MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADH
                     NGRVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSA
                     MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPD
                     APPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN
                     SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGV
                     IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSY
                     ELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD
                     VTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNT
                     EIADVSSPTSDYVKILVAAVAGTITVVVVIFITAVVRCRQAPHLKAAQKNKQNSEWAT
                     PNPENRQMIMMKKKKKKKKHSPKNLLLNFVTIEETKADDVDSDGNRVTLDLPIDLEEQ
                     TMGKYNWVTTPTTFKPDSPDLARHYKSASPQPAFQIQPETPLNSKHHIIQELPLDNTF
                     VACDSISKCSSSSSDPYSVSDCGYPVTTFEVPVSVHTRPPMKEVVRSCTPMKESTTME
                     IWIHPQPQRKSEGKVAGKSQRRVTFHLPEGSQESSSDGGLGDHDAGSLTSTSHGLPLG
                     YPQEEYFDRATPSNRTEGDGNSDPESTFIPGLKKAAEITVQPTVEEASDNCTQECLIY
                     GHSDACWMPASLDHSSSSQAQASALCHSPPLSQASTQHHSPRVTQTIALCHSPPVTQT
                     IALCHSPPPIQVSALHHSPPLVQATALHHSPPSAQASALCYSPPLAQAAAISHSSPLP
                     QVIALHRSQAQSSVSLQQGWVQGADGLCSVDQGVQGSATSQFYTMSERLHPSDDSIKV
                     IPLTTFTPRQQARPSRGDSPIMEEHPL"
     exon            1229..3721
                     /gene="PCDH11X"
                     /gene_synonym="PCDH-X; PCDH-Y; PCDH11; PCDH11Y; PCDH22;
                     PCDHX; PPP1R119"
                     /inference="alignment:Splign:2.1.0"
     exon            3722..3802
                     /gene="PCDH11X"
                     /gene_synonym="PCDH-X; PCDH-Y; PCDH11; PCDH11Y; PCDH22;
                     PCDHX; PPP1R119"
                     /inference="alignment:Splign:2.1.0"
     exon            3803..3832
                     /gene="PCDH11X"
                     /gene_synonym="PCDH-X; PCDH-Y; PCDH11; PCDH11Y; PCDH22;
                     PCDHX; PPP1R119"
                     /inference="alignment:Splign:2.1.0"
     exon            3833..4031
                     /gene="PCDH11X"
                     /gene_synonym="PCDH-X; PCDH-Y; PCDH11; PCDH11Y; PCDH22;
                     PCDHX; PPP1R119"
                     /inference="alignment:Splign:2.1.0"
     exon            4032..4055
                     /gene="PCDH11X"
                     /gene_synonym="PCDH-X; PCDH-Y; PCDH11; PCDH11Y; PCDH22;
                     PCDHX; PPP1R119"
                     /inference="alignment:Splign:2.1.0"
     exon            4056..9022
                     /gene="PCDH11X"
                     /gene_synonym="PCDH-X; PCDH-Y; PCDH11; PCDH11Y; PCDH22;
                     PCDHX; PPP1R119"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9001..9006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDH11X"
                     /gene_synonym="PCDH-X; PCDH-Y; PCDH11; PCDH11Y; PCDH22;
