LOCUS       NM_032961               8510 bp    mRNA    linear   PRI 20-AUG-2024
DEFINITION  Homo sapiens protocadherin 10 (PCDH10), transcript variant 1, mRNA.
ACCESSION   NM_032961
VERSION     NM_032961.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8510)
  AUTHORS   Li,W., Plante,J.A., Lin,C., Basu,H., Plung,J.S., Fan,X.,
            Boeckers,J.M., Oros,J., Buck,T.K., Anekal,P.V., Hanson,W.A.,
            Varnum,H., Wells,A., Mann,C.J., Tjang,L.V., Yang,P., Reyna,R.A.,
            Mitchell,B.M., Shinde,D.P., Walker,J.L., Choi,S.Y., Brusic,V.,
            Llopis,P.M., Weaver,S.C., Umemori,H., Chiu,I.M., Plante,K.S. and
            Abraham,J.
  TITLE     Shifts in receptors during submergence of an encephalitic arbovirus
  JOURNAL   Nature 632 (8025), 614-621 (2024)
   PUBMED   39048821
  REMARK    GeneRIF: Shifts in receptors during submergence of an encephalitic
            arbovirus.
REFERENCE   2  (bases 1 to 8510)
  AUTHORS   Zhen,Y., Pavez,M. and Li,X.
  TITLE     The role of Pcdh10 in neurological disease and cancer
  JOURNAL   J Cancer Res Clin Oncol 149 (10), 8153-8164 (2023)
   PUBMED   37058252
  REMARK    GeneRIF: The role of Pcdh10 in neurological disease and cancer.
            Review article
REFERENCE   3  (bases 1 to 8510)
  AUTHORS   Zhang,N., Gao,X., Yuan,Q., Fu,X., Wang,P., Cai,F., Liu,H.,
            Zhang,J., Liang,H., Nie,Y. and Deng,J.
  TITLE     E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to
            suppress the proliferation and metastasis of gastric cancer cells
            by promoting ubiquitination of DNMT1
  JOURNAL   Clin Epigenetics 15 (1), 77 (2023)
   PUBMED   37147733
  REMARK    GeneRIF: E3 ubiquitin ligase RNF180 prevents excessive PCDH10
            methylation to suppress the proliferation and metastasis of gastric
            cancer cells by promoting ubiquitination of DNMT1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8510)
  AUTHORS   Yang,J., Hou,C., Wang,H., Perez,E.A., Do-Umehara,H.C., Dong,H.,
            Arunagiri,V., Tong,F., Van Scoyk,M., Cho,M., Liu,X., Ge,X.,
            Winn,R.A., Ridge,K.M., Wang,X., Chandel,N.S. and Liu,J.
  TITLE     Miz1 promotes KRAS-driven lung tumorigenesis by repressing the
            protocadherin Pcdh10
  JOURNAL   Cancer Lett 555, 216025 (2023)
   PUBMED   36538983
  REMARK    GeneRIF: Miz1 promotes KRAS-driven lung tumorigenesis by repressing
            the protocadherin Pcdh10.
REFERENCE   5  (bases 1 to 8510)
  AUTHORS   Seo,S.I., Yoon,J.H., Byun,H.J. and Lee,S.K.
  TITLE     HOTAIR Induces Methylation of PCDH10, a Tumor Suppressor Gene, by
            Regulating DNMT1 and Sponging with miR-148b in Gastric
            Adenocarcinoma
  JOURNAL   Yonsei Med J 62 (2), 118-128 (2021)
   PUBMED   33527791
  REMARK    GeneRIF: HOTAIR Induces Methylation of PCDH10, a Tumor Suppressor
            Gene, by Regulating DNMT1 and Sponging with miR-148b in Gastric
            Adenocarcinoma.
REFERENCE   6  (bases 1 to 8510)
  AUTHORS   Wolverton,T. and Lalande,M.
  TITLE     Identification and characterization of three members of a novel
            subclass of protocadherins
  JOURNAL   Genomics 76 (1-3), 66-72 (2001)
   PUBMED   11549318
REFERENCE   7  (bases 1 to 8510)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
REFERENCE   8  (bases 1 to 8510)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   9  (bases 1 to 8510)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
REFERENCE   10 (bases 1 to 8510)
  AUTHORS   Cross,S.H., Charlton,J.A., Nan,X. and Bird,A.P.
