LOCUS       NM_025245               1495 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens PBX homeobox 4 (PBX4), transcript variant 1, mRNA.
ACCESSION   NM_025245
VERSION     NM_025245.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1495)
  AUTHORS   Song,Y. and Ma,R.
  TITLE     Identifying the Potential Roles of PBX4 in Human Cancers Based on
            Integrative Analysis
  JOURNAL   Biomolecules 12 (6), 822 (2022)
   PUBMED   35740947
  REMARK    GeneRIF: Identifying the Potential Roles of PBX4 in Human Cancers
            Based on Integrative Analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1495)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1495)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1495)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1495)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1495)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 1495)
  AUTHORS   Tai,E.S., Sim,X.L., Ong,T.H., Wong,T.Y., Saw,S.M., Aung,T.,
            Kathiresan,S., Orho-Melander,M., Ordovas,J.M., Tan,J.T. and
            Seielstad,M.
  TITLE     Polymorphisms at newly identified lipid-associated loci are
            associated with blood lipids and cardiovascular disease in an Asian
            Malay population
  JOURNAL   J Lipid Res 50 (3), 514-520 (2009)
   PUBMED   18987386
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1495)
  AUTHORS   Kathiresan,S., Melander,O., Guiducci,C., Surti,A., Burtt,N.P.,
            Rieder,M.J., Cooper,G.M., Roos,C., Voight,B.F., Havulinna,A.S.,
            Wahlstrand,B., Hedner,T., Corella,D., Tai,E.S., Ordovas,J.M.,
            Berglund,G., Vartiainen,E., Jousilahti,P., Hedblad,B.,
            Taskinen,M.R., Newton-Cheh,C., Salomaa,V., Peltonen,L., Groop,L.,
            Altshuler,D.M. and Orho-Melander,M.
  TITLE     Six new loci associated with blood low-density lipoprotein
            cholesterol, high-density lipoprotein cholesterol or triglycerides
            in humans
  JOURNAL   Nat Genet 40 (2), 189-197 (2008)
   PUBMED   18193044
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Erratum:[Nat Genet. 2008 Nov;40(11):1384]
REFERENCE   9  (bases 1 to 1495)
  AUTHORS   Laurent,A., Bihan,R., Omilli,F., Deschamps,S. and Pellerin,I.
  TITLE     PBX proteins: much more than Hox cofactors
  JOURNAL   Int J Dev Biol 52 (1), 9-20 (2008)
   PUBMED   18033668
  REMARK    Review article
REFERENCE   10 (bases 1 to 1495)
  AUTHORS   Wagner,K., Mincheva,A., Korn,B., Lichter,P. and Popperl,H.
  TITLE     Pbx4, a new Pbx family member on mouse chromosome 8, is expressed
            during spermatogenesis
  JOURNAL   Mech Dev 103 (1-2), 127-131 (2001)
   PUBMED   11335119
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC141859.1.
            
            On Nov 22, 2018 this sequence version replaced NM_025245.2.
            
            Summary: This gene encodes a member of the pre-B cell leukemia
            transcription factor family. These proteins are homeobox proteins
            that play critical roles in embryonic development and cellular
            differentiation both as Hox cofactors and through Hox-independent
            pathways. The encoded protein contains a homeobox DNA-binding
            domain, but specific functions of the protein have not been
            determined. Alternatively spliced transcript variants have been
            observed for this gene. [provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and is protein-coding.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141859.1, AK097427.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251203.14/ ENSP00000251203.5
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1495              BC141859.1         230-1724
FEATURES             Location/Qualifiers
     source          1..1495
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..1495
                     /gene="PBX4"
                     /note="PBX homeobox 4"
                     /db_xref="GeneID:80714"
                     /db_xref="HGNC:HGNC:13403"