                     PCDHX; PPP1R119"
                     /note="hexamer: AATAAA"
     polyA_site      9022
                     /gene="PCDH11X"
                     /gene_synonym="PCDH-X; PCDH-Y; PCDH11; PCDH11Y; PCDH22;
                     PCDHX; PPP1R119"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcggcg aactgtcggg gcgggaggag ccgtgagcag tagctgcact cagctgcccg
       61 cgcggcaaag aggaaggcaa gccaaacaga gtgcgcagag tggcagtgcc agcggcgaca
      121 caggcagcac aggcagcccg ggctgcctga atagcctcag aaacaacctc agcgactccg
      181 gctgctctgc ggactgcgag ctgtggcggt agagcccgct acagcagtcg cagtctccgt
      241 ggagcgggcg gaagcctttt ttctcccttt cgtttacctc ttcattctac tctaaaggca
      301 tcgttattag agggtgctta aaaagtacag atcaactgga tggatgaatg gatggaagag
      361 gatggaatat cttaacaaaa cacattttcc ttaagtaaat tcatgcatac tccaaataaa
      421 atacagaatg tgaagtatct ctgaactgtg ctgttgaata tggtagctac tagctacatg
      481 aaaatcctgt tgcgaataag aaggattcca cagatcacat accggagagg ttttgcctca
      541 gctgctctca actttgtaat cttgtgaaga agctgacaag cttggctgat tgcagagcac
      601 tatgaggact gaacgacagt gggttttaat tcagatattt caagtgttgt gcgggttaat
      661 acaacaaact gtaacaagtg tacctggtat ggacttgttg tccgggacgt acattttcgc
      721 ggtcctgcta gcatgcgtgg tgttccactc tggcgcccag gagaaaaact acaccatccg
      781 agaagaaatg ccagaaaacg tcctgatagg cgacttgttg aaagacctta acttgtcgct
      841 gattccaaac aagtccttga caactgctat gcagttcaag ctagtgtaca agaccggaga
      901 tgtgccactg attcgaattg aagaggatac tggtgagatc ttcactactg gcgctcgcat
      961 tgatcgtgag aaattatgtg ctggtatccc aagggatgag cattgctttt atgaagtgga
     1021 ggttgccatt ttgccggatg aaatatttag actggttaag atacgttttc tgatagaaga
     1081 tataaatgat aatgcaccat tgttcccagc aacagttatc aacatatcaa ttccagagaa
     1141 ctcggctata aactctaaat atactctccc agcggctgtt gatcctgacg taggaataaa
     1201 cggagttcaa aactacgaac taattaagag tcaaaacatt tttggcctcg atgtcattga
     1261 aacaccagaa ggagacaaga tgccacaact gattgttcaa aaggagttag atagggaaga
     1321 gaaggatacc tacgtgatga aagtaaaggt tgaagatggt ggctttcctc aaagatccag
     1381 tactgctatt ttgcaagtga gtgttactga tacaaatgac aaccacccag tctttaagga
     1441 gacagagatt gaagtcagta taccagaaaa tgctcctgta ggcacttcag tgacacagct
     1501 ccatgccaca gatgctgaca taggtgaaaa tgccaagatc cacttctctt tcagcaatct
     1561 agtctccaac attgccagga gattatttca cctcaatgcc accactggac ttatcacaat
     1621 caaagaacca ctggataggg aagaaacacc aaaccacaag ttactggttt tggcaagtga
     1681 tggtggattg atgccagcaa gagcaatggt gctggtaaat gttacagatg tcaatgataa
     1741 tgtcccatcc attgacataa gatacatcgt caatcctgtc aatgacacag ttgttctttc
     1801 agaaaatatt ccactcaaca ccaaaattgc tctcataact gtgacggata aggatgcgga
     1861 ccataatggc agggtgacat gcttcacaga tcatgaaatc cctttcagat taaggccagt
     1921 attcagtaat cagttcctcc tggagactgc agcatatctt gactatgagt ccacaaaaga
     1981 atatgccatt aaattactgg ctgcagatgc tggcaaacct cctttgaatc agtcagcaat