  TITLE     Purification of CpG islands using a methylated DNA binding column
  JOURNAL   Nat Genet 6 (3), 236-244 (1994)
   PUBMED   8012384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA318338.1, AB037821.1,
            AL157470.1, AC105383.3, BC039411.1 and CB052787.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032961.2.
            
            Summary: This gene belongs to the protocadherin gene family, a
            subfamily of the cadherin superfamily. This family member contains
            6 extracellular cadherin domains, a transmembrane domain and a
            cytoplasmic tail differing from those of the classical cadherins.
            The encoded protein is a cadherin-related neuronal receptor thought
            to function in the establishment of specific cell-cell connections
            in the brain. This gene plays a role in inhibiting cancer cell
            motility and cell migration. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.109019.1,
                                           SRR1660805.105537.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264360.7/ ENSP00000264360.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               DA318338.1         5-135
            132-151             AB037821.1         111-130
            152-273             DA318338.1         158-279
            274-4575            AB037821.1         253-4554
            4576-5256           AL157470.1         1637-2317
            5257-5257           AC105383.3         156648-156648
            5258-5387           AL157470.1         2319-2448
            5388-7178           AC105383.3         156779-158569
            7179-8300           BC039411.1         1-1122
            8301-8420           CB052787.1         28-147              c
            8421-8510           AC105383.3         159812-159901
FEATURES             Location/Qualifiers
     source          1..8510
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q28.3"
     gene            1..8510
                     /gene="PCDH10"
                     /gene_synonym="OL-PCDH; PCDH19"
                     /note="protocadherin 10"
                     /db_xref="GeneID:57575"
                     /db_xref="HGNC:HGNC:13404"
                     /db_xref="MIM:608286"
     exon            1..3478
                     /gene="PCDH10"
                     /gene_synonym="OL-PCDH; PCDH19"
                     /inference="alignment:Splign:2.1.0"
     CDS             848..3970
                     /gene="PCDH10"
                     /gene_synonym="OL-PCDH; PCDH19"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="protocadherin-10 isoform 1 precursor"
                     /protein_id="NP_116586.1"
                     /db_xref="CCDS:CCDS34063.1"
                     /db_xref="GeneID:57575"
                     /db_xref="HGNC:HGNC:13404"
                     /db_xref="MIM:608286"
                     /translation="MIVLLLFALLWMVEGVFSQLHYTVQEEQEHGTFVGNIAEDLGLD
                     ITKLSARGFQTVPNSRTPYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVFLENP
                     LELFQVEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYE
                     ITPNSYFSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGG
                     GGGAGLPPQQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATD
                     PDEGQNGEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLG
                     PNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQ
                     VQCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQ
                     VQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQ
                     GMSVFTYVSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVD
                     QNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGN
                     EMNLFRMDWRTGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVDGA
                     VEPQGGGGSGGGGSGEHQRPSRSGGGETSLDLTLILIIALGSVSFIFLLAMIVLAVRC
                     QKEKKLNIYTCLASDCCLCCCCCGGGGSTCCGRQARARKKKLSKSDIMLVQSSNVPSN
                     PAQVPIEESGGFGSHHHNQNYCYQVCLTPESAKTDLMFLKPCSPSRSTDTEHNPCGAI
                     VTGYTDQQPDIISNGSILSNETKHQRAELSYLVDRPRRVNSSAFQEADIVSSKDSGHG
                     DSEQGDSDHDATNRAQSAGMDLFSNCTEECKALGHSDRCWMPSFVPSDGRQAADYRSN
                     LHVPGMDSVPDTEVFETPEAQPGAERSFSTFGKEKALHSTLERKELDGLLTNTRAPYK
                     PPYLTRKRIC"
     exon            3479..3537
                     /gene="PCDH10"
                     /gene_synonym="OL-PCDH; PCDH19"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3644
                     /gene="PCDH10"
                     /gene_synonym="OL-PCDH; PCDH19"
                     /inference="alignment:Splign:2.1.0"
     exon            3645..3950
                     /gene="PCDH10"
                     /gene_synonym="OL-PCDH; PCDH19"
                     /inference="alignment:Splign:2.1.0"
     exon            3951..8510
                     /gene="PCDH10"
                     /gene_synonym="OL-PCDH; PCDH19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4578..4583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDH10"
                     /gene_synonym="OL-PCDH; PCDH19"
                     /note="hexamer: ATTATA"
     polyA_site      4597
                     /gene="PCDH10"
                     /gene_synonym="OL-PCDH; PCDH19"
                     /note="major polyA site"
     regulatory      5368..5373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDH10"
                     /gene_synonym="OL-PCDH; PCDH19"
                     /note="hexamer: ATTAAA"
     polyA_site      5387
                     /gene="PCDH10"
                     /gene_synonym="OL-PCDH; PCDH19"
                     /note="major polyA site"
     regulatory      8399..8404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDH10"
                     /gene_synonym="OL-PCDH; PCDH19"
                     /note="hexamer: AATAAA"
     polyA_site      8420
                     /gene="PCDH10"
                     /gene_synonym="OL-PCDH; PCDH19"
                     /note="major polyA site"
     regulatory      8470..8475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCDH10"
                     /gene_synonym="OL-PCDH; PCDH19"
                     /note="hexamer: AATAAA"
     polyA_site      8510
                     /gene="PCDH10"
                     /gene_synonym="OL-PCDH; PCDH19"
ORIGIN      
        1 agaaactgcc agcccagacc acaggctcag aggctgaagc aggaggaagg aaggactgga
       61 aggaaaaaga gacaggttag agggaaagag gcttgggaag aaaacagcag aaaagaaact
      121 gctcattaca cttacagaga ggcaagtaac ggtggagatg aggacagagg gaaccaagac
      181 tctgaaagac aaaaaataca aatagagcga aagaggaaaa aaatgtcaag aagaacatcc
      241 atccggagaa atgaagagaa tgaaagtttt aagctgcaga gccgttctgt gcttttccgg
      301 cacaaaatta tatcgctgat tttaagccct tttgcatttg ccagccgttg acattaagag
