LOCUS       NM_001029883            7303 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens photoreceptor cilium actin regulator (PCARE), mRNA.
ACCESSION   NM_001029883 XM_371488
VERSION     NM_001029883.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7303)
  AUTHORS   Jiang,S., He,Y., Li,R. and Zhao,X.
  TITLE     Association of chromosome 2 open reading frame 71 in colorectal
            cancer susceptibility
  JOURNAL   Int J Clin Oncol 28 (2), 240-254 (2023)
   PUBMED   36396885
  REMARK    GeneRIF: Association of chromosome 2 open reading frame 71 in
            colorectal cancer susceptibility.
REFERENCE   2  (bases 1 to 7303)
  AUTHORS   Gerth-Kahlert,C., Tiwari,A., Hanson,J.V.M., Batmanabane,V.,
            Traboulsi,E., Pennesi,M.E., Al-Qahtani,A.A., Lam,B.L.,
            Heckenlively,J., Zweifel,S.A., Vincent,A., Fierz,F., Barthelmes,D.,
            Branham,K., Khan,N., Bahr,A., Baehr,L., Magyar,I., Koller,S.,
            Azzarello-Burri,S., Niedrist,D., Heon,E. and Berger,W.
  TITLE     C2orf71 Mutations as a Frequent Cause of Autosomal-Recessive
            Retinitis Pigmentosa: Clinical Analysis and Presentation of 8 Novel
            Mutations
  JOURNAL   Invest Ophthalmol Vis Sci 58 (10), 3840-3850 (2017)
   PUBMED   28763557
  REMARK    GeneRIF: On the basis of our multicenter analysis, C2orf71 might
            represent a more frequently mutated gene in autosomal recessive
            retinitis pigmentosa in some populations.
REFERENCE   3  (bases 1 to 7303)
  AUTHORS   Liu,Y.P., Bosch,D.G., Siemiatkowska,A.M., Rendtorff,N.D.,
            Boonstra,F.N., Moller,C., Tranebjaerg,L., Katsanis,N. and
            Cremers,F.P.
  TITLE     Putative digenic inheritance of heterozygous RP1L1 and C2orf71 null
            mutations in syndromic retinal dystrophy
  JOURNAL   Ophthalmic Genet 38 (2), 127-132 (2017)
   PUBMED   27029556
  REMARK    GeneRIF: We propose that the combination of heterozygous
            loss-of-function mutations in these genes drives syndromic retinal
            dystrophy, likely through the genetic interaction of at least two
            loci.
REFERENCE   4  (bases 1 to 7303)
  AUTHORS   Khateb,S., Zelinger,L., Mizrahi-Meissonnier,L., Ayuso,C.,
            Koenekoop,R.K., Laxer,U., Gross,M., Banin,E. and Sharon,D.
  TITLE     A homozygous nonsense CEP250 mutation combined with a heterozygous
            nonsense C2orf71 mutation is associated with atypical Usher
            syndrome
  JOURNAL   J Med Genet 51 (7), 460-469 (2014)
   PUBMED   24780881
  REMARK    GeneRIF: A homozygous nonsense CEP250 mutation, in combination with
            a heterozygous C2orf71 nonsense mutation, causes an atypical form
            of Usher syndrome, characterised by early-onset sensorineural
            hearing loss and a relatively mild retinitis pigmentosa.
REFERENCE   5  (bases 1 to 7303)
  AUTHORS   Audo,I., Lancelot,M.E., Mohand-Said,S., Antonio,A., Germain,A.,
            Sahel,J.A., Bhattacharya,S.S. and Zeitz,C.
  TITLE     Novel C2orf71 mutations account for approximately 1% of cases in a
            large French arRP cohort
  JOURNAL   Hum Mutat 32 (4), E2091-E2103 (2011)
   PUBMED   21412943
  REMARK    GeneRIF: Novel C2orf71 mutations account for approximately 1% of
            cases in a large French arRP cohort.
REFERENCE   6  (bases 1 to 7303)
  AUTHORS   Sergouniotis,P.I., Li,Z., Mackay,D.S., Wright,G.A., Borman,A.D.,
            Devery,S.R., Moore,A.T. and Webster,A.R.