     2041 gctcttcatc aaagtgaaag atgaaaatga caatgctcca gttttcaccc agtctttcgt
     2101 aactgtttct attcctgaga ataactctcc tggcatccag ttgacgaaag taagtgcaat
     2161 ggatgcagac agtgggccta atgctaagat caattacctg ctaggccctg atgctccacc
     2221 tgaattcagc ctggattgtc gtacaggcat gctgactgta gtgaagaaac tagatagaga
     2281 aaaagaggat aaatatttat tcacaattct ggcaaaagat aacggggtac cacccttaac
     2341 cagcaatgtc acagtctttg taagcattat tgatcagaat gacaatagcc cagttttcac
     2401 tcacaatgaa tacaacttct atgtcccaga aaaccttcca aggcatggta cagtaggact
     2461 aatcactgta actgatcctg attatggaga caattctgca gttacgctct ccattttaga
     2521 tgagaatgat gacttcacca ttgattcaca aactggtgtc atccgaccaa atatttcatt
     2581 tgatagagaa aaacaagaat cttacacttt ctatgtaaag gctgaggatg gtggtagagt
     2641 atcacgttct tcaagtgcca aagtaaccat aaatgtggtt gatgtcaatg acaacaaacc
     2701 agttttcatt gtccctcctt ccaactgttc ttatgaattg gttctaccgt ccactaatcc
     2761 aggcacagtg gtctttcagg taattgctgt tgacaatgac actggcatga atgcagaggt
     2821 tcgttacagc attgtaggag gaaacacaag agatctgttt gcaatcgacc aagaaacagg
     2881 caacataaca ttgatggaga aatgtgatgt tacagacctt ggtttacaca gagtgttggt
     2941 caaagctaat gacttaggac agcctgattc tctcttcagt gttgtaattg tcaatctgtt
     3001 cgtgaatgag tcggtgacca atgctacact gattaatgaa ctggtgcgca aaagcactga
     3061 agcaccagtg accccaaata ctgagatagc tgatgtatcc tcaccaacta gtgactatgt
     3121 caagatcctg gttgcagctg ttgctggcac cataactgtc gttgtagtta ttttcatcac
     3181 tgctgtagta agatgtcgcc aggcaccaca ccttaaggct gctcagaaaa acaagcagaa
     3241 ttctgaatgg gctaccccaa acccagaaaa caggcagatg ataatgatga agaaaaagaa
     3301 aaagaagaag aagcattccc ctaagaactt gctgcttaat tttgtcacta ttgaagaaac
     3361 taaggcagat gatgttgaca gtgatggaaa cagagtcaca ctagaccttc ctattgatct
     3421 agaagagcaa acaatgggaa agtacaattg ggtaactaca cctactactt tcaagcccga
     3481 cagccctgat ttggcccgac actacaaatc tgcctctcca cagcctgcct tccaaattca
     3541 gcctgaaact cccctgaatt cgaagcacca catcatccaa gaactgcctc tcgataacac
     3601 ctttgtggcc tgtgactcta tctccaagtg ttcctcaagc agttcagatc cctacagcgt
     3661 ttctgactgt ggctatccag tgacgacctt cgaggtacct gtgtccgtac acaccagacc
     3721 gccaatgaag gaggttgtgc gatcttgcac ccccatgaaa gagtctacaa ctatggagat
     3781 ctggattcat ccccaaccac agcggaaatc tgaagggaaa gtggcaggaa agtcccagcg
     3841 gcgtgtcaca tttcacctgc cagaaggctc tcaggaaagc agcagtgatg gtggactggg
     3901 agaccatgat gcaggcagcc ttaccagcac atctcatggc ctgccccttg gctatcctca
     3961 ggaggagtac tttgatcgtg ctacacccag caatcgcact gaaggggatg gcaactccga
     4021 tcctgaatct actttcatac ctggactaaa gaaagctgca gaaataactg ttcaaccaac
     4081 tgtggaagag gcctctgaca actgcactca agaatgtctc atctatggcc attctgatgc
     4141 ctgctggatg ccggcatctc tggatcattc cagctcttcg caagcacagg cctctgctct
     4201 atgccacagc ccaccactgt cacaggcctc tactcagcac cacagcccac gagtgacaca
     4261 gaccattgct ctctgccaca gccctccagt gacacagacc atcgcattgt gccacagccc
     4321 accaccgata caggtgtctg ctctccacca cagtcctcct ctagtgcagg ctactgcact
