LOCUS       NM_020524               3207 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens PBX homeobox interacting protein 1 (PBXIP1),
            transcript variant 1, mRNA.
ACCESSION   NM_020524
VERSION     NM_020524.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3207)
  AUTHORS   Khumukcham,S.S., Penugurti,V., Bugide,S., Dwivedi,A., Kumari,A.,
            Kesavan,P.S., Kalali,S., Mishra,Y.G., Ramesh,V.A.,
            Nagarajaram,H.A., Mazumder,A. and Manavathi,B.
  TITLE     HPIP and RUFY3 are noncanonical guanine nucleotide exchange factors
            of Rab5 to regulate endocytosis-coupled focal adhesion turnover
  JOURNAL   J Biol Chem 299 (11), 105311 (2023)
   PUBMED   37797694
  REMARK    GeneRIF: HPIP and RUFY3 are noncanonical guanine nucleotide
            exchange factors of Rab5 to regulate endocytosis-coupled focal
            adhesion turnover.
REFERENCE   2  (bases 1 to 3207)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3207)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3207)
  AUTHORS   Zhao,Y.M., Yang,G., You,L., Hu,Y. and Zhao,Y.P.
  TITLE     [Effect of Hematopoietic Pre-B-cell Leukemia Transcription Factor
            Interacting Protein Knockdown on Proliferation,Cell Cycle and
            Apoptosis in Pancreatic Cancer Cells]
  JOURNAL   Zhongguo Yi Xue Ke Xue Yuan Xue Bao 42 (1), 7-15 (2020)
   PUBMED   32131934
  REMARK    GeneRIF: HPIP is overexpressed in pancreatic ductal adenocarcinoma
            tissue. Knockdown of HPIP promotes the apoptosis and inhibits the
            proliferation and G0/G1 to S transition of PDAC cells.
REFERENCE   5  (bases 1 to 3207)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3207)
  AUTHORS   Manavathi,B., Lo,D., Bugide,S., Dey,O., Imren,S., Weiss,M.J. and
            Humphries,R.K.
  TITLE     Functional regulation of pre-B-cell leukemia homeobox interacting
            protein 1 (PBXIP1/HPIP) in erythroid differentiation
  JOURNAL   J Biol Chem 287 (8), 5600-5614 (2012)
   PUBMED   22187427
  REMARK    GeneRIF: HPIP is a target of GATA1 and CTCF in erythroid cells and
            plays an important role in erythroid differentiation by modulating
            the PI3K/AKT pathway
REFERENCE   7  (bases 1 to 3207)
  AUTHORS   Wang,X., Yang,Z., Zhang,H., Ding,L., Li,X., Zhu,C., Zheng,Y. and
            Ye,Q.
  TITLE     The estrogen receptor-interacting protein HPIP increases
            estrogen-responsive gene expression through activation of MAPK and
            AKT
  JOURNAL   Biochim Biophys Acta 1783 (6), 1220-1228 (2008)
   PUBMED   18302941
REFERENCE   8  (bases 1 to 3207)
  AUTHORS   Manavathi,B., Acconcia,F., Rayala,S.K. and Kumar,R.
  TITLE     An inherent role of microtubule network in the action of nuclear
            receptor
  JOURNAL   Proc Natl Acad Sci U S A 103 (43), 15981-15986 (2006)
   PUBMED   17043237
REFERENCE   9  (bases 1 to 3207)
  AUTHORS   Abramovich,C., Chavez,E.A., Lansdorp,P.M. and Humphries,R.K.
  TITLE     Functional characterization of multiple domains involved in the
            subcellular localization of the hematopoietic Pbx interacting
            protein (HPIP)
  JOURNAL   Oncogene 21 (44), 6766-6771 (2002)
   PUBMED   12360403
REFERENCE   10 (bases 1 to 3207)
  AUTHORS   Abramovich,C., Shen,W.F., Pineault,N., Imren,S., Montpetit,B.,
            Largman,C. and Humphries,R.K.
  TITLE     Functional cloning and characterization of a novel nonhomeodomain
            protein that inhibits the binding of PBX1-HOX complexes to DNA
  JOURNAL   J Biol Chem 275 (34), 26172-26177 (2000)
   PUBMED   10825160
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY108652.1 and BC016852.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020524.3.
            
            Summary: The protein encoded by this gene interacts with the PBX1
            homeodomain protein, inhibiting its transcriptional activation
            potential by preventing its binding to DNA. The encoded protein,
            which is primarily cytosolic but can shuttle to the nucleus, also
            can interact with estrogen receptors alpha and beta and promote the
            proliferation of breast cancer, brain tumors, and lung cancer.