  TITLE     A survey of DNA variation of C2ORF71 in probands with progressive
            autosomal recessive retinal degeneration and controls
  JOURNAL   Invest Ophthalmol Vis Sci 52 (3), 1880-1886 (2011)
   PUBMED   20811058
  REMARK    GeneRIF: C2ORF71 is a highly polymorphic gene (average
            heterozygosity of coding region in controls: 2.118 x 10(-3)) with
            many rare variants that confound mutation detection.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7303)
  AUTHORS   Nishimura,D.Y., Baye,L.M., Perveen,R., Searby,C.C.,
            Avila-Fernandez,A., Pereiro,I., Ayuso,C., Valverde,D., Bishop,P.N.,
            Manson,F.D., Urquhart,J., Stone,E.M., Slusarski,D.C., Black,G.C.
            and Sheffield,V.C.
  TITLE     Discovery and functional analysis of a retinitis pigmentosa gene,
            C2ORF71
  JOURNAL   Am J Hum Genet 86 (5), 686-695 (2010)
   PUBMED   20398886
  REMARK    GeneRIF: Discovery and functional analysis of a retinitis
            pigmentosa gene, C2orf71, are reported.
REFERENCE   8  (bases 1 to 7303)
  AUTHORS   Collin,R.W., Safieh,C., Littink,K.W., Shalev,S.A., Garzozi,H.J.,
            Rizel,L., Abbasi,A.H., Cremers,F.P., den Hollander,A.I.,
            Klevering,B.J. and Ben-Yosef,T.
  TITLE     Mutations in C2ORF71 cause autosomal-recessive retinitis pigmentosa
  JOURNAL   Am J Hum Genet 86 (5), 783-788 (2010)
   PUBMED   20398884
  REMARK    GeneRIF: Mutations in C2orf71 cause autosomal-recessive retinitis
            pigmentosa.
REFERENCE   9  (bases 1 to 7303)
  AUTHORS   Fahim,A.T., Daiger,S.P. and Weleber,R.G.
  TITLE     Nonsyndromic Retinitis Pigmentosa Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301590
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105398.3, AK092250.1 and
            BM669582.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001029883.2.
            
            Summary: The protein encoded by this gene is highly expressed in
            photoreceptors and may associate with the primary cilium of the
            outer segment. The encoded protein appears to undergo
            post-translational lipid modification. Nonsense and missense
            variants of this gene appear to cause a recessive form of retinitis
            pigmentosa. [provided by RefSeq, Jun 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK092250.1, DA742287.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2147975
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331664.6/ ENSP00000332809.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3727              AC105398.3         107657-111383       c
            3728-6713           AK092250.1         1-2986
            6714-7058           AC105398.3         98800-99144         c
            7059-7303           BM669582.1         22-266              c
FEATURES             Location/Qualifiers
     source          1..7303
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.2"
     gene            1..7303
                     /gene="PCARE"
                     /gene_synonym="C2orf71; RP54"