     4381 tcaccacagc ccaccatcag cacaggcctc agccctctgc tacagccctc ctttagcaca
     4441 ggctgctgca atcagccaca gctctcctct gccacaggtt attgccctcc atcgtagtca
     4501 ggcccaatca tcagtcagtt tgcagcaagg ttgggtgcaa ggtgctgatg ggctatgctc
     4561 tgttgatcag ggagtgcaag gtagtgcaac atctcagttt tacaccatgt ctgaaagact
     4621 tcatcccagt gatgattcaa ttaaagtcat tcctttgaca accttcactc cacgccaaca
     4681 ggccagaccg tccagaggtg attcccccat tatggaagaa catcccttgt aaagctaaaa
     4741 tagttacttc aaattttcag aaaagatgta tatagtcaaa atttaagata caattccaat
     4801 gagtattctg attatcagat ttgtaaataa ctatgtaaat agaaacagat accagaataa
     4861 atctacagct agacccttag tcaatagtta accaaaaaat tgcaatttgt ttaattcaga
     4921 atgtgtattt aaaaagaaaa ggaatttaac aatttgcatc cccttgtaca gtaaggctta
     4981 tcatgacaga gcgcactatt tctgatgtac agtatttttt gttgttttta tcatcatgtg
     5041 caatattact gatttgtttc catgctgatt gtgtggaacc agtatgtagc aaatggaaag
     5101 cctagaaata tcttattttc taagtttacc tttagtttac ctaaactttt gttcagataa
     5161 cgttaaaagg tatacgtact ctagcctttt tttgggcttt ctttttgatt tttgtttgtt
     5221 gttttcagtt tttttgttgt tgttagtgag tctcccttca aaatacgcag taggtagtgt
     5281 aaatactgct tgtttgtgtc tctctgctgt catgttttct accttattcc aatactatat
     5341 tgttgataaa atttgtatat acattttcaa taaagaatat gtataaactg tacagatcta
     5401 gatctacaac ctatttctct actctttagt agagttcgag acacagaagt gcaataactg
     5461 ccctaattaa gcaactattt gttaaaaagg gcctcttttt actttaatag tttagtgtaa
     5521 agtacatcag aaataaagct gtatctgcca ttttaagcct gtagtccatt attacttggg
     5581 tctttacttc tgggaatttg tatgtaacag cctagaaaat taaaaggagg tggatgcatc
     5641 caaagcacga gtcacttaaa atatcgacgg taaactacta ttttgtagag aaactcagga
     5701 agatttaaat gttgatttga cagctcaata ggctgttacc aaagggtgtt cagtaaaaat
     5761 aacaaataca tgtaactgta gataaaacca tatactaaat ctataagact aagggatttt
     5821 tgttattcta gctcaactta ctgaagaaaa ccactaataa caacaagaat atcaggaagg
     5881 aacttttcaa gaaatgtaat tataaatcta catcaaacag aattttaagg aaaaatgcag
     5941 agggagaaat aaggcacatg actgcttctt gcagtcaaca agaaatacca ataacacaca
     6001 cagaacaaaa accatcaaaa tctcatatat gaaataaaat atattcttct aagcaaagaa
     6061 acagtactat tcatagaaaa cattagtttt cttctgttgt ctgttatttc cttcttgtat
     6121 cctcttaact ggccattatc ttgtatgtgc acattttata aatgtacaga aacatcacca
     6181 acttaatttt cttccatagc aaaactgaga aaataccttg tttcagtata acactaaacc
     6241 aagagacaat tgatgtttaa tgggggcggt tggggtgggg gggggagtca atatctccta
     6301 ttgattaact tagacataga ttttgtaatg tataacttga tatttaattt atgattaaac
     6361 tgtgtgtaaa ttttgtaaca taaactgtgg taattgcata atttcattgg tgaggatttc
     6421 cactgaatat tgagaaagtt tcttttcatg tgcccagcag gttaagtagc gttttcagaa
     6481 tatacattat tcccatccat tgtaaagttc cttaagtcat atttgactgg gcgtgcagaa
     6541 taacttctta acttttaact atcagagttt gattaataaa attaattaat gttttttctc
     6601 cttcgtgttg ttaatgttcc aagggatttg gagcatactg gttttccagg tgcatgtgaa
     6661 tcccgaagga ctgatgatat ttgaatgttt attaaattat tatcatacaa atgtgttgat
