LOCUS       NM_006196               1727 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens poly(rC) binding protein 1 (PCBP1), mRNA.
ACCESSION   NM_006196
VERSION     NM_006196.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1727)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1727)
  AUTHORS   Streitfeld,W.S., Dalton,A.C., Howley,B.V. and Howe,P.H.
  TITLE     PCBP1 regulates LIFR through FAM3C to maintain breast cancer stem
            cell self-renewal and invasiveness
  JOURNAL   Cancer Biol Ther 24 (1), 2271638 (2023)
   PUBMED   37927213
  REMARK    GeneRIF: PCBP1 regulates LIFR through FAM3C to maintain breast
            cancer stem cell self-renewal and invasiveness.
REFERENCE   3  (bases 1 to 1727)
  AUTHORS   Park,J., Shim,J.K., Lee,M., Kim,D., Yoon,S.J., Moon,J.H., Kim,E.H.,
            Park,J.Y., Chang,J.H. and Kang,S.G.
  TITLE     Classification of IDH wild-type glioblastoma tumorspheres into low-
            and high-invasion groups based on their transcriptional program
  JOURNAL   Br J Cancer 129 (7), 1061-1070 (2023)
   PUBMED   37558923
  REMARK    GeneRIF: Classification of IDH wild-type glioblastoma tumorspheres
            into low- and high-invasion groups based on their transcriptional
            program.
REFERENCE   4  (bases 1 to 1727)
  AUTHORS   Luo,Y., Zhang,Y., Pang,S., Min,J., Wang,T., Wu,D., Lin,C., Xiao,Z.,
            Xiang,Q., Li,Q. and Ma,L.
  TITLE     PCBP1 protects bladder cancer cells from mitochondria injury and
            ferroptosis by inducing LACTB mRNA degradation
  JOURNAL   Mol Carcinog 62 (7), 907-919 (2023)
   PUBMED   37157950
  REMARK    GeneRIF: PCBP1 protects bladder cancer cells from mitochondria
            injury and ferroptosis by inducing LACTB mRNA degradation.
REFERENCE   5  (bases 1 to 1727)
  AUTHORS   Chen,Y., Dou,Z., Chen,X., Zhao,D., Che,T., Su,W., Qu,T., Zhang,T.,
            Xu,C., Lei,H., Li,Q., Zhang,H. and Di,C.
  TITLE     Overexpression of splicing factor poly(rC)-binding protein 1
            elicits cycle arrest, apoptosis induction, and p73 splicing in
            human cervical carcinoma cells
  JOURNAL   J Cancer Res Clin Oncol 148 (12), 3475-3484 (2022)
   PUBMED   35896897
  REMARK    GeneRIF: Overexpression of splicing factor poly(rC)-binding protein
            1 elicits cycle arrest, apoptosis induction, and p73 splicing in
            human cervical carcinoma cells.
REFERENCE   6  (bases 1 to 1727)
  AUTHORS   Blyn,L.B., Swiderek,K.M., Richards,O., Stahl,D.C., Semler,B.L. and
            Ehrenfeld,E.
  TITLE     Poly(rC) binding protein 2 binds to stem-loop IV of the poliovirus
            RNA 5' noncoding region: identification by automated liquid
            chromatography-tandem mass spectrometry
  JOURNAL   Proc Natl Acad Sci U S A 93 (20), 11115-11120 (1996)
   PUBMED   8855318
REFERENCE   7  (bases 1 to 1727)
  AUTHORS   Tommerup,N. and Leffers,H.
  TITLE     Assignment of human KH-box-containing genes by in situ
            hybridization: HNRNPK maps to 9q21.32-q21.33, PCBP1 to 2p12-p13,
            and PCBP2 to 12q13.12-q13.13, distal to FRA12A
  JOURNAL   Genomics 32 (2), 297-298 (1996)
   PUBMED   8833161
REFERENCE   8  (bases 1 to 1727)
  AUTHORS   Kiledjian,M., Wang,X. and Liebhaber,S.A.