            Several transcript variants encoding different isoforms have been
            found for this gene. More variants exist, but their full-length
            natures have yet to be determined. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.214876.1,
                                           SRR1803615.35197.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368463.8/ ENSP00000357448.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 HY108652.1         65-72
            9-3207              BC016852.1         1-3199
FEATURES             Location/Qualifiers
     source          1..3207
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..3207
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /note="PBX homeobox interacting protein 1"
                     /db_xref="GeneID:57326"
                     /db_xref="HGNC:HGNC:21199"
                     /db_xref="MIM:618819"
     exon            1..31
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            32..118
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2263
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hematopoietic PBX-interacting protein; pre-B-cell leukemia
                     transcription factor-interacting protein 1; pre-B-cell
                     leukemia homeobox interacting protein 1"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription
                     factor-interacting protein 1 isoform 1"
                     /protein_id="NP_065385.2"
                     /db_xref="CCDS:CCDS1074.1"
                     /db_xref="GeneID:57326"
                     /db_xref="HGNC:HGNC:21199"
                     /db_xref="MIM:618819"
                     /translation="MASCPDSDNSWVLAGSESLPVETLGPASRMDPESERALQAPHSP
                     SKTDGKELAGTMDGEGTLFQTESPQSGSILTEETEVKGTLEGDVCGVEPPGPGDTVVQ
                     GDLQETTVVTGLGPDTQDLEGQSPPQSLPSTPKAAWIREEGRCSSSDDDTDVDMEGLR
                     RRRGREAGPPQPMVPLAVENQAGGEGAGGELGISLNMCLLGALVLLGLGVLLFSGGLS
                     ESETGPMEEVERQVLPDPEVLEAVGDRQDGLREQLQAPVPPDSVPSLQNMGLLLDKLA
                     KENQDIRLLQAQLQAQKEELQSLMHQPKGLEEENAQLRGALQQGEAFQRALESELQQL
                     RARLQGLEADCVRGPDGVCLSGGRGPQGDKAIREQGPREQEPELSFLKQKEQLEAEAQ
                     ALRQELERQRRLLGSVQQDLERSLQDASRGDPAHAGLAELGHRLAQKLQGLENWGQDP
                     GVSANASKAWHQKSHFQNSREWSGKEKWWDGQRDRKAEHWKHKKEESGRERKKNWGGQ
                     EDREPAGRWKEGRPRVEESGSKKEGKRQGPKEPPRKSGSFHSSGEKQKQPRWREGTKD
                     SHDPLPSWAELLRPKYRAPQGCSGVDECARQEGLTFFGTELAPVRQQELASLLRTYLA
                     RLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFVDALEDSLEEVAVQQTGDDDEVD
                     DFEDFIFSHFFGDKALKKRSGKKDKHSQSPRAAGPREGHSHSHHHHHRG"
     exon            119..245
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            246..310
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            311..476
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            477..710
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            711..734
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            735..805
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            806..937
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            938..2169
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..3207
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2826..2831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /note="hexamer: AATAAA"
     polyA_site      2846
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
     regulatory      3186..3191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /note="hexamer: AATAAA"
     polyA_site      3207
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /note="major polyA site"
ORIGIN      
        1 aagctgaaga ccgaagcaag agctggttca ggtggcagcc acagcagcct cagggacctc
       61 agcaactatg gcctcctgcc cagactctga taatagctgg gtgcttgctg gctccgagag
