LOCUS       NM_006195               2840 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens PBX homeobox 3 (PBX3), transcript variant 1, mRNA.
ACCESSION   NM_006195
VERSION     NM_006195.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2840)
  AUTHORS   Zheng,X., Xiao,H., Liu,X., Huang,T. and Deng,C.
  TITLE     Exosomal circKIAA1797 Regulates Cell Progression and Glycolysis by
            Targeting miR-4429/PBX3 Pathway in Gastric Cancer
  JOURNAL   Biochem Genet 62 (3), 1762-1778 (2024)
   PUBMED   37730964
  REMARK    GeneRIF: Exosomal circKIAA1797 Regulates Cell Progression and
            Glycolysis by Targeting miR-4429/PBX3 Pathway in Gastric Cancer.
REFERENCE   2  (bases 1 to 2840)
  AUTHORS   Li,D., Yuan,Y., Meng,C., Lin,Z., Zhao,M., Shi,L., Li,M., Ye,D.,
            Cai,Y., He,X., Ye,H., Zhou,S., Zhou,H. and Gao,S.
  TITLE     Low expression of miR-182 caused by DNA hypermethylation
            accelerates acute lymphocyte leukemia development by targeting PBX3
            and BCL2: miR-182 promoter methylation is a predictive marker for
            hypomethylation agents + BCL2 inhibitor venetoclax
  JOURNAL   Clin Epigenetics 16 (1), 48 (2024)
   PUBMED   38528641
  REMARK    GeneRIF: Low expression of miR-182 caused by DNA hypermethylation
            accelerates acute lymphocyte leukemia development by targeting PBX3
            and BCL2: miR-182 promoter methylation is a predictive marker for
            hypomethylation agents + BCL2 inhibitor venetoclax.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2840)
  AUTHORS   Pan,C., Bai,X., Li,N., Zheng,N., Si,Y. and Zhao,Y.
  TITLE     PBX3 as a biomarker for the early diagnosis and prediction of
            prognosis of glioma
  JOURNAL   PLoS One 19 (2), e0293647 (2024)
   PUBMED   38324550
  REMARK    GeneRIF: PBX3 as a biomarker for the early diagnosis and prediction
            of prognosis of glioma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2840)
  AUTHORS   Xia,Z., Wang,Q. and Lu,P.
  TITLE     LncRNA LINC00885 promotes bladder cancer progression by targeting
            the miR-98-5p/PBX3 axis
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (3), 163-168 (2023)
   PUBMED   37300672
  REMARK    GeneRIF: LncRNA LINC00885 promotes bladder cancer progression by
            targeting the miR-98-5p/PBX3 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2840)
  AUTHORS   Wang,D., Jin,X., Lei,M., Jiang,Y., Liu,Y., Yu,F., Guo,Y., Han,B.,
            Yang,Y., Sun,W., Liu,Y., Zeng,G., Liu,F., Hu,J. and Chen,X.
  TITLE     USF1-ATRAP-PBX3 Axis Promote Breast Cancer Glycolysis and Malignant
            Phenotype by Activating AKT/mTOR Signaling
  JOURNAL   Int J Biol Sci 18 (6), 2452-2471 (2022)
   PUBMED   35414770
  REMARK    GeneRIF: USF1-ATRAP-PBX3 Axis Promote Breast Cancer Glycolysis and
            Malignant Phenotype by Activating AKT/mTOR Signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2840)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Behal,A., Touchman,J.W.,
            Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human lens for the NEIBank
            Project: over 2000 non-redundant transcripts, novel genes and
            splice variants
  JOURNAL   Mol Vis 8, 171-184 (2002)
   PUBMED   12107413
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2840)
  AUTHORS   Knoepfler,P.S., Sykes,D.B., Pasillas,M. and Kamps,M.P.
  TITLE     HoxB8 requires its Pbx-interaction motif to block differentiation
            of primary myeloid progenitors and of most cell line models of
            myeloid differentiation
  JOURNAL   Oncogene 20 (39), 5440-5448 (2001)
   PUBMED   11571641
REFERENCE   8  (bases 1 to 2840)
  AUTHORS   Fujino,T., Yamazaki,Y., Largaespada,D.A., Jenkins,N.A.,
            Copeland,N.G., Hirokawa,K. and Nakamura,T.