      361 gcatgtttaa cggtgccaac agcatctcct tttccttctc ctcttcctct tcttcttctt
      421 cctcctcctc ctcctctttt tcctcctcct cgttctcctc ccatcagcaa gaagacaaac
      481 cgaggacagt cttgaaatat cgaaatttcc tctttgggat ttgccagcgc caagactgtc
      541 ggaataaagg acgctgacta ttgtattatt gttattttat taattagtca gtggaaagat
      601 tacagatgag gaaaggggac gcctgtcacc cttcctgtgc taagatttaa aaaaaaatga
      661 ggctggattg cgggaagctc taaaatgaag caaaaggagt aagattttta aagacagaaa
      721 gccacaggag cccccacgta gcgcactttt atttgtattt tttcagattt ttttttgttt
      781 cgtggtggtg ggggaggtga ttgggtggct gactggctgc gggaagctac ttcctttcct
      841 tttggagatg attgtgctat tattgtttgc cttgctctgg atggtggaag gagtcttttc
      901 ccagcttcac tacacggtac aggaggagca ggaacatggc actttcgtgg ggaatatcgc
      961 tgaagatctg ggtctggaca ttacaaaact ttcggctcgc gggtttcaga cggtgcccaa
     1021 ctcaaggacc ccttacttag acctcaacct ggagacaggg gtgctgtacg tgaacgagaa
     1081 aatagaccgc gaacaaatct gcaaacagag cccctcctgt gtcctgcacc tggaggtctt
     1141 tctggagaac cccctggagc tgttccaggt ggagatcgag gtgctggaca ttaatgacaa
     1201 ccccccctct ttcccggagc cagacctgac ggtggaaatc tctgagagcg ccacgccagg
     1261 cactcgcttc cccttggaga gcgcattcga cccagacgtg ggcaccaact ccttgcgcga
     1321 ctacgagatc acccccaaca gctacttctc cctggacgtg cagacccagg gggatggcaa
     1381 ccgattcgct gagctggtgc tggagaagcc actggaccga gagcagcaag cggtgcaccg
     1441 ctacgtgctg accgcggtgg acggaggagg tgggggagga gtaggagaag gagggggagg
     1501 tggcggggga gcaggcctgc ccccccagca gcagcgcacc ggcacggccc tactcaccat
     1561 ccgagtgctg gactccaatg acaatgtgcc cgctttcgac caacccgtct acactgtgtc
     1621 cctaccagag aactctcccc caggcactct cgtgatccag ctcaacgcca ccgacccgga
     1681 cgagggccag aacggtgagg tcgtgtactc cttcagcagc cacatttcgc cccgggcgcg
     1741 ggagcttttc ggactctcgc cgcgcactgg cagactggag gtaagcggcg agttggacta
     1801 tgaagagagc ccagtgtacc aagtgtacgt gcaagccaag gacctgggcc ccaacgccgt
     1861 gcctgcgcac tgcaaggtgc tagtgcgagt actggatgct aatgacaacg cgccagagat
     1921 cagcttcagc accgtgaagg aagcggtgag tgagggcgcg gcgcccggca ctgtggtggc
     1981 ccttttcagc gtgactgacc gcgactcaga ggagaatggg caggtgcagt gcgagctact
     2041 gggagacgtg cctttccgcc tcaagtcttc ctttaagaat tactacacca tcgttaccga
     2101 agcccccctg gaccgagagg cgggggactc ctacaccctg actgtagtgg ctcgggaccg
     2161 gggcgagcct gcgctctcca ccagtaagtc gatccaggta caagtgtcgg atgtgaacga
     2221 caacgcgccg cgtttcagcc agccggtcta cgacgtgtat gtgactgaaa acaacgtgcc
     2281 tggcgcctac atctacgcgg tgagcgccac cgaccgggat gagggcgcca acgcccagct
     2341 tgcctactct atcctcgagt gccagatcca gggcatgagc gtcttcacct acgtttctat
     2401 caactctgag aacggctact tgtacgccct gcgctccttc gactatgagc agctgaagga
     2461 cttcagtttt caggtggaag cccgggacgc tggcagcccc caggcgctgg ctggtaacgc
     2521 cactgtcaac atcctcatag tggatcaaaa tgacaacgcc cctgccatcg tggcgcctct
     2581 accagggcgc aacgggactc cagcgcgtga ggtgctgccc cgctcggcgg agccgggtta
     2641 cctgctcacc cgcgtggccg ccgtggacgc ggacgacggc gagaacgccc ggctcactta
     2701 cagcatcgtg cgtggcaacg aaatgaacct ctttcgcatg gactggcgca ccggggagct
     2761 gcgcacagca cgccgagtcc cggccaagcg cgacccccag cggccttatg agctggtgat
     2821 cgaggtgcgc gaccatgggc agccgcccct ttcctccacc gccaccctgg tggttcagct
     2881 ggtggatggc gccgtggagc cccagggcgg gggcgggagc ggaggcggag ggtcaggaga
     2941 gcaccagcgc cccagtcgct ctggcggcgg ggaaacctcg ctagacctca ccctcatcct
     3001 catcatcgcg ttgggctcgg tgtccttcat cttcctgctg gccatgatcg tgctggccgt