      121 cctgccagtg gagacactgg gcccggcatc caggatggac ccagaatctg agagagccct
      181 gcaggcccct cacagcccct ccaagacaga tgggaaagaa ttagctggga ccatggatgg
      241 agaagggacg ctcttccaga ctgaaagccc tcagtctggc agcattctaa cagaggagac
      301 tgaggtcaag ggcaccctgg aaggtgatgt ttgtggtgtg gagcctcctg gcccaggaga
      361 cacagtagtc cagggagacc tgcaggagac caccgtggtg acaggcctgg gaccagacac
      421 acaggacctg gaaggccaga gccctccaca gagcctgcct tcaaccccca aagcagcttg
      481 gatcagggag gagggccgct gctccagcag tgacgatgac accgacgtgg acatggaggg
      541 tctgcggaga cggcggggcc gggaggccgg cccacctcag cccatggtgc ccctggctgt
      601 ggagaaccag gctgggggtg agggtgcagg cggggagctg ggcatctccc tcaacatgtg
      661 cctccttggg gccctggttc tgcttggcct gggggtcctc ctcttctcag gtggcctctc
      721 agagtctgag actgggccca tggaggaagt ggagcggcag gtcctcccag accccgaggt
      781 gctggaagct gtgggggaca ggcaggatgg gctaagggaa cagctgcagg ccccagtgcc
      841 tcctgacagt gtccccagcc tgcaaaacat gggtcttctg ctggacaagc tggccaagga
      901 gaaccaggac atccggctgc tgcaggccca gctgcaggcc caaaaggaag agcttcagag
      961 cctgatgcac cagcccaaag ggctagagga ggagaatgcc cagctccggg gggctctgca
     1021 gcagggcgaa gccttccagc gggctctgga gtcagagctg cagcagctgc gggcccggct
     1081 ccaggggctg gaggccgact gtgtccgggg cccagatggg gtgtgcctca gtgggggtag
     1141 aggcccacag ggtgacaagg ccatcaggga gcaaggcccc agggagcagg agccagaact
     1201 cagcttcctg aagcagaagg aacagctgga ggctgaggca caggcattaa ggcaagagtt
     1261 agagaggcag cgacggctgc tggggtctgt acagcaggat ctggagagga gcttgcagga
     1321 tgccagccgc ggggacccag ctcatgctgg cttggctgag ctgggccaca gattggccca
     1381 gaaactgcag ggcctggaga actggggcca ggaccctggg gtctctgcca atgcctcaaa
     1441 ggcctggcac cagaagtccc acttccagaa ttctagggag tggagtggaa aggaaaagtg
     1501 gtgggatggg cagagagacc ggaaggctga gcactggaaa cataagaagg aagaatctgg
     1561 ccgggaaagg aagaagaact ggggaggtca ggaggacagg gagccagcag gaaggtggaa
     1621 ggagggcagg ccaagggtgg aggagtcggg gagcaagaag gagggcaagc gacagggccc
     1681 gaaggaaccc ccaaggaaaa gtggtagctt ccactcctct ggagaaaagc agaagcaacc
     1741 tcggtggagg gaagggacta aggacagcca tgaccccctg ccatcctggg cagagctgtt
     1801 gaggcccaag taccgggcac cccagggctg ctcaggtgtg gacgagtgtg cccggcagga
     1861 gggcctgact ttctttggca cagagctagc cccagtgcgg caacaggagc tggcctctct
     1921 gctaagaaca tacttggcac ggctgccctg ggctgggcag ctgaccaagg agctacccct
     1981 ctcacctgct ttctttggtg aggatggcat cttccgtcat gaccgcctcc gcttccggga
     2041 ttttgtggat gccctggagg acagcttgga ggaggtggct gtgcaacaga caggtgatga
     2101 tgatgaagta gatgactttg aggacttcat cttcagccac ttctttggag acaaagcact
     2161 gaagaagagg tcagggaaga aggacaagca ctcacagagc ccaagagctg cggggcccag
     2221 ggaggggcac agccatagcc accaccacca ccaccggggc tgacaccctg ccccacaggg
     2281 aatggccttg gcctggccca gcccaagatc ccagcgttat ctaactcctg gagggtggac
     2341 tctgtcctgg cttgtttggt gtcctcagat atctttcaca cagtagagca aaatcaccag
     2401 ccctgcactg atgtcacttt atgtagaaaa aggccttagc tggacctgcg ttgccgtcta
     2461 tgcaaatgca tgcaaatact ccaggccctg ggatgtgggc ttgtgttttg tcactgtgaa
     2521 gggggagatg ggagaggagc ctgttttggg gtggggtctg gggaaggcaa tctgattctg
     2581 aagctaaaga gctttcatcc tcttgagtgt atgtccccat agtgggcccc ttgacccaca
     2641 tgctgaccgg tgccttggga tttgactaga gttgctggct cgaggcccag cacgaggact
     2701 taccctgggg ttttgttagg tttggaagca gctgtcccta gggggtgaag tcccccccct
     2761 tttttttttt acccctgctt ctcccacggc ttcacctccc tatgtgaact gtagactcag
     2821 atcccaataa agtgctgttg cagctatgat gctaggtggt ttctaagcac aggggacacc
     2881 ccacaccccc tgcctgaatg gatgggtcca tcccaggcac tggtacttgc ccccttgttc
     2941 tgtatccccc tttgcccttg ccttgccctt ccaacaaacc ctaggccctt gagaagctga
     3001 tacttctcct tttgctcaca gctgccttgg ccccacccct gggagatgta gcaaattgag
     3061 tgtgggtttt ggagtctgag cctcaggctc aaatccaggc caagtgatct tgggcaagtt
     3121 aatctctggg aactttgggt ttcttatcct caaaaaaggc gatggaaggg ctggggaagt
     3181 gattaaataa aagcaacgca agaaaaa
//