  TITLE     Identification of two KH domain proteins in the alpha-globin mRNP
            stability complex
  JOURNAL   EMBO J 14 (17), 4357-4364 (1995)
   PUBMED   7556077
REFERENCE   9  (bases 1 to 1727)
  AUTHORS   Leffers,H., Dejgaard,K. and Celis,J.E.
  TITLE     Characterisation of two major cellular poly(rC)-binding human
            proteins, each containing three K-homologous (KH) domains
  JOURNAL   Eur J Biochem 230 (2), 447-453 (1995)
   PUBMED   7607214
REFERENCE   10 (bases 1 to 1727)
  AUTHORS   Aasheim,H.C., Loukianova,T., Deggerdal,A. and Smeland,E.B.
  TITLE     Tissue specific expression and cDNA structure of a human transcript
            encoding a nucleic acid binding [oligo(dC)] protein related to the
            pre-mRNA binding protein K
  JOURNAL   Nucleic Acids Res 22 (6), 959-964 (1994)
   PUBMED   8152927
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM794597.1, BC039742.1 and
            Z29505.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_006196.3.
            
            Summary: This intronless gene is thought to have been generated by
            retrotransposition of a fully processed PCBP-2 mRNA. This gene and
            PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have
            arisen as a result of duplication events of entire genes. The
            protein encoded by this gene appears to be multifunctional. It
            along with PCBP-2 and hnRNPK corresponds to the major cellular
            poly(rC)-binding protein. It contains three K-homologous (KH)
            domains which may be involved in RNA binding. This encoded protein
            together with PCBP-2 also functions as translational coactivators
            of poliovirus RNA via a sequence-specific interaction with
            stem-loop IV of the IRES and promote poliovirus RNA replication by
            binding to its 5'-terminal cloverleaf structure. It has also been
            implicated in translational control of the 15-lipoxygenase mRNA,
            human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA.
            The encoded protein is also suggested to play a part in formation
            of a sequence-specific alpha-globin mRNP complex which is
            associated with alpha-globin mRNA stability. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1163657.369363.1,
                                        SRR1163655.462887.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303577.7/ ENSP00000305556.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               BM794597.1         25-150
            127-1688            BC039742.1         12-1573
            1689-1727           Z29505.1           1499-1537
FEATURES             Location/Qualifiers
     source          1..1727
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..1727
                     /gene="PCBP1"
                     /gene_synonym="HEL-S-85; hnRNP-E1; hnRNP-X; HNRPE1; HNRPX"
                     /note="poly(rC) binding protein 1"
                     /db_xref="GeneID:5093"
                     /db_xref="HGNC:HGNC:8647"
                     /db_xref="MIM:601209"
     exon            1..1727
                     /gene="PCBP1"
                     /gene_synonym="HEL-S-85; hnRNP-E1; hnRNP-X; HNRPE1; HNRPX"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..1338
                     /gene="PCBP1"
                     /gene_synonym="HEL-S-85; hnRNP-E1; hnRNP-X; HNRPE1; HNRPX"
                     /note="heterogeneous nuclear ribonucleoprotein E1;
                     alpha-CP1; heterogenous nuclear ribonucleoprotein E1;
                     epididymis secretory protein Li 85; heterogenous nuclear