  TITLE     Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis
            homeobox genes
  JOURNAL   Exp Hematol 29 (7), 856-863 (2001)
   PUBMED   11438208
REFERENCE   9  (bases 1 to 2840)
  AUTHORS   Shen,W.F., Rozenfeld,S., Kwong,A., Kom ves,L.G., Lawrence,H.J. and
            Largman,C.
  TITLE     HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells
  JOURNAL   Mol Cell Biol 19 (4), 3051-3061 (1999)
   PUBMED   10082572
REFERENCE   10 (bases 1 to 2840)
  AUTHORS   Monica,K., Galili,N., Nourse,J., Saltman,D. and Cleary,M.L.
  TITLE     PBX2 and PBX3, new homeobox genes with extensive homology to the
            human proto-oncogene PBX1
  JOURNAL   Mol Cell Biol 11 (12), 6149-6157 (1991)
   PUBMED   1682799
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X59841.1, BC094883.1 and BC016977.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006195.5.
            
            Transcript Variant: This variant (1) utilizes an alternate first
            exon containing a predicted translation initiation site with a
            strong Kozak signal; the resulting protein isoform (1) is predicted
            to have a signal peptide.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094883.1, SRR1803612.71953.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373489.10/ ENSP00000362588.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                X59841.1           36-49
            15-1587             BC094883.1         1-1573
            1588-2567           BC016977.1         1307-2286
            2568-2840           BC094883.1         2556-2828
FEATURES             Location/Qualifiers
     source          1..2840
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.3"
     gene            1..2840
                     /gene="PBX3"
                     /note="PBX homeobox 3"
                     /db_xref="GeneID:5090"
                     /db_xref="HGNC:HGNC:8634"
                     /db_xref="MIM:176312"
     exon            1..281
                     /gene="PBX3"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1386
                     /gene="PBX3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pre-B-cell leukemia transcription factor 3; homeobox
                     protein PBX3; pre-B-cell leukemia homeobox 3"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription factor 3
                     isoform 1"
                     /protein_id="NP_006186.1"
                     /db_xref="CCDS:CCDS6865.1"
                     /db_xref="GeneID:5090"
                     /db_xref="HGNC:HGNC:8634"
                     /db_xref="MIM:176312"
                     /translation="MDDQSRMLQTLAGVNLAGHSVQGGMALPPPPHGHEGADGDGRKQ
                     DIGDILHQIMTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIRGAQEED
                     PPDPQLMRLDNMLLAEGVSGPEKGGGSAAAAAAAAASGGSSDNSIEHSDYRAKLTQIR
                     QIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLK
                     QSTCEAVMILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCS
                     ITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTP
                     NSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGL
                     GGNSLYSPHNLNANGGWQDATTPSSVTSPTEGPGSVHSDTSN"
     exon            282..355
                     /gene="PBX3"
                     /inference="alignment:Splign:2.1.0"
     exon            356..597
                     /gene="PBX3"
                     /inference="alignment:Splign:2.1.0"
     exon            598..788
                     /gene="PBX3"
                     /inference="alignment:Splign:2.1.0"
     exon            789..924
                     /gene="PBX3"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1090
                     /gene="PBX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1203
                     /gene="PBX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1293