                     /note="photoreceptor cilium actin regulator"
                     /db_xref="GeneID:388939"
                     /db_xref="HGNC:HGNC:34383"
                     /db_xref="MIM:613425"
     exon            1..3930
                     /gene="PCARE"
                     /gene_synonym="C2orf71; RP54"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..4129
                     /gene="PCARE"
                     /gene_synonym="C2orf71; RP54"
                     /note="uncharacterized protein C2orf71"
                     /codon_start=1
                     /product="photoreceptor cilium actin regulator"
                     /protein_id="NP_001025054.1"
                     /db_xref="CCDS:CCDS42669.1"
                     /db_xref="GeneID:388939"
                     /db_xref="HGNC:HGNC:34383"
                     /db_xref="MIM:613425"
                     /translation="MGCTPSHSDLVNSVAKSGIQFLKKPKAIRPGCQGGSERGSIPLL
                     VKNSTCYDAGEGLAEEQPSPRRNQTTAKGLCQLMGDPASGKRKDMEGLIPGTKTSSSQ
                     LNKSQSHMAKDIPFKTQGSHGSQGADFSGDESEESSTQDTSKWKRTAKCHTSSTQSHC
                     YQTIHPAHEPEGKVDFPEPLVKAHQQAYTYLHSSLSKYEAILCIIHQATQTRELLQPM
                     VSFLLLCFEEISQLLGEISKDGEVLLQEVREDLAWPLKKREPQEQPNLLQQLLQYTVS
                     KLQVLNGTVASLTGSFLEGSSSYLHSTATHLENKLSTKRNVDERLLRALRQLESLASG
                     CGDPGVQGLPLCSEDSGIGADNESVQSVDKLGKQTSWDLAPEPEEWKSVTSPHTEARQ
                     SGHTWQQSPFCLGSGRPQDCLLSGAPMAKVQPRAQDEARSPCLSSTSPENITSPPLKL
                     GTSTPCDSFGIGVSVEPHLSKTSRPMDASSLSDSEDSSPEEEEEDKMSSMSLCAWQEK
                     TPHSRPQSSPADRESPFQARTRRLRSLQAQEMILKMKESISERIKFVPVPCGHQDWSE
                     EEEGRTVVPPRPSTVSGSRRAPERQTRSQSESCLQSHVEDPTFQELRRVQRDLSQKLE
                     AFYALGAKGQGQSQEQILQPRAAAVWPNGTCRVSPSNTTSRLKASLTKNFSILPSQDK
                     SILQKCNPHPEDEQGKAGKLPNAIPSGEVSEAAKATDWNVRGCPTRTSVKKLIETFSP
                     TESLRMLGDSKDAGASPCLRNCIMPPRFPKYTGLAPLYPKPQISPASGRESLKMGIGW
                     KPLAPIFPPLPKAEAAKSEELSCEMEGNLEHLPPPPMEVLMDKSFASLESPESSKSTE
                     NSPKETQEPGPGEAGPTRRTWASPKLRASVSPLDLLPSKSTASLTKPHSTGPGSGRSS
                     CQPRKPALDLSSPPATSQSPEVKGGTWSQAEKATSLYRQPRKAIAWHHSGPPSGQNRT
                     SESSLARPRQSRERSPPVGRKASPTRTHWVPQADKRRRSLPSSYRPAQPSPSAVQTPP
                     SPPVSPRVLSPPTTKRRTSPPHQPKLPNPPPESAPAQCKVPSPPTQHPEASPPFSIPS
                     PSPPMSPSQEHKETRDSEDSQAVIAKVSGNTHSIFCPATSSLFEAKPPLSTAHPLTPP
                     SLPPEAGGPLGNPAECWKNSSGPWLRADSQRRAALCALNPLPFLRRTASDRQPGGRPQ
                     PPTLDPTSTSYESQLGQNSSSEESPKKDTEPGSSPCSPELQGGTRRASPPEFCVLGHG
                     LQPEPRTGHIQDKSQPEAQPQQEEVS"
     exon            3931..7303
                     /gene="PCARE"
                     /gene_synonym="C2orf71; RP54"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7275..7280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCARE"
                     /gene_synonym="C2orf71; RP54"
                     /note="hexamer: AATAAA"
     polyA_site      7303
                     /gene="PCARE"
                     /gene_synonym="C2orf71; RP54"