                     ribonucleoprotein X; nucleic acid-binding protein SUB2.3"
                     /codon_start=1
                     /product="poly(rC)-binding protein 1"
                     /protein_id="NP_006187.2"
                     /db_xref="CCDS:CCDS1898.1"
                     /db_xref="GeneID:5093"
                     /db_xref="HGNC:HGNC:8647"
                     /db_xref="MIM:601209"
                     /translation="MDAGVTESGLNVTLTIRLLMHGKEVGSIIGKKGESVKRIREESG
                     ARINISEGNCPERIITLTGPTNAIFKAFAMIIDKLEEDINSSMTNSTAASRPPVTLRL
                     VVPATQCGSLIGKGGCKIKEIRESTGAQVQVAGDMLPNSTERAITIAGVPQSVTECVK
                     QICLVMLETLSQSPQGRVMTIPYQPMPASSPVICAGGQDRCSDAAGYPHATHDLEGPP
                     LDAYSIQGQHTISPLDLAKLNQVARQQSHFAMMHGGTGFAGIDSSSPEVKGYWASLDA
                     STQTTHELTIPNNLIGCIIGRQGANINEIRQMSGAQIKIANPVEGSSGRQVTITGSAA
                     SISLAQYLINARLSSEKGMGCS"
     regulatory      1664..1669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCBP1"
                     /gene_synonym="HEL-S-85; hnRNP-E1; hnRNP-X; HNRPE1; HNRPX"
                     /note="hexamer: ATTAAA"
     polyA_site      1688
                     /gene="PCBP1"
                     /gene_synonym="HEL-S-85; hnRNP-E1; hnRNP-X; HNRPE1; HNRPX"
                     /note="major polyA site"
     polyA_site      1727
                     /gene="PCBP1"
                     /gene_synonym="HEL-S-85; hnRNP-E1; hnRNP-X; HNRPE1; HNRPX"
ORIGIN      
        1 agaccgccga ggctgccgcc ggagtcgcca ccgccgcgcc ctcgcccacc cgcccgcccg
       61 ccgctcccgg ccccgctcgc cccctccgcc gccgccgccc gcccctgcga ctacgctgcg
      121 gcctcccgcc cgctcccgct cgctcccgcg gccctcgctc gcctcgcgcc ggcagttttg
      181 ggcctacacc tcccctcccc ccgccagccg ccaaagactt gaccacgtaa cgagcccaac
      241 tcccccgaac gccgcccgcc gctcgccatg gatgccggtg tgactgaaag tggactaaat
      301 gtgactctca ccattcggct tcttatgcac ggaaaggaag taggaagcat cattgggaag
      361 aaaggggagt cggttaagag gatccgcgag gagagtggcg cgcggatcaa catctcggag
      421 gggaattgtc cggagagaat catcactctg accggcccca ccaatgccat ctttaaggct
      481 ttcgctatga tcatcgacaa gctggaggaa gatatcaaca gctccatgac caacagtacc
      541 gcggccagca ggcccccggt caccctgagg ctggtggtgc cggccaccca gtgcggctcc
      601 ctgattggga aaggcgggtg taagatcaaa gagatccgcg agagtacggg ggcgcaggtc
      661 caggtggcgg gggatatgct gcccaactcc accgagcggg ccatcaccat cgctggcgtg
      721 ccgcagtctg tcaccgagtg tgtcaagcag atttgcctgg tcatgctgga gacgctctcc
      781 cagtctccgc aagggagagt catgaccatt ccgtaccagc ccatgccggc cagctcccca
      841 gtcatctgcg cgggcggcca agatcggtgc agcgacgctg cgggctaccc ccatgccacc
      901 catgacctgg agggaccacc tctagatgcc tactcgattc aaggacaaca caccatttct
      961 ccgctcgatc tggccaagct gaaccaggtg gcaagacaac agtctcactt tgccatgatg
     1021 cacggcggga ccggattcgc cggaattgac tccagctctc cagaggtgaa aggctattgg
     1081 gcaagtttgg atgcatctac tcaaaccacc catgaactca ccattccaaa taacttaatt
     1141 ggctgcataa tcgggcgcca aggcgccaac attaatgaga tccgccagat gtccggggcc
     1201 cagatcaaaa ttgccaaccc agtggaaggc tcctctggta ggcaggttac tatcactggc
     1261 tctgctgcca gtattagtct ggcccagtat ctaatcaatg ccaggctttc ctctgagaag
     1321 ggcatggggt gcagctagaa cagtgtaggt tccctcaata acccctttct gctgttctcc
     1381 catgatccaa ctgtgtaatt tctggtcagt gattccaggt tttaaataat ttgtaagtgt
     1441 tcagtttcta cacaacttta tcatccgcta agaatttaaa aatcacattc tctgttcagc
     1501 tgttaatgct gggatccata tttagtttta taagcttttc cctgttttta gttttgtttt
     1561 gggttttttg gctcatgaat tttatttctg tttgtcgata agaaatgtaa gagtggaatg
     1621 ttaataaatt tcagtttagt tctgtaatgt caagaattta agaattaaaa aacggattgg
     1681 ttaaaaaatg cttcatattt gaaaaagctg ggaattgctg tcttaaa
//