                     /db_xref="MIM:608127"
     exon            1..177
                     /gene="PBX4"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1183
                     /gene="PBX4"
                     /note="homeobox protein PBX4; pre-B-cell leukemia homeobox
                     4"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription factor 4"
                     /protein_id="NP_079521.1"
                     /db_xref="CCDS:CCDS12406.1"
                     /db_xref="GeneID:80714"
                     /db_xref="HGNC:HGNC:13403"
                     /db_xref="MIM:608127"
                     /translation="MAAPPRPAPSPPAPRRLDTSDVLQQIMAITDQSLDEAQARKHAL
                     NCHRMKPALFSVLCEIKEKTVVSIRGIQDEDPPDAQLLRLDNMLLAEGVCRPEKRGRG
                     GAVARAGTATPGGCPNDNSIEHSDYRAKLSQIRQIYHSELEKYEQACREFTTHVTNLL
                     QEQSRMRPVSPKEIERMVGAIHGKFSAIQMQLKQSTCEAVMTLRSRLLDARRKRRNFS
                     KQATEVLNEYFYSHLNNPYPSEEAKEELARKGGLTISQVSNWFGNKRIRYKKNMGKFQ
                     EEATIYTGKTAVDTTEVGVPGNHASCLSTPSSGSSGPFPLPSAGDAFLTLRTLASLQP
                     PPGGGCLQSQAQGSWQGATPQPATASPAGDPGSINSSTSN"
     exon            178..251
                     /gene="PBX4"
                     /inference="alignment:Splign:2.1.0"
     exon            252..499
                     /gene="PBX4"
                     /inference="alignment:Splign:2.1.0"
     exon            500..690
                     /gene="PBX4"
                     /inference="alignment:Splign:2.1.0"
     exon            691..826
                     /gene="PBX4"
                     /inference="alignment:Splign:2.1.0"
     exon            827..983
                     /gene="PBX4"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1090
                     /gene="PBX4"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1495
                     /gene="PBX4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1472..1477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PBX4"
                     /note="hexamer: ATTAAA"
     polyA_site      1495
                     /gene="PBX4"
                     /note="major polyA site"
ORIGIN      
        1 agtggtagtg ctccaggctc gacggcaccc tcacagcgcc cgcccggccc tgccgctcat
       61 ggccgccccg ccgcgccccg cgccatcgcc ccccgccccg cggcgcctcg acacgagcga
      121 cgtcctgcag cagatcatgg ccatcaccga ccagagcctg gacgaggcac aggccagaaa
      181 gcatgctctg aattgccatc ggatgaagcc tgctctgttc agcgtgctct gtgagatcaa
      241 ggaaaagaca gtggtaagca tccgtggcat tcaagacgaa gatccccctg acgcccagct
      301 cctgaggctg gataacatgc tgctggctga gggcgtgtgc aggcccgaga agagaggaag
      361 aggaggagcg gtggccaggg ccggcacagc aacaccaggt ggctgtccaa atgacaatag
      421 cattgagcac tctgactaca gggccaagct gtcccagatc cgacagattt accactctga
      481 gctagagaaa tatgaacagg cctgtcgtga gttcaccacg cacgtcacca acctcctcca
      541 ggagcagagc aggatgaggc ctgtctcccc taaggagatt gagcgcatgg tcggcgccat
      601 tcacggcaag ttcagcgcca tccagatgca gttgaagcag agcacctgtg aggcagtgat
      661 gaccctgcgt tcgcggctgc tcgatgccag gcgcaagcgg cggaatttca gcaagcaggc
      721 gacggaagtg ctgaatgagt atttttactc ccatctgaac aacccttacc ccagcgaaga
      781 agccaaagaa gagctggcca ggaagggcgg cctcaccatc tcccaggtct ctaactggtt
      841 tggcaacaaa agaatccggt ataaaaagaa catggggaag tttcaagaag aggctaccat
      901 ttacacgggt aaaacggctg tggataccac ggaagttggg gtcccaggga accacgccag
      961 ctgcctgtca acacctagct ccggctcctc tggacccttc ccgctgccca gcgctgggga
     1021 cgccttcctc accctgcgga ctctggcctc tctccagcct cctcctgggg gaggctgcct
     1081 gcagtcccag gcccagggta gctggcaggg ggccaccccc caacctgcaa ctgcctcacc
     1141 tgctggagac cctggcagca tcaactccag tacatctaat taagtttggg ggataagcag
     1201 gaaagagcgc tgcgtgagct gccatgtatc gccagccgtt gctttgttac tgaacgtgcc
     1261 gccgacgacc tcagaaaacc cagatgggtg gtggtgccca tgagcccctg ctcctcagcc
     1321 aggcccgtgg cgccggctca tgtgtctgct gcgactcgag atggcctgaa acgccactca
     1381 ttctcccact tcagttcgtt tttttgacag taattttatg gtaacgctat gaattgaatt
     1441 gtctgttcta ggactgggca cagattttcc cattaaaatt tttgacttat tttaa
//