                     /note="major polyA site"
ORIGIN      
        1 agaattgtcc cgctgctcac taacagcaga gggttccaaa cttagaacaa caacaggacg
       61 acaggtacca ctccctcttc acatttggac caagaaaata aagaaagctg gttccaagtt
      121 taggatattg taccatggac ttcaaagaat tctggcctga aaattgcctg gatggactag
      181 taagattgcc ttttgttcct atttcaaata tgattcttgg aaaattgtga aggtgggtgg
      241 aagatgacta caagctgaaa tcatggggtg tacaccttca cacagtgacc ttgtaaacag
      301 cgttgcaaag agtggcattc agttcttgaa aaagcccaaa gcaattcggc caggatgtca
      361 gggcggaagt gaaagaggtt ccatcccttt gctggttaaa aactccacct gctatgacgc
      421 tggggagggc ctggcagagg agcagccaag tcccaggagg aaccaaacca cagctaaagg
      481 tctttgtcag ctcatgggag atcctgcttc aggcaaaagg aaagatatgg aaggactgat
      541 cccaggaacc aaaacctctt catcccagct gaacaaatca caaagccaca tggctaagga
      601 tattccgttc aagacacagg gttcccatgg atcacaaggg gcagactttt ctggagatga
      661 gagtgaggaa agtagtaccc aagatacttc caaatggaaa aggacagcaa aatgtcacac
      721 gtcaagcaca cagagccact gctaccaaac catccaccct gctcatgagc ctgaaggcaa
      781 agtggacttc ccggagcctc tggtaaaggc ccaccagcag gcttacacct atctacactc
      841 cagcctctcc aaatatgaag caattctgtg catcatccat caggccaccc agacccggga
      901 gctgctgcag cccatggtca gcttcttgct gctgtgcttt gaggagatca gccagctgtt
      961 gggggagatc tccaaggatg gagaagtgct cctgcaggaa gtcagggagg atctggcttg
     1021 gcctttgaag aaaagagagc cccaggagca gccaaatctc ctgcaacagc tgctacagta
     1081 cacagtcagc aagctgcagg tgctcaatgg cacagtggcc tcgctcaccg gcagcttcct
     1141 ggagggctcc agcagctacc tccactccac tgcaacccac ttggaaaata agctgagcac
     1201 aaaaaggaat gtggatgaac gcctcctgag ggctctgagg cagctagaga gcctggcgag
     1261 tggctgtggc gaccctgggg tgcagggtct ccccttatgc tctgaggaca gtggcattgg
     1321 tgctgacaat gagtccgtgc agtcggtgga caagctgggc aagcaaacca gctgggacct
     1381 tgcaccagag cccgaagaat ggaagtcggt gacttcaccc cacacagagg ccaggcagtc
     1441 aggacacacc tggcagcaaa gtccattctg tttgggctca ggcagacccc aggactgcct
     1501 gctctcaggg gctcctatgg caaaggttca gccacgagca caggacgaag caaggagccc
     1561 atgcctctcc agtacaagcc cagaaaatat cacctcccca cctttgaagc tggggacaag
     1621 caccccatgt gattcctttg ggattggggt ctctgtggaa ccacaccttt ccaaaacctc
     1681 caggccgatg gacgcttcat ctcttagtga cagcgaggac agcagcccag aggaggagga
     1741 ggaagacaaa atgagcagca tgagtctgtg tgcctggcag gaaaaaactc cacattcaag
     1801 gccacaatct tcacctgctg accgggaaag cccatttcag gcccgcacca ggaggcttag
     1861 gagcctccag gcccaggaaa tgattctgaa gatgaaggag tcaatcagcg aaaggatcaa
     1921 gtttgtccct gtgccctgtg ggcaccagga ctggtctgag gaggaggagg ggaggacagt
     1981 ggtcccccca agacctagca cggtaagtgg cagcaggagg gcccctgaga ggcagacgag
     2041 gtcccagtca gagtcgtgtc tccagagtca cgtggaggac cccacctttc aggagctgcg
     2101 aagggtccag agggacctca gtcagaagct ggaggcattt tatgccctgg gtgccaaagg
     2161 gcaggggcag agccaggagc aaattctgca gcccagagca gccgccgtgt ggcccaatgg
     2221 cacctgcagg gtcagtccaa gcaacaccac cagcaggctc aaggcatccc tcaccaagaa
     2281 cttcagtatt ttgcctagtc aggacaagag catcttgcag aaatgcaatc cccatcctga
     2341 ggacgaacaa ggcaaagctg ggaagcttcc aaatgccatc ccatcaggag aggtcagtga
