LOCUS       NM_002586               3229 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens PBX homeobox 2 (PBX2), mRNA.
ACCESSION   NM_002586
VERSION     NM_002586.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3229)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3229)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3229)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3229)
  AUTHORS   Lin,J., Zhu,H., Hong,L., Tang,W., Wang,J., Hu,H., Wu,X., Chen,Y.,
            Liu,G., Yang,Q., Li,J., Wang,Y., Lin,Z., Xiao,Y., Dai,W., Huang,M.,
            Li,G., Li,A., Wang,J., Xiang,L. and Liu,S.
  TITLE     Coexpression of HOXA6 and PBX2 promotes metastasis in gastric
            cancer
  JOURNAL   Aging (Albany NY) 13 (5), 6606-6624 (2021)
   PUBMED   33535170
  REMARK    GeneRIF: Coexpression of HOXA6 and PBX2 promotes metastasis in
            gastric cancer.
REFERENCE   5  (bases 1 to 3229)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3229)
  AUTHORS   Katsanis,N., Fitzgibbon,J. and Fisher,E.M.
  TITLE     Paralogy mapping: identification of a region in the human MHC
            triplicated onto human chromosomes 1 and 9 allows the prediction
            and isolation of novel PBX and NOTCH loci
  JOURNAL   Genomics 35 (1), 101-108 (1996)
   PUBMED   8661110
REFERENCE   7  (bases 1 to 3229)
  AUTHORS   Aguado,B. and Campbell,R.D.
  TITLE     The novel gene G17, located in the human major histocompatibility
            complex, encodes PBX2, a homeodomain-containing protein
  JOURNAL   Genomics 25 (3), 650-659 (1995)
   PUBMED   7759099
REFERENCE   8  (bases 1 to 3229)
  AUTHORS   Sugaya,K., Fukagawa,T., Matsumoto,K., Mita,K., Takahashi,E.,
            Ando,A., Inoko,H. and Ikemura,T.
  TITLE     Three genes in the human MHC class III region near the junction
            with the class II: gene for receptor of advanced glycosylation end
            products, PBX2 homeobox gene and a notch homolog, human counterpart
            of mouse mammary tumor gene int-3
  JOURNAL   Genomics 23 (2), 408-419 (1994)
   PUBMED   7835890
REFERENCE   9  (bases 1 to 3229)
  AUTHORS   Lu,Q., Wright,D.D. and Kamps,M.P.
  TITLE     Fusion with E2A converts the Pbx1 homeodomain protein into a
            constitutive transcriptional activator in human leukemias carrying
            the t(1;19) translocation
  JOURNAL   Mol Cell Biol 14 (6), 3938-3948 (1994)
   PUBMED   7910944
REFERENCE   10 (bases 1 to 3229)
  AUTHORS   Monica,K., Galili,N., Nourse,J., Saltman,D. and Cleary,M.L.
  TITLE     PBX2 and PBX3, new homeobox genes with extensive homology to the
            human proto-oncogene PBX1
  JOURNAL   Mol Cell Biol 11 (12), 6149-6157 (1991)
   PUBMED   1682799
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL662884.11, X59842.1,
            BC082261.1, DB162975.1 and BQ182713.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002586.4.