                     /gene="PBX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..2840
                     /gene="PBX3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2814..2819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PBX3"
                     /note="hexamer: AATAAA"
     polyA_site      2840
                     /gene="PBX3"
                     /note="major polyA site"
ORIGIN      
        1 ctcctccctc gtcgccgccg ccgccgccgc cgcctcagcc ttcgcctcag ccgccgcccg
       61 ctcccgcccg cgcgcggcgg gatggacgat caatccagga tgctgcagac tctggccggg
      121 gtgaacctgg ctggccactc ggtgcagggg ggcatggccc tgccgcctcc cccgcacggc
      181 cacgaagggg cggacggcga cggcaggaag caggacatcg gcgacatcct ccaccagatc
      241 atgaccatca ccgaccagag cttggacgag gcgcaagcaa agaaacatgc cctgaactgt
      301 cacagaatga aaccagcgct cttcagcgtc ctgtgtgaga tcaaagagaa aacaggtctc
      361 agcatcagag gagcccagga ggaggaccct cccgatcccc agctaatgag actggacaat
      421 atgcttttgg cagaaggggt ttcaggtcct gagaaaggtg ggggatcggc ggcagcagct
      481 gcagccgcgg cagcctctgg aggttcttca gataactcta ttgaacactc agattacaga
      541 gccaaattga cccagatcag acaaatctat cacacagaac tggagaaata tgaacaggca
      601 tgtaatgaat ttactacaca tgtgatgaac cttctccgag aacagagtag aacacgtccc
      661 atttctccaa aagagattga aagaatggtg ggcatcatcc atcgaaaatt tagttccatt
      721 cagatgcagc tcaaacaaag cacttgtgaa gcagttatga ttttaagatc aaggttcctt
      781 gatgccagac ggaaaaggcg taacttcagt aaacaggcca cagaaatctt gaatgaatat
      841 ttttactcac acctcagcaa cccctacccc agtgaagaag ccaaagagga gctggccaag
      901 aaatgcagca tcacagtgtc acaggtatcc aattggtttg gcaacaaacg aatcaggtac
      961 aagaagaaca ttggcaagtt tcaggaagaa gccaacctct atgctgcaaa gacggccgtg
     1021 acagctgcac acgcagtagc agcagctgtg cagaacaacc agaccaattc gcccaccaca
     1081 ccaaattccg gttcttctgg ttcttttaac ctcccaaatt ctggggacat gttcatgaac
     1141 atgcagagtc tgaatgggga ttcttaccaa gggtcccaag tcggagccaa tgtgcaatca
     1201 caggtggata ccctccgtca tgttatcaat cagacgggag gctacagtga tggccttgga
     1261 ggaaattcac tgtacagtcc acataattta aatgctaatg gaggctggca ggacgcaaca
     1321 actccatctt ctgtgacttc tcctacagaa ggcccaggaa gtgtgcactc ggatacctct
     1381 aactaatctc tggccacact tttccctgag ctacatgcct tgataagtgc attcagagca
     1441 ataggaggaa aaggaaagcg tttttgtagc ccaccatcta cagctttact gtaaaacctt
     1501 gtcttattcg agaacttggt aaatctgttt tttaaggaat cataatcatt tgtatttata
     1561 cttaaaaaca cacaatgtta aaaaaaataa agcactttat ccaattaggc caagatttaa
     1621 cattgttgac agtcctgtag ctattttatc ataatttatt atcaatattt tacattaatg
     1681 gtttcacagt tgccaattac ttggccttaa gggtaaaaag tacaatatac actaaacctc
     1741 aaccgttaaa gcagatgcaa aaattcacct cacctaaatt gaacttcttg catatttcca
     1801 ttactgactt ggattgtctt tctttcatat cactaatgga gttggaataa agagctgttt
     1861 gcctatccct gttaatgatg gttgtgttta agaatcttcc tcgtcacgtt tgtgttcaga
     1921 tctcttatgt tataattaga tcagagactg gtagcatcgt ttctctctct gaaagcacca
     1981 gtgcccagag tctgctcggt aataaaatta tggatccaga ttgttctgag agacgaagat
     2041 acttgctgct gatagaggtg aaaacgagat tgatccgtct ggggttttac ggtgtgcact
     2101 gggtgctgca cagacttgtc aaggtttgct acgtcctctg ggcatctgca aaaggccctg
     2161 ctctctggag tgttgtatat agtgtagcaa aagagtattt atacatccca ccaatcaaaa
     2221 cacagcttta ttacctcatg cgaactcata caaaccaata gaatttcaac atgttctgta
     2281 gcttagagtg ctcacttact acctctgaac aatactcacg ctgtagtttg tctctttctt
     2341 atctttttgc atcttgtaat taactctttg tttcccttca taaaatgtaa tgtacattgt
     2401 aatcttttaa aagaaaaatc agggttgcac ttgcaacttt taaaaaaccg agtgtggaaa
     2461 cattgggtct taattcaaca caggatcggt aaaactgttg taaatactga gaaacatttt
     2521 gaatgttctt catcttatta ctaatccatg caaaaaaaaa aaaaaaagca gcgactaatt
     2581 gtgatgcatt cagatttcag tattcagtac tgtatatttc accctgtgta atggggcccc
     2641 ctctcctttc tctctttttg tattgtatgc gattctgaaa ctgattgagt catgaaaata
     2701 atttgtggcg gtgattctaa tgtattaaaa acgtttcgtg ttcctttcta actggattac
     2761 accctggatt gaaaaagtct tcctcgtggt agttatatgt agtttcaaac atgaataaac
     2821 tttttgcttt catgattaaa
//