     2401 ggctgccaag gccacagact ggaatgtcag aggctgtccc accagaacat ccgtcaagaa
     2461 gcttattgaa actttcagtc ccacggagag tctgaggatg ctgggggact ctaaggacgc
     2521 tggggcaagt ccctgcctca ggaattgcat catgcccccc agatttccca agtacacagg
     2581 gcttgcccct ttgtatccga agccccaaat ttctccagca tcaggcagag aatctctcaa
     2641 aatgggcata ggctggaagc ccttagcacc tatctttccc cctctgccta aagcagaagc
     2701 agccaagagt gaggagctca gctgtgaaat ggaggggaac ctcgagcacc tccctccacc
     2761 gcctatggaa gttctgatgg acaaatcatt cgcttctctg gagtccccag aaagcagcaa
     2821 gtccacagag aactccccca aggaaaccca ggagccaggg ccgggagagg ctggccccac
     2881 caggagaaca tgggcttccc caaagctgag ggcctctgtg agccccctgg acttgctgcc
     2941 cagcaagagc accgccagcc tgaccaagcc tcacagcaca gggccaggga gtggcaggag
     3001 cagctgccag cccaggaagc cagccctgga cctgagcagc ccaccagcca ccagccaaag
     3061 ccccgaggtg aagggtggga cttggagtca ggcagagaag gccaccagcc tctacaggca
     3121 gccccggaag gccatcgcct ggcaccactc cggccctcca tctggacaaa acaggacctc
     3181 agagtccagc ctggccagac caaggcagag ccgagagaga agcccccctg tgggcagaaa
     3241 ggcctctccc acgaggacac actgggtgcc tcaagcagac aagaggcgcc ggagccttcc
     3301 ctcctcttac agacctgccc agccaagccc ctctgctgtg cagacgcccc ccagcccacc
     3361 tgtgagcccc agggtgctaa gcccacccac cacaaagcgg cgaacttccc caccgcacca
     3421 gcccaagttg cccaaccctc cccccgagag tgcacctgct cagtgcaagg tccccagccc
     3481 cccaacccag cacccagaag caagcccccc tttctcgatt ccctccccat cacccccaat
     3541 gtccccttct caggagcaca aggaaacaag agactctgaa gacagccaag cagtcatagc
     3601 caaagtgtct gggaacacac attccatatt ctgcccagct acctcctctc tgtttgaagc
     3661 taaaccgcca ctctcaacag cccacccact gaccccacca tcgctgccgc cagaggctgg
     3721 gggccctctc gggaacccag cagaatgctg gaagaacagc tcagggcctt ggctgagagc
     3781 agactcgcag cggagagcag ctctgtgtgc cctcaaccct ctgcctttcc tcaggaggac
     3841 agcttctgac cgccagccag gtggccgacc gcagcctccc accttggacc ccaccagcac
     3901 ctcttatgaa tcccagctcg gccagaacag cagcagcgag gagagcccta agaaggacac
     3961 agagccgggg agcagcccct gttcccctga actgcagggc ggcaccaggc gtgcatctcc
     4021 cccagagttc tgtgtgctgg gccacgggct gcaaccggag cctcggaccg gccacatcca
     4081 ggacaaatcc cagccagagg cgcagcccca gcaagaggag gtgtcctgac aggctgacga
     4141 gggggccaca ctcacgcagt caccccagaa ggccaagtgt gacagccaag tgtccagcct
     4201 gacccagaga tgatgggcaa accaaactcc tactgaggtg tcctggaaag gcctggaagg
     4261 tgcactgccc agtgggtctg ctgaatttta aacaatcgcc gttttcagtc ccagatcttg
     4321 ctctgccttg gggttcaaag gttaaccaga acttttagac cccacaatga cagtatttaa
     4381 tgcttcaagt gctggcctta atttggggtg gggtgggggg tggagaatgt atagttgcat
     4441 gcttgatagg gttttaactg ggttcattcc ttgagatcac ttaagcctca caacagtgaa
     4501 tgaagcacat agcattcttc agttttgcgc atatgaaaac cgaaggtgtg gggagaggcc
     4561 ccctcaagtg tctggctgaa ggtcatacag ctaagaagag aatagagcaa aattttgcac
     4621 agatgagtct ggtgttagaa tctctctgct ctttttatta cattccattg cccgtaacta
     4681 ttgcgtcact ccacctgcct aaagcagaca tgggtgcgca aatggtcgca aagcttcttt
     4741 gttgtaaggt taagtagcgg cacagcattg acaaagtccc tattgagagc tttgtttaga
     4801 agtgcatggc tcccaaaatg agaaggctga gtgagccagg attaaaacac acagccccac