            
            Summary: This gene encodes a ubiquitously expressed member of the
            TALE/PBX homeobox family. It was identified by its similarity to a
            homeobox gene which is involved in t(1;19) translocation in acute
            pre-B-cell leukemias. This protein is a transcriptional activator
            which binds to the TLX1 promoter. The gene is located within the
            major histocompatibility complex (MHC) on chromosome 6. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X59842.1, BC082261.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375050.6/ ENSP00000364190.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AL662884.11        103014-103029       c
            17-1465             X59842.1           26-1474
            1466-2329           BC082261.1         1202-2065
            2330-2430           X59842.1           2339-2439
            2431-3017           DB162975.1         15-601
            3018-3229           BQ182713.1         19-230              c
FEATURES             Location/Qualifiers
     source          1..3229
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..3229
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /note="PBX homeobox 2"
                     /db_xref="GeneID:5089"
                     /db_xref="HGNC:HGNC:8633"
                     /db_xref="MIM:176311"
     exon            1..508
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..1580
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /note="homeobox 12; homeobox protein PBX2;
                     XXbac-BPG300A18.13; pre-B-cell leukemia homeobox 2"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription factor 2"
                     /protein_id="NP_002577.2"
                     /db_xref="CCDS:CCDS4748.1"
                     /db_xref="GeneID:5089"
                     /db_xref="HGNC:HGNC:8633"
                     /db_xref="MIM:176311"
                     /translation="MDERLLGPPPPGGGRGGLGLVSGEPGGPGEPPGGGDPGGGSGGV
                     PGGRGKQDIGDILQQIMTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSI
                     RSSQEEEPVDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGGVSPDNSIEHSD
                     YRSKLAQIRHIYHSELEKYEQACNEFTTHVMNLLREQSRTRPVAPKEMERMVSIIHRK
                     FSAIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQATEVLNEYFYSHLSNPYPSEEA
                     KEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAVKTAVSVTQGGHSRTSS
                     PTPPSSAGSGGSFNLSGSGDMFLGMPGLNGDSYSASQVESLRHSMGPGGYGDNLGGGQ
                     MYSPREMRANGSWQEAVTPSSVTSPTEGPGSVHSDTSN"
     exon            509..582
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /inference="alignment:Splign:2.1.0"
     exon            583..830
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /inference="alignment:Splign:2.1.0"
     exon            831..1021
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1157
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1311
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1400
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1487
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..3229
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2151..2156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /note="hexamer: AATAGA"
     polyA_site      2169
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /note="major polyA site"
     regulatory      3203..3208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /note="hexamer: AATAAA"
     polyA_site      3229
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /note="major polyA site"
ORIGIN      
        1 ctcctccctc ctccctctct ctcacacaca cccccgcttg ggcctcctct ctctctccgg
       61 ctccattttc tccgccgccg ggggccgggg tctcctgtgg ggggcccagc cggtatccca
      121 ggtctccctt cagtgccggg gtgaaccccc gggggagccg ggagccgggg gcagacgggc