     6721 attgtggcta ttgttgatgt tgaaaatttt aaacttgggg aagattaaga aaagaaccaa
     6781 tagtgacaaa aatcagtgct tccagtagat tttagaacat tctttgcctc aaaaaacctg
     6841 caaagatgat gtgagatttt ttcttgtgtt ttaattattt tcacattttc tctctgcaaa
     6901 actttagttt tctgatgatc tacacacaca cacacacaca cacgtgcaca cacacacaca
     6961 tttaaatgat ataaaaagaa gaggttgaaa gattattaaa taacttatca ggcatctcaa
     7021 tggttactat ctatgttagt gaaaatcaaa taggactcaa agttggatat ttgggatttt
     7081 tcttctgaca gtataattta ttgagttact agggaggttc ttaaatcctc atatctggaa
     7141 acttgtgacg ttttgacacc tttcctatag atgatatagg aatgaaccaa tacgctttta
     7201 ttaccctttc taactctgat tttataatca gacttagatt gtgtttagaa tattaaatga
     7261 ctgggcaccc tcttcttggt ttttaccaga gaggctttga atggaagcag gctgagagta
     7321 gccaaagagg caaggggtat tagcccagtt attctcccct atgccttcct tctctttcta
     7381 agcgtccact aggtctggcc ttggaaacct gttacttcta gggcttcaga tctgatgata
     7441 tctttttcat cacattacaa gttatttctc tgactgaata gacagtggta taggttgaca
     7501 cagcacacaa gtggctattg tgatgtatga tgtatgtagt cctacaactg caaaacgtct
     7561 tactgaacca acaatcaaaa aatggttctg ttttaaaaag gattttgttt gatttgaaat
     7621 taaaacttca agctgaatga cttatatgag aataatacgt tcaatcaaag tagttattct
     7681 attttgtgtc catattccat tagattgtga ttattaattt tctagctatg gtattactat
     7741 atcacacttg tgagtatgta ttcaaatact aagtatctta tatgctacgt gcatacacat
     7801 tcttttctta aactttacct gtgttttaac taatattgtg tcagtgtatt aaaaattagc
     7861 ttttacatat gatatctaca atgtaataaa tttagagagt aattttgtgt attcttattt
     7921 acttaacatt ttacttttaa ttatgtaaat ttggttagaa aataataata aatggttagt
     7981 gctattgtgt aatggtagca gttacaaaga gcctctgcct tcccaaacta atatttatca
     8041 cacatggtca ttaaatggga aaaaaataga ctaaacaaat cacaaattgt tcagttctta
     8101 aaatgtaatt atgtcacaca cacaaaaaat ccttttcaat cctgagaaaa ttaaaggcgt
     8161 tttactcaca tggctatttc aacattagtt ttttttgttt gtttcttttt catggtatta
     8221 ctgaaggtgt gtatactccc taatacacat ttatgaaaat ctacttgttt aggcttttat
     8281 ttatactctt ctgatttata ttttttatta taattattat ttcttatctt tcttctttta
     8341 tattttttgg aaaccaaatt tatagttagt ttaggtaaac tttttattat gaccattaga
     8401 aactattttg aatgcttcca actggctcaa ttggccggga aaacatggga gcaagagaag
     8461 ctgaaatata tttctgcaag aacctttcta tattatgtgc caattaccac accagatcaa
     8521 ttttatgcag aggccttaaa atattctttc acagtagctt tcttacacta accgtcatgt
     8581 gcttttagta aatatgattt ttaaaagcag ttcaagttga caacagcaga aacagtaaca
     8641 aaaaaatctg ctcagaaaaa tgtatgtgca caaataaaaa aaattaatgg caattgttta
     8701 gtgattgtaa gtgatacttt ttaaagagta aactgtgtga aatttatact atccctgctt
     8761 aaaatattaa gatttttatg aaatatgtat ttatgtttgt attgtgggaa gattcctcct
     8821 ctgtgatatc atacagcatc tgaaagtgaa cagtatccca aagcagttcc aaccatgctt
     8881 tggaagtaag aaggttgact attgtatggc caaggatggc agtatgtaat ccagaagcaa
     8941 acttgtatta attgttctat ttcaggttct gtattgcatg ttttcttatt aatatatatt
     9001 aataaaagtt atgagaaata aa
//