     4861 ccgtcctctg tcctctcctc cttcccaagc tcagtttcaa tgctgtaaac ttaaagctga
     4921 cagctcacaa taccagccac gctgcctctc ggcctaagca tgtagcaaat gctctcactg
     4981 ccctacgcat tacatgcttc tcgacggagt agggtaaacc aagcctccca aacaaggcag
     5041 cccattctcc acatgccgtg ggtgctggag ctcagaagat agcgtgggtg aggcatacgt
     5101 actcacacgc cgatctcccc tcggaggctt cttggccaac tttattccca ggtcatcttg
     5161 cagaacttct gctggagtcg aaatcaaagt gaaaaacagt tgttcatgcc aaaaacctgc
     5221 ttctgccaat gagctagata tttgctgcag atcttggaat gcttccactg gaggctgtgg
     5281 tgtgcgttct atttagaaaa gattttgcag taattgagtg attcaatgcc ggctcaatgg
     5341 gttggcaaaa gacaagaatt cttacccact ggggtacagc aaagggacga tcctccagat
     5401 ctgctgcaaa gctgattttt aaagtttggg gtaattatag acctcaaacc cattcttgct
     5461 gggactgtgg gctcaaaaac ttgttaaact gggtccctag ggactatagc aacctccccc
     5521 agagagaggc tatgactctg agtaaatgaa tcccaccttg acttgtccaa ttattattca
     5581 aaggcaccca aagaacagct gattaaacta ccaagagggg ccacaaccca cccctctgct
     5641 ggaaagggac acacccagct gtctgctcgc atttgctcct gttgccgccc tcatctcaga
     5701 gaagtgctca ggcagtgccc aggccagccg attctagagc caagccacac ccactgctgg
     5761 gtggacactt aggagctgcc tggactgcag gcaacgcagg gaagtccagc cacccaggca
     5821 gggcaggggc caaggtaagc acgtgaggat ggaccaggtt cagcaaactt gcccgacaga
     5881 gatctgggca ttctccctaa atggttgggc agaccaacca ttgggtcacc atggggtgag
     5941 ccttaggtaa gctgggcact gagctgagtg agcaggagac acacagtgtg agcggccttt
     6001 gaggtctagc tcacaagtaa gtggcttcag gtgggactgc tcagaaagtg ggccctgcct
     6061 gggctcagat ttaggggcag gattcctgga ggtccgagga aacgaagctg ttccccagct
     6121 gcagggagac tggagtggga cacagtgggt gaaactgggg taccatgagg ggtggaaccc
     6181 caggaattat acacattttc attactggaa ccgggatatg aagtggagcc actccagcag
     6241 tgaggggaag caaggctgag tctccagccc aggcctcctt ccgtaaaggg cctcatctta
     6301 aaagtccagg gctgggtaga aagtggaaag ggtggccgag tgccccctgc tgtggccatg
     6361 caagctagcg gcagcaggga gccaggcaga ttattccacc acagaagggg tcagtatcat
     6421 ggagaacacg caggaagggt ccggaatgaa caacggtgct ttccgtgagc atgcatggca
     6481 ggaggctgtc tgagactaga ggttgtccct cgccaggcta ggctggcaag cagcaggaag
     6541 tgcccaccca ccatattgca ggcagcagac gaaggggtac agggcacccg ggatcctgcc
     6601 atcagctgtg gagatgccca tgatgcctcc ttgtccctct ggaggacctc cacgtttgct
     6661 tggggccaac gtgtgccagg acagggcgag gctcctgcca taggtcccca cacacgatgt
     6721 cataaaagcc cccagctgcc accagaccca ggcagccggg acagtgagct ggtgacacca
     6781 ttgtgttgcc cagtaacctt aggctactgg aattccaagt cagcttcccc cactccaggg
     6841 aagatgggga ggggttgcca aggtgctggg ggctgggggt caattaggtc aaaggtgaag
     6901 cagtgctgag ccgacatagg agcaggcggg tcaaagatgt gtttttggct accataccaa
     6961 ctaccagact tagctcaaat tacatgtgaa ttagactttg tacaaaagga attaaatcca
     7021 caatggaaca gttttgtggc atctggtcag ttttgcctcc tagagaccag gtcttccaca
     7081 aacttgagtc tgccttggag cacgcattgc tggtggcagg aggggcaaac ccagctgtac
     7141 agcttctcag acaagggctg ctcacgccca ccatctccct tctacccaag aatggtatcc
     7201 ttgctgggcc aaatccactt cctttgccca agggggaagg gaggacagtt tttctttgtt
     7261 ctgctttttg ttttaataaa aattattaag ccaatgaacc caa
//