      181 gggggttggg gcggagggag cagcggcccc agcgagtttg gggggagaag taaccaggcg
      241 gggggagggg cggagcaggg agggggcctc agggcccccc cccagctatg gacgaacggc
      301 tactggggcc gccccctcca ggcgggggcc gggggggcct gggattggtg agtggggagc
      361 ctgggggccc tggcgagcct cccggtggcg gagaccccgg tgggggtagc gggggggtcc
      421 cgggaggccg agggaagcaa gacatcgggg acattctgca gcagataatg accatcaccg
      481 accagagcct ggacgaggcc caggccaaga aacacgccct aaactgccac cgaatgaagc
      541 ctgctctctt tagcgtcctg tgtgaaatca aggagaaaac tggcctcagc attcggagct
      601 cccaggagga ggagccggtg gacccacagc tgatgcgctt ggacaacatg cttctggcag
      661 agggtgtggc tgggcccgag aaagggggcg gctcagcagc agcagctgca gccgctgcag
      721 cctctggtgg tggtgtgtcc cctgacaact ccatcgaaca ctcggactat cgcagcaaac
      781 ttgcccagat ccgtcacata taccactcgg agctggagaa gtatgagcag gcatgtaatg
      841 agttcacgac ccatgtcatg aacctgctga gggagcagag ccgcaccagg cccgtggccc
      901 ccaaagagat ggaacgcatg gtgagcatca tccatcgaaa gttcagcgcc atccagatgc
      961 agctgaagca gagcacctgc gaggctgtga tgatcctgcg ctcccgtttc ctggatgcca
     1021 gacgaaagcg ccgtaacttc agcaaacagg ccactgaggt cctaaatgag tatttctact
     1081 cccacctgag taacccatat cctagtgagg aggccaagga ggagcttgcc aagaagtgtg
     1141 gcatcaccgt gtctcaggtc tccaactggt ttggcaacaa gaggattcgc tataagaaaa
     1201 acatcggaaa gttccaagag gaggcaaaca tctatgctgt caagaccgcc gtgtcagtca
     1261 cccagggggg ccacagccgc accagctccc cgacaccccc ttcctctgca ggctctggcg
     1321 gctctttcaa tctctcagga tctggagaca tgtttctggg gatgcctggg ctcaacggag
     1381 attcctattc tgcttcccag gtggaatcac tccgacactc gatggggcca gggggctatg
     1441 gggataacct cgggggaggc cagatgtaca gcccacggga aatgagggca aatggcagct
     1501 ggcaagaggc tgtgaccccc tcttcagtga catccccaac ggagggacca gggagtgttc
     1561 actctgatac ctccaactga tcttgcccct cagggtcaca ggggtggggg ctctcacaag
     1621 gcgacttgaa gaggacgcag gcttccagag gacaaacccc aatacaggag aagcacaaga
     1681 cagagaaggg ccaatggggt catcccctcc ctaacgagac tctctgtgct gggggtgcta
     1741 attacatggc aggaagaatg gggcctctaa ggggagtgtg gggtctgtct ctcccttttt
     1801 tccatctttt tcctctctcg ctttctttct tacacagaaa catacacata ccgagaaacc
     1861 tatttctcag accccttttt ctcctctgtc tttctctctc cctctcccac acctcacaca
     1921 cacatactcc cacttgcaac tattctgttt ctctcctggg ctcccccact ttcccttccc
     1981 caccccactt gtatgctctg gaatctgtgg agacgccagc cctgcccaat cagagatgcc
     2041 aaaaatgggg acatgacttc tggacagagg acatgggcca cgcccccatg catccccacc
     2101 cccgcccctc cggacggctt acttacctca tacgcagctc atcttaaacc aatagaatcg
     2161 ctcggtggac gagagtgtct gactcagata tctacctcgg agggagtttc tgctacttta
     2221 gggaattatt gactgggctt tggggttgaa cttttttttt tttaaagaaa gaaaaagaaa
     2281 ccctgggatc catctgtttt ttttgttgtt gttgttgttt ttgttgttgt tggtggtggt
     2341 ggtggtggtg gttcttaatt tttaatttag tttggggaag tagcttgttt ttttttttat
     2401 aaatatgttg atttcttgtc tttttttttt tttatttctt actttcccat attaggggtg
     2461 atagccaaag gggttctggt aagagaaagg gggacaaaca gaactggtaa agaggccccc
     2521 ctggctccag gcctgtccat caggaagtaa attttacagg gcaccaagct ttgcccccta
     2581 aaatccctta ggtgttcttt gttcatgcag gcaggtttct gccgcatttg atgtggaggc
     2641 agtgaagggc ttgccctgct ggcctctcat cccccttctt cccacaaccc ttgggcaggg
     2701 ctggactcag taattttgag gaaattgaag atgccatctt cccctgtgag tgacatgtct
     2761 ttaatttttt aaaaaactac tatttgaaaa ttggaggggg aagaatggga agggagttat
     2821 tgccaaatat gttaaatatg ggttggggtg cttgtatatg tatcttcctc aatttcccca
     2881 taaatgaggt atctttttgt cacaccaaaa tcaaggggta gggagaggga ggaggttgca
     2941 aaaagccaga tgtgggggaa aagtaacatc aacactgtcc catcctcagc cctgaactag
     3001 ctaccatctg atcccctcag acattctcag gattttacaa gactgtcaga gtggggaacc
     3061 cctcccatta aagatccggg caggactggg gacaggttgg aagtgtgatg ggtggggggg
     3121 tgggaggcat gggccggggg cagttctctc ctcacttgta aacttgtgta gtttcacaga
     3181 aaaaaaacaa aatgcagttt taaataaaga aatttctttt ttccctggg
//