     3061 gcgttgccaa aaagagaaga agctcaacat ctatacttgt ctggccagcg attgctgcct
     3121 ctgctgctgc tgctgcggtg gcggaggttc gacctgctgt ggccgccaag cccgggcgcg
     3181 caagaagaaa ctcagcaagt cagacatcat gctggtgcag agctccaatg tacccagtaa
     3241 cccggcccag gtgccgatag aggagtccgg gggctttggc tcccaccacc acaaccagaa
     3301 ttactgctat caggtatgcc tgacccctga gtccgccaag accgacctga tgtttcttaa
     3361 gccctgcagc ccttcgcgga gtacggacac tgagcacaac ccctgcgggg ccatcgtcac
     3421 cggttacacc gaccagcagc ctgatatcat ctccaacgga agcattttgt ccaacgagac
     3481 taaacaccag cgagcagagc tcagctatct agttgacaga cctcgccgag ttaacagttc
     3541 tgcattccag gaagccgaca tagtaagctc taaggacagt ggtcatggag acagtgaaca
     3601 gggagatagt gatcatgatg ccaccaaccg tgcccagtca gctggtatgg atctcttctc
     3661 caattgcact gaggaatgta aagctctggg ccactcagat cggtgctgga tgccttcttt
     3721 tgtcccttct gatggacgcc aggctgctga ttatcgcagc aatctgcatg ttcctggcat
     3781 ggactctgtt ccagacactg aggtgtttga aactccagaa gcccagcctg gggcagagcg
     3841 gtccttttcc acctttggca aagagaaggc ccttcacagc actctggaga ggaaggagct
     3901 ggatggactg ctgactaata cgcgagcgcc ttacaaacca ccatatttga cacggaaaag
     3961 gatatgctag tcaattctac aggacttacc tgaagcagca tgatttgcac aaagtcgacc
     4021 aacaaaagca tcaacttttc aacttcatta tcttggccat ccagttagtc atgtgtaact
     4081 gagtattaga tttcggatgg agtcatcatg gccaattata ggacctaatt gctctcagca
     4141 ggcctgagaa atgagttgaa atgtgcagaa ctgtagaaac tttagaggca acagattttg
     4201 cctccccgat cagtgtgtgc ctgtttacag cactatctat ctttctctct ccaaatgtca
     4261 ctgagccctt tagatgttta tattcaccac gagaagccag tcataaagat aaaggaaatt
     4321 tgtgcattat aaatgcaata tcactgtttt aaacttgact gttttatatt atttttgtgt
     4381 gatcaagtgt tccgcaagct attccaactt tacaagagaa attgtgatta tgttcttttc
     4441 acctgtgggt tataaaaaat gttgtattct gaagacccac aaaatatcaa agacattctg
     4501 tagtttatac accgtgttgc aaagtgttta ctgtactatt tcaaagcttc taaataaata
     4561 taaaatatat atattatatt atataatttt cctaaaatgt ggtacaactc agttggtttt
     4621 taaatggatg catacagtcc acatcataca ataaaataaa aggtaattca gggtcccaaa
     4681 gacaaactta ctaagaaaaa atcattaata gttttctccc aatttccata tcttactcaa
     4741 ccgtgttttt ccttgtttaa aagaaaatga tgctctaagc tacaaaattt tgtcaaaaac
     4801 tcatattgaa ttttcaatgc caaagatgta gctattgatg ttatcagaca gagcactgac
     4861 tatgtactat caaactatct aacaatctgc ataagtctga ttctatttct atgactttga
     4921 atttagaatc acttaaagct tttataaaga atcgataaat tcacctgtat ttgttgttag
     4981 aaaaaaactg ggtgtctgta cattttgtgg tgtaaaatat gtaattgaag attactattt
     5041 taagaagtca tcagtcatat cactcacaca gaattttatt ttacatagtt ttgtgactta
     5101 attacacatg aatataaaat ctataattct atatgaatat atagagatat agaaacatct
     5161 gaactggtaa agaataacta taaaatatga aagctctaaa tttaaaataa atttagagat
     5221 agaatcatgg tacattattg tttcagtatt ccatgtgaaa attttatagc ttaaatgtag
     5281 tcagtgtttg attaatgaaa aaattcttca tgagtcagcc ttcaaaagtt aagcttgcct
     5341 tttactttta tgtcaacaat attaattatt aaatttagta agacgcactt tcctttcttt
     5401 tatatatttt ttctactgtt gtgtatgcct tgttagaaca cattcgagag aggaaaaaaa
     5461 tcagagaata taagataatc tttcaagcaa aaaacagaat tgtcacagct cccctcgccc
     5521 tctaaactat gatatcaaaa catcatatca aagcttcaac attatatcaa aatgtttgcc
     5581 cagttcaaat tagaaacctg ttttgaaata ctttccttaa tttttaactg atcttatatt
     5641 caatgacagt ttgagctgca ctgtgttatt aaagaataga ctaaaactta acatttgaca
     5701 aatgttcttc atcaaatttt atgtaactta agtggaaatt tttccctaga tttaacttta
     5761 aaatacatat atatacacac acacacacac acacacacac acacacttag gtcctgatat
     5821 gtacatttag agtgatatat tggtatcact catttgactg ttatcaaatt agatattaat
     5881 atatcatatt ccaatcagtt catatatcaa aataatgtat gtaatgttcc agccttttga
     5941 agtctcttta aacatatatg aagctaacag atcatatgta atacaaaaag cacataaatt
     6001 cactaagtgc agcagtaaca ttttcttaaa ctttggcatt actacattaa tattttgaat
     6061 gatagactat tttagtaagg aaatgtttat acataattta actggaaaaa agtctgtttg
     6121 ttccaactct tttttttagc aagaaaatga ttttcttgtt gagtcactct gctttaatta
     6181 aaatgtttca cgcatcattt tgcaatcatg ggtgaatatc cacatccatc ttccttactg
     6241 catgcattga aaataagatt atactcactt catgtatagt aattatattg tcatttacct
     6301 caaagacatt ttctttaatt atttaacctt ttatatcatt gtatataatc tcctttgaac
     6361 caactttttt attatatatt tgtgtattag ttattttcat atatcctagg aactagttat
     6421 actaacttac attttagtta tcatcaatct acaaaaccaa aaccagaact tcttcctaat
     6481 ttgcgggaca aatagaattg tttaaggata aaatgctaca ttattaggtc attaatcaac
     6541 ttatctgttg catccaaagt aaattagaag ttacaacaga gtaaggatat gattcttgta
     6601 agttggttaa aatgttttct tccaatgagg gggactataa aatggaaagt gcaaccaaca
     6661 aataatgaag gtttctaatt aagcatttac tagattaata tatcaaggaa ttttaggata
     6721 ggttttctct ttaatctggt cattctaata tccaatctta cataatttta tatacatcaa
     6781 agaataatat ccatcgtatt agacagtatt tcgtcaataa attatttcag aaaaaaaaat
     6841 catgtcattt actccttgtt aacatggtta gttttagagc agtcaaagtc aaaaaaaatt
     6901 tcctgtggaa acagtgtctt aatgtttcaa aggtatgtca aaagacaatt tttagaaaat
     6961 atttcatcca catgtagaat tctaattttt aacgtgtgaa catagtttgg tgaaatcatc
     7021 ttaaatcaaa tttaaatatc acatcagaat tacttcacag atataatagc gtcaatgata
     7081 tatgtatcat cttttcttgg caaatattaa ggaaatatgt gtattttatt ttttaaagat
     7141 attaaatgca ctgcctttat caaacattgc aaattaagaa ctatagtaga atatttaaat
     7201 attttaattt ctcattgttt tatttgttaa ttggattgta atttgccatc agattctctg
     7261 tattatagaa gctatcttgc ttcttcaata agaggaggaa aaagaatctc acaattccca
     7321 atataatctt taacaactgt acgttaattg taccatttta ccttctaaac attatttact
     7381 ggagctcagt tagtctttaa aacaattact caggcagagt gtggcaaaag ttcagcaaga
     7441 tcaagaaaag tatttaagtt attgactgat catagcactg ttatttgtca ttgcatgtgt
     7501 ttttccccct catgtttcta tgtgtgctat tgatacccaa ggaactcaaa aatacttaaa
     7561 atattggtat acttgatgat ttttctgaaa atcttatatt tttcatatta caaattcttg
     7621 agttctttat ctttttcaag tctaattttg tagtggtaaa ggctttgcac ttaacatcct
     7681 tttgtgttcc tttttaacaa ggaaaaacag aaaataatgg aattccatat tttttacacc
     7741 atggagtagt aaaattattt tatatattgt tagtacttca acaaacatcc ctctgctaag
     7801 tcagacaaaa tccttataca gtaatttgtg aaactgttca gtagagtatt cttttcttca
     7861 aatcttggca taggttttag attatagcat tctgtatgaa tgcaggtaga tgggtgccgc
     7921 cagagtattg caggcaataa tacgactaaa attctaatac ttttagtgtg catgcgtgta
     7981 tttctaatca ctgttatttt ttaagtattt gtaaaattag aaaaattgct tttatttctt
     8041 gaaaagttgt cacatgctta gtttgaagtt ttactctcca gatgtttttg agttgcataa
     8101 aaatcttgca ttcatcattc aaaaaatact aaatttcaca tgagactcaa aaatttctga
     8161 atgatggaac tcagacttcc aatacattca tacatgctag agctgaaagt aagcagggaa
     8221 tttcagctct aaacacattt ttgagacagt tatctgtgag tgaaaacagg gtattataac
     8281 aaaagatgag tttcaatctt aactacagtg tttgttactg tgaatgctat aataatacat
     8341 aagtaaaatg agtgtaaatg taataaatta ttttatactg ctgtatacat atgaaataaa
     8401 taaaactagg atacatatta tgccattttt ccatgcatgg atcttccact gacgcctgtg
     8461 ggagctttga ataaaaatca gtggcaaata tggctctaag tttaaaaaca
//
